The invention discloses a medicine for treating early severe acute pancreatitis. The medicine is prepared from the following raw materials in parts by weight: 10-20 parts of radix et rhizoma rhei, 5-10 parts of radix scutellariae, 10-15 parts of rhizoma acori graminei, 5-10 parts of andrographolide, 10-20 parts of delavay pararuellia herb, 5-10 parts of caulis bambusae in taeniam, 10-20 parts of fructus aurantii immaturus, 5-10 parts of L-glutamine, 10-20 parts of unprocessed gardenia jasminoides, 5-15 parts of herba gerberae piloselloidis, 5-15 parts of jatamans valeriana rhizome and 5-15 parts of emilia Herb. According to the medicine, the formula of the medicine is safe and reliable, the components complement each other, the effects of clearing away heat and toxic materials, removing blood stasis and relieving pain, clearing the organs and relieving pancreas, strengthening the spleen and liver, protecting gastrointestinal cells and enhancing defense function of a body are achieved,the translocation of endotoxin and bacteria can be inhibited, and the inflammation is inhibited.