Application of chloroquine in promoting repair of spinal cord injury

Abstract

The invention provides an application of chloroquine to promote spinal cord damage repair. Chloroquine can inhibit degradation of ubiquitinated protein I-kB[alpha], so that autophagy regulating inflammation can be inhibited to promote spinal cord damage repair. Degradation of ubiquitinated protein I-kB[alpha] can be regulated according to a reaction mechanism of p62-mediated autophagy regulating inflammation LC3-II-p62-I-kB[alpha]. Chloroquine is further introduced to intervene in degradation of ubiquitinated protein I-kB[alpha].

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to the application of chloroquine to promote the repair of spinal cord injury and inhibit the inflammatory response through the regulation of cell autophagy and inflammatory response. Background technique [0002] Spinal cord injury (SCI) is a serious trauma to the nervous system. With the sharp increase in the incidence of SCI, it has brought a heavy burden to patients and the whole society. It is frustrating that despite the efforts of neuroscience researchers all over the world for more than a hundred years, the treatment effect of spinal cord injury is still unsatisfactory. The factors are diverse and the environment is complex. Current studies suggest that spinal cord injury includes two mechanisms, namely primary injury and secondary injury. Among them, the primary injury is the injury caused by external force or fracture and dislocation at the moment of injury, wh...

AI Technical Summary

Problems solved by technology

However, the regulatory role of autophagy on inflammation mediated by ubiquitinated proteins has not been deeply studied in the past, especially the significance in the repair and reconstruction of spinal cord injury has not been explored

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