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Wbp2 as a co-prognostic factor with her2 for stratification of patients for treatment

A patient, prognostic technology for applications in the field of cancer therapy, systems and kits, prognostic methods for breast cancer, identification of cancer markers, breast cancer prognosis, stratification of patient populations

Active Publication Date: 2018-03-27
NAT UNIV OF SINGAPORE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, not all patients with HER2-positive cancers respond to treatment, and some HER2-positive cancers are self-limited even without treatment

Method used

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  • Wbp2 as a co-prognostic factor with her2 for stratification of patients for treatment
  • Wbp2 as a co-prognostic factor with her2 for stratification of patients for treatment
  • Wbp2 as a co-prognostic factor with her2 for stratification of patients for treatment

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Experimental program
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Effect test

Embodiment

[0097] In an analysis involving more than 200 clinical samples (n=221), the combination of WBP2 and HER2 was found to be more powerful than WBP2 or HER2 alone in predicting poorer overall survival and disease-free survival (see Table 3 and figure 1 ). Reference measures only HER2-positive and HER2-negative ( figure 1 C and 1D) and measure the stratification of HER2-negative patients with low WBP2 levels, HER2-negative patients with high WBP2 levels, HER2-positive patients with low WBP2 levels, and HER2-positive patients with high WBP2 levels, see The difference is bigger. For example, with reference to HER2-negative patients with low WBP2 levels, the odds of overall survival in HER2-positive patients with high WBP2 levels were about 4.5-fold lower, and in HER2-positive patients with low WBP2 levels, the odds of overall survival were about 1.7-fold lower; and HER2-positive patients had an approximately 2.6-fold higher chance of relapse, while HER2-positive patients with low W...

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Abstract

The present invention provides a method for the prognosis of overall survival, cancer recurrence or response to treatment for a patient suffering from cancer, the method comprising: (a) examining a sample from the patient to determine whether the patient is human epidermal growth factor receptor 2 (HER2) positive or negative; and (b) measuring WW domain-binding protein 2 (WBP2) levels in the patient's sample, wherein a result in step (a) and a result in step (b) provides a prognosis of overall survival, cancer recurrence or response to treatment for the patient. The present invention also provides a kit carrying out the method of the present invention.

Description

technical field [0001] The present invention relates to methods, systems and kits for the prognosis of cancer, especially breast cancer. The present invention also relates to the stratification of patient populations for cancer treatment, particularly breast cancer treatment. The present application also relates to the identification of cancer markers in methods, systems and kits for the prognosis of cancer, especially breast cancer. Background technique [0002] The following discussion of the background to the invention is intended to facilitate an understanding of the invention. It should be understood, however, that the discussion is not an acknowledgment or admission that any of the material referred to was published, known or part of the common general knowledge in any jurisdiction as at the priority date of the application. [0003] Breast cancer is the second most common type of cancer worldwide and one of the most common causes of cancer death in humans. The dise...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/57415G01N2333/71G01N2800/52G01N2800/54G01N2333/4703
Inventor 林允斌
Owner NAT UNIV OF SINGAPORE
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