Unlock instant, AI-driven research and patent intelligence for your innovation.

Antiphlogistic medicinal composition and preparation method thereof

A technology of anti-inflammatory drugs and compositions, applied in the field of traditional Chinese medicine preparations, to achieve the effects of improving drug efficacy, simplifying material composition, and reducing dosage

Inactive Publication Date: 2009-12-09
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nucleosides are compounds linked by purine bases or pyrimidine bases and ribose or deoxyribose. They are the precursors of genetic material DNA and RNA. They are abundant in organisms. There is no literature on whether nucleosides have anti-inflammatory activity. and patent reports

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antiphlogistic medicinal composition and preparation method thereof
  • Antiphlogistic medicinal composition and preparation method thereof
  • Antiphlogistic medicinal composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take mussel meat, wash it, mince it, add three times the amount of water to decoct and extract 3 times, each time for 30 minutes, combine and collect the decoction liquid, concentrate under reduced pressure to 1 / 9 of the total volume, add 95% ethanol until the alcohol volume is 100 The fraction content was 80%, centrifuged at 6000rmp for 10min, discarded the precipitate and collected the supernatant, concentrated under reduced pressure and evaporated ethanol to obtain the total extract part. The total extract is dissolved with an appropriate amount of water, the resulting solution is extracted with an equal volume of ethyl acetate / petroleum ether mixed solvent, and the remaining solution is extracted with an equal volume of n-butanol to obtain n-butanol extract, and n-butanol is recovered to obtain n-butanol Extract the extract from the alcohol part and dry it to obtain the total extraction part of nucleoside alkaloids.

Embodiment 2

[0023] Take mussel meat, wash it, mince it, add three times the amount of water and ultrasonically extract it for 3 times, each time for 30 minutes, combine and collect the decoction liquid, concentrate it under reduced pressure to 1 / 9 of the total volume, add 95% ethanol to the volume percentage of alcohol The content is 80%, centrifuged at 6000rmp for 10min, discarding the precipitate to collect the supernatant, concentrating under reduced pressure and evaporating ethanol to obtain the total extract part, the total extract is dissolved with an appropriate amount of water, and the obtained solution is mixed with an equal volume of ethyl acetate / petroleum ether Solvent extraction, extracting the remaining solution with an equal volume of n-butanol to obtain n-butanol extract, recovering n-butanol to obtain n-butanol extract, drying to obtain the total extraction fraction of nucleoside alkaloids.

Embodiment 3

[0025] Take mussel meat, wash, mince, freeze-dry, and pulverize. The powder is extracted with 80% ethanol under reflux. The extract is centrifuged to get the supernatant, and the solvent is evaporated to obtain the alcohol extraction extract. The extract is dissolved in an appropriate amount of water to obtain the total extract. site, the total extract is dissolved with an appropriate amount of water, the resulting solution is extracted with an equal volume of ethyl acetate / petroleum ether mixed solvent, and the remaining solution is extracted with an equal volume of n-butanol to obtain an n-butanol extract, and the n-butanol is recovered to obtain The extract from the n-butanol part is dried to obtain the total extraction part of nucleoside alkaloids.

[0026] (2) Compositional analysis of nucleoside alkaloids

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an antiphlogistic medicinal composition, which comprises the following compositions in portion by mass: 5 to 30 portions of hypoxanthine, 5 to 15 portions of xanthine, 20 to 40 portions of thymine, 10 to 15 portions of uracil and 4 to 10 portions of uridine. The antiphlogistic medicinal composition has obvious activity to restrain mouse ear edema and mouse cotton ball granuloma caused by dimethylbenzene. Meanwhile, the invention provides a method for extracting the antiphlogistic medicinal composition from the Chinese medicament, river clam flesh.

Description

1. Technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to an anti-inflammatory pharmaceutical composition, specifically a composition composed of several nucleoside alkaloid components, and the invention also relates to extracting the anti-inflammatory pharmaceutical composition from mussel meat method. 2. Background technology [0002] Mussel meat is the soft body of mussels such as mussels in the clam family, pleated clam, triangular sail mussel, and odontophyllum. Sweet in taste and cold in nature, it has the functions of nourishing yin, clearing heat, nourishing liver, improving eyesight, quenching thirst, cooling blood, etc., and can treat diseases such as liver heat, kidney failure, macule, pox, red eyes, and burns. Mussel meat is rich in nutrients and various minerals and trace elements, and has health care effects on the human body. According to analysis and research, mussel meat extract contains a var...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7072A61K31/522A61K31/513A61P29/00A61K35/56A61K35/618
Inventor 吴皓王令充姚静倩金燕狄留庆
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE