42 results about "Anagen cycle" patented technology

The present invention relates to the treatment of skin defects by organotypically-cultured autologous keratinocytes isolated from the outer root sheath of anagen or growing hair. Methods for primary, as well as subsequent organotypic cultures (i.e., epidermal equivalents) in fully-defined media supplemented by autologous human serum and substances isolated form blood components, with minimal allogeneic biological supplements, are disclosed herein. Techniques to prepare epidermal equivalents for transplantation by use of a biocompatible glue are also disclosed herein.

The invention discloses a compound plant anti-hair loss hair growth lotion. The compound plant anti-hair loss hair growth lotion includes the following components in percentages by mass: 1-5% of cacumen platycladi extract, 1-5% of camellia seed cake extract, 1-5% of ginger root extract, 1-5% of ginseng root extract, 1-5% of fructus forsythiae extract, 1-5% of radix polygoni multiflori extract, 0-0.05% of caffeine, 0.1-0.4% of an antibacterial agent, 0.1-0.5% of a moisturizer, and the balance of water. The compound plant anti-hair loss hair growth lotion provided by the invention takes hair follicle stem cells as a target, and induces the expression of multiple growth factors, thereby regulating the proliferation and differentiation of the hair follicle stem cells, improving the supply of blood to scalp, and inducing hair follicles during dormancy to return to an active growth period; and the lotion can effectively end abnormal hair loss and promote hair regeneration.

The invention provides a compound external preparation for preventing and treating alopecia and promoting hair growth. The compound external preparation comprises the following specific components andformula weight proportions: every 100 ml of a solvent contains 1 to 50 g of metformin, 0.1 to 10 mg of finasteride, 0.1 to 50 g of minoxidil, 0.1 to 50 mg of vitamin B1 and 0.1 to 50 mg of vitamin B6; and the solvent is water or ethanol. Compared with single minoxidil, metformin, vitamins B1+B6 or combination of two drugs (combination of oral administration of the finasteride and external application of the minoxidil, combination of the minoxidil and the vitamin B1), the compound external preparation has the advantages that the hair follicle stem cells can be activated, and more hair folliclecells enter the growth period after the rest period is ended; new hair follicles in the growing period can be longer, and hair papillae are larger in size; and the component medicines in a formula can achieve a synergistic effect, and the compound external preparation has remarkable effects in the aspects of treating the alopecia and promoting the hair growth.

The present invention is directed to a method for treating a hair disorder in a human or animal in need thereof, involving topically applying to the human or animal an effective amount of at least one 6-substituted 2-pyridinol N-oxide compound, a tautomer, or a cosmetically acceptable salt thereof wherein a hair count is increased by at least 0.5 hairs / cm2 and / or an increase the number of anagen hairs and maintain the number of telogen hairs when compared to a baseline and / or vehicle.

The present invention relates to a composition for preventing hair loss and promoting hair regrowth, the composition comprising an ingredient for inducing anagen hair growth and hair growth promotionto promote the growth of hairs. The composition for preventing hair loss and promoting hair regrowth according to the present invention promotes hair regrowth by shortening the period of transition from the telogen stage to the anagen stage and delays the transition to catagen stage in the hair growth cycle, thereby exhibiting an excellent effect of preventing hair loss and promoting hair regrowth. In addition, the composition of the present invention is safe to the human body, with no side effects thereto, promotes the proliferation of dermal papilla cells, and has an excellent effect of increasing hair elasticity.

The invention relates to a freeze-dried powder preparation for hair regeneration and healing as well as a preparation method and application thereof. The preparation method comprises a step 1 that an available healthy umbilical cord is taken and cleaned, Wharton's jelly is stripped and cut into small pieces, the small pieces are spread in a culture container, a culture solution is added, the culture container is placed in an incubator for culture, and P0-generation cells are collected after culture is conducted for 13-15 days; a step 2 that the P0-generation cells are put into an incubator according to the density of 1.4 million cells per bottle, and subjected to subculture for 3 days; and a step 3 that culture is terminated when the the fusion degree of the cells reaches 90% during culturing the P0 generation cells, a supernate liquid is collected and continuously freeze-dried in a freeze dryer for 50-54 hours to obtain the freeze-dried powder. The stem cell supernate contains various growth factors, so that hair follicles can be induced to be converted into a growth period from a resting period, hair growth can be promoted, and the problem of alopecia can be fundamentally solved.

The invention relates to the technical field of skin hair regeneration, in particular to glucohexaose and a preparation method and application thereof, and a hair regeneration preparation. The molecular structure of the glucohexaose is Man-Man-Man-Man-Glc-Glc. The gulcohexaose can specifically stimulate local macrophages to release a cytokine network mainly comprising CCL5 chemotactic factors, recruit lymphocytes mainly comprising regulatory T cells, induce immune cascade reaction, regulate immune microenvironment, activate rapid proliferation and differentiation of hair follicle stem cells at hair follicle carina and at the lower end of the carina, remarkably promote periodic regeneration of hair follicles and accelerate the process of driving the hair follicles to enter a growth period from a resting period, so as to achieve the effect of treating alopecia.

The invention relates to the field of medicines, and relates to a novel application of L-fucose, in particular to an application of L-fucose in preparation of products with hair loss preventing and hair growing effects. In-vitro experiments find that L-fucose can significantly up-regulate expression (p is smaller than 0.001) of a beta-catenin gene, an IGF-1 gene, a KGF-2 gene and VEGF gene and promote expression (p is smaller than 0.001) of an MMP-2 gene and an MMP-9 gene, and is helpful for inducing or maintaining hair follicle growth period and promoting hair follicle growth and dermal papilla extracellular matrix remodeling; and meanwhile, the expression (p is smaller than 0.001) of the anti-apoptosis gene bcl-2 is remarkably up-regulated, and the ratio (p is smaller than 0.005) of Bax / Bcl-2 is down-regulated, so that the apoptosis of dermal papilla cells is inhibited. The result shows that the L-fucose has good hair loss preventing and hair growing effects.

The invention relates to a biological polysaccharide with the functions of hair growth, hair fixation and hair loss prevention and its application. Specifically, the β-glucan in the present invention, especially the β-glucan with natural solubility, high molecular weight and high viscosity (such as Schizophyllum β-glucan), can very effectively promote hair growth and / or to prevent hair loss. Experiments have shown that β-glucan can significantly promote the telogen hair follicles to enter the growth phase, make them stay in the growth phase for a long time, promote hair regeneration and hair growth, prevent hair loss, strengthen hair roots, and have the ability to remove and prevent dandruff, and Antipruritic effect.

The invention relates to a preparation method of artificial skin by taking VEGF165 gene modified hair follicle stem cells as seed cells. The preparation method comprises following step: 1) hair follicle stem cells, which possess excellent cellular morphology and are in growing period, are collected; 2) the collected hair follicle stem cells are purified; 3) the hair follicle stem cells are identified; 4) lentivirus are packaged; 5) the hair follicle stem cells are infected by lentivirus; 6) gelatin sponge three-dimensional tissue scaffolds are prepared; 7) the gelatin sponge three-dimensional tissue scaffolds which are preserved at a temperature of 4 DEG C are taken, and the modified hair follicle stem cells are inoculated in the gelatin sponge three-dimensional tissue scaffolds or on the surfaces of the gelatin sponge three-dimensional tissue scaffolds by injection so as to obtain the artificial skin. According to the preparation method, the VEGF165 gene modified hair follicle stem cells are taken as the seed cells, rapid and large-scaled amplification of the hair follicle stem cells can be realized by in vitro culture, resources of the hair follicle stem cells are quite abundant, and the hair follicle stem cells are capable of reducing immunological rejection. In addition, the hair follicle stem cells are transfected and modified by VEGF165 gene, so that novel engineering blood vessel systems with expansion and contraction functions can be formed, and problems of easily caused artificial skin necrosis in transplanting and low survival rate are solved perfectly.

The invention discloses a traditional Chinese medicinal anti-hair loss and hair growth liquid composition for women. The traditional Chinese medicinal anti-hair loss and hair growth liquid composition is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 150-170 parts of cortex lycii radicis, 120-140 parts of notopterygium, 180-200 parts of fructus crataegi cuneatae, 100-120 parts of asarum roots, 160-180 parts of ajuga multiflora, 180-200 parts of sanguisorba officinalis, 170-190 parts of rice bran and 150-170 parts of pu'er tea, wherein the components are mixed by using 70% ethyl alcohol at the ratio of traditional Chinese medicines to the ethyl alcohol of 1:6, and are soaked at a room temperature for 7d; and a soak solution is filtered through a 200-mesh stainless steel screen and then mixed to prepare a traditional Chinese medicinal anti-hair and loss hair growth liquid for women. According to the traditional Chinese medicinal anti-hair loss and hair growth liquid for women, excessive secretion of FGF5 of follicle cells is blocked through inhibiting FGF5 gene expression of the follicle cells, combination with a follicular papillary receptor is controlled, the hair follicle growth period is prolonged, the normal growth state of hair is restored and hair loss can be quickly stopped. Meanwhile, the problems of pruritus capitis and too much hair oil are solved, and the traditional Chinese medicinal anti-hair loss and hair growth liquid composition has the hair growth and hair-blacking efficacies.

Cosmetic skin and hair care compositions for enhancing the growth and appearance of mammalian hair in an individual are provided, which compositions comprise a dose of an R-spondin agonist effective to promote anagen phase of the hair cycle.

The invention provides the use of crocin II in the preparation of a medicine for preventing and treating hair loss by acting on hair follicle tissue. The present invention also provides the use of crocin II in the preparation of a drug for improving the activity of hair follicle tissue. The drug is directly smeared or sprayed on the scalp to promote hair follicles in the telogen phase to enter a regeneration cycle and promote hair growth. The present invention also provides the use of crocin II in the preparation of a drug for improving the activity of hair follicle tissue cultured in vitro, making the crocin II into a tissue culture solution and acting on the hair follicle tissue in vitro to improve the microenvironment of the hair follicle tissue, Promote the transformation of hair follicle tissue in the telogen and catagen states into hair follicle tissue in the anagen phase, thereby increasing the activity of the cultured hair follicle tissue, and significantly improving the survival rate of transplanted hair follicles.

The invention relates to an anti-hair loss and hair growth composition and its application. The raw material components of the hair loss prevention and hair growth composition include: hydrolyzed lupine protein, yeast extract, licorice extract, orientalis leaf extract, hydrolyzed sericin protein. The anti-hair loss and hair growth composition of the present invention can provide essential trace element nutrition for each stage of hair growth, shorten the process of hair entering the growth phase from the telogen phase, delay the transformation from the growth phase to the catagen phase, and effectively repair the scalp Damage hair follicles, promote hair growth, nourish and strengthen hair, and prevent hair loss. The invention has obvious effects on hair loss caused by various reasons, and has the characteristics of quick effect, wide application population and mild effect.