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Method of treating a hair disorder with n-hydroxypyridinones

一种毛发、疾病的技术，应用在处理毛发疾病领域

Active Publication Date: 2018-12-21
PROCTER & GAMBLE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

) While finasteride has been shown to slow hair loss in men, the drug has been associated with a variety of side effects, including gynecomastia and sexual dysfunction

Method used

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  • Method of treating a hair disorder with n-hydroxypyridinones
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  • Method of treating a hair disorder with n-hydroxypyridinones

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 4

[0179] The tonic of the present invention is prepared by conventional methods from the following exemplary components.

[0180]

[0181]

[0182] 1 Carbopol Ultrez 10, Carbopol, available from Lubrizol

[0183] 2 Arlasolve DMI, dimethylisosorbide, purchased from Croda

[0184] 3 Hydrolite-5, pentylene glycol, purchased from Symrise

[0185] 4 Klucel, hydroxypropyl cellulose, purchased from Ashland

Embodiment 5

[0187] The shampoos of the present invention are prepared by conventional methods according to the following exemplary components described in International Patent Publication WO 2008 / 027541 and US Patent Application Publication 20080059313:

[0188]

[0189]

[0190] 1 Stabileze 06, poly(methyl vinyl ether / decadiene maleic anhydride) crosspolymer, available from Ashland

[0191] 2 Laponite XLS, sodium magnesium silicate, purchased from Eckart America

[0192] 3 PrimaFlo HP22, hydroxypropyl cellulose, purchased from Ashland

[0193] 4 Ucare Polymer LR 400, polyquaternium-10, purchased from Dow

[0194] 5 Monamid DMA, Coconut Monoethanolamide, available from Croda

[0195] 6 Tegobetaine F-B, cocamidopropyl betaine, purchased from Goldschmidt Chemicals

[0196] 7 Viscasil 3000,000,: polydimethylsiloxane, purchased from Momentive

[0197] 8 Polyox WSR N-750, PEG-7M, available from Dow

[0198] 9 Kathon CG, purchased from Dow

Embodiment 6

[0200] Conditioners of the present invention are prepared by conventional methods according to the following components described in International Patent Publication WO 2008 / 027541 and US Patent Application Publication 20080059313:

[0201]

[0202]

[0203] 1 Dimethicone / Cyclomethicone: a blend of Dimethicone and Cyclomethicone with a viscosity of 18,000,000 mPas, available from GE Toshiba

[0204]2 Dimethicone Blend: Blend of Dimethicone with a viscosity of 18,000,000 mPas and Dimethicone with a viscosity of 200 mPas, available from GE Toshiba

[0205] 3 Available from GE, has a viscosity of 10,000 mPas and has the following formula (I): (R 1 ) a G3 a -Si-(-OSiG 2 ) n -(-OSiG b (R 1 ) 2-b ) m -O-SiG 3-a (Ri) a (I)

[0206] Wherein G is a methyl group; a is an integer 1; b is 0, 1 or 2, preferably 1; n is a number from about 400 to about 600; m is an integer 0; R 1 In order to meet the general formula CqH 2q A monovalent group of L, wherein q is an intege...

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PUM

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Abstract

The present invention is directed to a method for treating a hair disorder in a human or animal in need thereof, involving topically applying to the human or animal an effective amount of at least one6- substituted 2-pyridinol N-oxide compound, a tautomer, or a cosmetically acceptable salt thereof wherein a hair count is increased by at least 0.5 hairs / cm2 and / or an increase the number of anagenhairs and maintain the number of telogen hairs when compared to a baseline and / or vehicle.

Description

technical field [0001] The present invention relates to methods of treating hair disorders by topical application of 6-substituted 2-pyridinol N-oxide compounds. Background technique [0002] Hair loss and skin appearance can have profound effects on an individual's mental health and quality of life. Anti-aging products account for a large percentage of skin and hair care sales in the United States and abroad, and sales are expected to increase in many Western markets with aging populations. (Lennard, "Recent hair care thinning growth," Global Cosmetic Industry Journal, May 2009.) Consumers seek these products to counteract age-related changes to epithelial biology that lead to skin defects (e.g., loss of elasticity, discoloration , dryness and rough surface texture) and hair loss and thinning. [0003] In many cultures, thinning hair and significant hair loss (ie, "baldness") are considered unattractive. Hair growth is a cyclical process that includes a growth phase (ana...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61Q7/00A61P17/14A61Q1/10A61Q5/02
CPCA61Q1/10A61Q5/02A61K8/4926A61Q7/00A61P17/14A61K8/27A61K8/4933A61K2800/74
Inventor M·G·戴维斯R·S·扬奎斯特
Owner PROCTER & GAMBLE CO