Parotitis tablets and preparation method thereof
A technique for mumps and supercritical extraction, which is applied in the field of mumps tablets and their preparation, and can solve the problems of slow disintegration, unsatisfactory curative effect, low curative effect and the like
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Embodiment 1
[0024] Take 150g of Polygonum chinensis, 80g of Chinese toon bark, 150g of Radix Radix, 150g of forsythia, 150g of dandelion, pulverize into 60 mesh coarse powder, and extract with carbon dioxide supercritical extraction method, extraction pressure 20Mpa, extraction temperature 20 °C, separator pressure 15Mpa, separator temperature 40°C, separation time 2 hours, carbon dioxide flow rate 20L per hour, to obtain the extract; take the extract and dry it under reduced pressure at 60°C to obtain a dry paste; take the dry paste and add 80g of fructose, and use high-energy Nano-impact grinding into mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder, microcrystalline cellulose 35g, cross-linked polyvinylpyrrolidone 35g, cross-linked carmellose sodium 35g, hypromellose 25g, 15g of micropowder silica gel, mixed evenly, wet granulated with 50% ethanol, dried at 60°C, added 7g of leucine, granulated, pressed into 1000 tablets, and obtained mumps table...
specific Embodiment 2
[0026] Take 150g Polygonum chinensis leaves, 80g Chinese toon bark, 150g Radix Isatidis, 150g Forsythia, 150g Dandelion, grind them into 60-mesh coarse powder, use carbon dioxide supercritical extraction method to extract, extraction pressure 40Mpa, extraction temperature 40 °C, separator pressure 25Mpa, separator temperature 60°C, separation time 4 hours, carbon dioxide flow rate 40L per hour, to obtain the extract; take the extract and dry it under reduced pressure at 80°C to obtain a dry paste; take the dry paste and add 120g of fructose, and use high-energy Nano-impact grinding into mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder, microcrystalline cellulose 45g, cross-linked polyvinylpyrrolidone 45g, cross-linked sodium carboxymethyl cellulose 45g, hypromellose 35g, 25g of micropowder silica gel, mixed evenly, wet granulated with 70% ethanol, dried at 80°C, added 9g of leucine, granulated, pressed into 1000 tablets, and obtained mum...
Embodiment 3
[0028] Take 150g of Polygonum chinensis leaves, 80g of Chinese toon bark, 150g of Radix Radix, 150g of forsythia, 150g of dandelion, grind into 60-mesh coarse powder, use carbon dioxide supercritical extraction method to extract, extraction pressure 30Mpa, extraction temperature 30 °C, separator pressure 20Mpa, separator temperature 50°C, separation time 3 hours, carbon dioxide flow rate 30L per hour, to obtain the extract; take the extract and dry it under reduced pressure at 70°C to obtain a dry cream; take the dry cream and add 100g of fructose, and use Nano-impact grinding into mixed dry cream powder with a particle size of 200-300nm; take the mixed dry cream powder, microcrystalline cellulose 40g, cross-linked polyvinylpyrrolidone 40g, cross-linked carmellose sodium 40g, hypromellose 30g, 20g of micro-powdered silica gel, mixed evenly, wet granulated with 60% ethanol, dried at 70°C, added 8g of leucine, granulated, pressed into 1000 tablets, and obtained mumps tablets.
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