52 results about "Anagen cycle" patented technology

The present invention relates to use of a JWA polypeptide in the preparation of a drug for resisting androgenetic alopecia. An amino acid sequence of the polypeptide is shown as I or II: I: FPGSDRF-Z; II: X-FPGSDRF-Z, wherein an amino acid S is subjected to phosphorylation modification, and X and Z are an amino acid or an amino acid sequence, respectively. The described JWA polypeptide can directly target integrin molecules onto hair follicle cells and enter the cells to play a role in regulating and controlling hair follicle proliferation, promoting hair growth and the like; the telogen phase of the hair follicles is significantly shortened, and the anagen phase of the hair follicles is prolonged; the hair shaft and follicle volume is increased; and the expression level of the target cell integrin molecule αvβ1 can be improved, and the hair follicle stem cell signal channel MEK / ERK / E2F1 / SP1 / Wnt10a / 10b / β-catenin can be accurately activated.

The invention relates to the technical field of daily chemicals, in particular to an anti-hair-loss composition containing hexapeptide-11 and application of the anti-hair-loss composition. The composition comprises a foaming agent, a suspending agent, a hair conditioner, a foaming agent, a thickening agent, an emollient, a preservative, a PH regulator, a chelating agent, hexapeptide-11 and a solvent. The hexapeptide-11 can promote metabolism and proliferation of hair papilla cells; the ginseng and black bean hydrolysate provides plant hormone-like components; the radix scutellariae extract effectively inhibits scalp inflammation, and the three components have a remarkable synergistic effect in the aspects of regulating and controlling the hair follicle cycle and prolonging the growth period. Through synergistic fermentation conversion of probiotics, the molecular structure and skin absorption capacity of original components are improved, meanwhile, various active substances such as small molecular peptides, organic acids and B vitamins are released, and the scalp microenvironment can be improved. The hexapeptide-11 is not obviously degraded in the fermentation process, and forms a composite stable system together with the plant extract, so that the hexapeptide-11 has good pH adaptability and storage stability, and is suitable for daily scalp care.

The invention discloses a composition for growing and nourishing hair as well as a preparation method and application thereof. The composition is prepared from various components including 20 to 30 parts of cacumen biotae extract, 2 to 7 parts of eclipta prostrata extract, 3 to 9 parts of specnuezhenide and the like. The preparation method comprises the steps of raw material pretreatment, active ingredient extraction, compound blending, microcapsule embedding and preparation forming, the cacumen biotae is subjected to a supercritical extraction process, and the eclipta prostrata is subjected to an ultrasonic-assisted enzymolysis-subcritical water extraction combined process. Experiments show that the composition can significantly increase the hair growth rate, maintain the hair follicle growth period, increase the diameter of a hair bulb part, effectively improve hair follicle health through the synergistic effects of activating hair follicle stem cells, inhibiting apoptosis and the like, and can be applied to preparation of hair care products for promoting hair growth.

This invention belongs to the fields of biomedicine and cosmetics, and discloses the application of holly glycoside in promoting hair growth and preventing hair loss. Holly glycoside promotes the transition of hair follicles from the telogen phase to the anagen phase (i.e., shortening the telogen phase and prolonging the anagen phase), and inhibits cyclophosphamide-induced apoptosis of hair follicle cells and DHT-induced miniaturization of hair follicles. In androgenetic alopecia, telogen effluvium, and chemical alopecia models, its hair growth-promoting effect is comparable to that of the positive control drug minoxidil. It has broad application prospects in pharmaceutical formulations, cosmetics, skincare products, and beauty products.

The invention provides an application of dimethylformamide in preparation of a product for preventing or treating androgenetic alopecia. When DHT (dihydrotestosterone) is used for constructing an androgenetic alopecia mouse model, it is found that after 30 mg / kg / d of dimethylformamide is given, the growth period of hair follicles is obviously accelerated, the hair density of a model mouse is effectively increased, and the hair recovery time is shortened. Organ-like experiments find that after the dimethylformamide treatment, the aggregation and fusion of the organ-like are obviously increased, and the NRF2 expression is also obviously enhanced. Therefore, the dimethylformamide has an effect of promoting the recovery of androgenetic alopecia and has the potential of being developed into corresponding medicines or cosmetics.

The invention belongs to the technical field of exosomes, and particularly relates to an engineered exosome for overexpressing EGF and FGF as well as a preparation method, a product and application of the engineered exosome. An LAMP2B fusion expression technology is adopted, EGF and FGF are directionally anchored to the surface of a 293T cell source exosome membrane, free factor degradation is avoided, and the problem that the carrying amount of natural exosome factors is insufficient is solved. Through the synergistic effect of two factors, the exosome can reverse proliferation inhibition of DHT on hair follicle hair papilla cells, improve the cell migration ability, promote AGA mouse hair follicles to recover from a resting period to a growing period and block hair follicle microminiaturization, and finally reconstruct an AGA hair follicle microenvironment to achieve functional hair growth. Cell experiments confirm that the compound can repair hair follicle cells damaged by DHT, animal experiments show that the AGA mouse hair coverage rate is increased, the safety is good, the primary clinical effect is achieved, an efficient, safe and flexible new scheme is provided for AGA treatment, and the compound has good clinical transformation potential.

This invention belongs to the field of traditional Chinese medicine technology and discloses the application of *Saposhnikovia divaricata* in the preparation of drugs for treating alopecia areata. The preparation method of *Saposhnikovia divaricata* extract is as follows: *Saposhnikovia divaricata* is dried in the shade, pulverized, and then soaked in ethanol for at least 24 hours. The supernatant is then collected. This invention's *Saposhnikovia divaricata* extract can significantly shorten the time for skin to darken and the time for new hair to grow, enabling skin and hair to enter the growth phase more quickly. It can significantly increase the length and weight of newly grown hair and increase the number of primary hair follicles in the skin, thus promoting hair growth in alopecia areata and providing ideas and theoretical basis for the research and development of new drugs.

This invention relates to the field of biomedicine, disclosing the application of UAP1 as a target in the preparation of drugs for treating hair loss. This invention discovers that UAP1 is highly expressed in hair follicles in the bald areas of AGA patients, and can serve as a therapeutic target for hair loss. Simultaneously, this invention applies agents that reduce UAP1 expression to hair follicles, finding that downregulating UAP1 expression increases the diameter of the hair bulb, enhances follicle activity, prolongs the anagen phase, and delays the catagen phase. This invention is the first to discover that UAP1 can serve as a therapeutic target for hair loss, and designs corresponding nucleic acid molecules capable of reducing UAP1 expression, providing new targets and directions for the development of drugs for hair loss.

The invention provides a traditional Chinese medicine composition for preventing hair loss and promoting hair growth and application thereof, and relates to the technical field of hair loss prevention and promoting hair growth, the traditional Chinese medicine composition is composed of Chinese doughnut, cockscomb, albizia flower, Chinese honey locust, schizonepeta, lithospermum, polygonum multiflorum, prepared rehmannia root, notopterygium root, radix angelicae pubescentis, ruddle and periostracum cicada; in-vitro experiments show that the traditional Chinese medicine composition can promote proliferation of human dermal papilla cells HDPC, relieve the damage degree of HDPC and induce cycle transformation of hair follicles, so that the effect of promoting hair growth is achieved; animal experiments show that the traditional Chinese medicine composition can significantly increase the number of hair follicles and the thickness of skin and dermis fat of mice, reduce the levels of mouse serum IL-2, TNF-alpha and TGF-beta1 and reduce the levels of testosterone, dihydrotestosterone and estradiol in mouse skin tissue, so that hair follicle fibrosis is inhibited, the growth period of hair follicles is accelerated, the growth period is prolonged, the hair loss phenomenon is improved, and the hair loss rate is increased. The hair growth is promoted.

The invention provides an anti-hair loss composition based on an extraction technology, a preparation method and a tea drink. Relates to the technical field of anti-hair-loss products and hair growth. The composition is prepared from the following raw materials: radix polygoni multiflori, mulberries, rhizoma polygonati, black beans, black rice, lycium ruthenicum, rosa roxburghii tratt fruits, radix codonopsis, raspberries, radix rehmanniae praeparata and trace additives. The ratio of the polygonum multiflorum to the mulberry to the rhizoma polygonati to the black beans to the black rice to the lycium ruthenicum to the roxburgh rose to the codonopsis pilosula to the raspberry to the prepared rehmannia root to the trace additive is 7: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 4. Experiments prove that the composition formed according to the formula can improve the resistance of hair follicles to dihydrotestosterone, increase the self-repairing capacity of the hair follicles and enable the atrophic or dormant hair follicles to enter the growth period again, so that hair growth is promoted, and the composition further has the effect of reducing alopecia.

The invention provides an anti-hair loss and hair growth composition based on cyclic polypeptide c8DSS as well as a preparation method and application of the anti-hair loss and hair growth composition, and relates to the technical field of anti-hair loss and hair growth compositions. The hair loss preventing and hair growing composition based on the cyclic polypeptide c8DSS is prepared from the following components in percentage by mass: 0.45 percent to 1.36 percent of the cyclic polypeptide c8DSS, 0.45 percent of a stable protective agent, 2.73 percent of a penetration enhancer, 2.912 percent of a moisturizing stabilizer and the balance of purified water. The straight-chain 8DSS polypeptide is cyclized into c8DSS, so that the stability and the biological activity of the c8DSS polypeptide are remarkably improved; meanwhile, the annular structure keeps the optimal spatial configuration, the binding capacity with a cell receptor is enhanced, the hair follicle growth cycle can be regulated and controlled through hair follicle sebaceous gland deep penetration, and hair follicles are promoted to enter a growth period from a resting period in advance. The traditional Chinese medicine composition is scientific and reasonable in formula, can be prepared into various dosage forms, is convenient to use, good in safety, free of obvious side effects and wide in application range, and has good market application prospects.

The application discloses a nitric oxide liposome hydrogel drug delivery system for treating alopecia, and a preparation method and application thereof, and belongs to the technical field of alopecia treatment. The application uses a slow-release NO donor material Cho-SNO as a part of the liposome hydrogel drug delivery system, and makes the NO-releasing liposome hydrogel participate in liposome assembly as a liposome skeleton molecule, so that the NO-releasing liposome hydrogel and the loaded therapeutic drug are synergistic, thereby effectively promoting hair growth and prolonging the hair growth period, and showing important application prospects for treating diseases related to NO synergistic drug treatment. Meanwhile, the transdermal delivery of the therapeutic drug is carried out through the drug delivery system, the stability and long-term performance of the drug are improved, and the side effects such as short drug storage time in the skin, difficulty in continuously exerting the curative effect, causing other parts of the body to be hairy, and blood pressure reduction are improved. The hydrogel is used as a carrier, has good biological safety, and is suitable for the physiological environment of human skin.

This invention belongs to the field of animal genetic engineering technology, specifically relating to a cashmere goat circRNA, an interference vector, and their application in regulating cashmere goat hair follicle development. The cashmere goat circRNA is circ-0000987; the base sequence of circ-0000987 is shown in SEQ ID NO.1, and it is used to regulate cashmere goat hair follicle development. This invention reveals for the first time the inhibitory effect of circ-0000987 on the proliferation of cashmere goat papillary cells. The results of this invention show that circ-0000987 plays a proliferative inhibitory role in cashmere goat papillary cells, inhibiting their activity by negatively regulating cell proliferation-related pathways; and participating in the transition of hair follicles from the anagen to catagen phase by inhibiting cell proliferation and promoting apoptosis.

The invention relates to the technical field of cosmetics, in particular to polypeptide essence with an anti-alopecia function and a preparation method of the polypeptide essence. The polypeptide composite component is formed by mixing acetyl tetrapeptide-3 and oligopeptide-54 according to the mass ratio of 1: (1-3). The acetyl tetrapeptide-3 can activate fibroblasts, promote synthesis of laminin, III type collagen and VII type collagen, reinforce an epidermis-dermis connecting structure, reduce the hair loss rate and prolong the hair growth period; the oligopeptide-54 can lower hair loss related signal molecules such as DKK-1, stimulate hair follicle activity, promote melanogenesis and improve the problem of premature graying of hair. The combination of the two can synergistically improve the anti-hair loss effect from different action targets, experiments prove that the polypeptide activity in the proportion range is the highest, the excessive addition easily causes component agglomeration and reduces bioavailability, and the expected effect cannot be achieved if the addition is insufficient. The invention has the beneficial effect of high-efficiency hair loss prevention: the polypeptide and the plant extract have a synergistic effect, and the problem of hair loss is solved from multiple dimensions of activating hair follicles, strengthening hair anchoring and improving scalp environment.

The present invention relates to a hair cosmetic composition containing an enzyme-converted Sophora flavescens extract and a method for producing the same. More specifically, it relates to a hair cosmetic composition containing an extract of Sophora flavescens in which the content of trifolirhizin, an active ingredient in Sophora flavescens, has been increased by enzymatic treatment, as an active ingredient, i.e., a hair cosmetic composition having the efficacy of strengthening hair follicles, promoting hair growth, and alleviating hair loss. When using the hair cosmetic composition containing the enzyme-converted Sophora flavescens extract of the present invention as an active ingredient, it not only stimulates hair growth factors to strengthen hair follicles and promote hair growth, but also inhibits hair loss inducing factors that shorten the hair follicle growth phase and promote the transition to the hair regression phase, and shortens the resting phase of hair in an inflammatory environment through anti-inflammatory activity, thus providing an excellent effect in alleviating hair loss.

The present invention relates to a composition for preventing or ameliorating hair loss. The composition for preventing or ameliorating hair loss, according to the present invention, is a composition comprising sandal pentanol, in which, when diffused into the air, the ingredient diffused into the air comes into contact with hair follicles in the human scalp, thereby binding to olfactory receptor 2AT4 (OR2AT4), which is an olfactory cell receptor of hair follicles, and activating IGF-1 protein, which extends the anagen phase of hair follicle cells. Thus, the composition for preventing or ameliorating hair loss can provide the effect of preventing or ameliorating hair loss without being applied onto the scalp.

The application discloses a hair loss prevention shampoo targeting CD133 positive hair follicle dermal papilla cells and a preparation method thereof. The shampoo comprises a hair follicle targeting single-domain antibody-active peptide fusion, a liposome-encapsulated compound plant extract, a biological surfactant, a protein stability surfactant and an auxiliary material. The fusion is formed by fusing an anti-CD133 VHH single-domain antibody and a 5alpha-reductase inhibiting peptide DK-HP-7 through a flexible connecting peptide. Based on the discovery that CD133 positive dermal papilla cells are a key cell group driving hair follicle formation, the application uses single-domain antibodies to achieve precise targeting of active ingredients. The DK-HP-7 designed through molecular docking has an IC 50 of 4.28 μM. The rhamnolipid and Kolliphor HS 15 complex system can make the fusion protein activity retention rate higher than 89% after being stored at 40 ℃ for 3 months. The shampoo can significantly antagonize dihydrotestosterone-induced hair follicle growth inhibition, promote hair follicles to enter the growth phase and increase hair follicle density, and has good skin safety and stability.

The invention relates to the field of hair loss prevention, in particular to a hair loss prevention composition of a fibroblast growth factor 7, a preparation method and a beverage. The anti-hair loss composition of the fibroblast growth factor 7 disclosed by the invention is prepared from the following raw materials: the fibroblast growth factor 7, Noggin recombinant protein, Omega-3 fatty acid, gingerol, ginsenoside and trace additives, the mass ratio of the fibroblast growth factor 7 to the Noggin recombinant protein to the Omega-3 fatty acid to the gingerol to the ginsenoside to the trace additive is 2: 3: 1: 4: 1: 1: 1, and the trace additive comprises the following raw materials: water, a zinc element, vitamin B7, theanine and a copper element. Experiments prove that the anti-hair loss composition containing the fibroblast growth factor 7, provided by the invention, has the advantages that the self-repairing capability of hair follicles can be improved, and the atrophic or dormant hair follicles can enter a growth period again, so that the hair growth is promoted, and the composition also has an effect of reducing hair loss.

The present invention relates to a hair cosmetic composition containing an enzymatically converted sophora flavescens extract and a method for preparing the same, and more specifically, to a sophora flavescens extract having an increased content of trifolhizin, which is an active ingredient in sophora flavescens, prepared by enzymatic treatment, and a hair cosmetic composition containing the same as an active ingredient, i.e., a hair cosmetic composition containing trifolhizin, which is a hair cosmetic composition containing trifolhizin, which is a hair cosmetic composition containing trifolhizin, which is a hair cosmetic composition containing trifolhizin. The hair cosmetic composition has the effects of strengthening hair roots, growing hair and relieving alopecia. When using a hair cosmetic composition containing the enzymatically converted sophora flavescens extract of the present invention as an active ingredient, hair root strengthening and hair growth can be promoted by stimulating hair growth factors, and hair loss-inducing factors, which are promoted to a degeneration period by shortening the hair follicle growth period, can be inhibited. An excellent alopecia relieving effect can be expected by shortening the resting period of hair in an inflammatory environment through the anti-inflammatory activity.

The application discloses ALDH1A1 The application discloses a gene and a protein in application of promoting hair follicle cell proliferation, and belongs to the technical field of functional gene application. ALDH1A1 The application discloses that overexpression of the gene can significantly promote hair follicle cell proliferation, and the ALDH1A1 protein is expected to be used for preparing a product for promoting hair follicle cell proliferation or damage repair, thereby providing a new and safe candidate preparation for improving the problem of hair loss. ALDH1A1 The application discloses that the expression amount of the gene in skin tissue is significantly higher than that in other tissues; compared with hair follicles in a regression period and a resting period, the expression amount of the gene in hair follicles in a growth period is the highest; and the structural and composition analysis results of the ALDH1A1 protein are provided.

This invention provides a sustained delivery hydrogel comprising a crosslinked minoxidil-aldehyde-modified polymer for treatment of hair loss. Also provided herein is a sustained delivery hydrogel comprising a crosslinked minoxidil-aldehyde-modified hyaluronic acid derivative for treatment of hair loss. The invention also relates to methods for inducing anagen phase of hair growth, prolonging the anagen phase, increasing hair follicle size, reversing, preventing or inhibiting miniaturization of the hair follicle, and combinations thereof in a subject having hair loss, comprising administering the sustained delivery hydrogel comprising the crosslinked minoxidil-aldehyde-modified hyaluronic acid derivative to an area of hair loss of the subject, and to methods for inducing anagen phase of hair growth, prolonging the anagen phase, increasing hair follicle size, reversing, preventing or inhibiting miniaturization of the hair follicle, and combinations thereof in a subject having hair loss, comprising administering the sustained delivery hydrogel comprising the crosslinked minoxidil-aldehyde-modified polymer to an area of hair loss of the subject.

The invention provides an exosome for promoting hair follicle cell growth and a preparation method and application thereof.The method comprises the steps that firstly, Triton X-100 with extremely low concentration is adopted, and reversible micropores are formed in the surface of a membrane on the premise that the overall structure of the exosome is stable; and then effectively introducing astragaloside and oleanolic acid into the exosome under the action of ultrasonic waves. Compared with a traditional electrotransfection method, the method has the advantages that the damage to the exosome membrane is remarkably reduced, and the integrity of membrane protein and natural functions is maintained. Meanwhile, the anti-apoptosis effect of astragaloside and the Wnt / beta-catenin activation effect of oleanolic acid cooperate with each other, hair follicle cell proliferation can be promoted more remarkably, the growth period of hair follicles can be prolonged more remarkably, and therefore a brand new technical path is provided for alopecia treatment and hair follicle regeneration.

The invention belongs to the technical field of biological medicines, and discloses a quercetin-loaded VEGF (vascular endothelial growth factor) overexpressed mesenchymal stem cell apoptosis vesicle, which is prepared by the following steps: firstly, preparing stable VEGF overexpressed mesenchymal stem cells, then inducing apoptosis of the VEGF overexpressed mesenchymal stem cells to generate apoptosis vesicles, and adding quercetin in the induction process to wrap the quercetin into the apoptosis vesicles. The quercetin can play a role in promoting the hair follicle to enter the growth period again from the rest period; the drug can be actively loaded into the vesicles to generate drug-loaded apoptosis vesicles by utilizing the self-encapsulation characteristic of cell apoptosis, so that the damage to the integrity of the vesicles in the drug loading process is reduced, the half-life period of the drug is prolonged, and the problem of drug hydrophobicity is solved. The mesenchymal stem cell-derived apoptosis vesicles can exert a tissue repair function similar to that of mesenchymal stem cells, synergistically promote hair growth, overexpress VEGF (vascular endothelial growth factor) through a genetic engineering means, enhance the angiogenesis promoting capability of the apoptosis vesicles, promote vascularization of hair follicle endings and accelerate hair regeneration.

The invention discloses a spermidine composition for inhibiting aging of hair follicle stem cells and promoting growth period entry and application, and relates to the technical field of biological medicine and functional skin care. The invention discloses a spermidine composition for inhibiting aging of hair follicle stem cells and promoting growth period entry. The skin care product is prepared from the following components in parts by mass: 0.5 to 3 parts of spermidine, 0.2 to 2 parts of an autophagy activator, 0.5 to 4 parts of an antioxidant, 0.1 to 2 parts of a mitochondrial function accelerant, 0.2 to 3 parts of a microcirculation accelerant, 1 to 6 parts of a skin penetration accelerant, 0.2 to 1 part of a preservative, 0.05 to 0.4 part of a pH regulator and 60 to 95 parts of a carrier matrix. The composition can effectively reduce the aging rate of hair follicle stem cells and remarkably improve the proliferation activity of the hair follicle stem cells, active oxygen free radicals around the hair follicle stem cells can be effectively removed by adding the antioxidant of a novel structure, damage of external stimulation to hair follicles is reduced, and a systematic cell protection and repair mechanism is formed.

The invention discloses a scalp care composition and application thereof. Effective components of the scalp care composition are agilawood extract and tetrahydromethylpyrimidine carboxylic acid or derivatives thereof. Through reasonable compounding of the agilawood extract and the tetrahydromethylpyrimidine carboxylic acid or the derivative thereof, secretion of insulin-like growth factor-1 (IGF-1) is effectively promoted, so that the number of hair follicles is increased, the growth period of the hair follicles is prolonged, the hair follicle health is promoted and / or maintained, and the scalp health can be promoted and / or maintained; the effects of improving or / and preventing alopecia, growing hair, increasing hair density, strengthening hair roots, improving head blood circulation and the like are achieved.

The invention discloses a hair loss prevention and hair densification composition, relates to the technical field of washing and care formulas, and particularly relates to a hair loss prevention and hair densification auxiliary hair loss prevention composition, essence and shampoo. The composition comprises the following components in percentage by weight: 0.01%-50% of XVII type collagen; 0.1%-6% of a yeast extract; 0.01% to 4% of III type collagen; 1%-50% of a polypeptide compound; the polypeptide compound comprises oligopeptide 1, palmitoyl tripeptide 1, acetyl tetrapeptide 3 and acetyl heptapeptide 4; the anti-hair loss and dense hair essence and shampoo containing the composition also respectively comprise a water-based excipient and a corresponding functional auxiliary material. According to the composition for preventing hair loss and densification, through synergistic compatibility of the four components, multi-element synergistic intervention on hair follicle stem cell homeostasis, hair papilla cell energy metabolism, signal channels and extracellular matrixes is achieved, hair follicle microminiaturization is remarkably improved, the growth period is prolonged, the hair density is increased, and the composition has the excellent hair loss and densification preventing effect.

The invention relates to a hair growth moisturizing essence preparation, which is prepared from the following raw materials in percentage by weight: 1 to 15 percent of active composition, 1.3 to 3.0 percent of nutritional supplement, 2 to 6 percent of humectant, 0.1 to 2 percent of vitamin, 1 to 5 percent of antioxidant, 0.1 to 0.5 percent of coolant, 10 to 20 percent of surfactant, 1 to 5 percent of glycerol, 3 to 8 percent of chitosan and the balance of carrier. The active composition is introduced and comprises the hydrolyzed yeast protein, the schizophyllan, the L-arginine, the biotin, the pyrrolidinyl diaminopyrimidine oxide and the hydrolyzed corn protein, so that hair follicle cells in a resting period are quickly reactivated to a growth period, a relatively long hair growth period is maintained, hair regeneration is effectively promoted, scalp health is improved, and hair color is recovered; the hair thickness is increased, and meanwhile, scurf is reduced.

The invention belongs to the technical field of medicines, and particularly relates to application of combination of gelatin and chaotropic agent in preparation of a medicine for treating androgenetic alopecia. The invention provides a chaotropic agent-gelatin collaborative engineering strategy, and a protein microneedle composed of gelatin and a chaotropic agent is constructed. Through the screening preparation method, the protein microneedle has high mechanical properties and high skin puncture efficiency. When the protein microneedle is used for treating androgenetic alopecia, compared with a single NaI or gelatin protein microneedle, the protein microneedle has a synergistic effect in the aspects of improving new hair, improving the number of hair follicles and promoting hair follicles in a resting period to be converted into a growing period, and the effect of the protein microneedle is superior to that of minoxidil medicine; the combination of the gelatin and chaotropic agent has a good application prospect in preparation of the medicine for treating androgenetic alopecia.

The application discloses an effect of 4-HIL in promoting hair follicle health, inhibiting androgenetic alopecia and dandruff generation and application thereof, and belongs to the technical field of application of non-protein amino acids. It is found for the first time that 4-HIL has the effects of promoting hair follicle proliferation, reducing hair follicle apoptosis, increasing the number of hair follicles in a growth period and the total number of hair follicles; promoting the growth speed of androgenetic alopecia scalp hair, increasing hair length and hair weight; and inhibiting the effect of keratinocyte apoptosis caused by Malassezia. 4-HIL can be used for preparing a medicament for inhibiting androgenetic alopecia, inhibiting dandruff generation and maintaining the protection function of the stratum corneum and / or a hair washing and caring product. The 4-HIL has the advantages of good effect, high safety, good biological activity, wide application range and low price, and has a great application prospect in the preparation of products for promoting hair follicle health, inhibiting androgenetic alopecia and dandruff generation.

The application discloses a traditional Chinese medicine shampoo capable of inducing hair follicle regeneration and promoting hair growth and a preparation method thereof, and relates to the technical field of daily chemical products. The shampoo comprises the following components in parts by weight: Bacillus amyloliquefaciens fermentation extract 10-20 parts, Amoora roxburghii Benth extract 25-40 parts, tryptophan 1-4 parts, Myristica fragrans Houtt extract 20-35 parts, Platycladus orientalis (L.) Franco extract 20-30 parts, seaweed extract 18-26 parts, surfactant 6-15 parts, foaming agent 1-3 parts, thickening agent 0.5-1.5 parts, lubricant 0.1-0.8 parts, humectant 0.5-2.5 parts and water 800-1000 parts. The effective components of the shampoo can rapidly penetrate into the keratin layer barrier of the scalp and be absorbed by the scalp, promote the proliferation of hair follicle stem cells, prolong the growth period of the hair follicles, delay the entry of the hair follicles into the involution period, prevent the atrophy of the hair follicles and realize rapid hair growth.