Method for increasing number of skin hair and accelerating hair growth speed

A technology for hair growth and hair growth, applied in the field of biomedicine, to achieve the effect of accelerating hair growth, accelerating hair growth, and promoting hair growth

Inactive Publication Date: 2021-02-26
TAIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether AQP8 regulates hair follicle development and hair growth has not been reported

Method used

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  • Method for increasing number of skin hair and accelerating hair growth speed
  • Method for increasing number of skin hair and accelerating hair growth speed
  • Method for increasing number of skin hair and accelerating hair growth speed

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1, the comparison of AQP8+ / + and AQP8- / - mouse skin hair follicles and hair quantity

[0022] like figure 1 As shown, in the present invention, the skin of the same part of 6-week-old, male, AQP8+ / + and AQP8- / - mice born on the same day was taken, fixed with 4% paraformaldehyde, stained with eosin dye, and observed under an optical microscope Distribution of hair follicles. The results showed that compared with AQP8+ / +, the skin hair follicles of AQP8- / - mice were disorderly arranged and the number was significantly increased; in addition, the number of skin hairs and the number of hair roots in a single hair follicle were observed. like figure 2 It shows that the number of hair roots in a single hair follicle of AQP8+ / + mice is mainly 1-2, while that of AQP- / - mice is mainly 3-4. Statistical analysis shows that inhibiting the expression of AQP8 can increase the number of hair follicles The number can also increase the number of hairs in the hair follicl...

Embodiment 2

[0023] Embodiment 2, the hair growth rate comparison of AQP8+ / + and AQP8- / - mice

[0024] like image 3 As shown, the present invention takes 6-week-old, male, AQP8+ / + and AQP8- / - mice born on the same day, depilates their backs simultaneously, and observes the hair growth. The results showed that after 10 days of hair removal, the hair of AQP8- / - mice almost covered the hair removal area, while only part of the hair grew in the back hair removal area of ​​AQP8+ / + mice, indicating that inhibiting the expression of AQP8 effectively accelerated the growth of skin hair.

Embodiment 3

[0025] Example 3, AQP8+ / + and AQP8- / - mice's skin color changes at the time nodes of the first growth cycle of hair follicles

[0026] like Figure 4 As shown, the first growth cycle of mouse hair follicles is from postnatal day 1 to day 21. Among them, 1-14 days is the growth period (the skin color is black); 15-16 days, it begins to enter the degenerative period (the skin color gradually changes to flesh-colored); after 18 days, it enters the resting period (the skin is all flesh-colored); 22 days into the second growth cycle. In the present invention, male, AQP8+ / + and AQP8- / - mice born on the same day are taken, and the hair is removed 16 days after birth, the skin color is observed, and the changes in the first growth cycle are detected. The results showed that at 16 days after birth, the hair follicles of AQP8+ / + mice began to enter the degenerative phase of the first growth cycle, and the skin color changed from the neck to flesh-colored, while the AQP8- / - mice were s...

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Abstract

The invention discloses a method for increasing the number of skin hair and accelerating the hair growth speed. The method comprises the steps that the number of skin hair follicles and the number ofhair in the hair follicles can be increased by inhibiting the protein expression level of aquaporin 8 (AQP8), and therefore the number of the hair is increased; and meanwhile, the growth period of thefirst growth period of the hair follicles is prolonged, the time course of the retrogression period is shortened, and the hair growth speed is effectively increased.

Description

technical field [0001] The invention belongs to the field of biomedicine, and discloses a method for increasing the number of skin hairs and accelerating hair growth rate. By inhibiting the expression of aquaporin 8, the number of skin hair follicles and the number of hairs in the hair follicles are increased, and the method for accelerating hair growth rate. [0002] technical background [0003] The hair follicle is one of the appendages of the skin. The sac-like tissue surrounding the root of the hair, the skin cells that make the hair grow, is composed of the hair matrix, dermal papilla, inner root sheath and outer root sheath. It is formed in the early embryo, through epithelial cells The interaction between mesenchymal cells and mesenchymal cells is cyclical. The growth cycle of hair follicles is divided into growth phase (Anagen), degenerative phase (Catagen) and resting phase (Telogen). In the anagen, the hair mother cells proliferate rapidly, differentiate into the ...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P17/14
CPCA61K45/00A61P17/14
Inventor 李丽华翁志勇
Owner TAIZHOU UNIV
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