The present application provides a novel lipid compound, a lipid
nanoparticle comprising the same, and use thereof in targeted delivery of a
drug. Specifically, the present application provides a compound of Formula I or a pharmaceutically acceptable salt, a
prodrug, or a stereoisomer thereof. Furthermore, the present application provides a lipid
nanoparticle comprising the compound of Formula I or a pharmaceutically acceptable salt, a
prodrug, or a stereoisomer thereof, still further, the lipid
nanoparticle may further comprise a cationic lipid; yet still further, the lipid nanoparticle may further comprise a helper lipid. A composition comprising the above compound or a pharmaceutically acceptable salt, a
prodrug, or a stereoisomer thereof, or the lipid nanoparticle can achieve the organ-targeted delivery of a therapeutic / prophylactic agent.