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2 results about "Selective receptor modulator" patented technology
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In the field of pharmacology, a selective receptor modulator or SRM is a type of drug that has different effects in different tissues. A SRM may behave as an agonist in some tissues while as an antagonist in others. Hence selective receptor modulators are sometimes referred to as tissue selective drugs or mixed agonists / antagonists. This tissue selective behavior is in contrast to many other drugs that behave either as agonists or antagonists regardless of the tissue in question.
Selective ampa receptor modulators
The present application provides compounds of Formula (I) and related compositions and methods, including methods of therapy for treating nervous system diseases and disorders, including multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS), and methods for in vivo imaging of AMPA receptors or surrogates thereof in the brain. (I)
Owner:CENT FOR ADDICTION & MENTAL HEALTH +1
Novel functionalized lactams as modulators of 5-hydroxytryptamine receptor 7 and their method of use
To provide novel functionalized lactams as modulators of the 5-hydroxytryptamine receptor 7 and methods of using the same.SOLUTION: Described herein are new, selective modulators of the 5-HT7 receptor. These selective compounds may be useful for the treatment of CNS and non-CNS indications. The compounds described herein may be selective in targeting 5-HT7 receptors as compared to other receptors and / or by selectively targeting 5-HT7 receptors expressed in certain tissues or organs, thereby providing effective selectivity through a particular partitioning profile of the 5-HT7 modulator.SELECTED DRAWING: None
Owner:TEMPLE UNIV +1