The invention discloses a hyperbranched polyether modified polysiloxane defoamer containing nanosilicon dioxide. The hyperbranched polyether modified polysiloxane defoamer is prepared from, by weight, 25-40 parts of polysiloxane, 13-23 parts of hyperbranched polyether, 16-26 parts of allyl glycidyl ether, 38-58 parts of epoxypropane, 0.3-0.5 part of double metal cyanide, 50-70 parts of isopropanol, 0.2-0.5 part of a chloroplatinic acid catalyst, 2-6 parts of ultra-fine aluminum silicate, 1-2 parts of sorbitol, 1-2 parts of tween-60, 2-4 parts of sodium carboxymethylcellulose, an appropriate amount of deionized water, 4-11 parts of nanosilicon dioxide powder and 45-60 parts of dodecyl alcohol. The hyperbranched polyether containing a large number of hydroxyls at the tail end is adopted as a raw material, end-allyl hyperbranched polyether is prepared, a modified polyether end group double-bond structure and polysiloxane are adopted for performing a hydrosilylation reaction, the hyperbranched polyether modified polysiloxane is synthesized, and the defoamer prepared through the hyperbranched polyether modified polysiloxane has the excellent anti-shearing performance.