A sleep-promoting formula and its preparation method and application

Abstract

The present invention provides a sleep-promoting formula and its preparation method and application, and specifically relates to the technical field of health care products. The sleep-promoting formula includes the following raw material components by weight: 1-7 parts of ginseng, 1-9 parts of wolfberry, 10-30 parts of spiny jujube seeds, 5-20 parts of Poria cocos, 1-8 parts of kelp, 1-13 parts of kudzu root, 1-7 parts of bamboo shavings, and 1-15 parts of chicken gizzard lining. The raw materials also include 1-9 parts of licorice and 1-6 parts of polygonatum. A sleep-promoting formula provided by the present invention can effectively improve sleep, especially suitable for insomnia groups of patients with depression, without any toxic and side effects, can be used as ordinary food, positioned in the markets of functional foods, health care products, etc., easy to use, good effect, and has very good market prospects. The preparation method of the present invention is simple and easy to operate, and is convenient for promotion and use.

Description

Technical Field

[0001] The invention belongs to the technical field of health care products, and specifically relates to a sleep-promoting formula and a preparation method and application thereof. Background Art

[0002] Insomnia is a chronic disease in which people have difficulty falling asleep and insufficient sleep in their daily lives. With the accelerating pace of life and the increase in work pressure, the proportion of people suffering from insomnia is increasing year by year. According to a survey by the World Health Organization (WHO), about one-third of people worldwide have insomnia symptoms or sleep dysfunction. Studies have found that insomnia can cause daily phenomena such as memory loss and lack of concentration, which can cause irreversible damage to the brain, and it is a complication of various cardiovascular and cerebrovascular diseases and neurodegenerative diseases.

[0003] Modern medical research believes that the mechanism of improving sleep is mainly related to regulating the serotonin (5-hydroxytryptamine, 5-HT) system, glutamate (Glu) and γ-aminobutyric acid (GABA) balance. At present, the drugs for the treatment of insomnia mainly include tranquilizers (benzodiazepines), antidepressants, etc. Due to the difficulty in treating insomnia and the long medication cycle, side effects such as drug dependence and rebound may occur. Insomnia is a chronic disease induced by multiple factors, and single-target research will have certain limitations. Traditional Chinese herbal medicine has the characteristics of multiple components and multiple targets, and can effectively improve the effect through multiple pathways, playing a unique advantage in the prevention, treatment and rehabilitation of diseases.

[0004] Depression is a common mental illness, and insomnia is a common comorbid symptom of depression. When patients with depression are depressed, the content of central neurotransmitters or receptor function decreases, affecting their mood and sleep, manifesting as early awakening, reduced total sleep time, and increased number of awakenings at night.

[0005] Traditional Chinese medicine calls insomnia "insomnia", and believes that insomnia is a disease caused by the disharmony of internal organs and the imbalance of qi and blood, which leads to the lack of nourishment of the mind and restlessness. Traditional Chinese medicine has higher safety. Therefore, the development of an efficient and safe product to improve sleep has important social significance. Summary of the invention

[0006] The purpose of the present invention is to provide a sleep-promoting formula and a preparation method and application thereof, which can effectively improve sleep, and is especially suitable for insomniacs in patients with depression, has no toxic side effects, can be used as an ordinary food, and is positioned in the markets of functional foods, health products, etc. It is easy to use, has good effects, and has very good market prospects.

[0007] In order to achieve the above object, the present invention provides the following technical solutions:

[0008] A sleep-promoting formula comprises the following raw material components in parts by weight: 1-7 parts of ginseng, 1-9 parts of wolfberry, 10-30 parts of spiny jujube seeds, 5-20 parts of tuckahoe, 1-8 parts of kelp, 1-13 parts of kudzu root, 1-7 parts of bamboo shavings and 1-15 parts of chicken's gizzard lining.

[0009] The present invention compounds the above components to achieve a synergistic effect, improve the sleep quality of insomnia patients, and alleviate the clinical symptoms of insomnia patients.

[0010] Furthermore, the raw materials also include 1-9 parts of liquorice and 1-6 parts of polygonatum.

[0011] The present invention can prolong the total sleep time of patients with depression by adding licorice and polygonatum. It is speculated that licorice has a sedative effect on the central nervous system, and licorice has a bidirectional effect of excitation and inhibition on nerve endings, while polygonatum has the functions of nourishing yin and moistening dryness, promoting body fluid and quenching thirst, and can play a role in calming the mind and relaxing the spirit, and has a good conditioning effect on some neurasthenia, insomnia, and dreaminess, and can also play a role in relieving high mental tension and excessive fatigue. Licorice and polygonatum are used in combination with other drugs to have obvious synergistic effects, which can enhance the sedative effect.

[0012] Further, the following raw material components are included in parts by weight: 1-5 parts of ginseng, 1-4 parts of wolfberry, 17-23 parts of spiny jujube seeds, 6-12 parts of poria, 1-5 parts of kelp, 3-7 parts of kudzu root, 1-3 parts of bamboo shavings, 5-8 parts of chicken gizzard lining, 2-6 parts of licorice and 1-3 parts of polygonatum.

[0013] Furthermore, the mass ratio of ginseng, wolfberry, spiny jujube seed and poria is 0.3-0.6:1:9-10:5-6.

[0014] The raw materials of the present invention are based on the formula product of "both food and Chinese medicinal material", which can not only ensure the quality of sleep, but also ensure the safety of long-term use. Ginseng has the effects of greatly replenishing vitality, tonifying the spleen and lungs, promoting the production of body fluids, calming the mind and improving intelligence. It can replenish qi and strengthen the spleen, improve symptoms such as weakness in the limbs and palpitations, and has a significant effect on improving the body's immunity, learning and memory ability, and calming the mind and improving intelligence. Lycium barbarum has the effects of nourishing the liver and kidneys, improving the essence and improving eyesight. Ziziphus jujuba seeds have the effects of nourishing the heart and liver, calming the mind and calming the mind, astringing sweat, and promoting the production of body fluids. Ziziphus jujuba seeds total saponins and alkaloids can regulate the content of Glu, GABA and 5-HT in the cerebral cortex and hippocampus; the active ingredient of flavonoid glycosides, spinosin, can prolong sleep time. Poria cocos has the functions of promoting water and dampness, strengthening the spleen, calming the mind and calming the mind. The effective ingredient of Poria cocos, tuckahoe polysaccharide, has a good regulating effect on sleep. The inventor unexpectedly discovered that when the mass ratio of ginseng, wolfberry, spiny jujube seed and poria is 0.3-0.6:1:9-10:5-6, the early awakening of insomnia patients can be improved.

[0015] Furthermore, the following raw material components are included in parts by weight: 1 part of ginseng, 2 parts of wolfberry, 20 parts of spiny jujube seeds, 10 parts of poria, 3 parts of kelp, 5 parts of kudzu root, 2 parts of bamboo shavings, 6 parts of chicken gizzard lining, 4 parts of licorice and 2 parts of polygonatum.

[0016] The present invention also provides a preparation method of the sleep-promoting formula, which specifically comprises the following steps: weighing and mixing each raw material by weight, boiling with water for 2-3 times to obtain a decoction, combining the decoctions, filtering with a 200-mesh filter, and concentrating under reduced pressure to obtain a clear paste.

[0017] Furthermore, the decoction time for each time is 1-2 hours, and the weight of water added during each decoction is 8-10 times the total weight of the raw materials.

[0018] Furthermore, the temperature of the reduced pressure concentration is 60-70°C.

[0019] The present invention also provides the use of the sleep-promoting formula, which is the use of the sleep-promoting formula in preparing food or health products for patients with depression.

[0020] Furthermore, the sleep-promoting formula is added with auxiliary materials to prepare powder, granules or oral liquid.

[0021] Compared with the prior art, the advantages and beneficial effects of the present invention are:

[0022] 1. The present invention provides a sleep-promoting formula and a preparation method and application thereof, which can effectively improve sleep, and is especially suitable for insomniacs in patients with depression, has no toxic side effects, can be used as an ordinary food, and is positioned in the functional food, health care product and other markets. It is easy to use, has good effects, and has very good market prospects.

[0023] 2. The present invention compounds ginseng, wolfberry, spiny jujube seed, tuckahoe, kelp, kudzu root, bamboo shavings and chicken's gizzard lining to achieve a synergistic effect, improve the sleep quality of insomnia patients, and alleviate the clinical symptoms of insomnia patients.

[0024] 3. The present invention can prolong the total sleep time of patients with depression by adding licorice and polygonatum, and the combination of licorice and polygonatum with other drugs has obvious synergistic effect and can enhance the sedative effect.

[0025] 4. The mass ratio of ginseng, wolfberry, spiny jujube seed and poria cocos of the present invention is 0.3-0.6:1:9-10:5-6, which can improve the early awakening of insomnia patients when used in combination with other components. DETAILED DESCRIPTION

[0026] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] Example 1

[0028] The present embodiment provides a sleep-promoting formula, comprising the following raw material components in parts by weight: 1 part of ginseng, 2 parts of wolfberry, 20 parts of spiny jujube seeds, 10 parts of poria, 3 parts of kelp, 5 parts of kudzu root, 2 parts of bamboo shavings, 6 parts of chicken gizzard lining, 4 parts of licorice and 2 parts of polygonatum.

[0029] This embodiment also provides a method for preparing the sleep-promoting formula. The preparation method is specifically as follows: weigh and mix the raw materials in parts by weight, add water and boil for 3 times to obtain a decoction, combine the decoctions, filter with a 200-mesh filter, and concentrate under reduced pressure to obtain a clear paste.

[0030] The decoction time is 1.5 hours each time, and the weight of water added during each decoction is 9 times the total weight of the raw materials. The temperature for reduced pressure concentration is 65°C.

[0031] Example 2

[0032] The difference between this embodiment and embodiment 1 is: a sleep-promoting formula, comprising the following raw material components in parts by weight: 1 part of ginseng, 9 parts of wolfberry, 15 parts of spiny jujube seeds, 10 parts of poria, 8 parts of kelp, 4 parts of kudzu root, 7 parts of bamboo shavings, 12 parts of chicken gizzard lining, 9 parts of licorice and 1 part of polygonatum.

[0033] Example 3

[0034] The difference between this embodiment and embodiment 1 is: a sleep-promoting formula, comprising the following raw material components in parts by weight: 1 part of ginseng, 2 parts of wolfberry, 20 parts of spiny jujube seeds, 10 parts of poria, 3 parts of kelp, 5 parts of kudzu root, 2 parts of bamboo shavings, and 6 parts of chicken's gizzard lining.

[0035] Example 4

[0036] The difference between this embodiment and embodiment 1 is: a sleep-promoting formula, comprising the following raw material components in parts by weight: 6 parts of ginseng, 7 parts of wolfberry, 15 parts of spiny jujube seeds, 5 parts of poria, 3 parts of kelp, 5 parts of kudzu root, 2 parts of bamboo shavings, 6 parts of chicken gizzard lining, 4 parts of licorice and 2 parts of polygonatum.

[0037] Example 5

[0038] The difference between this embodiment and embodiment 1 is: a sleep-promoting formula, comprising the following raw material components in parts by weight: 2 parts of ginseng, 6 parts of wolfberry, 14 parts of spiny jujube seeds, 11 parts of poria, 5 parts of rose, 2 parts of chamomile, 3 parts of cinnamon and 8 parts of julibrissin bark.

[0039] Performance Testing

[0040] 1. (1) Granulation: Add dextrin to the product prepared in Example and mix well. Then, dry and pulverize the mixture in sequence to obtain a drug powder. Then, add the same amount of dextrin as that added last time to granulate the mixture and dry it at 65°C. The sum of the weights of the two dextrin additions is equal to the total weight of the raw materials.

[0041] (2) Experimental method: 60 non-depressed volunteers aged 30-40 were selected, with PSQI scores exceeding 13 points, excluding other safety hazards. Volunteers were divided into 6 groups in equal proportion according to their PSQI scores, and various factors affecting the results, including gender, age, sleep habits and occupational characteristics, were considered to ensure balance between groups as much as possible. Five groups of volunteers took 3 granules prepared in the embodiment 1 hour before going to bed, and the sixth group did not take any product. During the trial, the subjects' original eating habits were not changed, and they ate normally. This lasted for 30 consecutive days. At the end of the trial, the volunteers were re-evaluated for PSQI and the average early awakening time one month before the trial and the average early awakening time one month after the trial were calculated. The results are shown in Table 1.

[0042] Table 1 Changes of volunteers before and after 30 days of feeding

[0043]

[0044] 2. 300 18-22g Kunming mice with depression of the same age were selected, half male and half female, and randomly divided into 6 groups. One granule prepared in the embodiment was fed every day, and the control group did not take any product. According to statistics, the average sleep time of normal healthy Kunming mice is about 14 hours. The sleep time of mice was recorded, and the results are shown in Table 2.

[0045] Table 2 Daily sleep duration of mice before and after 30 days (h)

[0046]

[0047] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A sleep-promoting composition, characterized in that: The invention is composed of the following raw materials in parts by weight: 1-7 parts of ginseng, 1-9 parts of wolfberry, 10-30 parts of spiny jujube seeds, 5-20 parts of tuckahoe, 1-8 parts of kelp, 1-13 parts of kudzu root, 1-7 parts of bamboo shavings, 1-15 parts of chicken gizzard lining, 1-9 parts of liquorice and 1-6 parts of polygonatum odoratum; The mass ratio of ginseng, wolfberry, spinach seed and poria is 0.3-0.6:1:9-10:5-6.

2. The sleep-promoting composition according to claim 1, characterized in that: The invention is composed of the following raw materials in parts by weight: 1-5 parts of ginseng, 1-4 parts of wolfberry, 17-23 parts of spiny jujube seeds, 6-12 parts of tuckahoe, 1-5 parts of kelp, 3-7 parts of kudzu root, 1-3 parts of bamboo shavings, 5-8 parts of chicken gizzard lining, 2-6 parts of liquorice and 1-3 parts of polygonatum.

3. The sleep-promoting composition according to claim 1, characterized in that: The invention is composed of the following raw materials in parts by weight: 1 part of ginseng, 2 parts of wolfberry, 20 parts of spiny jujube seeds, 10 parts of tuckahoe, 3 parts of kelp, 5 parts of kudzu root, 2 parts of bamboo shavings, 6 parts of chicken gizzard lining, 4 parts of liquorice and 2 parts of polygonatum.

4. The method for preparing the sleep-promoting composition according to any one of claims 1 to 3, characterized in that: The preparation method is specifically as follows: weighing and mixing each raw material by weight, adding water and boiling for 2-3 times to obtain a decoction, combining the decoctions, filtering with a 200-mesh filter, and concentrating under reduced pressure to obtain a clear paste.

5. The preparation method according to claim 4, characterized in that: The decoction time is 1-2 hours each time, and the weight of water added each time is 8-10 times the total weight of the raw materials.

6. The preparation method according to claim 4, characterized in that: The temperature of the reduced pressure concentration is 60-70°C.

7. The use of the sleep-promoting composition according to any one of claims 1 to 3, characterized in that: Application of the sleep-promoting composition in preparing food or health products for patients with depression.

8. The use according to claim 7, characterized in that: The sleep-promoting composition is added with auxiliary materials to prepare powder, granules or oral liquid.

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