88 results about "Anagen cycle" patented technology

The invention provides a composition for promoting hair regeneration after chemotherapy as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: modifying the surface of a gold nanocage with polydopamine, loading the modified gold nanocage on an exosome, complexing magnesium ions and zinc ions to prepare a modified exosome, preparing a nano drug-loaded liposome from curcumin, resveratrol and epigallocatechin gallate, mixing the nano drug-loaded liposome with the modified exosome to prepare a multi-layer liposome, and preparing the multi-layer liposome from the nano drug-loaded liposome. And mixing with a penetration enhancer, and adding into a temperature-sensitive hydrogel system to prepare the composition for promoting hair regeneration after chemotherapy. The composition for promoting hair regeneration after chemotherapy has a good transdermal absorption promoting effect, can slowly release drugs, promotes hair follicles to be converted from a resting stage to a growing stage under the synergistic effect of the drugs, regulates and controls multiple pathways (such as anti-apoptosis, angiogenesis promotion and anti-inflammation) at the same time, is matched with a complex pathological mechanism of hair regeneration after chemotherapy, and can promote hair regeneration after chemotherapy. Wide application prospects are realized.

The invention relates to application of a platelet reaction protein 4 in preparation of an alopecia medicine, and belongs to the field of medical biology. The invention aims to solve the technical problems of limited curative effect, obvious side effect and narrow application range of the existing alopecia treatment medicine. The invention provides an application of a platelet reaction protein 4 (THBS4) in preparation of an alopecia medicinal preparation, which can promote hair follicles to be converted from a resting period to a growing period by regulating and controlling a mechanical microenvironment around the hair follicles, enhancing the interaction between fibroblasts and hair follicle stem cells and activating regeneration signal channels in hair papilla and hair bud areas. The traditional Chinese medicine composition breaks through the limitation that existing treatment only aims at specific alopecia types, and can be widely applied to various alopecia diseases such as androgenetic alopecia, pressure alopecia and alopecia after chemotherapy. And compared with the traditional medicine, the traditional Chinese medicine composition has the advantages of quick response, no skin irritation reaction and improved hair follicle regeneration efficiency, and provides a brand new solution for safe and efficient treatment of alopecia.

The invention discloses an engineered exosome for promoting hair regeneration and a preparation method and application thereof, Wnt10b gene is inserted into a plasmid vector to construct a target plasmid, the target plasmid and a lentivirus packaging plasmid are co-transfected to packaging cells to generate lentivirus particles, and then target stem cells are infected. Screening to obtain a cell strain capable of stably expressing a target gene, culturing the stably transfected strain, and collecting the engineered exosome generated by the stably transfected strain. The exosomes are rich in Wnt10b protein and can promote proliferation and differentiation of hair follicle stem cells on a molecular level, so that hair follicle tissues in a resting period are activated and enter a growing period again, and hair regeneration is realized. Meanwhile, the exosome is high in safety, and adverse reactions caused by traditional chemical synthesis drugs are avoided. The exosome can be applied to the preparation of hair regeneration products, and the accurate symptomatic treatment capability of the exosome provides a hair growth method aiming at pathogenesis for alopecia patients, and provides a new hope for patients who seek safe and effective hair growth solutions.

The invention provides a stem cell extract composition for promoting hair growth and a preparation method thereof, and belongs to the technical field of cosmetics. Fetal calf serum, dexamethasone, penicillin, streptomycin, interleukin-2 and magnetic composite particles are added into a DMEM culture medium to prepare the culture medium, the culture medium is used for in-vitro culture of stem cells, during culture, a stem cell solution is prepared by combining a low-frequency magnetic field with low-energy laser culture, exosomes are extracted from an extracting solution, the exosomes and the stem cells are mixed and embedded to prepare embedded microspheres, and the embedded microspheres are used for in-vitro culture of the stem cells. The stem cell extract composition for promoting hair growth is prepared by uniformly mixing the stem cell extract with extracts extracted from fresh ginger, ginseng and polygonum multiflorum, the storage stability of stem cells and exosomes is obviously improved, hair growth is promoted, hair follicle development is promoted, mouse hair is induced and maintained in a growth period, and the stem cell extract composition is free of hormone addition, safe and non-irritant, and has a good application prospect. Wide application prospects are realized.

The invention relates to the technical field of daily chemicals, in particular to a cacumen biotae fermentation filtrate, a caviar and cacumen biotae nano-coated slow-release composition, shampoo and application. The fermentation filtrate is prepared from cacumen biotae through a liquid fermentation method; wherein the used strain is bacillus and / or aspergillus. The cacumen biotae fermented filtrate provided by the invention contains flavonoid compounds (such as quercetin) and volatile oil (such as cacumen biotae ketone) which can improve scalp blood circulation, nourish hair follicles and promote healthy growth of hair. The shampoo can inhibit hair follicle inflammation and prevent hair follicle atrophy, thereby reducing alopecia. Tannin components can balance grease secretion of scalp, and hair follicle blockage caused by excessive grease is avoided. The shampoo is particularly friendly to oily scalp and is beneficial to keeping the scalp fresh and cool. Polysaccharide and flavonoid substances in the cacumen biotae can prolong the hair growth period and stimulate the activity of hair follicles, so that new hair regeneration is promoted. The plant extract mildly stimulates scalp and does not damage hair follicle tissues.

The invention provides an anti-hair loss and hair growth composition and application thereof, the composition comprises exosome freeze-dried powder, collagen freeze-dried powder and a traditional Chinese medicine extract, the exosome freeze-dried powder is obtained by extracting exosome from umbilical cord or umbilical cord blood and freeze-drying; the traditional Chinese medicine extract is selected from at least two of a lucid ganoderma extract, a ginseng extract, a honeysuckle flower extract and a polygonum multiflorum extract. The preparation formed by the hair loss prevention and hair growth composition can promote the generation of hair follicle cells, and stimulate hair follicles to enter a growth period while repairing the hair follicles, so that the growth of new hair is promoted, the problem of hair loss is remarkably improved, and the hair is densified and blackened.

The present invention relates to use of a JWA polypeptide in the preparation of a drug for resisting androgenetic alopecia. An amino acid sequence of the polypeptide is shown as I or II: I: FPGSDRF-Z; II: X-FPGSDRF-Z, wherein an amino acid S is subjected to phosphorylation modification, and X and Z are an amino acid or an amino acid sequence, respectively. The described JWA polypeptide can directly target integrin molecules onto hair follicle cells and enter the cells to play a role in regulating and controlling hair follicle proliferation, promoting hair growth and the like; the telogen phase of the hair follicles is significantly shortened, and the anagen phase of the hair follicles is prolonged; the hair shaft and follicle volume is increased; and the expression level of the target cell integrin molecule αvβ1 can be improved, and the hair follicle stem cell signal channel MEK / ERK / E2F1 / SP1 / Wnt10a / 10b / β-catenin can be accurately activated.

The invention belongs to the technical field of biology, and particularly relates to an anti-hair-loss fish collagen peptide composition with a hair follicle signal channel regulating and controlling function and application of the anti-hair-loss fish collagen peptide composition. The composition can activate a Wnt / beta-catenin signal channel, inhibit a BMP channel, promote hair follicle growth period conversion and hair papilla cell proliferation, repair hair quality and improve the scalp microenvironment at the same time. The composition can be prepared into an oral preparation or an external scalp care product, has the advantages of safety, high efficiency and multi-target regulation, and is suitable for alopecia prevention and hair quality repair.

The invention relates to the technical field of daily chemicals, in particular to an anti-hair-loss composition containing hexapeptide-11 and application of the anti-hair-loss composition. The composition comprises a foaming agent, a suspending agent, a hair conditioner, a foaming agent, a thickening agent, an emollient, a preservative, a PH regulator, a chelating agent, hexapeptide-11 and a solvent. The hexapeptide-11 can promote metabolism and proliferation of hair papilla cells; the ginseng and black bean hydrolysate provides plant hormone-like components; the radix scutellariae extract effectively inhibits scalp inflammation, and the three components have a remarkable synergistic effect in the aspects of regulating and controlling the hair follicle cycle and prolonging the growth period. Through synergistic fermentation conversion of probiotics, the molecular structure and skin absorption capacity of original components are improved, meanwhile, various active substances such as small molecular peptides, organic acids and B vitamins are released, and the scalp microenvironment can be improved. The hexapeptide-11 is not obviously degraded in the fermentation process, and forms a composite stable system together with the plant extract, so that the hexapeptide-11 has good pH adaptability and storage stability, and is suitable for daily scalp care.

The invention discloses a composition for growing and nourishing hair as well as a preparation method and application thereof. The composition is prepared from various components including 20 to 30 parts of cacumen biotae extract, 2 to 7 parts of eclipta prostrata extract, 3 to 9 parts of specnuezhenide and the like. The preparation method comprises the steps of raw material pretreatment, active ingredient extraction, compound blending, microcapsule embedding and preparation forming, the cacumen biotae is subjected to a supercritical extraction process, and the eclipta prostrata is subjected to an ultrasonic-assisted enzymolysis-subcritical water extraction combined process. Experiments show that the composition can significantly increase the hair growth rate, maintain the hair follicle growth period, increase the diameter of a hair bulb part, effectively improve hair follicle health through the synergistic effects of activating hair follicle stem cells, inhibiting apoptosis and the like, and can be applied to preparation of hair care products for promoting hair growth.

The invention discloses an anti-hair-loss natural plant composition and application thereof. The anti-hair-loss natural plant composition comprises the following components: a cacumen biotae alcohol extract, a ginseng aqueous extract, a gynostemma pentaphylla alcohol extract and undaria pinnatifida crude polysaccharide. The anti-hair loss and hair growth activity of the composition is evaluated by establishing an androgenetic alopecia mouse model, the result shows that the composition can accelerate the transition of hair follicles of the androgenetic alopecia mouse from a resting period to a growing period, and the hair growth length of the androgenetic alopecia mouse model reaches 9.94 + / -0.13 mm 21 days after the composition is externally applied. The hair coverage rate reaches 96.74 + / -1.98%, the vellus hair proportion is 20.1%, and the composition can significantly improve the hair growth speed of mice with androgenetic alopecia.

This invention belongs to the fields of biomedicine and cosmetics, and discloses the application of holly glycoside in promoting hair growth and preventing hair loss. Holly glycoside promotes the transition of hair follicles from the telogen phase to the anagen phase (i.e., shortening the telogen phase and prolonging the anagen phase), and inhibits cyclophosphamide-induced apoptosis of hair follicle cells and DHT-induced miniaturization of hair follicles. In androgenetic alopecia, telogen effluvium, and chemical alopecia models, its hair growth-promoting effect is comparable to that of the positive control drug minoxidil. It has broad application prospects in pharmaceutical formulations, cosmetics, skincare products, and beauty products.

The invention provides an application of dimethylformamide in preparation of a product for preventing or treating androgenetic alopecia. When DHT (dihydrotestosterone) is used for constructing an androgenetic alopecia mouse model, it is found that after 30 mg / kg / d of dimethylformamide is given, the growth period of hair follicles is obviously accelerated, the hair density of a model mouse is effectively increased, and the hair recovery time is shortened. Organ-like experiments find that after the dimethylformamide treatment, the aggregation and fusion of the organ-like are obviously increased, and the NRF2 expression is also obviously enhanced. Therefore, the dimethylformamide has an effect of promoting the recovery of androgenetic alopecia and has the potential of being developed into corresponding medicines or cosmetics.

The invention belongs to the technical field of exosomes, and particularly relates to an engineered exosome for overexpressing EGF and FGF as well as a preparation method, a product and application of the engineered exosome. An LAMP2B fusion expression technology is adopted, EGF and FGF are directionally anchored to the surface of a 293T cell source exosome membrane, free factor degradation is avoided, and the problem that the carrying amount of natural exosome factors is insufficient is solved. Through the synergistic effect of two factors, the exosome can reverse proliferation inhibition of DHT on hair follicle hair papilla cells, improve the cell migration ability, promote AGA mouse hair follicles to recover from a resting period to a growing period and block hair follicle microminiaturization, and finally reconstruct an AGA hair follicle microenvironment to achieve functional hair growth. Cell experiments confirm that the compound can repair hair follicle cells damaged by DHT, animal experiments show that the AGA mouse hair coverage rate is increased, the safety is good, the primary clinical effect is achieved, an efficient, safe and flexible new scheme is provided for AGA treatment, and the compound has good clinical transformation potential.

The invention belongs to the field of extraction, processing and application of natural plant products, and particularly relates to a preparation method of a grape seed extract and application of the grape seed extract in preparation of a composition for preventing hair loss and growing hair. Tests prove that the grape seed extract can remarkably promote proliferation of hair papilla cells, inhibit apoptosis of the hair papilla cells and remarkably promote expression of factors representing that hair papilla enters an active cycle, is beneficial to inducing or maintaining the growth period of hair follicles and achieving self-rebuilding of the hair follicles, has good effects of preventing hair loss and growing hair, and can be used for preventing hair loss. A new way is provided for development and utilization of the grape seed extract.

This invention belongs to the field of traditional Chinese medicine technology and discloses the application of *Saposhnikovia divaricata* in the preparation of drugs for treating alopecia areata. The preparation method of *Saposhnikovia divaricata* extract is as follows: *Saposhnikovia divaricata* is dried in the shade, pulverized, and then soaked in ethanol for at least 24 hours. The supernatant is then collected. This invention's *Saposhnikovia divaricata* extract can significantly shorten the time for skin to darken and the time for new hair to grow, enabling skin and hair to enter the growth phase more quickly. It can significantly increase the length and weight of newly grown hair and increase the number of primary hair follicles in the skin, thus promoting hair growth in alopecia areata and providing ideas and theoretical basis for the research and development of new drugs.

The present invention discloses a new therapeutic target and small molecule inhibitor for promoting hair growth and improving androgenic alopecia. We found that the key molecule of necroptosis, the mixed lineage kinase domain-like protein (MLKL), plays a key role in the regulation of the hair cycle. The small molecule drug NSA is used to target and inhibit the activation of MLKL, which can accelerate the transition from the resting phase to the growth phase of the hair follicles on the back of mice, thereby promoting hair growth. Furthermore, we used dihydrotestosterone DHT to induce an AGA mouse model. In the AGA mouse model, it was found that inhibiting MLKL can antagonize the inhibitory effect of DHT on mouse hair growth, indicating that inhibiting MLKL may have a certain improvement effect on AGA. Therefore, MLKL can be used as a therapeutic target for promoting hair growth and improving AGA, and its inhibitor NSA can target and inhibit MLKL activity to promote hair growth and treat AGA.

This invention relates to the field of biomedicine, disclosing the application of UAP1 as a target in the preparation of drugs for treating hair loss. This invention discovers that UAP1 is highly expressed in hair follicles in the bald areas of AGA patients, and can serve as a therapeutic target for hair loss. Simultaneously, this invention applies agents that reduce UAP1 expression to hair follicles, finding that downregulating UAP1 expression increases the diameter of the hair bulb, enhances follicle activity, prolongs the anagen phase, and delays the catagen phase. This invention is the first to discover that UAP1 can serve as a therapeutic target for hair loss, and designs corresponding nucleic acid molecules capable of reducing UAP1 expression, providing new targets and directions for the development of drugs for hair loss.

The invention provides a traditional Chinese medicine composition for preventing hair loss and promoting hair growth and application thereof, and relates to the technical field of hair loss prevention and promoting hair growth, the traditional Chinese medicine composition is composed of Chinese doughnut, cockscomb, albizia flower, Chinese honey locust, schizonepeta, lithospermum, polygonum multiflorum, prepared rehmannia root, notopterygium root, radix angelicae pubescentis, ruddle and periostracum cicada; in-vitro experiments show that the traditional Chinese medicine composition can promote proliferation of human dermal papilla cells HDPC, relieve the damage degree of HDPC and induce cycle transformation of hair follicles, so that the effect of promoting hair growth is achieved; animal experiments show that the traditional Chinese medicine composition can significantly increase the number of hair follicles and the thickness of skin and dermis fat of mice, reduce the levels of mouse serum IL-2, TNF-alpha and TGF-beta1 and reduce the levels of testosterone, dihydrotestosterone and estradiol in mouse skin tissue, so that hair follicle fibrosis is inhibited, the growth period of hair follicles is accelerated, the growth period is prolonged, the hair loss phenomenon is improved, and the hair loss rate is increased. The hair growth is promoted.

The invention provides an anti-hair loss composition based on an extraction technology, a preparation method and a tea drink. Relates to the technical field of anti-hair-loss products and hair growth. The composition is prepared from the following raw materials: radix polygoni multiflori, mulberries, rhizoma polygonati, black beans, black rice, lycium ruthenicum, rosa roxburghii tratt fruits, radix codonopsis, raspberries, radix rehmanniae praeparata and trace additives. The ratio of the polygonum multiflorum to the mulberry to the rhizoma polygonati to the black beans to the black rice to the lycium ruthenicum to the roxburgh rose to the codonopsis pilosula to the raspberry to the prepared rehmannia root to the trace additive is 7: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 4. Experiments prove that the composition formed according to the formula can improve the resistance of hair follicles to dihydrotestosterone, increase the self-repairing capacity of the hair follicles and enable the atrophic or dormant hair follicles to enter the growth period again, so that hair growth is promoted, and the composition further has the effect of reducing alopecia.

The invention provides an anti-hair loss and hair growth composition based on cyclic polypeptide c8DSS as well as a preparation method and application of the anti-hair loss and hair growth composition, and relates to the technical field of anti-hair loss and hair growth compositions. The hair loss preventing and hair growing composition based on the cyclic polypeptide c8DSS is prepared from the following components in percentage by mass: 0.45 percent to 1.36 percent of the cyclic polypeptide c8DSS, 0.45 percent of a stable protective agent, 2.73 percent of a penetration enhancer, 2.912 percent of a moisturizing stabilizer and the balance of purified water. The straight-chain 8DSS polypeptide is cyclized into c8DSS, so that the stability and the biological activity of the c8DSS polypeptide are remarkably improved; meanwhile, the annular structure keeps the optimal spatial configuration, the binding capacity with a cell receptor is enhanced, the hair follicle growth cycle can be regulated and controlled through hair follicle sebaceous gland deep penetration, and hair follicles are promoted to enter a growth period from a resting period in advance. The traditional Chinese medicine composition is scientific and reasonable in formula, can be prepared into various dosage forms, is convenient to use, good in safety, free of obvious side effects and wide in application range, and has good market application prospects.

The application discloses a nitric oxide liposome hydrogel drug delivery system for treating alopecia, and a preparation method and application thereof, and belongs to the technical field of alopecia treatment. The application uses a slow-release NO donor material Cho-SNO as a part of the liposome hydrogel drug delivery system, and makes the NO-releasing liposome hydrogel participate in liposome assembly as a liposome skeleton molecule, so that the NO-releasing liposome hydrogel and the loaded therapeutic drug are synergistic, thereby effectively promoting hair growth and prolonging the hair growth period, and showing important application prospects for treating diseases related to NO synergistic drug treatment. Meanwhile, the transdermal delivery of the therapeutic drug is carried out through the drug delivery system, the stability and long-term performance of the drug are improved, and the side effects such as short drug storage time in the skin, difficulty in continuously exerting the curative effect, causing other parts of the body to be hairy, and blood pressure reduction are improved. The hydrogel is used as a carrier, has good biological safety, and is suitable for the physiological environment of human skin.

The present invention discloses a composition with hair growth and hair strengthening functions, a preparation method and an application, belonging to the technical field of hair growth and hair strengthening. The raw materials of the composition include, by weight: main components, including 1020 - 3050 parts of protein and 22.4 - 140 parts of nutritional fortifier; efficacy components, including 20 - 200 parts of powdered plant sterol ester, 100 - 500 parts of millet extract, 100 - 500 parts of polygonatum sibiricum powder, 100 - 400 parts of mulberry powder and 100 - 500 parts of aronia melanocarpa fruit powder; auxiliary components, including 200 - 1800 parts of flavoring agent. The composition of the present invention has no toxic and side effects, can promote the metabolism and proliferation of hair follicle cells, can effectively promote the formation of melanin in hair follicles, shorten the time for hair follicles to enter the growth phase from the resting phase and grow hair, and can strengthen the tightness of hair on the scalp, thereby achieving the effect of preventing hair loss and strengthening hair.

This invention belongs to the field of animal genetic engineering technology, specifically relating to a cashmere goat circRNA, an interference vector, and their application in regulating cashmere goat hair follicle development. The cashmere goat circRNA is circ-0000987; the base sequence of circ-0000987 is shown in SEQ ID NO.1, and it is used to regulate cashmere goat hair follicle development. This invention reveals for the first time the inhibitory effect of circ-0000987 on the proliferation of cashmere goat papillary cells. The results of this invention show that circ-0000987 plays a proliferative inhibitory role in cashmere goat papillary cells, inhibiting their activity by negatively regulating cell proliferation-related pathways; and participating in the transition of hair follicles from the anagen to catagen phase by inhibiting cell proliferation and promoting apoptosis.

The invention discloses a fusion polypeptide for preventing alopecia, a modified exosome and a composition thereof. A Wnt3a active peptide and an LGR5 targeting peptide are connected in series through a flexible connecting peptide to obtain a fusion polypeptide, and the fusion polypeptide has a specific targeting effect on hair follicle stem cells and can activate a Wnt pathway; an exosome is modified by the fusion polypeptide to prepare a fusion polypeptide-exosome (FP-Exo), and the fusion polypeptide-exosome (FP-Exo) is mixed with an anti-DKK1 monoclonal antibody to prepare the anti-hair loss composition. An in-vitro experiment shows that the composition can remarkably promote hair follicle stem cell proliferation, an in-vivo experiment proves that the composition can effectively promote hair follicle regeneration of mice with androgenetic alopecia, and compared with common exosomes and minoxidil, the composition is better in key indexes such as hair follicle density, hair follicle growth period proportion and cell proliferation, and the composition has good application prospects. And a new effective means is provided for alopecia treatment.

The present disclosure relates to the technical field of skin hair regeneration, and in particular to glucohexaose and a preparation method therefor and an application thereof, and a hair regeneration preparation. The molecular structure of the glucohexaose is Man-Man-Man-Man-Glc-Glc. The gulcohexaose can specifically stimulate local macrophages to release a cytokine network mainly comprising CCL5 chemotactic factors, recruit lymphocytes mainly comprising regulatory T cells, induce an immune cascade reaction, regulate an immune microenvironment, activate rapid proliferation and differentiation of hair follicle stem cells at a hair follicle carina and at the lower end of the carina, remarkably promote periodic regeneration of hair follicles, and accelerate the process of driving the hair follicles to enter a growth period from a resting period, so as to achieve the effect of treating alopecia.

The invention relates to the technical field of cosmetics, in particular to polypeptide essence with an anti-alopecia function and a preparation method of the polypeptide essence. The polypeptide composite component is formed by mixing acetyl tetrapeptide-3 and oligopeptide-54 according to the mass ratio of 1: (1-3). The acetyl tetrapeptide-3 can activate fibroblasts, promote synthesis of laminin, III type collagen and VII type collagen, reinforce an epidermis-dermis connecting structure, reduce the hair loss rate and prolong the hair growth period; the oligopeptide-54 can lower hair loss related signal molecules such as DKK-1, stimulate hair follicle activity, promote melanogenesis and improve the problem of premature graying of hair. The combination of the two can synergistically improve the anti-hair loss effect from different action targets, experiments prove that the polypeptide activity in the proportion range is the highest, the excessive addition easily causes component agglomeration and reduces bioavailability, and the expected effect cannot be achieved if the addition is insufficient. The invention has the beneficial effect of high-efficiency hair loss prevention: the polypeptide and the plant extract have a synergistic effect, and the problem of hair loss is solved from multiple dimensions of activating hair follicles, strengthening hair anchoring and improving scalp environment.

The present invention relates to a hair cosmetic composition containing an enzyme-converted Sophora flavescens extract and a method for producing the same. More specifically, it relates to a hair cosmetic composition containing an extract of Sophora flavescens in which the content of trifolirhizin, an active ingredient in Sophora flavescens, has been increased by enzymatic treatment, as an active ingredient, i.e., a hair cosmetic composition having the efficacy of strengthening hair follicles, promoting hair growth, and alleviating hair loss. When using the hair cosmetic composition containing the enzyme-converted Sophora flavescens extract of the present invention as an active ingredient, it not only stimulates hair growth factors to strengthen hair follicles and promote hair growth, but also inhibits hair loss inducing factors that shorten the hair follicle growth phase and promote the transition to the hair regression phase, and shortens the resting phase of hair in an inflammatory environment through anti-inflammatory activity, thus providing an excellent effect in alleviating hair loss.

This invention reverses male pattern baldness by shocking dormant hair follicles out of their androgen induced hibernation phase back to the active hair-growing anagenic phase. The invention integrates two functions: 1) It blocks synthesis of compounds holding the follicles in the telogenic / hibernating phase and 2) It stimulates synthesis of compounds animating the hair-growing / anagenic phase in the follicular activity cycle. One preferred embodiment comprises an enzyme inhibitor blocking the conversion of testosterone to dihydrotestosterone (DHT), a flavonoid simultaneously increasing synthesis of prostaglandins alternative to prostaglandin D2, and a selected cannabinoid compound stimulating restore the hair follicle to its normal growth cycle. This novel trimodal therapy restores the hair follicles to their normal cycling processes and maintains these restorative properties so long as this rebalance in maintained.

The present invention relates to a composition for preventing or ameliorating hair loss. The composition for preventing or ameliorating hair loss, according to the present invention, is a composition comprising sandal pentanol, in which, when diffused into the air, the ingredient diffused into the air comes into contact with hair follicles in the human scalp, thereby binding to olfactory receptor 2AT4 (OR2AT4), which is an olfactory cell receptor of hair follicles, and activating IGF-1 protein, which extends the anagen phase of hair follicle cells. Thus, the composition for preventing or ameliorating hair loss can provide the effect of preventing or ameliorating hair loss without being applied onto the scalp.