2 results about "Cephalomannine" patented technology

This invention belongs to the field of material extraction technology, and relates to a method for preparing an extract of *Taxus wallichiana*, its product, and its application. The preparation method includes: mixing *Taxus wallichiana* with an aqueous two-phase system, extracting, allowing to stand and separate phases, collecting phase A and filtering to obtain a filtrate; treating the filtrate with an adsorbent and filtering to obtain the final product; the aqueous two-phase system includes phase A and phase B; phase A includes ethanol and behenamidopropyl dimethylamine; phase B includes inorganic salts and water. The *Taxus wallichiana* extract prepared by this invention does not contain four substances: taxine B, paclitaxel, 10-deacetylated paclitaxel, and cephalotaxine, and the extract has excellent antioxidant, soothing, moisturizing, and anti-aging effects.

The invention discloses an application of combination of paclitaxel and cephalomannine in preparation of an anti-breast cancer product, and particularly provides an application of combination of paclitaxel and cephalomannine in preparation of a medicine for treating and / or preventing breast cancer. The invention finds that the combination of paclitaxel and cephalomannine has the effect of enhancing the breast cancer treatment effect, not only can promote tumor cell death through a traditional apoptosis pathway, but also can enhance the anti-tumor effect by remarkably activating cell death pathways such as pyroptosis (NLRP3 / GSDMD) and necrotic apoptosis (RIPK1 / RIPK3 / MLKL). The treatment strategy of the synergistic effect of various cell death mechanisms can alleviate the reduction of the curative effect caused by the drug resistance of the traditional paclitaxel, overcomes the drug resistance problem in the traditional paclitaxel single-drug treatment, and has wide application prospects.