The invention relates to the technical field of prefabricated buildings, in particular to a multi-directional support and guide system for prefabricated building wall assembly, comprising a U-shaped plate, a side guide mechanism, an auxiliary support mechanism, a fastening mechanism, a support rod, a fan-shaped Plates, sockets, reinforcement blocks and fixed columns can fix the U-shaped plate, adjust the angle of the support rod, and make the support rod and the wall column fixedly installed, so as to support the wall column, and then guide the side guide mechanism Installed between the U-shaped plate and the side prefabricated wall, it can guide the angle adjustment of the side prefabricated wall, support the azimuth through the support rod and two side guide mechanisms, and fit the reinforcement block. Install it to the side end of the support rod, and then insert the fixed column into the socket on the fan-shaped plate, so that the use of two reinforcing blocks and two fan-shaped plates can effectively prevent the support rod from shaking, with high stability and high stability. Increase the mechanical strength of the support rod, effectively prevent the support rod from being deformed, and improve the use effect and life.