Humanized antibody binding to claudin for treating cancer

A technology of humanized antibodies and claudin, applied in the direction of antibodies, immunoglobulins, anti-animal/human immunoglobulins, etc., can solve problems such as tight junction damage and Claudin18.2 unable to perform normal functions

Active Publication Date: 2020-10-23
BEIJING KAWIN TECH SHARE HLDG
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Problems solved by technology

In tumors, the tight junctions between cells are disru

Method used

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  • Humanized antibody binding to claudin for treating cancer
  • Humanized antibody binding to claudin for treating cancer
  • Humanized antibody binding to claudin for treating cancer

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Embodiment Construction

[0092] 1. Definition:

[0093]An "antibody" as used herein is an immunoglobulin molecule consisting of four peptide chains, two heavy (H) chains and two light (L) chains interconnected by disulfide bonds, each heavy chain comprising a heavy chain variable region ( HVR or VH) and a heavy chain constant region, the heavy chain constant region contains three domains CH1, CH2 and CH3, each light chain includes a light chain variable region (LVR or VL) and a light chain constant region, a light chain constant region Consisting of one domain (CL1), the VH and VL regions can be further divided into hypervariable regions called complementarity determining regions (CDRs), interspersed with more conserved regions called framework regions (FRs), each VH and VL consists of three CDRs and four FRs, arranged in the following order from amino-terminus to carboxy-terminus: FR1, CDR1, FR2, CDR2, FR3, CDR3, FR4. Herein, the heavy chain constant region may be selected from IgG1, IgG2, IgG3 or I...

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Abstract

The present invention relates to a humanized antibody binding to claudin 18.2 for treating cancer. The antibody does not bind to Claudin 18.1, but selectively binds to Claudin 18.2 to destroy tight connection between cells, so that the Claudin 18.2 cannot exert normal functions, and the antibody can be used for preventing or treating tumors, especially advanced gastric cancer.

Description

technical field [0001] The invention relates to a humanized antibody binding to claudin 18.2 for treating cancer, which belongs to the technical field of antibody drugs. Background technique [0002] Gastric cancer is one of the most common cancers worldwide and the second most common cancer in China. According to the disclosure at the 12th International Gastric Cancer Conference held in Beijing in April 2017, about 680,000 new cases of gastric cancer are discovered in China every year, accounting for about half of the total number of cases in the world. Compared with the 446,500 cases announced in 2012, the average annual increase rate exceeded 13%. The death rate of gastric cancer in China is 4 to 8 times that of developed countries in Europe and the United States. About every 2 to 3 minutes, one Chinese person dies of gastric cancer. Compared with other countries, the situation of gastric cancer in China is more serious. [0003] When most gastric cancer patients in Ch...

Claims

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Application Information

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IPC IPC(8): C07K16/28C12N15/13A61K39/395A61P35/00B65D25/02
CPCC07K16/28A61P35/00C07K2317/92C07K2317/56C07K2317/565C07K2317/732C07K2317/734C07K2317/94A61K2039/505C07K2317/24C07K2317/73
Inventor 许铮李响刘影熊国裕李峰史继峰
Owner BEIJING KAWIN TECH SHARE HLDG
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