46 results about "Anagen cycle" patented technology

The present invention relates to the treatment of skin defects by organotypically-cultured autologous keratinocytes isolated from the outer root sheath of anagen or growing hair. Methods for primary, as well as subsequent organotypic cultures (i.e., epidermal equivalents) in fully-defined media supplemented by autologous human serum and substances isolated form blood components, with minimal allogeneic biological supplements, are disclosed herein. Techniques to prepare epidermal equivalents for transplantation by use of a biocompatible glue are also disclosed herein.

The present invention is directed to a method for treating a hair disorder in a human or animal in need thereof, involving topically applying to the human or animal an effective amount of at least one 6-substituted 2-pyridinol N-oxide compound, a tautomer, or a cosmetically acceptable salt thereof wherein a hair count is increased by at least 0.5 hairs / cm2 and / or an increase the number of anagen hairs and maintain the number of telogen hairs when compared to a baseline and / or vehicle.

The invention relates to a biological polysaccharide with the functions of hair growth, hair fixation and hair loss prevention and its application. Specifically, the β-glucan in the present invention, especially the β-glucan with natural solubility, high molecular weight and high viscosity (such as Schizophyllum β-glucan), can very effectively promote hair growth and / or to prevent hair loss. Experiments have shown that β-glucan can significantly promote the telogen hair follicles to enter the growth phase, make them stay in the growth phase for a long time, promote hair regeneration and hair growth, prevent hair loss, strengthen hair roots, and have the ability to remove and prevent dandruff, and Antipruritic effect.

The invention relates to a preparation method of artificial skin by taking VEGF165 gene modified hair follicle stem cells as seed cells. The preparation method comprises following step: 1) hair follicle stem cells, which possess excellent cellular morphology and are in growing period, are collected; 2) the collected hair follicle stem cells are purified; 3) the hair follicle stem cells are identified; 4) lentivirus are packaged; 5) the hair follicle stem cells are infected by lentivirus; 6) gelatin sponge three-dimensional tissue scaffolds are prepared; 7) the gelatin sponge three-dimensional tissue scaffolds which are preserved at a temperature of 4 DEG C are taken, and the modified hair follicle stem cells are inoculated in the gelatin sponge three-dimensional tissue scaffolds or on the surfaces of the gelatin sponge three-dimensional tissue scaffolds by injection so as to obtain the artificial skin. According to the preparation method, the VEGF165 gene modified hair follicle stem cells are taken as the seed cells, rapid and large-scaled amplification of the hair follicle stem cells can be realized by in vitro culture, resources of the hair follicle stem cells are quite abundant, and the hair follicle stem cells are capable of reducing immunological rejection. In addition, the hair follicle stem cells are transfected and modified by VEGF165 gene, so that novel engineering blood vessel systems with expansion and contraction functions can be formed, and problems of easily caused artificial skin necrosis in transplanting and low survival rate are solved perfectly.

The invention discloses a traditional Chinese medicinal anti-hair loss and hair growth liquid composition for women. The traditional Chinese medicinal anti-hair loss and hair growth liquid composition is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 150-170 parts of cortex lycii radicis, 120-140 parts of notopterygium, 180-200 parts of fructus crataegi cuneatae, 100-120 parts of asarum roots, 160-180 parts of ajuga multiflora, 180-200 parts of sanguisorba officinalis, 170-190 parts of rice bran and 150-170 parts of pu'er tea, wherein the components are mixed by using 70% ethyl alcohol at the ratio of traditional Chinese medicines to the ethyl alcohol of 1:6, and are soaked at a room temperature for 7d; and a soak solution is filtered through a 200-mesh stainless steel screen and then mixed to prepare a traditional Chinese medicinal anti-hair and loss hair growth liquid for women. According to the traditional Chinese medicinal anti-hair loss and hair growth liquid for women, excessive secretion of FGF5 of follicle cells is blocked through inhibiting FGF5 gene expression of the follicle cells, combination with a follicular papillary receptor is controlled, the hair follicle growth period is prolonged, the normal growth state of hair is restored and hair loss can be quickly stopped. Meanwhile, the problems of pruritus capitis and too much hair oil are solved, and the traditional Chinese medicinal anti-hair loss and hair growth liquid composition has the hair growth and hair-blacking efficacies.

Cosmetic skin and hair care compositions for enhancing the growth and appearance of mammalian hair in an individual are provided, which compositions comprise a dose of an R-spondin agonist effective to promote anagen phase of the hair cycle.