Ganoderma lucidum spore powder tablet and preparation method thereof

Abstract

A ganoderma lucidum spore powder tablet and a preparation method thereof, the tablet comprising ganoderma lucidum spore powder and sargassum polysaccharide, the method comprising the following steps: (A) performing ultrafine-grinding the ganoderma lucidum spore powder to prepare wall-broken ganoderma lucidum spore powder; (B) weighing the wall-broken ganoderma lucidum spore powder and sargassum polysaccharide in proportion; (C) mixing the materials; and (D) performing granulating, sieving, drying, and tableting.

Description

Ganoderma lucidum spore powder tablet and preparation method thereof Technical Field

[0001] The present invention relates to the field of health-care foods, and in particular to a ganoderma lucidum spore powder tablet and a preparation method thereof. Background Art

[0002] Lingzhi, often called "immortal grass" or "immortal ganoderma," is a precious medicinal herb known for its nourishing properties, strengthening the body, invigorating qi and calming the mind, and prolonging life. Lingzhi spores, the essence of Lingzhi, are the seeds released during its maturation phase. They are the reproductive cells of Lingzhi and contain all of its genetically active substances. Their pharmacological effects include anti-tumor, immune regulation, lipid regulation, and modulating and improving the nervous, cardiovascular, and respiratory systems. Lingzhi spore powder, a brown powder released during maturation, is rich in polysaccharides, organic germanium, peptides, triterpenes, and sterols. It effectively prevents tumor development and significantly inhibits telomerase activity in tumor cells, inhibiting tumor cell growth. When used in conjunction with tumor treatment, it can mitigate the effects of radiotherapy or chemotherapy. It can enhance cellular immunity, thereby boosting the body's own immune system and delaying aging. It also has a role as an adjunct therapeutic for chronic conditions such as hepatitis, cardiovascular disease, leukopenia, muscular dystrophy, neurasthenia, bronchitis, and asthma. Lingzhi spore powder is gaining increasing attention for its medicinal value. Currently, Ganoderma lucidum spore powder-related products on the market are mainly in the form of powders, granules, capsules and other dosage forms. Tablets are relatively rare. Tablets can solve the problems of powder easily absorbing moisture and degenerating, affecting product quality, and easily sticking to the surface of containers or packaging. Tablets are also easy to carry and eat.

[0003] Because Ganoderma lucidum spore powder is rich in oil and fiber, and has a small particle size, low mass, relatively light weight, high toughness, and high oil content, tablets containing Ganoderma lucidum spore powder at least 50% are difficult to compress into tablets, resulting in loose tablets and substandard hardness and brittleness. CN100508956C discloses Ganoderma lucidum spore powder tablets and a preparation method thereof, wherein Ganoderma lucidum spore powder accounts for less than 30% of the Ganoderma lucidum spore powder formulation; CN104719874 A discloses a Ganoderma lucidum full-ingredient mixed chewable tablet and a preparation method thereof, wherein 50%-80% Ganoderma lucidum fruiting body ultrafine powder, 10%-30% β-cyclodextrin, 5%-10% magnesium stearate, 5%-10% xylitol, and 5% low-substituted hydroxypropyl cellulose are mixed and the mixed powder is compressed into tablets. Although cyclodextrin treatment is used, the maximum content of Ganoderma lucidum spore powder is 30%. A higher content will cause problems such as low tablet hardness and high brittleness. CN 108464497 A discloses a Dendrobium officinale and Ganoderma lucidum spore powder tablet based on a new process. The tablet is composed of Dendrobium officinale, Ganoderma lucidum spore powder, lactitol and magnesium stearate. The tablet is made by secondary crushing Dendrobium officinale into ultrafine powder, mixing it with Ganoderma lucidum spore powder in proportion, and then supplementing it with lactitol and magnesium stearate. It does not require complex and energy-consuming processes such as soft material preparation, granulation, drying, and granulation, and can be directly tableted. However, the proportion of Ganoderma lucidum spore powder in the tablet formula is less than 40%.

[0004] Summary of the Invention

[0005] The object of the present invention is to provide a high-content ganoderma lucidum spore powder tablet, which is brown and has appropriate hardness and friability.

[0006] Another object of the present invention is to provide a preparation process of the Ganoderma lucidum spore powder tablets.

[0007] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0008] A ganoderma lucidum spore powder tablet comprises ganoderma lucidum spore powder and sargassum polysaccharide.

[0009] Preferably, it comprises the following components and weight ratios:

[0010] Ganoderma lucidum spore powder 40-160;

[0011] Sargassum polysaccharide 40-160.

[0012] Preferably, it comprises the following components and weight ratios:

[0013] Ganoderma lucidum spore powder 80-120;

[0014] Sargassum polysaccharide 60-80.

[0015] Preferably, water is also included.

[0016] Preferably, the water content of the Ganoderma lucidum spore powder tablet is 2% to 6%.

[0017] A method for preparing the above-mentioned Ganoderma lucidum spore powder tablet comprises the following steps:

[0018] A. Taking Ganoderma lucidum spore powder as raw material, performing ultrafine grinding to prepare wall-broken Ganoderma lucidum spore powder;

[0019] B. weighing the broken-wall Ganoderma lucidum spore powder and the Sargassum polysaccharide according to proportion;

[0020] C. adding the Sargassum polysaccharide to the broken-wall Ganoderma lucidum spore powder to obtain a mixed material;

[0021] D. granulating, sieving, drying and tableting the mixture to obtain the Ganoderma lucidum spore powder tablets.

[0022] Preferably, in step A, the wall-breaking rate of the broken Ganoderma lucidum spore powder is greater than 99%.

[0023] Unbroken spores or low spore breaking rate have little effect on the tablet preparation process, but will affect the absorption of Ganoderma lucidum spore polysaccharides in the body. Therefore, Ganoderma lucidum spore powder with a spore breaking rate greater than 99% is preferably used to prepare tablets.

[0024] Preferably, in step C, the granules are granulated with purified water, passed through a 20-mesh sieve, and dried at a temperature of 30-60°C.

[0025] Preferably, in step C, the mixture further comprises microcrystalline cellulose, sorbitol, and maltodextrin.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] (1) The present invention solves the problem of Ganoderma lucidum spore powder being difficult to take in the form of granules and powders in the current medical field, and the tablets have the advantages of being easy to swallow and carry. The tablets are of stable quality and easy to carry and take.

[0028] (2) Since Ganoderma lucidum spore powder has a high oil content, is light in weight and has a small particle size, the higher the content of Ganoderma lucidum spore powder in the tablet, the worse the formability of the preparation. The present invention adopts a specific excipient as a binder to improve the powder properties of Ganoderma lucidum spore powder. After increasing the content of Ganoderma lucidum spore powder, the surface of the Ganoderma lucidum spore powder tablets obtained has a smooth and complete surface, and the hardness and friability indexes are both qualified. By converting the amount of Ganoderma lucidum spore powder taken daily, taking the tablets of the present invention can reduce the number of tablets and the frequency of daily administration, thereby improving the convenience of administration. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 is the appearance of sample ① of effect example 1;

[0030] Figure 2 is the appearance of sample ② of effect example 1;

[0031] Figure 3 is the appearance of sample ③ of effect example 1;

[0032] Figure 4 is the appearance of sample ④ of effect example 1;

[0033] FIG5 is an appearance diagram of the sample product of Comparative Example 1;

[0034] FIG6 is an appearance diagram of the sample product of Comparative Example 2;

[0035] FIG7 is an appearance diagram of the sample product of Comparative Example 3;

[0036] FIG8 is an appearance diagram of the sample product of Comparative Example 4;

[0037] FIG9 is an appearance diagram of the sample product of Comparative Example 5;

[0038] FIG10 is an appearance diagram of the sample product of Comparative Example 6;

[0039] FIG11 is an appearance diagram of the sample product of Comparative Example 7;

[0040] FIG12 is an appearance diagram of the sample product of Comparative Example 8. DETAILED DESCRIPTION

[0041] In order to make the objectives, technical solutions and advantages of the present invention more clear, the present invention will be described in further detail below with reference to the accompanying drawings.

[0042] Example 1

[0043] A ganoderma lucidum spore powder tablet comprises 120 parts of broken-wall ganoderma lucidum spore powder and 80 parts of sargassum polysaccharide, and is specifically prepared by the following method:

[0044] Take Ganoderma lucidum spore powder and perform ultrafine grinding to achieve a wall-breaking rate of greater than 99%. Take the wall-broken Ganoderma lucidum spore powder, add Sargassum polysaccharide, pass through a 20-mesh sieve, and dry at 30-60°C. Press the dried mixture into tablets and test the hardness and friability. The specific steps are as follows:

[0045] ①Total mixing: weigh the above materials according to the formula and mix until the material has uniform color and texture.

[0046] ② Granulation: Add water to the mixed powder, knead with water until it forms a ball that can be easily crushed and dispersed by light pressure, pass through a 20-mesh sieve, and dry to a moisture content of 2%-6%.

[0047] ③ Tablet pressing: Use a tablet press to press the tablets, adjust the filling amount and pressure to make the tablet weight meet the requirements, adjust the appropriate speed, and set the tablet weight to 0.5g / tablet.

[0048] Table 1 Experimental results of Example 1

[0049] The tablet weights of the obtained tablets were stable. The batch with 80g of Sargassum polysaccharide added had good appearance, hardness and friability. The hardness of this batch was greater than 4.7, the weight loss of friability was 0%, there were no cracks, fragments or fallen edges, and the tablet weights were within the deviation range, meeting the tablet requirements.

[0050] Example 2

[0051] A ganoderma lucidum spore powder tablet comprises 100 parts of ganoderma lucidum spore powder and 100 parts of sargassum polysaccharide, and is specifically prepared by the following method:

[0052] Take Ganoderma lucidum spore powder and perform ultrafine grinding to achieve a wall-breaking rate of greater than 99%. Take the broken wall Ganoderma lucidum spore powder, add Sargassum polysaccharide, pass through a 20-mesh sieve, and dry it. The dried mixture is pressed into tablets and tested for hardness and friability. The specific steps are as follows:

[0053] ①Total mixing: weigh the above materials according to the formula and mix until the material has uniform color and texture.

[0054] ② Granulation: Add water to the mixed powder, knead with water until it forms a ball that can be easily crushed and dispersed by light pressure, pass through a 20-mesh sieve, and dry at 30-60℃ to a moisture content of 2%-6%.

[0055] ③ Tablet pressing: Use a tablet press to press the tablets, adjust the filling amount and pressure to make the tablet weight meet the requirements, adjust the appropriate speed, and set the tablet weight to 0.5g / tablet.

[0056] Table 2: Example 2 test results

[0057] The tablet weights of the obtained tablets were stable. The batch with 80g of Sargassum polysaccharide added had good appearance, hardness and friability. The hardness of this batch was greater than 4.7, the weight loss of friability was 0%, there were no cracks, fragments or fallen edges, and the tablet weights were within the deviation range, meeting the tablet requirements.

[0058] Example 3

[0059] A ganoderma lucidum spore powder tablet comprises 120 parts of ganoderma lucidum spore powder, 60 parts of sargassum polysaccharide, 5 parts of microcrystalline cellulose, 10 parts of sorbitol, and 5 parts of maltodextrin, and is specifically prepared by the following method:

[0060] Take Ganoderma lucidum spore powder and perform ultrafine grinding to achieve a cell wall breaking rate of greater than 99%. Take the broken cell wall Ganoderma lucidum spore powder and sequentially add Sargassum polysaccharide, microcrystalline cellulose, sorbitol, and maltodextrin. Add purified water to granulate, pass through a 20-mesh sieve, and dry. The dried mixture is pressed into tablets and tested for hardness and friability. The specific steps are as follows:

[0061] ①Total mixing: weigh the above materials according to the formula and mix until the material has uniform color and texture.

[0062] ② Granulation: Add water to the mixed powder, knead with water until it forms a ball that can be easily crushed and dispersed by light pressure, pass through a 20-mesh sieve, and dry at 30-60℃ to a moisture content of 2%-6%.

[0063] ③ Tablet pressing: Use a tablet press to press the tablets, adjust the filling amount and pressure to make the tablet weight meet the requirements, adjust the appropriate speed, and set the tablet weight to 0.5g / tablet.

[0064] Table 3 Experimental results of Example 3

[0065] The batches with added Sargassum polysaccharide were good in appearance, hardness and friability. The hardness of the batches with added Sargassum polysaccharide was greater than 2.5, the friability was below 0.5%, there were no cracks, fragments or fallen edges, the tablet weight was within the deviation range, and all met the tablet requirements.

[0066] Example 4

[0067] A ganoderma lucidum spore powder tablet comprises 80 parts of ganoderma lucidum spore powder, 60 parts of sargassum polysaccharide, 5 parts of microcrystalline cellulose, 10 parts of sorbitol, and 5 parts of maltodextrin, and is specifically prepared by the following method:

[0068] Take Ganoderma lucidum spore powder and perform ultrafine grinding to achieve a cell wall breaking rate of greater than 99%. Take the broken cell wall Ganoderma lucidum spore powder and sequentially add Sargassum polysaccharide, microcrystalline cellulose, sorbitol, and maltodextrin. Add purified water to granulate, pass through a 20-mesh sieve, and dry. The dried mixture is pressed into tablets and tested for hardness and friability. The specific steps are as follows:

[0069] ①Total mixing: weigh the above materials according to the formula and mix until the material has uniform color and texture.

[0070] ② Granulation: Add water to the mixed powder, knead with water until it forms a ball that can be easily crushed and dispersed by light pressure, pass through a 20-mesh sieve, and dry at 30-60℃ to a moisture content of 2%-6%.

[0071] ③ Tablet pressing: Use a tablet press to press the tablets, adjust the filling amount and pressure to make the tablet weight meet the requirements, adjust the appropriate speed, and set the tablet weight to 0.5g / tablet.

[0072] Table 4 Experimental results of Example 4

[0073] The batches with added Sargassum polysaccharide were good in appearance, hardness and friability. The hardness of the batches with added Sargassum polysaccharide was greater than 2.5, the friability was below 0.5%, there were no cracks, fragments or fallen edges, the tablet weight was within the deviation range, and all met the tablet requirements.

[0074] Effect Example 1

[0075] Ganoderma lucidum spore powder is ultrafinely ground to a wall breaking rate of more than 99%. The types and amounts of auxiliary materials such as Sargassum polysaccharide, microcrystalline cellulose, sorbitol, and maltodextrin are screened using Ganoderma lucidum spore powder as raw material.

[0076] Table 5 Effect Example 1 Prescription

[0077] Manufacturing process:

[0078] ①Total mixing: weigh the above materials according to the formula and mix until the material has uniform color and texture.

[0079] ② Granulation: Add water to the mixed powder, knead with water until it forms a ball that can be easily crushed and dispersed by light pressure, pass through a 20-mesh sieve, and dry at 30-60℃ until the moisture content is below 5%.

[0080] Tablet pressing: Use a tablet press to press the tablets, adjust the filling amount and pressure to make the tablet weight meet the requirements, adjust the appropriate speed, and set the tablet weight to 0.5g / tablet.

[0081] Table 6 Appearance of Tablets of Effect Example 1

[0082] Table 7 Effect Example 1 Tablet Index

[0083] From Table 6, Table 7 and Figures 1 to 4, it can be seen that the tablet weights of the obtained tablets are stable. The surface of the tablets made from the samples with added microcrystalline cellulose is not very smooth, there is a lot of broken powder, and the hardness is not enough. The surface of the tablets made from the samples with added sorbitol and maltodextrin is relatively smooth, but the tablet weight varies greatly, the product is relatively unstable, and the hardness is low. The batch with an addition of 80g of Sargassum polysaccharide has good appearance, hardness, and friability. The hardness of this batch is greater than 4.7, the weight loss of friability accounts for 0%, there are no cracks, fragments, or falling edges, and the tablet weight is within the deviation range, which meets the requirements. The reproducibility of various indicators is good and all meet the requirements of the quality standards, indicating that this molding process is stable and reliable.

[0084] Comparative Example 1

[0085] prescription:

[0086] Manufacturing process:

[0087] Ganoderma lucidum spore powder is ultrafinely ground to a wall-breaking rate of greater than 99%. Fucoidan, microcrystalline cellulose, sorbitol, and maltodextrin are sequentially added to the wall-broken Ganoderma lucidum spore powder, and purified water is added to granulate the granules. The granules are passed through a 20-mesh sieve and dried at 30-60° C. to a moisture content of 2%-6%. The dried mixture is then tableted.

[0088] Comparative Example 2

[0089] prescription:

[0090] Manufacturing process:

[0091] Ganoderma lucidum spore powder is ultrafinely ground to a wall-breaking rate of greater than 99%. Pullulan, microcrystalline cellulose, sorbitol, and maltodextrin are sequentially added to the wall-broken Ganoderma lucidum spore powder, and purified water is added to granulate the powder. The powder is passed through a 20-mesh sieve and dried at 30-60° C. to a moisture content of 2%-6%. The dried mixture is then tableted.

[0092] Comparative Example 3

[0093] prescription:

[0094] Manufacturing process:

[0095] Ganoderma lucidum spore powder is ultrafinely ground to a wall-breaking rate of greater than 99%. Ganoderma lucidum polysaccharide extract, microcrystalline cellulose, sorbitol, and maltodextrin are sequentially added to the wall-broken Ganoderma lucidum spore powder, and purified water is added to granulate the granules. The granules are passed through a 20-mesh sieve and dried at 30-60° C. to a moisture content of 2%-6%. The dried mixture is then tableted.

[0096] Comparative Example 4

[0097] prescription:

[0098] Manufacturing process:

[0099] Ganoderma lucidum spore powder is ultrafinely ground to a wall-breaking rate of greater than 99%. A composite thickener, microcrystalline cellulose, sorbitol, and maltodextrin are sequentially added to the wall-broken Ganoderma lucidum spore powder, and purified water is added to granulate the powder. The powder is passed through a 20-mesh sieve and dried at 30-60° C. to a moisture content of 2%-6%. The dried mixture is then tableted.

[0100] Comparative Example 5

[0101] prescription:

[0102] Manufacturing process:

[0103] Ganoderma lucidum spore powder is ultrafinely ground to a wall-breaking rate of greater than 99%. Xuancha papaya polysaccharide, microcrystalline cellulose, sorbitol, and maltodextrin are sequentially added to the wall-broken Ganoderma lucidum spore powder, and purified water is added to granulate the granules. The granules are passed through a 20-mesh sieve and dried at 30-60° C. to a moisture content of 2%-6%. The dried mixture is then tableted.

[0104] Comparative Example 6

[0105] prescription:

[0106] Ganoderma lucidum spore powder 120g

[0107] Fucoidan 60g

[0108] Manufacturing process:

[0109] Ganoderma lucidum spore powder is ultrafinely ground to a wall-breaking rate of greater than 99%. Fucoidan and purified water are added to the wall-breaking Ganoderma lucidum spore powder, granulated, passed through a 20-mesh sieve, and dried at 30-60° C. to a moisture content of 2%-6%. The dried mixture is tableted.

[0110] Comparative Example 7

[0111] prescription:

[0112] Ganoderma lucidum spore powder 120g

[0113] Pullulan 60g

[0114] Manufacturing process:

[0115] Ganoderma lucidum spore powder is ultrafinely ground to a wall-breaking rate of greater than 99%. Pullulan and purified water are sequentially added to the wall-broken Ganoderma lucidum spore powder to prepare granules, the granules are passed through a 20-mesh sieve, and the granules are dried at 30-60° C. to a moisture content of 2%-6%. The dried mixture is then tableted.

[0116] Comparative Example 8

[0117] prescription:

[0118] Ganoderma lucidum spore powder 120g

[0119] Xuan papaya polysaccharide 60g

[0120] Manufacturing process:

[0121] The spore powder of Ganoderma lucidum is ultrafinely pulverized to a wall-breaking rate of more than 99%. The broken spore powder of Ganoderma lucidum is sequentially added with Xuancha papaya polysaccharide and purified water to granulate, passed through a 20-mesh sieve, and dried at 30-60° C. to a moisture content of 2%-6%, and the dried mixture is tableted.

[0122] Effect Example 2

[0123] The tablets obtained in Comparative Examples 1-8 are shown in Figures 5 to 12, and the specific comparison is as follows:

[0124] Table 8 Appearance and tablet indicators of comparative examples 1 to 8

[0125] It can be seen that the samples with the compound thickener as the binder were loose and could not be tableted, while the samples with the Ganoderma lucidum polysaccharide extract as the binder had loose and cracked tablets. The addition of polysaccharides other than Sargassum polysaccharides, such as fucoidan, pullulan, and papaya polysaccharide, made it difficult to directly tablet and suffered from severe powder loss. The tableting effect after further adding the compound thickener was also unsatisfactory, with appearance, hardness, friability, and other indicators all inferior to the batch using Sargassum polysaccharide in the examples.

[0126] The invention solves the problem that ganoderma lucidum spore powder is rich in oil and fiber, but is difficult to compress into tablets because the spore powder has small particle size, small weight, relatively light weight, high toughness and high oil content.

[0127] The above disclosure is merely a preferred embodiment of the present invention and is not intended to limit the scope of the present invention. Therefore, equivalent changes made according to the claims of the present invention are still within the scope of the present invention.

Claims

1. A Ganoderma lucidum spore powder tablet, characterized in that: Including Ganoderma lucidum spore powder and Sargassum polysaccharide.

2. The Ganoderma lucidum spore powder tablet according to claim 1, characterized in that: The composition and weight ratio are as follows: Ganoderma lucidum spore powder 40-160; Sargassum polysaccharide 40-160.

3. The Ganoderma lucidum spore powder tablet according to claim 1, characterized in that: The composition and weight ratio are as follows: Ganoderma lucidum spore powder 80-120; Sargassum polysaccharide 60-80.

4. The Ganoderma lucidum spore powder tablet according to claim 1, characterized in that: Also includes water.

5. The Ganoderma lucidum spore powder tablet according to claim 1, characterized in that: The water content of the ganoderma lucidum spore powder tablet is 2% to 6%.

6. A method for preparing the Ganoderma lucidum spore powder tablet according to claim 1, characterized in that: The steps include: A. Taking ganoderma lucidum spore powder as raw material, ultrafine grinding is performed to prepare wall-broken ganoderma lucidum spore powder; B. weighing the broken-wall Ganoderma lucidum spore powder and the Sargassum polysaccharide according to proportion; C. adding the Sargassum polysaccharide to the broken-wall Ganoderma lucidum spore powder to obtain a mixed material; D. granulating, sieving, drying and tableting the mixture to obtain the Ganoderma lucidum spore powder tablets.

7. The method for preparing the Ganoderma lucidum spore powder tablet according to claim 6, characterized in that: In step A, the wall-breaking rate of the broken spore powder of Ganoderma lucidum is greater than 99%.

8. The method for preparing the Ganoderma lucidum spore powder tablet according to claim 6, characterized in that: In step C, granulation is performed with purified water, passed through a 20-mesh sieve, and the drying temperature is 30-60°C.

9. The method for preparing the Ganoderma lucidum spore powder tablet according to claim 6, characterized in that: In step C, the mixed material further includes microcrystalline cellulose, sorbitol and maltodextrin.

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