The present invention discloses a 4-benzylidene
pyrazolone derivative and a synthesis method thereof, belonging to the technical field of
organic synthesis. The 4-benzylidene
pyrazolone derivative is obtained by reacting an α-ketoester with a 1,2-diaza-1,3-butadiene compound under the promotion of a
phosphorus reagent; the raw materials used in the present invention are simple and easily available, and have good stability; the
reaction conditions are mild, and the types of substituents on the synthesized 4-benzylidene
pyrazolone product are rich and can be flexibly changed; the 4-benzylidene pyrazolone derivative provided by the present invention has rich
drug activities, and provides candidate compounds for the design, synthesis and development of novel
drug molecules containing a 4-benzylidene pyrazolone structure.