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Kit for detecting human Card9 gene polymorphism, detection method and application

A technology of gene polymorphism and detection method, which is applied in the field of kits for detecting human Card9 gene polymorphism, can solve the problems of poor clinical curative effect of patients

Active Publication Date: 2021-04-30
上海市松江区中心医院
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Problems solved by technology

[0004] Somatostatin inhibits the body's pancreatic enzyme secretion and inflammatory response, and has

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  • Kit for detecting human Card9 gene polymorphism, detection method and application
  • Kit for detecting human Card9 gene polymorphism, detection method and application
  • Kit for detecting human Card9 gene polymorphism, detection method and application

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specific Embodiment

[0058] In addition, the present invention also provides specific examples of the research on the effect of Card9 gene polymorphism on the curative effect of somatostatin in treating acute pancreatitis, including the following steps:

[0059] S1. Collect research objects: Select a predetermined number of patients with acute pancreatitis and the same number of healthy people as subjects, excluding chronic infectious diseases, autoimmune diseases, tumors and other interference indicators detection; preset number of cases Patients with acute pancreatitis included patients with mild acute pancreatitis, patients with moderate to severe acute pancreatitis, and patients with severe acute pancreatitis. Patients with acute pancreatitis are hereinafter referred to as AP patients.

[0060] In this embodiment, 70 patients with AP who were treated in our hospital from June 2019 to February 2020 were selected as the AP group. There were 34 cases of pancreatitis (MAP), 27 cases of moderate t...

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Abstract

The invention is applicable to the technical field of gene polymorphism detection kits, and provides a kit for detecting human Card9 gene polymorphism, a detection method and application, and the polymorphism of rs10870077, rs4077515, rs10781499, rs141999399 and rs139265120 sites of Card9 genes of pancreatitis patients is detected by adopting a TaqMan probe method kit. According to the invention, the fact that the Card9 gene rs10870077C > G polymorphism is a high-risk factor of acute pancreatitis is illustrated for the first time, and the causes of different clinical effects of somatostatin on treating acute pancreatitis are explained from the perspective of Card9 gene polymorphism, so that clinical reference is provided for individualized administration of somatostatin on treating acute pancreatitis. The Card9 gene polymorphism kit and the detection method thereof provided by the invention have very important clinical application value for diagnosis and treatment of pancreatitis patients.

Description

technical field [0001] The invention belongs to the technical field of gene polymorphism detection kits, in particular to a kit, detection method and application for detecting human Card9 gene polymorphism. Background technique [0002] Acute pancreatitis (AP) is a common and frequently-occurring disease of the digestive system. It is caused by abnormal activation of pancreatic enzymes caused by various etiologies, followed by local inflammation of the pancreas as the main feature, with or without other organ function changes. In clinical practice, the course of most AP patients is self-limiting, but about 20% to 30% of patients progress to severe acute pancreatitis, which is difficult to treat, accompanied by multiple organ failure, and the mortality rate is as high as 10% to 20%. [0003] Gene polymorphism may be one of the important influencing factors in patients with AP, which can increase the risk of acute pancreatitis. Known, TRLs (Toll-like receptors), TNF-α (tumor ...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/106C12Q2600/156
Inventor 杨志文徐萍王学敏王静盛阮妹
Owner 上海市松江区中心医院