A continuous sample loading syringe pump structure

Abstract

The present invention discloses a syringe pump structure for continuous loading, including a multi-way valve, a large syringe pump, the multi-way valve including a NO normally open port, an NC normally closed port, a COM common port, a small syringe pump and a driving mechanism, the NO normally open port is connected to the sample solution, and the COM common port is connected to the pump port of the large syringe pump; the volume specification of the large syringe pump exceeds the volume specification of the small syringe pump, the NC normally closed port is provided with a flow path leading to an SPE column, and the pump port of the small syringe pump is connected in parallel to the flow path; the driving mechanism is provided with a first output end and a second output end with opposite moving directions, the pusher head of the large syringe pump is connected to the first output end, and the pusher head of the small syringe pump is connected to the second output end, and when the pusher head of the small syringe pump pushes toward the pump port of the small syringe pump, the pusher head of the large syringe pump is away from the pump port of the large syringe pump. The present case can push liquid while absorbing liquid, realize continuous loading, and improve the efficiency and accuracy of large volume loading.

Description

Technical Field

[0001] The invention relates to the technical field of experimental instruments, and in particular to a continuous sample loading injection pump structure. Background Art

[0002] Laboratories often need to perform sample loading operations, which require extracting solutions and pushing solutions (also called pumping) through SPE columns at a certain speed.

[0003] At present, the common pumps used for pushing liquids on the market include syringe pumps, peristaltic pumps, diaphragm pumps, vane pumps, gear pumps, etc. Among them, the pumping method of peristaltic pumps and diaphragm pumps is to push liquids section by section, which cannot be used in some applications that require stable flow rate and continuous pushing of liquids; the pumping method of vane pumps and gear pumps is sustainable, but the flow rate, accuracy and stability cannot be controlled. At present, all syringe pumps on the market use a motor to drive a syringe pump 1' to suck and push liquids, such as Figure 1 In the liquid aspiration process shown in the figure, the NC normally closed port of the three-way valve 2' is in a normally closed state, the NO normally open port is in a normally open state, and the push head 11' of the syringe pump gradually moves backward, so that the pump 12' of the syringe pump can absorb the sample solution from the NO normally open port and then push the liquid, as shown in FIG. Figure 2 In the liquid pushing process shown, the NC normally closed port is opened, the NO normally open port is closed, and the push head 11' of the syringe pump moves forward while pushing the solution to the SPE column 3'. As can be seen from the above, although the syringe pump is different from other pump structures, the principles are the same. The disadvantage of the old syringe pump method is that it cannot push the liquid at the same time when aspirating the liquid, and the continuous loading function cannot be achieved. If the liquid volume to be loaded is large, it is necessary to continuously aspirate and push the liquid. Each aspiration takes a lot of time, which greatly delays work efficiency. Summary of the invention

[0004] The object of the present invention is to provide a continuous sample loading syringe pump structure to solve the above-mentioned problem, to be able to push liquid while aspirating liquid, to achieve continuous sample loading, and to improve the efficiency and accuracy of large volume sample loading.

[0005] To achieve the above object, the solution of the present invention is: a continuous sample loading syringe pump structure, comprising a multi-way valve and a large syringe pump, wherein the multi-way valve comprises at least a NO normally open port, an NC normally closed port and a COM common port, wherein the NO normally open port is connected to a sample solution, and the COM common port is connected to a pump port of the large syringe pump;

[0006] The injection pump structure also includes a small injection pump and a driving mechanism, the volume specification of the large injection pump exceeds the volume specification of the small injection pump, the NC normally closed port is provided with a flow path leading to the SPE column, and the pump port of the small injection pump is connected in parallel to the flow path; the driving mechanism is provided with a first output end and a second output end with opposite moving directions, the pusher head of the large injection pump is connected to the first output end, and the pusher head of the small injection pump is connected to the second output end, when the pusher head of the small injection pump pushes toward the pump port of the small injection pump, the pusher head of the large injection pump is away from the pump port of the large injection pump, and when the pusher head of the large injection pump pushes toward the pump port of the large injection pump, the pusher head of the small injection pump is away from the pump port of the small injection pump.

[0007] Preferably, the volume specification of the large-sized syringe pump is twice the volume specification of the small-sized syringe pump.

[0008] Preferably, the volume specification of the large-sized syringe pump is 10 ml, and the volume specification of the small-sized syringe pump is 5 ml.

[0009] Preferably, the transmission ratio between the first output end and the second output end is 1:1.

[0010] Preferably, the driving mechanism may adopt a pulley transmission structure.

[0011] Preferably, the pulley transmission structure includes a driving wheel, a driven wheel, a belt, a first slider and a second slider, the motor is connected to the driving wheel, the belt is tightly sleeved on the driving wheel and the driven wheel, the first slider and the second slider are respectively arranged on both sides of the belt between the driving wheel and the driven wheel, the first slider is the first output end, the first slider is connected to the push head of the large injection pump, the second slider is the second output end, and the second slider is connected to the push head of the small injection pump.

[0012] Preferably, the multi-way valve, large injection pump, small injection pump and driving mechanism are all installed on a flat base, and the flat base is provided with a first slide rail and a second slide rail, the first slide rail is slidably fitted on the first slide rail, and the second slide rail is slidably fitted on the second slide rail.

[0013] After adopting the above scheme, compared with the traditional injection pump that first draws liquid, then pushes liquid, then draws liquid again, and then pushes liquid repeatedly, the beneficial effect of the present invention is: the present invention designs two injection pumps, one large and one small, and a driving mechanism that links the two injection pumps and acts in opposite directions. When one of the injection pumps is drawing liquid, the other injection pump can take over to push liquid, thereby realizing continuous uniform speed loading and continuous variable speed loading that cannot be achieved by existing injection pumps, without the need for drawing and pushing liquid in batches, and the volume specifications of the injection pump are replaceable, so as to achieve adjustable accuracy, improve accuracy and stability, and if continuous variable speed loading is to be achieved, the desired speed change can be achieved by changing the multiples of the volume specifications between the large and small injection pumps or the transmission ratio of the driving mechanism. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 It is a simplified structural diagram of the existing syringe pump in the state of liquid aspiration;

[0015] Figure 2 This is a simplified structural diagram of the existing syringe pump in the liquid pushing state;

[0016] Figure 3 It is a front view schematic diagram of the overall structure of an embodiment of the present invention;

[0017] Figure 4 It is a schematic diagram of the back side of the overall structure of an embodiment of the present invention;

[0018] Figure 5 It is a simplified structural diagram of the overall structure of an embodiment of the present invention;

[0019] Figure 6 This is a simplified structural diagram of a small-sized syringe pump for pushing liquid according to an embodiment of the present invention;

[0020] Figure 7 It is a simplified structural diagram of a large-sized injection pump for pushing liquid according to an embodiment of the present invention.

[0021] Description of labels:

[0022] Multi-way valve 1, NO normally open port 11, NC normally closed port 12, COM common port 13, large syringe pump 2, pump port 21, push head 22, small syringe pump 3, pump port 31, push head 32, drive mechanism 4, motor 41, driving wheel 42, driven wheel 43, belt 44, first slider 45, second slider 46, first slide rail 47, second slide rail 48, flow path 5, SPE column 6, and flat base 7. DETAILED DESCRIPTION

[0023] The present invention is described in detail below with reference to the accompanying drawings and specific embodiments.

[0024] The present invention provides a continuous sample injection pump structure, such as Figures 1 to 3As shown, it includes a multi-way valve 1, a large syringe pump 2, a small syringe pump 3, a driving mechanism 4 and a flat base 7. The multi-way valve 1, the large syringe pump 2, the small syringe pump 3 and the driving mechanism 4 are all stably mounted on the flat base 7. Among them, the multi-way valve 1 includes at least three ports, namely, a NO normally open port 11, a NC normally closed port 12 and a COM common port 13. In fact, multiple ports can be additionally provided as needed, which is not limited in this case; the NO normally open port 11 is connected to the sample solution, the COM common port 13 is connected to the pump port 21 of the large syringe pump 2, the NC normally closed port 12 is provided with a flow path 5 leading to the SPE column 6, and the pump port 31 of the small syringe pump 3 is connected in parallel to the flow path 5; the driving mechanism 4 is provided with a first output end and a second output end with opposite moving directions.

[0025] In one embodiment, the transmission ratio between the first output end and the second output end is designed to be 1:1. The drive mechanism 4 can select different types of transmission structures to adapt to different installation environments. The types of transmission structures include gear transmission, screw transmission, etc. The drive mechanism 4 in this embodiment can adopt a pulley transmission structure with a simpler structure and less noise.

[0026] The pulley transmission structure includes a motor 41, a driving wheel 42, a driven wheel 43, a belt 44, a first slider 45 and a second slider 46. The motor 41 is connected to the driving wheel 42. The belt 44 is tightly sleeved on the driving wheel 42 and the driven wheel 43. The first slider 45 and the second slider 46 are respectively arranged on both sides of the belt 44 between the driving wheel 42 and the driven wheel 43. A first slide rail 47 is provided on the flat base 7 at a position corresponding to the first slider 45, and a second slide rail 48 is provided at a position corresponding to the second slider 46. The first slider 45 is slidably fitted on the first slide rail 47, and the second slide rail 48 is slidably fitted on the second slide rail 48. The first slider 45 is the first output end, and the first slider 45 is connected to the pusher head 22 of the large injection pump 2. The second slider 46 is the second output end, and the second slider 46 is connected to the pusher head 32 of the small injection pump 3. When the pusher head 32 of the small injection pump 3 is pushed toward the pump port 31 of the small injection pump 3, the pusher head 22 of the large injection pump 2 is away from the pump port 21 of the large injection pump 2. When the pusher head 22 of the large injection pump 2 is pushed toward the pump port 21 of the large injection pump 2, the pusher head 32 of the small injection pump 3 is away from the pump port 31 of the small injection pump 3.

[0027] The volume specification of the large syringe pump 2 exceeds the volume specification of the small syringe pump 3. In one embodiment, the volume specification of the large syringe pump 2 is twice the volume specification of the small syringe pump 3. The working process is described in detail below using the example that the volume specification of the large syringe pump 2 is 10ml and the volume specification of the small syringe pump 3 is 5ml.

[0028] During operation, first, the motor 41 drives the driving wheel 42 to rotate counterclockwise, and drives the driven wheel 43 to rotate through the belt 44. The NO normally open port 11 of the multi-way valve 1 is connected to the COM common port 13, and the NC normally closed port 12 is in a closed state. Figure 6 As shown, at this time, the first slider 45 on one side of the belt 44 drives the pusher head 22 of the large syringe pump 2 away from the pump port 21 of the large syringe pump at a speed of 20ml / min to extract the sample solution, and the liquid flows into the large syringe pump 2. At the same time, the second slider 46 on the other side of the belt 44 drives the pusher head 32 of the small syringe pump 3 to push toward the pump port 31 of the small syringe pump 3 to push the liquid, and the liquid flows from the flow path 5 to the SPE column 6. Since the volume specification of the small syringe pump 3 is half of that of the large syringe pump 2, the flow rate through the SPE column 6 is 10ml / min; the moment the large syringe pump 2 is pumped to the bottom, the multi-way valve 1 switches to the NC normally closed port 12 to open and connect to the COM common port 13, the NO normally open port 11 is in a closed state, and the motor 41 drives the driving wheel 42 to rotate clockwise, as shown in FIG. Figure 7 As shown, the first slider 45 drives the pusher head 22 of the large syringe pump 2 to push toward the pump port 21 of the large syringe pump 2 at a speed of 20 ml / min and pushes toward the flow path 5 from the NC normally closed port 12. At the same time, the second slider 46 drives the pusher head 32 of the small syringe pump 3 away from the pump port 31 of the small syringe pump 3. Since the volume specification of the small syringe pump 3 is half of that of the large syringe pump 2, and the pumping speed of the small syringe pump 3 is 10 ml / min, half of the sample solution flowing out of the pump port 21 of the large syringe pump 2 will be sucked into the small syringe pump 3, so the actual flow rate through the SPE column 6 is 10 ml / min. Therefore, the flow rate through the SPE column 6 is continuously maintained at 10 ml / min.

[0029] From the above, it can be seen that the transmission ratio of the driving mechanism 4 of the present invention and the multiples of the volume specifications between the large and small syringe pumps 3 will affect the final flow rate through the SPE column 6. The volume specification of the large syringe pump 2 is twice the volume specification of the small syringe pump 3, and the transmission ratio of 1:1 is a prerequisite for ensuring a certain column speed, that is, continuous and uniform sample loading. Of course, if the present invention is to achieve continuously variable speed sample loading, the desired speed change can be achieved by changing the multiples of the volume specifications between the large and small syringe pumps 3 or the transmission ratio of the driving mechanism 4.

[0030] The above description is only a preferred embodiment of the present invention and is not a limitation on the design of this case. Any equivalent changes made based on the design key of this case shall fall within the protection scope of this case.

Claims

1. A continuous loading syringe pump structure, comprising a multi-way valve and a large syringe pump, wherein the multi-way valve comprises a NO normally open port, an NC normally closed port and a COM common port, wherein the NO normally open port is connected to a sample solution, and the COM common port is connected to a pump port of the large syringe pump; characterized in that: The injection pump structure also includes a small injection pump and a driving mechanism, the volume specification of the large injection pump is twice the volume specification of the small injection pump, the NC normally closed port is provided with a flow path leading to the SPE column, and the pump port of the small injection pump is connected in parallel to the flow path; the driving mechanism is provided with a first output end and a second output end with opposite moving directions, the transmission ratio of the first output end and the second output end is 1:1, the driving mechanism adopts a pulley transmission structure, the pulley transmission structure includes a driving wheel, a driven wheel, a belt, a first slider and a second slider, the motor is connected to the driving wheel, the belt is tightly sleeved on the driving wheel and the driven wheel, and the first sliders are respectively provided on both sides of the belt between the driving wheel and the driven wheel and a second slider, the first slider is the first output end, the first slider is connected to the pusher head of the large injection pump, the second slider is the second output end, and the second slider is connected to the pusher head of the small injection pump; when the NO normally open port of the multi-way valve is connected to the COM common port and the NC normally closed port is in a closed state, the pusher head of the large injection pump is away from the pump port of the large injection pump, and the pusher head of the small injection pump is pushed toward the pump port of the small injection pump; when the multi-way valve is switched to the NC normally closed port to open and connect the COM common port and the NO normally open port is in a closed state, the pusher head of the large injection pump is pushed toward the pump port of the large injection pump, and the pusher head of the small injection pump is away from the pump port of the small injection pump.

2. A continuous loading syringe pump structure as claimed in claim 1, characterized in that: The volume specification of the large-sized syringe pump is 10 ml, and the volume specification of the small-sized syringe pump is 5 ml.

3. A continuous loading syringe pump structure as claimed in claim 1, characterized in that: The multi-way valve, large injection pump, small injection pump and driving mechanism are all installed on a flat base, and the flat base is provided with a first slide rail and a second slide rail. The first slide rail is slidably matched on the first slide rail, and the second slide rail is slidably matched on the second slide rail.

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