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Application of chloroquine in promoting repair of spinal cord injury

A technology for spinal cord injury and chloroquine, applied in the field of pharmaceutical compositions, can solve the problems of unexplored spinal cord injury and in-depth research on inflammation.

Active Publication Date: 2020-08-07
慈溪市人民医院医疗健康集团
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the regulatory role of autophagy on inflammation mediated by ubiquitinated proteins has not been deeply studied in the past, especially the significance in the repair and reconstruction of spinal cord injury has not been explored

Method used

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  • Application of chloroquine in promoting repair of spinal cord injury
  • Application of chloroquine in promoting repair of spinal cord injury
  • Application of chloroquine in promoting repair of spinal cord injury

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Embodiment Construction

[0020] The following description serves to disclose the present invention to enable those skilled in the art to carry out the present invention. The preferred embodiments described below are only examples, and those skilled in the art can devise other obvious variations. The basic principles of the present invention defined in the following description can be applied to other embodiments, variations, improvements, equivalents and other technical solutions without departing from the spirit and scope of the present invention.

[0021] Chloroquine of the present invention and / or its composition refers to comprise according to known chloroquine (Chloroquine, CQ) and / or its pharmaceutically acceptable carrier, adjuvant or vehicle, its specific usage amount and In addition to the method provided by the present invention, the method of use also includes other medical methods.

[0022] According to an embodiment of the present invention, at first make blow type rat spinal cord injury...

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Abstract

The invention provides an application of chloroquine to promote spinal cord damage repair. Chloroquine can inhibit degradation of ubiquitinated protein I-kB[alpha], so that autophagy regulating inflammation can be inhibited to promote spinal cord damage repair. Degradation of ubiquitinated protein I-kB[alpha] can be regulated according to a reaction mechanism of p62-mediated autophagy regulating inflammation LC3-II-p62-I-kB[alpha]. Chloroquine is further introduced to intervene in degradation of ubiquitinated protein I-kB[alpha].

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to the application of chloroquine to promote the repair of spinal cord injury and inhibit the inflammatory response through the regulation of cell autophagy and inflammatory response. Background technique [0002] Spinal cord injury (SCI) is a serious trauma to the nervous system. With the sharp increase in the incidence of SCI, it has brought a heavy burden to patients and the whole society. It is frustrating that despite the efforts of neuroscience researchers all over the world for more than a hundred years, the treatment effect of spinal cord injury is still unsatisfactory. The factors are diverse and the environment is complex. Current studies suggest that spinal cord injury includes two mechanisms, namely primary injury and secondary injury. Among them, the primary injury is the injury caused by external force or fracture and dislocation at the moment of injury, wh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D215/46A61P25/00G01N33/68
CPCC07D215/46G01N33/6893
Inventor 邬芬赞肖健张宏宇魏晓捷童松林
Owner 慈溪市人民医院医疗健康集团