The invention discloses an intelligent network-connected automobile operation system based on vehicle-road collaboration. The intelligent networked automobile operation system comprises a high-precision map platform, a cloud control platform, a vehicle-mounted terminal platform, a vehicle-mounted computing platform and an information security platform. The high-precision map platform provides a real-time dynamic high-precision map; the cloud control platform and the vehicle-mounted terminal platform are subjected to cooperative management and control through a communication network; the cloudcontrol platform executes data storage, cloud computing and standardized data interconnection; the vehicle-mounted terminal platform executes information reporting; wherein the vehicle-mounted computing platform is connected with the vehicle-mounted terminal platform through the vehicle-mounted Ethernet, over-the-horizon perception data, map data, environment data and the like are obtained, a vehicle driving scheme is formulated through fusion calculation, and the cloud control platform, the vehicle-mounted terminal platform, the vehicle-mounted computing platform and the map platform are allprovided with safety monitors. Common basic services are provided for operation of the intelligent network connection automobile, and national and industrial development requirements are met.