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STING-targeted precursor compound, nuclide marker, preparation method and application of nuclide marker, pharmaceutical composition and application of pharmaceutical composition

The invention relates to the technical field of radiopharmaceuticals and medical imaging, in particular to an STING-targeted precursor compound, a nuclide marker, a preparation method and application of the STING-targeted precursor compound, a nuclide marker, a pharmaceutical composition and application of the pharmaceutical composition. The STING targeting precursor compound, the pharmaceutically acceptable form of the STING targeting precursor compound, the nuclide marker of the STING targeting precursor compound and the pharmaceutically acceptable form of the STING targeting precursor compound have excellent in-vivo biological performance, can have high specific uptake in tumors or inflammations with high expression of interferon stimulating factors STING, has a high target-to-non-target ratio, and can be used for preparing the target-to-non-target tumor marker of the STING targeting precursor compound and the nuclide marker of the STING targeting precursor compound and the pharmaceutically acceptable form of the STING targeting precursor compound and the nuclide marker of the STING targeting precursor compound. And the non-specific background is low, and unnecessary radioactive injury can be reduced by lower non-target visceral organ uptake, so that the medication safety is high.
Owner:XIAMEN UNIV