13 results about "Outer root sheath" patented technology

The present invention relates to a peptide having an activity of promoting hair growth or preventing or inhibiting hair loss. The peptide of the present invention has an activity of promoting proliferation of hair follicle dermal papilla cells (HFDPC), activating a cell proliferation-related signal protein in human dermal papilla cells, activating β-catenin, improving expression levels of factors downstream of β-catenin, down-regulating expression levels of hair-loss protein DKK-1, and increasing expression of keratins in hair outer root sheath cells (HORSC).

The present invention relates to a peptide with the activity of promoting hair growth or preventing or inhibiting alopecia. The peptide of the present invention promotes the proliferation of human follicular dermal papilla cells (HFDPC), activates cell proliferation-related signaling proteins and beta-catenin in human dermal papilla cells, enhances the expression levels of beta-catenin downstream genes, down-regulates the expression levels of the hair loss protein DKK-1, increases the expression of keratin proteins in hair outer root sheath cells (HORSC) and up-regulates the expression of transcription factors involved in cell activation in germinal matrix cells (GMC).

This invention provides a method for obtaining and expanding mesenchymal stem cells (MSCORS) from the outer root sheath of hair follicles. The invention further provides a method for differentiating the expanded stem cells into other cells and tissues, and provides various cell types obtainable through this method.

The invention provides a method for promoting the transdermal performance of nucleic acid-lipid nanoparticles through ultrasonic synergistic enhancement, and belongs to the technical field of transdermal drug delivery. The invention provides a method for promoting the transdermal performance of nucleic acid-lipid nanoparticles through ultrasonic synergistic enhancement, which comprises the following steps: (1) treating the surface of skin by using a transdermal agent containing ethanol and other components, and then coating the surface of skin with lipid nanoparticles loaded with nucleic acid; and (2) ultrasonic treatment is conducted on the coating area, the ultrasonic frequency is set to be 20 kHz-1 MHz, the ultrasonic intensity is set to be 0.3 W / cm to 2.0 W / cm, and treatment is conducted for 1 min to 3 min in a continuous or 10%-50% duty ratio. According to the method, the strongest and widest-range signal can be obtained in the aspect of delivery efficiency, meanwhile, the epidermal tissue is in a continuous strip shape and is obviously positive to the hair follicle outer root sheath, and the superficial dermis is visible and expanded; the apoptosis of the TUNEL is not increased; the method comprises the following steps: carrying out Masson and Hamp; e, the collagen is continuous, the structure is complete, the inflammation is slight, and no obvious difference exists from the contrast, so that the safety and the biocompatibility are high.

The present application belongs to the field of biomedical and cosmetic technology, and particularly relates to the application of periostin in the preparation of preparations for promoting the activity of hair follicle cells or for preventing and treating alopecia. The present application first discovers that periostin has the activity of regulating hair follicle papilla cells, hair matrix cells and outer root sheath cells, can promote the proliferation of hair follicle papilla cells, hair matrix cells and outer root sheath cells, improve the hair induction ability of hair follicle papilla cells, and promote the hair follicle cycle transformation, hair growth and thickening, and can be applied to the preparation of preparations for treating alopecia.

This invention relates to peptides with activity that promotes hair growth or prevents or inhibits hair loss. The peptides of this invention promote the proliferation of human follicular dermal papilla cells (HFDPC), activate cell proliferation-related signaling proteins and β-catenin in HFDPC, enhance the expression levels of downstream genes of β-catenin, downregulate the expression level of the hair loss protein DKK-1, increase the expression of keratin in hair follicle outer root sheath cells (HORSC), and upregulate the expression of transcription factors involved in cell activation in germinal stromal cells (GMC).

The invention discloses a hair growth composition for enhancing hair follicle microcirculation by using cacumen biotae volatile oil and a kaoliang spirit alcohol extract and a preparation method thereof, and belongs to the technical field of hair growth and care products, the hair growth composition comprises the following components in percentage by mass: a hair follicle microcirculation activation component: 0.01-0.05 wt% of cacumen biotae volatile oil and 0.1-5.0 wt% of kaoliang spirit alcohol extract; an extracellular matrix strengthening and intercellular communication promoting component: 0.001 to 0.05 wt% of acetyl tetrapeptide-3; 0.1 to 2.0 wt% of an angelica polysaccharide extract; 0.1 to 1.0 wt% of sodium hyaluronate; and 0.05-2.0 wt% of carbenoxolone acid, which is used for up-regulating the expression of Connexin43 (Cx43) protein in hair follicle outer root sheath cells. The composition aims at solving the technical problems that an existing hair growth product only improves hair follicle microcirculation but cannot effectively wake up the activity of hair follicle stem cells, and continuous hair growth is difficult to achieve.

The invention relates to a peptide capable of promoting hair growth and preventing and inhibiting alopecia and application thereof. The peptide provided by the invention has the following activities: promoting proliferation of hair follicle dermal papilla cells (HFDPC), activating cell proliferation-related signaling proteins and beta-catenin in human dermal papilla cells, enhancing the expression level of growth factor-related genes, enhancing the expression level of beta-catenin downstream genes, reducing the expression level of alopecia protein DKK-1, and promoting the growth of the hair follicle dermal papilla cells. Increasing the expression of keratin in hair outer root sheath cells (HORSC), and increasing the expression of transcription factors involved in cell activation in hair growth stromal cells (GMC); and promoting differentiation of hair follicle stem cells (HFSC).

The peptide of the present invention has the activity of promoting the proliferation of hair follicle dermal papilla cells (HFDPC); the composition can be used for activating cell proliferation related signal transduction protein and beta-catenin, up-regulating the expression level of growth factor related genes, up-regulating the expression level of beta-catenin subgenes and down-regulating the expression level of alopecia protein DKK-1 in human dermal papilla cells; increasing the expression of keratin in hair outer root sheath cells (HORSC); enhancing expression of transcription factors involved in cell activation in HGMC (Hair Growth Matrix Cells); and promoting differentiation of hair follicle stem cells (HFSC). Therefore, the peptide of the present invention can be used to promote hair growth or to inhibit, prevent, alleviate or treat alopecia.

The invention belongs to the field of bioactive preparations and tissue regeneration, and particularly discloses herbal active hair growth liquid as well as a preparation method and application thereof. The herbal active hair growth liquid is prepared by compounding deionized water, medicinal-grade butanediol, an astragalus membranacus root extract, a ganoderma atrum extract, an angelica sinensis root extract, a cordyceps sinensis extract, a ginseng extract and phenoxyethanol according to a specific weight percentage, dissolving, stirring, controlling the temperature, monitoring the particle size, defoaming and the like. The herbal active hair growth liquid prepared by the invention can remarkably promote proliferation of human hair follicle outer root sheath cells, can realize complete hair regeneration, remarkably increases the number of hair follicles and the diameter of the hair follicles, is superior to existing products, and is suitable for industrial production and application.

The present application belongs to the field of biomedical and cosmetic technology, and particularly relates to the application of protein AMBP in the preparation of a preparation for promoting the activity of hair follicle cells or for preventing and treating alopecia. The present application first discovers that the protein AMBP has the activity of regulating the hair follicle hair papilla cells, hair matrix cells and outer root sheath cells, can promote the proliferation of the hair papilla cells, the hair matrix cells and the outer root sheath cells, and improve the ability of the outer root sheath cells to remove active oxygen; also has the effects of promoting the hair follicle cycle transition, promoting hair growth and hair thickening. Therefore, the protein AMBP can be applied to the preparation of a preparation for treating alopecia.

The invention belongs to the technical field of biomedicine and cosmetics, and particularly relates to application of periostin in preparation of a preparation for promoting hair follicle cell activity or preventing and treating alopecia. It is found for the first time that periostin has the activity of adjusting hair follicle hair papilla cells, hair parent cells and outer root sheath cells, proliferation of the hair papilla cells, the hair parent cells and the outer root sheath cells can be promoted, the hair induction capacity of the hair papilla cells is improved, hair follicle cycle transformation and hair growth and thickening are promoted, and the hair growth rate is increased. The traditional Chinese medicine composition can be used for preparing preparations for treating alopecia.

The invention belongs to the technical field of biomedicine and cosmetics, and particularly relates to application of protein AMBP in preparation of a preparation for promoting hair follicle cell activity or preventing and treating alopecia. It is found for the first time that the protein AMBP has the activity of adjusting hair follicle papilla cells, hair parent cells and outer root sheath cells, proliferation of the hair papilla cells, the hair parent cells and the outer root sheath cells can be promoted, and the capacity of removing active oxygen of the outer root sheath cells is improved; the hair follicle cycle transformation is promoted, and the hair growth and the hair thickening are promoted. Therefore, the protein AMBP can be applied to preparation of a preparation for treating alopecia.