Functional ceramic polymer active ingredient composite containing microcurrent self-generation material, skin patch using same, manufacturing method therefor, and use method therefor

Abstract

A functional ceramic polymer active ingredient composite containing a microcurrent self-generation material, a skin patch using same, a manufacturing method therefor, and a use method therefor are provided. The functional ceramic polymer active ingredient composite can be prepared through: a first stirring step of stirring a solvent and a formulation material for composite production, thereby forming a fluid liquid formulation material; a second stirring step of forming a ceramic polymer composite by stirring the liquid formulation material and a ceramic powder, which produces energy; and a third stirring step of stirring the ceramic polymer composite and an active ingredient material.

Description

A functional ceramic polymer active ingredient complex containing its own microcurrent generating material, a skin patch using the same, a method for manufacturing the same, and a method for using the same

[0001] The present application relates to a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material, a skin patch using the same, a method for manufacturing the same, and a method for using the same. More specifically, the present application relates to a functional ceramic polymer active ingredient complex manufactured through a first stirring step of stirring a formulation material and a solvent for forming a complex to form a liquid formulation material having fluidity, a second stirring step of stirring the liquid formulation material and a ceramic powder generating energy to form a ceramic polymer complex, and a third stirring step of stirring the ceramic polymer complex and the active ingredient material.

[0002]

[0003] Human skin performs various functions such as protecting the body, regulating body temperature, perceiving, absorbing, secreting, and transmitting emotions. However, human skin changes over time due to various internal and external factors.

[0004] That is, internally, the secretion of various hormones that regulate metabolism decreases, the function of immune cells and the activity of cells decrease, which reduces the biosynthesis of immune proteins and biological components necessary for the body. Externally, as the content of ultraviolet rays in sunlight increases due to the destruction of the ozone layer and environmental pollution worsens, free radicals and reactive harmful oxygen species increase, which causes various changes such as an increase in wrinkles on the skin overall, a decrease in skin elasticity, and an increase in blemishes, freckles, and liver spots. In particular, the skin aging process occurs due to loss of skin elasticity and flexibility, a decrease in skin moisture content, and a decrease in skin regenerative power.

[0005] Accordingly, much research is being conducted on methods and materials that can prevent and improve such skin damage and aging phenomena, and in particular, much research has been conducted on skin and transdermal absorption formulations as formulations for continuously applying and attaching skin-beneficial ingredients to the skin.

[0006] These formulations include, for example, cosmetic packs or mask packs, cataplasma, patches, aerosols, lotions, ointments, creams, and liquids, but among these, a patch-type formulation in which skin-beneficial ingredients and adhesive ingredients are placed on a support and attached to the skin is frequently used.

[0007] However, conventional patch formulations had a problem in that the active ingredients contained in the patch did not penetrate deep into the skin when applied to the skin.

[0008]

[0009] The technical problem to be solved by the present application is to provide a functional ceramic polymer active ingredient complex manufactured by a method for manufacturing a functional ceramic polymer active ingredient complex, which method includes a first stirring step of forming a liquid formulation material having fluidity by stirring a formulation material and a solvent for forming a complex, a second stirring step of forming a ceramic polymer complex by stirring the liquid formulation material and a ceramic powder that generates energy, and a third stirring step of stirring the ceramic polymer complex and an active ingredient material.

[0010] Another technical problem to be solved by the present application is to provide a functional ceramic polymer active ingredient complex, wherein the liquid formulation material includes at least one of purified water, glycerin, niacinamide, methylpropanediol, shea butter, 1,2-hexanediol, Irish moss extract, carob gum, glucomannan, PEG-60 hydrogenated castor oil, xanthan gum, disodium EDTA, dextrin, adenosine, sodium hyaluronate, and a fragrance.

[0011] Another technical problem to be solved by the present application is to provide a functional ceramic polymer active ingredient complex including at least one matrix material capable of containing particles of the ceramic powder, such as a nonwoven fabric, a polyurethane film, a silk fabric, a hydrogel, a nanocellulose + hydrogel, a hydrocolloid, a biodegradable polymer, a polymer, silicone, a carbohydrate, polyethylene glycol, a natural polymer seaweed, silicone, polyacrylic acid, polyvinyl alcohol, polyvinylpyrrolidone, polyacrylamide, polyethylene oxide, a hydrogel, a cellulose, a silk material series polyamide, PDMS (polydimethylsiloxane), PVDF (polyvinylidene fluoride), etc.

[0012] Another technical problem to be solved by the present application is to provide a functional ceramic polymer active ingredient complex, wherein the ceramic powder includes a piezoelectric powder having a piezoelectric effect, and the piezoelectric powder is added in an amount of 0.4 wt% to 20 wt% based on the weight of the liquid formulation material.

[0013] Another technical problem to be solved by the present application is to provide a functional ceramic polymer active ingredient complex, wherein the ceramic powder includes a conductive powder, and the conductive powder is added in an amount of 0.1 wt% to 10 wt% based on the weight of the liquid formulation material.

[0014] Another technical problem to be solved by the present application is to provide a functional ceramic polymer active ingredient complex, wherein the solvent includes mineral water, and the mineral water includes 4 to 230 ppm of potassium, 700 to 9,500 ppm of sodium, 300 to 1,700 ppm of calcium, and 20 to 1,100 ppm of magnesium, and is mixed in a ratio of 20 wt% to 80 wt% based on the total weight of the functional ceramic polymer active ingredient complex.

[0015] Another technical problem to be solved by the present application is to provide a functional ceramic polymer active ingredient composite, which includes the active ingredient material mixed in a ratio of 0.04 wt% to 25 wt% based on the weight of the ceramic polymer composite.

[0016] Another technical problem to be solved by the present application is to provide a skin patch including a functional ceramic polymer active ingredient complex manufactured by a method for manufacturing a functional ceramic polymer active ingredient complex, the method including a first stirring step of forming a liquid formulation material having fluidity by stirring a formulation material and a solvent for forming a complex, a second stirring step of forming a ceramic polymer complex by stirring the liquid formulation material and a ceramic powder that generates energy, and a third stirring step of adding an active ingredient material to the ceramic polymer complex and stirring.

[0017] Another technical problem to be solved by the present application is to provide a method of using a skin patch including a functional ceramic polymer active ingredient complex manufactured by a method for manufacturing a functional ceramic polymer active ingredient complex, the method including a first stirring step of forming a liquid formulation material having fluidity by stirring a formulation material and a solvent for forming a complex, a second stirring step of forming a ceramic polymer complex by stirring the liquid formulation material and a ceramic powder that generates energy, and a third stirring step of adding an active ingredient material to the ceramic polymer complex and stirring.

[0018] Another technical problem to be solved by the present application is to provide a piezoelectric sensor including a functional ceramic polymer active ingredient complex manufactured by a method for manufacturing a functional ceramic polymer active ingredient complex, the method including a first stirring step of forming a liquid formulation material having fluidity by stirring a formulation material and a solvent for forming a complex, a second stirring step of forming a ceramic polymer complex by stirring the liquid formulation material and a ceramic powder that generates energy, and a third stirring step of adding an active ingredient material to the ceramic polymer complex and stirring.

[0019] Another technical problem to be solved by the present application is to provide an energy harvester including a functional ceramic polymer active ingredient complex manufactured by a method for manufacturing a functional ceramic polymer active ingredient complex, the method including a first stirring step of forming a liquid formulation material having fluidity by stirring a formulation material and a solvent for forming a complex, a second stirring step of forming a ceramic polymer complex by stirring the liquid formulation material and a ceramic powder that generates energy, and a third stirring step of adding an active ingredient material to the ceramic polymer complex and stirring.

[0020] The technical problems that this application seeks to solve are not limited to those described above.

[0021]

[0022] To solve the above technical problem, the present application provides a functional ceramic polymer active ingredient composite.

[0023] According to one embodiment, the functional ceramic polymer active ingredient complex may be manufactured through a first stirring step of stirring a formulation material and a solvent for forming a complex to form a liquid formulation material having fluidity, a second stirring step of stirring the liquid formulation material and a ceramic powder that generates energy to form a ceramic polymer composite, and a third stirring step of adding an active ingredient material to the ceramic polymer composite and stirring.

[0024] According to one embodiment, the ceramic powder may include a piezoelectric powder having a piezoelectric effect, and the piezoelectric powder may be included in an amount of 0.4 wt% to 20 wt% based on the weight of the liquid formulation material.

[0025] According to one embodiment, the ceramic powder may include a conductive powder, and the conductive powder may be added in an amount of 0.1 wt% to 10 wt% based on the weight of the liquid formulation material.

[0026] According to one embodiment, the solvent may include mineral water, wherein the mineral water includes 4 to 230 ppm of potassium, 700 to 9,500 ppm of sodium, 300 to 1,700 ppm of calcium, and 20 to 1,100 ppm of magnesium, and may be mixed in a ratio of 20 wt% to 80 wt% based on the total weight of the functional ceramic polymer active ingredient complex.

[0027] According to one embodiment, the active ingredient material may be mixed in a ratio of 0.04 wt% to 25 wt% based on the weight of the ceramic polymer composite.

[0028] To solve the above technical problem, the present application provides a skin patch.

[0029] According to one embodiment, the skin patch includes the functional ceramic polymer active ingredient complex, and the functional ceramic polymer active ingredient complex may include a functional ceramic polymer active ingredient complex manufactured through a first stirring step of stirring a formulation material and a solvent for forming a complex to form a liquid formulation material having fluidity, a second stirring step of stirring the liquid formulation material and a ceramic powder that generates energy to form a ceramic polymer complex, and a third stirring step of adding an active ingredient material to the ceramic polymer complex and stirring.

[0030] To solve the above technical problem, the present application provides a piezoelectric sensor.

[0031] According to one embodiment, the piezoelectric sensor includes the functional ceramic polymer active ingredient complex, and the functional ceramic polymer active ingredient complex may include a functional ceramic polymer active ingredient complex manufactured through a first stirring step of stirring a formulation material and a solvent for forming a complex to form a liquid formulation material having fluidity, a second stirring step of stirring the liquid formulation material and a ceramic powder that generates energy to form a ceramic polymer complex, and a third stirring step of adding an active ingredient material to the ceramic polymer complex and stirring.

[0032] To solve the above technical problem, the present application provides an energy harvester.

[0033] According to one embodiment, the energy harvester includes the functional ceramic polymer active ingredient complex, and the functional ceramic polymer active ingredient complex may include a functional ceramic polymer active ingredient complex manufactured through a first stirring step of stirring a formulation material and a solvent for forming a complex to form a liquid formulation material having fluidity, a second stirring step of stirring the liquid formulation material and a ceramic powder that generates energy to form a ceramic polymer complex, and a third stirring step of adding an active ingredient material to the ceramic polymer complex and stirring.

[0034]

[0035] According to a method for manufacturing a functional ceramic polymer active ingredient complex according to an embodiment of the present application, the method may include a first stirring step of stirring a formulation material and a solvent for forming a complex to form a liquid formulation material having fluidity, a second stirring step of stirring the liquid formulation material and a ceramic powder that generates energy to form a ceramic polymer composite, and a third stirring step of adding an active ingredient to the ceramic polymer composite and stirring. Accordingly, energy (microcurrent and voltage) can be generated through the combined or individual effects of the piezoelectric effect, the bending effect, the triboelectric effect due to friction, the thermoelectric effect, and the photovoltaic effect, and thus it can be used as a sensor or an energy production harvester (generator), or it can be applied to skin patch products such as cosmetic and therapeutic packs or patches using the generated microcurrent and voltage, and the generated energy can provide a more effective function for the absorption and delivery of the active ingredient material or the skin improvement active ingredient material to the human body (skin).

[0036] In addition, the present invention is an application technology for manufacturing a composite of a ceramic powder having piezoelectric, high-dielectric, thermoelectric and photoelectric effects and a functional polymer material, and for applying it to a sensor and an energy production harvester using the energy generation effect, and for applying it to a cosmetic and therapeutic patch for skin care and wrinkle improvement by adding an effective ingredient (sterilization, fragrance, moisturizing, etc.). Each function and effect can be further improved through the energy (microcurrent and voltage) generated by the functional ceramic polymer effective ingredient complex itself.

[0037]

[0038] FIG. 1 is a flowchart illustrating a method for manufacturing a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to an embodiment of the present application.

[0039] FIG. 2 is a flowchart illustrating a method for manufacturing a skin patch using a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to an embodiment of the present application.

[0040] FIG. 3 is a drawing for explaining a skin patch to which a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to an embodiment of the present application is applied.

[0041] FIG. 4 is a drawing for explaining a skin patch to which a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to a first modified example of the present application is applied.

[0042] FIG. 5 is a cross-sectional view illustrating microneedles of a skin patch to which a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to a first modified example of the present application is applied.

[0043] FIG. 6 is a drawing for explaining a skin patch to which a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to a second modified example of the present application is applied.

[0044] FIG. 7 is a drawing for explaining a skin patch to which a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to an experimental example and a comparative example of the present application is applied.

[0045] Figure 8 is a graph for explaining the viscosity according to the weight ratio of mineral water contained in a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to an experimental example of the present application.

[0046] Figure 9 is a graph for explaining the change in piezoelectric constant according to the pressing force of a skin patch to which a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to an experimental example of the present application is applied.

[0047]

[0048] Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the attached drawings. However, the technical concept of the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, the embodiments introduced herein are provided to ensure that the disclosed content is thorough and complete and to sufficiently convey the spirit of the present invention to those skilled in the art.

[0049] Also, although terms such as first, second, and third have been used to describe various components in various embodiments of this specification, these components should not be limited by these terms. These terms are only used to distinguish one component from another. Thus, what is referred to as a first component in one embodiment may be referred to as a second component in another embodiment. Each embodiment described and illustrated herein also includes its complementary embodiments. Also, the term "and / or" has been used herein to mean including at least one of the components listed before and after.

[0050] In the specification, singular expressions include plural expressions unless the context clearly dictates otherwise. In addition, terms such as "comprise" or "have" are intended to indicate the presence of a feature, number, step, component, or combination thereof described in the specification, and should not be construed as excluding the possibility of the presence or addition of one or more other features, numbers, steps, components, or combinations thereof. In addition, in the following description of the present invention, if a detailed description of a related known function or configuration is determined to unnecessarily obscure the gist of the present invention, the detailed description thereof will be omitted.

[0051]

[0052] FIG. 1 is a flowchart illustrating a method for manufacturing a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to an embodiment of the present application.

[0053] Referring to FIG. 1, a method for manufacturing a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to an embodiment of the present application may include a first stirring step (S100) of forming a liquid formulation material, a second stirring step (S200) of forming a ceramic polymer complex, and a third stirring step (S300) of forming a functional ceramic polymer active ingredient complex.

[0054] A liquid formulation material with fluidity is formed by stirring the formulation material and solvent for complex formation (S100).

[0055] The above formulation material is not limited to the types listed above, as long as it can be dissolved in purified water (distilled water, mineral water) or an alcohol-based solvent and has fluidity. Furthermore, two or more of the above materials may be mixed and used. The formulation material may be mixed in a ratio of 30 wt% to 50 wt% based on the weight of the liquid formulation material.

[0056] For example, the formulation material may be made of at least one of matrix materials that may contain ceramic powder particles, such as non-woven fabric, polyurethane film, silk fabric, hydrogel, nanocellulose + hydrogel, hydrocolloid, biodegradable polymer, polymer, silicone, carbohydrate, polyethylene glycol, natural polymer seaweed, silicone, polyacrylic acid, polyvinyl alcohol, polyvinylpyrrolidone, polyacrylamide, polyethylene oxide, hydrogel, cellulose, silk material series polyamide, PDMS (polydimethylsiloxane), PVDF (polyvinylidene fluoride).

[0057] As described above, the solvent can dissolve the formulation material. The solvent can be mixed in a ratio of 50 wt% to 70 wt% based on the weight of the liquid formulation material. For example, the solvent can include at least one of purified water, distilled water, mineral water, and 1,2-hexanediol.

[0058] The mineral water described above contains inorganic salts (sodium salt, magnesium salt, potassium salt, calcium salt, ammonium salt, etc.), which have sterilizing and skin-soothing properties and can aid in cell tissue production. Furthermore, when deeply absorbed into the skin, the mineral water can promote cell activation, blood circulation, fat breakdown, and waste removal, thereby promoting anti-aging and skin improvement. Generally, the mineral water may include naturally occurring spring water.

[0059] The above mineral water may contain potassium (K), sodium (Na), calcium (Ca), and magnesium (Mg). For example, the mineral water may contain 4 to 230 ppm of potassium, 700 to 9,500 ppm of sodium, 300 to 1,700 ppm of calcium, 20 to 1,100 ppm of magnesium, 0.02 to 9 ppm of zinc, 25 to 35 ppm of strontium, 0.004 to 0.1 ppm of manganese, 0.02 to 0.15 ppm of lithium, 1,400 to 19,500 ppm of chloride ions, 1.5 to 3 ppm of fluoride ions, 180 to 4,500 ppm of sulfate ions, 13 to 15 ppm of silica, 300 to 350 ppm of bicarbonate, and 3 to 4.5 ppm of carbonic acid.

[0060] The above mineral water can be mixed in a ratio of 20 wt% to 80 wt% based on the total weight of the functional ceramic polymer active ingredient complex.

[0061] The above liquid formulation material can be formed by first stirring the formulation material and the solvent. The liquid formulation material can have fluidity because the formulation material is dissolved in the solvent.

[0062] As shown in [Table 1] below, the liquid formulation material may include purified water, glycerin, niacinamide, methylpropanediol, shea butter, 1,2-hexanediol, Irish moss extract, carob gum, glucomannan, PEG-60 hydrogenated castor oil, xanthan gum, disodium EDTA, dextrin, adenosine, sodium hyaluronate, fragrance, etc.

[0063] Ingredients (Korean) Ingredients (English) CAS No. Function: Purified Water 7732-18-5 Solvent: Glycerin 56-81-5 Skin-Conditioning Agent: Niacinamide 98-92-0 Skin-Conditioning Agent: Methylpropanediol 2163-42-0 Skin-Conditioning Agent: Butyrospermum Parkii (Shea) Butter 91080-23-8 Skin-Conditioning Agent 194043-92-0 1,2-Hexanediol 122-99-6 Solvent: Chondrus Crispus Extract - Skin-Conditioning Agent: Ceratonia Siliqua (Carob) Gum 9000-40-2 Viscosity Increasing Agent Glucomannan 11078-30-1 Skin-Conditioning Agent PEG-60 Hydrogenated Castor Oil 61788-85-0 Surfactant Xanthan Gum 11138-66-2 Viscosity Increasing Agent Disodium EDTA 139-33-3 Sequestering Agent Dextrin 9004-53-9 Viscosity Increasing Agent Adenosine 58-61-7 Skin-Conditioning Agent Sodium Hyaluronate 9067-32-7 Skin-Conditioning Agent Fragrance-Fragrance

[0064] A ceramic polymer composite is formed by stirring the above liquid formulation material and the energy-generating ceramic powder (S200).

[0065] The above ceramic powder may have a piezoelectric effect, a bending effect, a triboelectric effect, a thermoelectric effect, and a photovoltactic effect, and may increase the conductivity of a functional ceramic polymer active ingredient complex. The above ceramic powder may include a piezoelectric powder and a conductive powder.

[0066] The above piezoelectric powder may have a piezoelectric effect and a bending effect. The above piezoelectric powder may include perovskite powder having an ABO3 crystal structure, such as quartz, ZnO, and PZT [Pb(Zr,Ti)O3], KNN [(K,Na)NbO3], and BNKT [Bi(Na,K)TiO3]. The above piezoelectric powder may be mixed in a ratio of 0.4 wt% to 20 wt% with respect to the weight of the liquid formulation material.

[0067] The conductive powder has high conductivity and can have a constant current distribution. The conductive powder may include an ABO3-based perovskite powder such as PMN-PT [Pb(Mg1 / 3Nb2 / 3)O3-PbTiO3], BTO [BaTiO3], CCTO [CaCu3Ti4O12], etc., having a high dielectric constant. The conductive powder may be mixed in a ratio of 0.1 wt% to 10 wt% based on the weight of the liquid formulation material.

[0068] When manufacturing skin patches and sheet products, the ceramic powder is selected from the group consisting of polyethylene oxide (PEO), sodium chloride, glycerin, potassium chloride, magnesium sulfate, copper peptide, gold, silver, copper, zinc, iron, peptides, polymers, alginate, protein peptide-1, kelp, cannellonicanin, peptide-4, alginate, hyaluronic acid, vitamin C, coenzyme Q10, polyvinyl alcohol (PVA), (methyl) acrylate polymer, polyether, polyamide, May contain polycarbonate and polyurethane.

[0069] In addition, the ceramic powder may further include TiO2, ZrO2, Al2O3, ZnO, and ABO3 perovskite powders that generate microcurrent and voltage by a light source or have an ultraviolet ray blocking effect.

[0070] The powders included in the above ceramic powder are not only applied to individual energy generation effects, but can also be applied to comprehensively exhibit five energy generation effects of piezoelectric effect, bending effect, electrostatic effect, thermoelectric effect, and photoelectric effect, such as ABO3 type perovskite type ceramic powder. In this case, if the purpose is not for sensor purpose but for manufacturing skin sheet product, lead (Pb-free) ceramic powder without hazardous substance component is used. The particles of the ceramic powder used in this case are in the range of 100 nm to 25 um, and the particle size can be applied in various ways depending on the use and purpose of the application product. In addition, the above-mentioned piezoelectric powder and conductive powder can be used in a mixture of two or more.

[0071] As described above, the ceramic polymer composite can be formed by secondarily stirring the liquid formulation material and the ceramic powder.

[0072] A functional ceramic polymer active ingredient complex is formed by stirring the above ceramic polymer complex and the active ingredient material (S300).

[0073] The above-mentioned effective ingredient material is not limited in its amount to be added, and may be functional ingredients such as skin whitening, moisturizing, wrinkle improvement, pigmentation improvement, nutritional ingredients, eco-friendly raw materials, medical ingredients for wound healing or disinfection, acne improvement, UV protection, etc., and may be added differently depending on the use and purpose of the application product. The above-mentioned effective ingredient material may be mixed in a ratio of 0.04 wt% to 25 wt% based on the weight of the ceramic polymer composite.

[0074] As described above, the functional ceramic polymer active ingredient complex can be formed by three-stage stirring of the ceramic polymer complex and the active ingredient material.

[0075] In other words, the functional ceramic polymer active ingredient complex can be formed by first stirring the formulation material and the solvent to form a liquid formulation material, second stirring the liquid formulation material and ceramic powder to form a ceramic polymer composite, and third stirring the ceramic polymer composite and the active ingredient material.

[0076] The above functional ceramic polymer active ingredient complex may be pushed or crushed when the formulation material, solvent, ceramic powder, and active ingredient are stirred simultaneously.

[0077] Alternatively, the functional ceramic polymer active ingredient complex may be easily torn when the formulation material and the solvent are first stirred to form a liquid formulation material, and then the liquid formulation material, ceramic powder, and active ingredient material are simultaneously stirred for a second time.

[0078] That is, as described above, the functional ceramic polymer active ingredient complex can be manufactured without defects when the formulation material and the solvent are first stirred to form a liquid formulation material, the liquid formulation material and the ceramic powder are secondarily stirred to form a ceramic polymer composite, and then the ceramic polymer composite and the active ingredient are thirdly stirred.

[0079] As a result, by sequentially performing the first, second, and third stirring, the functional ceramic polymer active ingredient complex can be prevented from having defects such as being pushed, crushed, or torn. Accordingly, the quality and productivity of the functional ceramic polymer active ingredient complex can be improved.

[0080] FIG. 2 is a flowchart for explaining a method for manufacturing a skin patch using a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to an embodiment of the present application, and FIG. 3 is a drawing for explaining a skin patch to which a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to an embodiment of the present application is applied.

[0081] Referring to FIGS. 2 and 3, a method for manufacturing a skin patch using a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to an embodiment of the present application may include a step (S400) of manufacturing a functional ceramic polymer active ingredient complex manufactured according to the method for manufacturing a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to an embodiment of the present application into a solid flexible complex through a roll or film, and a step (S500) of manufacturing a self-energy generating product using the solid flexible complex.

[0082] A high-quality, flexible composite is manufactured through rolls or films (S400).

[0083] The functional ceramic polymer active ingredient complex having fluidity can be manufactured into a size and thickness suitable for the application through roll or film printing or tape casting. The functional ceramic polymer active ingredient complex having fluidity can be manufactured into a non-flowable, flexible solid complex by cooling at room temperature.

[0084] A self-energy generating product is produced using the above flexible composite of high quality (S500).

[0085] The above flexible complex of high quality can be applied to a skin patch depending on the presence, type, and content of the added active ingredient.

[0086] A skin patch (SP) using a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to an embodiment of the present application may include a base (BL) made of a ceramic polymer complex and an active ingredient (M) contained in the base (BL). In addition, the active ingredient (M) may be formed as a separate layer from the base (BL).

[0087] FIG. 4 is a drawing for explaining a skin patch to which a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to a first modified example of the present application is applied, and FIG. 5 is a cross-sectional view for explaining a microneedle of a skin patch to which a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to a first modified example of the present application is applied.

[0088] Referring to FIGS. 4 and 5, a skin patch (SP-1) using a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to a first modified example of the present application may include a base (BL) made of a functional ceramic polymer active ingredient complex and microneedles (MN). For example, it may include microneedles (MN) arranged on one surface of the base (BL).

[0089] The above base (BL) may be formed of a functional ceramic polymer active ingredient complex manufactured using a method for manufacturing a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to an embodiment of the present application. The functional ceramic polymer active ingredient complex may include a formulation material, a ceramic powder, and an active ingredient material.

[0090] The above formulation material may be composed of at least one matrix material that may contain ceramic powder particles, such as non-woven fabric, polyurethane film, silk fabric, hydrogel, nanocellulose + hydrogel, hydrocolloid, biodegradable polymer, polymer, silicone, carbohydrate, polyethylene glycol, natural polymer seaweed, silicone, polyacrylic acid, polyvinyl alcohol, polyvinylpyrrolidone, polyacrylamide, polyethylene oxide, hydrogel, cellulose, silk material series polyamide, PDMS (polydimethylsiloxane), PVDF (polyvinylidene fluoride).

[0091] The above ceramic powder and the above active ingredient material are substantially the same as the functional ceramic polymer active ingredient complex containing the self-microcurrent generating material according to the embodiment of the present application, and therefore, a detailed description thereof is omitted.

[0092] The above microneedle (MN) includes an attachment (A) capable of skin penetration and a base (B) supporting the attachment. The height (h) of the microneedle (MN) may, as a non-limiting example, range from 50 μm to 1,500 μm, and the diameter (r) of the base (B) of the microneedle (MN) may range from 10 μm to 1,000 μm, but is not limited thereto. In addition, the microneedle (MN) may include a functional ceramic polymer active ingredient complex.

[0093] As described above, the above-described flexible composite in a solid state can be applied to cosmetic patches such as mask packs, wrinkle improvement patches, and skin care products, and patches for delivering skin improvement ingredients such as acne improvement and wound treatment, depending on the presence, type, and content of the added active ingredient. In addition, although not illustrated, the above-described flexible composite in a solid state can be applied to sensors such as piezoelectric sensors, and energy generation devices such as energy harvesters, depending on the presence, type, and content of the added active ingredient, but is not limited thereto.

[0094] FIG. 6 is a drawing for explaining a skin patch to which a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to a second modified example of the present application is applied.

[0095] Referring to FIG. 6, a skin patch (SP-2) using a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to a second modified example of the present application may include a banding structure (BS). For example, the patch may include a banding structure (BS) arranged on one side of a base (BL) including a ceramic polymer composite. The banding structure (BS) may have a lower thermal expansion coefficient than the base (BL) or a lower water absorption rate than the base (BL).

[0096] Additionally, the banding structure (BS) may include a plurality of holes (H) of various shapes, but is not limited thereto. Alternatively, the banding structure of the present invention may not include holes.

[0097] The above banding structure (BS) may be formed of PET material, but is not limited thereto. The skin patch (SP-2) using a functional ceramic polymer active ingredient complex containing its own microcurrent generating material can prevent the lifting phenomenon of the middle part of the patch, which is a conventional problem, by including the above banding structure (BS), and thus, the active ingredient of the patch can be evenly delivered throughout the skin, that is, the drug can be efficiently delivered into the skin. In addition, since the patch can be attached to the skin in close contact without being lifted, it can be attached and fixed to the skin for a longer period of time, and since banding is possible at the same time, it can be used on various body parts.

[0098] FIG. 7 is a drawing for explaining a skin patch to which a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to experimental examples and comparative examples of the present application is applied, FIG. 8 is a graph for explaining viscosity according to the weight ratio of mineral water contained in a skin patch to which a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to experimental examples of the present application is applied, and FIG. 9 is a graph for explaining a change in a piezoelectric constant according to a pressing force of a skin patch to which a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to experimental examples of the present application is applied.

[0099] A skin patch can be manufactured according to the method for manufacturing a skin patch using a functional ceramic polymer active ingredient complex containing a self-microcurrent generating material described with reference to FIGS. 1 to 3 described above. Hereinafter, a skin patch according to an experimental example of the present application will be described with reference to FIGS. 7 to 9.

[0100]

[0101] Manufacturing of skin patches according to experimental examples

[0102] 15 to 25 g of formulation material for complex formation, 10 to 30 g of mineral water, 2.5 to 10 g of glycerin, 0.25 to 2 g of shea butter, 0.1 to 1.75 g of 1,2-hexanediol, 0.25 to 1 g of carob gum, 0.05 to 0.5 g of glucomannan, 0.05 to 0.5 g of PEG-60 hydrogenated castor oil, 0.025 to 0.25 g of xanthan gum, and 0.025 to 0.25 g of disodium EDTA are first stirred to form a liquid formulation material having fluidity.

[0103] The above liquid formulation material, 0.2 to 5 g of energy-generating piezoelectric powder, and 0.05 to 1 g of conductive powder are stirred a second time at 300 rpm using a 6-spin stirrer under conditions of 50 to 90°C to form a ceramic polymer composite.

[0104] The above ceramic polymer complex, 0.02 g of adenosine as an active ingredient, and 12.5 g of zinc oxide (ZnO) are stirred three times to form 50 g of a functional ceramic polymer active ingredient complex having a wrinkle improvement function.

[0105]

[0106] Referring to Fig. 7, when manufacturing the functional ceramic polymer active ingredient complex, when the formulation material, solvent, ceramic powder, and active ingredient material are stirred simultaneously, it can be confirmed that they are pushed or crushed as in (a) of Fig. 7.

[0107] Alternatively, when manufacturing the functional ceramic polymer active ingredient complex, if the formulation material and the solvent are first stirred to form a liquid formulation material, and then the liquid formulation material, ceramic powder, and active ingredient material are simultaneously stirred a second time, it can be confirmed that the composite is easily torn as shown in (b) of Fig. 7.

[0108] That is, as described above, when manufacturing the functional ceramic polymer active ingredient complex, when the formulation material and the solvent are first stirred to form a liquid formulation material, the liquid formulation material and the ceramic powder are secondarily stirred to form a ceramic polymer complex, and then the ceramic polymer complex and the active ingredient are thirdly stirred simultaneously, it can be confirmed that the complex is manufactured without defects, as shown in (c) of Fig. 7.

[0109] Referring to FIG. 8, the mineral water can be mixed in a ratio of 20 wt% to 80 wt% with respect to the total weight of the functional ceramic polymer active ingredient complex.

[0110] A skin patch applied with a functional ceramic polymer active ingredient complex according to an experimental example of the present application can be manufactured by first stirring the formulation material and the solvent as described above to form a liquid formulation material, second stirring the liquid formulation material and ceramic powder to form a ceramic polymer complex, and third stirring the ceramic polymer complex and the active ingredient material and then processing them.

[0111] As described above, when the mineral water is mixed in a ratio of 20 wt% to 80 wt% based on the total weight of the functional ceramic polymer active ingredient complex, it can be confirmed that the skin patch to which the functional ceramic polymer active ingredient complex is applied has a viscosity of 2000 CP to 3000 CP. Accordingly, the skin patch to which the functional ceramic polymer active ingredient complex is applied has a viscosity of 2000 CP to 3000 CP, and when applied to the user's skin, the active ingredient of the cosmetic can be efficiently delivered to the user's skin through contraction or relaxation.

[0112] Referring to FIG. 9, a method of using a skin patch having a functional ceramic polymer active ingredient complex applied thereto may include a user applying a pressing force of 0.5 N to 2.5 N after attaching the skin patch.

[0113] As described above, energy can be generated by applying a pressing force to a skin patch to which a functional ceramic polymer active ingredient complex is applied through a piezoelectric powder mixed in a ratio of 0.4 wt% to 20 wt% based on the weight of the liquid formulation material.

[0114] It was confirmed that when the user applied a pressing force of 0.5 N to 2.5 N after attaching the skin patch, the piezoelectric constant (d33) had a value of approximately 200 Pc / N. Accordingly, when the user applied a force of 0.5 N to 2.5 N after attaching the skin patch to which the functional ceramic polymer active ingredient complex was applied, current was easily generated, thereby efficiently delivering the active ingredient of the cosmetic to the user's skin.

[0115]

[0116] While the present invention has been described in detail using preferred embodiments, the scope of the present invention is not limited to the specific embodiments described above, and should be interpreted in accordance with the appended claims. Furthermore, those skilled in the art will appreciate that numerous modifications and variations are possible without departing from the scope of the present invention.

[0117]

[0118] A functional ceramic polymer active ingredient complex containing a self-microcurrent generating material according to the technical idea of ​​the present application, a skin patch using the same, a method for manufacturing the same, and a method for using the same can be utilized in the beauty industry, sensor industry, and energy harvester fields.

Claims

1. A first stirring step of forming a liquid formulation material with fluidity by stirring the formulation material and solvent for complex formation; A second stirring step of forming a ceramic polymer composite by stirring the above liquid formulation material and the energy-generating ceramic powder; and A functional ceramic polymer active ingredient complex manufactured by a method for manufacturing a functional ceramic polymer active ingredient complex, the method including a third stirring step of stirring the above ceramic polymer complex and an active ingredient material.

2. In paragraph 1, The above liquid formulation material is, A functional ceramic polymer active ingredient complex comprising at least one of purified water, glycerin, niacinamide, methylpropanediol, shea butter, 1,2-hexanediol, Irish moss extract, carob gum, glucomannan, PEG-60 hydrogenated castor oil, xanthan gum, disodium EDTA, dextrin, adenosine, sodium hyaluronate, and fragrance.

3. In paragraph 1, The above formulation material is, A functional ceramic polymer active ingredient complex comprising at least one matrix material capable of containing particles of the ceramic powder, such as non-woven fabric, polyurethane film, silk fabric, hydrogel, nanocellulose + hydrogel, hydrocolloid, biodegradable polymer, polymer, silicone, carbohydrate, polyethylene glycol, natural polymer seaweed, silicone, polyacrylic acid, polyvinyl alcohol, polyvinylpyrrolidone, polyacrylamide, polyethylene oxide, hydrogel, cellulose, silk material series polyamide, PDMS (polydimethylsiloxane), PVDF (polyvinylidene fluoride).

4. In paragraph 1, The above ceramic powder includes a piezoelectric powder having a piezoelectric effect, The above piezoelectric powder is, A functional ceramic polymer active ingredient complex comprising 0.4 wt% to 20 wt% of the weight of the above liquid formulation material.

5. In paragraph 4, The above ceramic powder includes conductive powder, The above conductive powder is, A functional ceramic polymer active ingredient complex comprising 0.1 wt% to 10 wt% of the weight of the above liquid formulation material.

6. In paragraph 5, The above solvent includes mineral water, The above mineral water is, Contains 4 to 230 ppm of potassium, 700 to 9500 ppm of sodium, 300 to 1,700 ppm of calcium, and 20 to 1,100 ppm of magnesium. A functional ceramic polymer active ingredient complex comprising a functional ceramic polymer active ingredient complex mixed in a ratio of 20 wt% to 80 wt% based on the total weight of the functional ceramic polymer active ingredient complex.

7. In paragraph 6, The above active ingredient is, A functional ceramic polymer active ingredient complex comprising a compound mixed in a ratio of 0.04 wt% to 25 wt% based on the weight of the ceramic polymer complex.

8. A skin patch comprising a functional ceramic polymer active ingredient complex according to any one of claims 1 to 7.

9. A method of using a skin patch comprising a functional ceramic polymer active ingredient complex according to any one of claims 1 to 7.

10. A piezoelectric sensor comprising a functional ceramic polymer active ingredient complex according to any one of claims 1 to 7.

11. An energy harvester comprising a functional ceramic polymer active ingredient complex according to any one of claims 1 to 7.

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