Pre-filled syringe having central positioning disc, and filling line

Abstract

The present invention belongs to the technical field of syringes, and in particular relates to a pre-filled syringe having a central positioning disc, and a filling line. In the present invention, a honeycomb plate comprises: a plate body, the plate body being transversely arranged; and cells, a plurality of cells being provided on the plate body, the cells each having an inner side annular surface; the pre-filled syringe comprises: a syringe barrel, mounted in a cell, wherein a piston wing is provided at the distal side of the syringe barrel, and the syringe barrel has an outer side annular surface; and a central positioning disc, provided between the outer side annular surface and the inner side annular surface, so as to eliminate the tendency of the syringe barrel wobbling in the cell. The pre-filled syringe is provided with the central positioning disc, such that during rapid movement on the filling line, the time for the syringe barrel to recover from wobbling in the honeycomb plate can be reduced, allowing same to more quickly return to the centered position for filling. The central positioning disc of the present invention can also enable the syringe to better fit to the hand during injection, thus dispersing the pressure applied by the fingers, and reducing hand discomfort caused by pressing.

Description

A pre-filled syringe and filling line with a central positioning disc Technical Field

[0001] This invention belongs to the field of syringe technology, and particularly relates to a pre-filled syringe and filling line with a central positioning disc. Background Technology

[0002] Pre-filled syringes combine the functions of traditional syringes and vials. These syringes are pre-filled with a precise dose of medication before leaving the factory and typically include a needle. The advantages of pre-filled syringes include reduced medication preparation time, lower risk of contamination, and improved dosing accuracy. They are particularly suitable for situations requiring rapid and precise medication administration, such as emergency care, operating room procedures, and vaccinations. Pre-filled syringes are usually for single use to ensure safety and hygiene.

[0003] The pre-filled syringe filling line is a highly automated production line specifically designed for the production of pre-filled syringes. During the filling stage, precise doses of medication are injected into the syringe barrel via an automated, high-precision metering system, ensuring accurate medication levels in each syringe.

[0004] On pre-filled syringe filling lines, honeycomb plates are specially designed tools for the efficient and orderly loading and transport of pre-filled syringes. Named for their honeycomb-like shape, honeycomb plates are characterized by multiple precisely shaped grooves or holes, called cells, each designed to hold exactly one syringe. This allows for the loading of multiple syringes at once, improving production line efficiency as they can be quickly transferred between different production stages, reducing the need for manual handling. Technical issues

[0005] However, the filling line operates at high speeds. When the honeycomb plate moves to the designated filling position, the syringe within the cells shakes significantly, delaying the production line cycle until the syringe stops shaking before filling can continue. Because waiting for the syringe to stop shaking and center itself causes a decrease in the overall production line speed, the extended production time means more energy and manpower are needed to maintain the same output, thus increasing production costs. Furthermore, it's impossible to precisely determine when the syringe shaking will stop. If filling is premature, the syringe may not be accurately aligned with the filling position while shaking, potentially leading to inaccurate filling or drug spillage, increasing quality control risks.

[0006] In summary, improvements are needed to the structure of syringes or honeycomb plates to reduce or eliminate the shaking that occurs when the honeycomb plate moves to the designated filling position. Technical solutions

[0007] The purpose of this invention is to provide a pre-filled syringe with a central positioning disc. The pre-filled syringe has a central positioning disc, which reduces the recovery time of the needle tube within the honeycomb plate after shaking during rapid movement of the filling line, allowing it to return to a centered state more quickly for filling.

[0008] The technical solution adopted by the present invention to solve the above problems is: a pre-filled syringe with a central positioning disk, wherein the pre-filled syringe is loaded on a honeycomb plate, and the honeycomb plate comprises:

[0009] The plate body is arranged horizontally;

[0010] Nesting holes, wherein a plurality of nesting holes are provided on the plate;

[0011] The nest opening has an inner annular surface;

[0012] The pre-filled syringe includes:

[0013] A syringe is inserted into the nest cavity;

[0014] The distal end of the syringe is provided with a piston wing;

[0015] The syringe has an outer annular surface;

[0016] A central positioning disk is disposed between the outer annular surface and the inner annular surface to eliminate the tendency of the syringe to sway within the nest.

[0017] A further preferred technical solution is that the central positioning disk is disposed on the outer ring surface of the syringe and forms at least one contact point with the inner ring surface.

[0018] A further preferred technical solution is that the central positioning disc and the syringe are integrally formed.

[0019] A further preferred technical solution is that the central positioning disk and the piston wing are integrally formed.

[0020] A further preferred technical solution is that the central positioning disk has an outward chamfer that gradually widens towards the distal end.

[0021] A further preferred technical solution is that the piston wing is used to be mounted on the top surface of the nest hole.

[0022] A further preferred technical solution is that the top surface of the nest hole is provided with an inner chamfer that gradually widens upwards.

[0023] A further preferred technical solution is that the outer chamfer is used to abut against the inner chamfer.

[0024] A further preferred technical solution is that the thickness of the central positioning disk is not less than 0.5mm.

[0025] A further preferred technical solution is that the pre-filled syringe further includes an injection needle, which is disposed on the proximal side of the syringe barrel.

[0026] A filling line, characterized in that it includes a honeycomb plate as described in any of the preceding claims, and is used for filling a pre-filled syringe with a central positioning disc as described in any of the preceding claims. Beneficial effects

[0027] In summary, the present invention has the following advantages:

[0028] 1. The central positioning disc of this application helps to more accurately position the pre-filled syringe during the filling process, ensuring the correct insertion position of the syringe, improving the accuracy of filling, and reducing the recovery time of the syringe after shaking inside the honeycomb plate while the filling line moves quickly, so as to return to the centered state more quickly for filling.

[0029] 2. The central positioning disc of this application also enables the syringe to fit more closely to the hand during injection, dispersing the pressure applied by the fingers and reducing discomfort from hand discomfort. Attached Figure Description

[0030] Figure 1 is a schematic diagram of the honeycomb board and the pre-filled syringe inserted into the honeycomb board cells.

[0031] Figure 2 is a schematic diagram of the vertical cross-section of the honeycomb plate and the pre-filled syringe.

[0032] Figure 3 is a schematic diagram of region B in Figure 2.

[0033] Figure 4 is a schematic diagram of the syringe and injection needle in Example 1.

[0034] Figure 5 is a schematic diagram of region A in Figure 4. The scale unit in the figure is mm.

[0035] Figure 6 is a schematic diagram of the syringe structure in Comparative Example 1. The scale unit in the figure is mm.

[0036] In the attached diagram, the components represented by each number are as follows: syringe 1, piston wing 2, central positioning disc 3, injection needle 4, plate 11, nest hole 12, outer annular surface 101, outer chamfer 301, inner annular surface 1201, and inner chamfer 1202. Embodiments of the present invention

[0037] definition

[0038] "Distal" and "Proximal": Taking the injection needle 4 on the syringe 1 as a reference, the end closer to the injection needle 4 is the proximal end, and the end farther away from the injection needle 4 is the distal end; in addition, this direction can be extended to other components, as long as the component can clearly distinguish the end closer to the injection needle 4 or the end farther away from the injection needle 4.

[0039] The present invention will be further described in detail below with reference to the accompanying drawings.

[0040] This specific embodiment is merely an explanation of the present invention and is not intended to limit the invention. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they are within the scope of the claims of the present invention. Example

[0041] A pre-filled syringe with a central positioning disk, the pre-filled syringe being mounted on a honeycomb plate, the honeycomb plate comprising:

[0042] Plate 11, wherein the plate 11 is arranged horizontally;

[0043] Nest holes 12, a plurality of nest holes 12 are provided on the plate 11;

[0044] The nest opening 12 has an inner annular surface 1201;

[0045] The pre-filled syringe includes:

[0046] Syringe 1 is installed in the nest hole 12;

[0047] The distal end of the syringe 1 is provided with a piston wing 2;

[0048] The syringe 1 has an outer annular surface 101;

[0049] A central positioning disk 3 is disposed between the outer annular surface 101 and the inner annular surface 1201 to eliminate the tendency of the syringe 1 to sway within the nest 12.

[0050] The plate 11 is arranged laterally, meaning it is placed horizontally to facilitate stable transport on the production line. The plate 11 is typically made of a robust material, such as plastic, metal, or composite material, to ensure sufficient strength and durability to support the nesting holes and the syringes within. The size and shape of the plate 11 will be determined based on the production line design and the syringe specifications; it needs to be large enough to accommodate the required number of nesting holes 12 while also facilitating movement and handling on the production line.

[0051] Several holes 12 are provided on the plate, the specific number depending on production needs and the size of the plate. Each hole 12 is used to accommodate one syringe. The shape and size of the hole 12 must be precisely matched to the size of the syringe 1 to ensure that the syringe 1 can be placed stably in it and reduce shaking during movement.

[0052] The inner annular surface 1201 is an annular surface inside the nest hole 12, used to better secure the neck of the distal end of the syringe 1 or to provide additional support to ensure the stability and positioning of the syringe in the nest hole.

[0053] The syringe 1 is inserted into the cavity 12 to facilitate movement along the filling line and to determine its position on the filling line for the filling process. The outer annular surface 101 is an annular surface on the outside of the syringe, which may be used to contact the central positioning disk 3 to ensure the correct position and stability of the syringe in the cavity.

[0054] The piston wing 2 is located on the distal side of the syringe, providing an easy-to-grip surface that allows the user to more easily push or pull the piston to control the flow of liquid within the syringe. The piston wing 2 may be mounted on the top surface of the cavity 12.

[0055] The central positioning disk 3 is positioned between the outer annular surface 101 of the syringe barrel and the inner annular surface 1201 of the cavity. The central positioning disk eliminates the tendency for the syringe barrel to wobble within the cavity, ensuring the stability and accuracy of the syringe on the production line. This can be achieved through a locking mechanism formed by one or more contact points.

[0056] There are several ways to set the central positioning disk 3, including the following:

[0057] Case 1: The central positioning disk 3 is disposed on the outer annular surface 101 of the syringe 1, and forms at least one contact point with the inner annular surface 1201. This arrangement makes the central positioning disk 3 a component of the syringe, used to ensure the precise position of the syringe within the nest opening.

[0058] Furthermore, the central positioning disk 3 is integrally formed with the syringe 1. This allows the central positioning disk 3 to guide the syringe 1 through the mold during the mold preparation process.

[0059] Scenario 2: The central positioning disc 3 is detachably mounted on the syringe 1 and forms at least one contact point with the inner annular surface 1201. Because the central positioning disc is detachable, when the syringe 1 and the aperture 12 do not match properly, the central positioning disc 3 can be quickly and easily replaced without changing the specifications of the entire syringe 1 or aperture 12, thus reducing maintenance costs and time. The detachable central positioning disc can be designed in various specifications and sizes to accommodate different models of syringes 1 and apertures 12. This flexibility allows the production line to handle multiple products, improving the versatility of the production line.

[0060] Case 3: The central positioning disk 3 is disposed on the inner annular surface 1201 and forms at least one contact point with the syringe 1.

[0061] Furthermore, the central positioning disk 3 is integrally formed with the inner annular surface 1201.

[0062] The central positioning disk 3 has an outer chamfer 301 that gradually widens towards the distal end. The design of the outer chamfer 301 makes it easier for the central positioning disk 3 to slide into the nest hole 12, improving the accuracy of insertion.

[0063] Furthermore, the top surface of the nest hole 12 is provided with an inner chamfer 1202 that gradually widens upwards, and the outer chamfer 301 is used to abut against the inner chamfer 1202. The design of the inner and outer chamfers allows the central positioning disk 3 to be precisely aligned with the nest hole 12, further ensuring the correct position of the syringe 1 in the nest hole 12.

[0064] In summary, several pre-filled syringes were tested to verify their various performance characteristics. Example 1

[0065] The pre-filled syringe includes:

[0066] Syringe 1 is installed in the nest hole 12;

[0067] The distal end of the syringe 1 is provided with a piston wing 2;

[0068] The syringe 1 has an outer annular surface 101; the central positioning disk 3 is disposed on the outer annular surface 101 of the syringe 1, and the central positioning disk 3 is integrally formed with the syringe 1.

[0069] The thickness of the central positioning disk 3 is 1.2 mm. Example 2

[0070] The pre-filled syringe includes:

[0071] Syringe 1 is installed in the nest hole 12;

[0072] The distal end of the syringe 1 is provided with a piston wing 2;

[0073] The syringe 1 has an outer annular surface 101; the central positioning disk 3 is disposed on the outer annular surface 101 of the syringe 1, and the central positioning disk 3 is integrally formed with the syringe 1.

[0074] The thickness of the central positioning disk 3 is 0.5 mm. Example 3

[0075] The pre-filled syringe includes:

[0076] Syringe 1 is installed in the nest hole 12;

[0077] The distal end of the syringe 1 is provided with a piston wing 2;

[0078] The syringe 1 has an outer annular surface 101; the central positioning disk 3 is disposed on the outer annular surface 101 of the syringe 1, and the central positioning disk 3 is integrally formed with the syringe 1.

[0079] The thickness of the central positioning disk 3 is 1 mm.

[0080] Comparative Example 1

[0081] The pre-filled syringe includes:

[0082] Syringe 1 is installed in the nest hole 12;

[0083] The distal end of the syringe 1 is provided with a piston wing 2;

[0084] The syringe 1 has an outer annular surface 101; the central positioning disk 3 is disposed on the outer annular surface 101 of the syringe 1, and the central positioning disk 3 is integrally formed with the syringe 1.

[0085] The thickness of the central positioning disk 3 is 0.3 mm.

[0086] Comparative Example 2

[0087] The pre-filled syringe differs from that in Example 1 in that it does not have a central positioning disc 3.

[0088] Experimental Example 1: Study on Shaking Recovery Time

[0089] Experimental steps:

[0090] S11. Prepare syringes: Prepare syringe 1, ensuring that all syringes 1 and the hole 12 are the same size to ensure the accuracy of the experiment.

[0091] S12. Install the syringe: Install the syringe 1 into the nest hole 12, ensuring that the syringe is installed correctly without any obvious deviation or looseness.

[0092] S13. Stability test: Set plate 11 on the filling line and start the filling line to the filling position. When the position is reached, start recording the time point as t1. When the syringe stops shaking, record the time point as t2. The shaking recovery time t = t2 - t1 is obtained.

[0093] S14. Data Analysis: Compare the data between groups and analyze the impact of the central positioning disc on the stability of the syringe.

[0094] Experimental Example 2: User Comfort Study

[0095] Experimental steps:

[0096] S21. Preparation stage: Prepare syringe 1, and ensure that all syringes 1 are the same size and weight to ensure the accuracy of the experiment.

[0097] S22. Volunteer selection: Select a certain number of volunteers, ensuring that they do not have hand diseases or discomfort and are able to perform normal gripping and operation.

[0098] S23. Comfort Test: Volunteers use syringe 1 to inject into simulated skin material. At the same time, volunteers rate the comfort of using the syringe according to a questionnaire or comfort rating scale. That is, after completing the simulated injection operation, volunteers choose the comfort level that best matches their experience based on their actual feelings.

[0099] S24. Data Analysis: Compare the comfort scores of each group and analyze the effect of the center positioning disc on reducing the feeling of discomfort.

[0100] The comfort level is divided into five levels, as follows:

[0101] Level 1 - Very uncomfortable

[0102] Description: Extreme discomfort when using a syringe, significant pain or pressure in the hand, difficulty in operation, and the need for extra effort to complete the injection.

[0103] Level 2 - Discomfort

[0104] Description: Discomfort is felt when using the syringe, with slight pain or pressure in the hand, making operation slightly difficult, but the injection can still be completed.

[0105] Level 3 - General

[0106] Description: The experience of using the syringe was normal, with no obvious pain or pressure in the hand. The operation was normal, and there was no particular discomfort.

[0107] Level 4 - Comfort

[0108] Description: The syringe feels comfortable to use, the hand feels good, the operation is smooth, there is no discomfort, and the injection process is easy.

[0109] Level 5 - Very Comfortable

[0110] Description: The syringe feels very comfortable to use, the hand feels great, the operation is very smooth, the injection process is almost imperceptible, and the experience is excellent.

[0111] Tests were conducted on Examples 1-3 and Comparative Examples 1-2 using Test Example 1 and Test Example 2. The results are shown in Table 1.

[0112] Table 1. Shaking recovery time and user comfort test results for Examples 1-3 and Comparative Examples 1-2

[0113] The data from the above tests were analyzed, and the results are as follows:

[0114] 1. Comparing the results of Examples 1-3 and Comparative Examples 1-2 regarding the shaking recovery time, it can be seen that when the thickness of the central positioning disk 3 is not less than 0.5mm, its shaking recovery time is not higher than 3.9s. When the thickness of the central positioning disk 3 is less than 0.5mm, the shaking recovery time is 6.2s, which is similar to the case of not setting the central positioning disk 3 (7.1s). In particular, when the thickness of the central positioning disk 3 is set to 1.2mm, the shaking recovery time is 3.2s, which is the best effect.

[0115] 2. Comparing the results of Examples 1-3 and Comparative Examples 1-2 regarding comfort level, it can be seen that when the thickness of the central positioning disc 3 is not less than 0.5mm, its comfort level is not less than 4. When the thickness of the central positioning disc 3 is less than 0.5mm, the comfort level is 3, which is similar to level 2 in the case where no central positioning disc 3 is set. In particular, when the thickness of the central positioning disc 3 is set to 1.2 or 1mm, the comfort level is the highest, which is level 5.

[0116] Filling line

[0117] A filling line for pre-filled syringes is a specially designed automated production line that can efficiently and accurately complete a series of processes such as liquid filling, syringe assembly, and packaging. In this embodiment, a pre-filled syringe filling line includes:

[0118] The feeding system, an automatic feeding device, neatly arranges the syringes on the honeycomb plate and transports them to the filling station.

[0119] A filling system in which several filling needles simultaneously fill multiple syringes.

[0120] The sealing system automatically inserts the piston precisely into the syringe barrel after filling, ensuring a seal and accurate dosage of the medicine.

[0121] Furthermore, the same or similar element symbols are used as far as possible in the accompanying drawings and description to refer to the same or similar parts or steps. The drawings are presented in a simplified form and are not drawn to scale. For convenience and clarity only, directional terms such as top, bottom, left, right, upward, above, above, below, behind, and front may be used to refer to the drawings. These and similar directional terms should not be construed as limiting the scope of this disclosure in any way.

Claims

1. A pre-filled syringe with a central positioning disk, characterized in that, The pre-filled syringe is loaded onto a honeycomb plate, the honeycomb plate comprising: Plate (11), wherein the plate (11) is arranged horizontally; Nest holes (12), a plurality of nest holes (12) are provided on the plate (11); The nest hole (12) has an inner annular surface (1201); The pre-filled syringe includes: A syringe (1) is installed in the nest hole (12); The syringe (1) is provided with a piston wing (2) at its distal end; The syringe (1) has an outer annular surface (101); A central positioning disk (3) is disposed between the outer annular surface (101) and the inner annular surface (1201) to eliminate the tendency of the syringe (1) to sway within the nest (12).

2. A pre-filled syringe with a central positioning disk according to claim 1, characterized in that, The central positioning disk (3) is disposed on the outer annular surface (101) of the syringe (1) and forms at least one contact point with the inner annular surface (1201).

3. A pre-filled syringe with a central positioning disk according to claim 1, characterized in that, The central positioning disc (3) is integrally formed with the syringe (1).

4. A pre-filled syringe with a central positioning disk according to claim 1, characterized in that, The central positioning disk (3) and the piston wing (2) are integrally formed.

5. A pre-filled syringe with a central positioning disk according to claim 1, characterized in that, The central positioning disk (3) has an outer chamfer (301) that gradually widens towards the far end.

6. A pre-filled syringe with a central positioning disk according to claim 1, characterized in that, The piston wing (2) is used to attach to the top surface of the nest hole (12).

7. A pre-filled syringe with a central positioning disk according to claim 1, characterized in that, The top surface of the nest hole (12) is provided with an inner chamfer (1202) that gradually widens upward.

8. A pre-filled syringe with a central positioning disk according to claim 1, characterized in that, The thickness of the central positioning disk (3) is not less than 0.5 mm.

9. A pre-filled syringe with a central positioning disk according to claim 1, characterized in that, The pre-filled syringe also includes an injection needle (4), which is located on the proximal side of the syringe (1).

10. A filling line, characterized in that, Includes a honeycomb plate as described in any one of claims 1-9, and is used for filling a pre-filled syringe with a central positioning disc as described in any one of claims 1-9.

Images