Traditional Chinese medicine composition for treating hypertension as well as preparation method and application thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating hypertension and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20 to 30 parts of rhizoma alismatis, 20 to 30 parts of fructus crataegi, 20 to 30 parts of poria cocos, 10 to 15 parts of persimmon leaves, 10 to 15 parts of folium mori, 20 to 30 parts of phellinus igniarius, 20 to 30 parts of bitter radix puerariae, 20 to 30 parts of ramulus uncariae cum uncis, 20 to 30 parts of rhizoma chuanxiong, 10 to 15 parts of spica prunellae, 20 to 30 parts of radix salviae miltiorrhizae, 10 to 15 parts of rhizoma gastrodiae and 10 to 15 The traditional Chinese medicine composition has the effect of reducing blood pressure, and is remarkable in curative effect and low in adverse reaction rate.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating hypertension, and a preparation method and application thereof. Background Art

[0002] There are many commonly used methods for the treatment and prevention of hypertension, including lifestyle and diet adjustment, attention to the combination of work and rest, adequate sleep, participation in work, physical labor and physical exercise within one's ability; attention to dietary adjustment, low-salt, low-animal fat diet is appropriate, and avoid eating foods rich in cholesterol; Western medicine mainly has diuretic antihypertensive agents: hydrochlorothiazide, cyclopenthiazide; central nervous and sympathetic nervous system inhibitors: reserpine, antihypertensive spirit, clonidine hydrochloride, etc. However, Western medicine has large toxic and side effects, high costs, and brings more burdens to patients. Chinese herbal medicine takes into account both the specimen and the toxic and side effects, but there are still some deficiencies and challenges in the clinical research of the treatment of hypertension in the field of traditional Chinese medicine, which requires further research and improvement. Therefore, it is of great significance to find an effective and safe Chinese medicine composition to achieve the purpose of lowering blood pressure. Summary of the invention

[0003] In view of this, the object of the present invention is to provide a Chinese medicine composition for treating hypertension and its preparation method and application. The Chinese medicine composition of the present invention has the effect of lowering blood pressure, has significant therapeutic effect and low adverse reaction rate.

[0004] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0005] The present invention provides a traditional Chinese medicine composition for treating hypertension, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight:

[0006] 20-30 parts of Alisma orientalis, 20-30 parts of hawthorn, 20-30 parts of Poria, 10-15 parts of persimmon leaves, 10-15 parts of mulberry leaves, 20-30 parts of mulberry linterus, 20-30 parts of Pueraria lobata, 20-30 parts of Uncaria rhynchophylla, 20-30 parts of Chuanxiong, 10-15 parts of Prunella vulgaris, 20-30 parts of Salvia miltiorrhiza, 10-15 parts of Gastrodia elata, and 10-15 parts of Carthamus tinctorius.

[0007] The present invention also provides a method for preparing the Chinese medicine composition, comprising the following steps:

[0008] The Chinese medicine composition is weighed according to the weight proportion, mixed, decocted for 20 to 50 minutes, and the medicinal liquid and the medicinal residue are collected by filtration; the collected medicinal residue is decocted again for 30 to 60 minutes, and the medicinal liquid is collected by filtration; and the medicinal liquids collected twice are combined.

[0009] Preferably, during the decocting process, after the water boils, the decocting is carried out on low heat.

[0010] The present invention also provides an application of the traditional Chinese medicine composition in preparing a drug for treating blood pressure.

[0011] Preferably, the dosage form of the drug includes pills, powders, solutions or granules.

[0012] Preferably, the method for preparing the pills comprises the following steps: grinding the medicinal materials into fine powder, sieving, adding auxiliary materials and making into pills.

[0013] Preferably, the preparation method of the powder comprises the following steps: mixing the medicinal materials evenly, crushing them into powder, and sieving.

[0014] Preferably, the mesh size of the sieving is 100 to 120 meshes.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] The drugs of the present invention are compatible and complement each other. In the prescription, oriental water chestnut, mulberry linterus, bitter pueraria root and gastrodia elata are the main drugs, which have the effects of promoting blood circulation and stopping bleeding, resolving phlegm and stopping diarrhea, calming the liver and calming wind, and have a good alleviating effect on the symptoms of dizziness, headache and the like caused by hypertension, and play a major therapeutic effect on the main disease and main syndrome; self-poison and uncaria are the assistant drugs, self-poison is mainly used to clear and reduce liver fire, and is particularly suitable for patients with hypertension accompanied by symptoms such as hyperactive liver fire, red and swollen eyes, etc., and can assist the main drug in strengthening the effect of treating hypertension; uncaria also has the effect of calming the liver and extinguishing wind, and is used together with gastrodia elata in the main drug, and can enhance the effect of calming the liver and lowering blood pressure; hawthorn, salvia miltiorrhiza, ligusticum chuanxiong and mulberry leaf are adjuvant drugs, hawthorn has the effects of digesting food and resolving accumulation, promoting blood circulation and removing blood stasis, and can improve the problems of poor blood circulation and high blood lipids that may exist in patients with hypertension; Salvia miltiorrhiza has the effects of promoting blood circulation and removing blood stasis, clearing the heart and removing vexation, can assist hawthorn in improving blood circulation, and relieve the symptoms of vexation and insomnia that may exist in patients with hypertension; Chuanxiong is a blood-qi medicine, which can promote blood circulation and qi, dispel wind and relieve pain, and has a good relieving effect on headaches, dizziness and other symptoms caused by hypertension; Mulberry leaf has the effects of lowering blood pressure and lipid, and can assist the monarch and minister medicines to strengthen the antihypertensive effect; Poria, safflower and persimmon leaves are the guiding medicines, Poria has the effects of promoting water and dampness, strengthening the spleen and calming the mind, can reconcile all medicines, and also has a certain therapeutic effect on patients with hypertension accompanied by edema symptoms; Safflower has the effects of promoting blood circulation and removing blood stasis, dredge menstruation and relieve pain, can assist Salvia miltiorrhiza and Chuanxiong in strengthening the effects of promoting blood circulation and removing blood stasis, and at the same time, as a guiding medicine, guides all medicines to reach the diseased area directly; Persimmon leaves have the effects of lowering blood pressure and lipid. The Chinese medicine composition of the present invention is scientifically compatible, and all medicines work together to achieve the effect of lowering blood pressure, with high medication safety, significant efficacy, short treatment course and low adverse reaction rate. DETAILED DESCRIPTION

[0017] The present invention provides a traditional Chinese medicine composition for treating hypertension, wherein the traditional Chinese medicine composition preferably comprises the following raw materials in parts by weight: 20-30 parts of oriental rhizome, 20-30 parts of hawthorn, 20-30 parts of poria, 10-15 parts of persimmon leaf, 10-15 parts of mulberry leaf, 20-30 parts of phellinus igniarius, 20-30 parts of kudzu root, 20-30 parts of Uncaria rhynchophylla, 20-30 parts of chuanxiong, 10-15 parts of selfheal, 20-30 parts of salvia miltiorrhiza, 10-15 parts of gastrodia elata, and 10-15 parts of safflower; more preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 22-25 parts of oriental rhizome, 22-25 parts of hawthorn, 20-30 parts of poria, 10-15 parts of persimmon leaf, 10-15 parts of mulberry leaf, 20-30 parts of phellus igniarius, 20-30 parts of kudzu root, 20-30 parts of uncaria, 20-30 parts of chuanxiong, 10-15 parts of selfheal, 20-30 parts of salvia miltiorrhiza, 10-15 parts of gastrodia elata, and 10-15 parts of safflower. 2-25 parts, persimmon leaf 12-14 parts, mulberry leaf 12-14 parts, mulberry linterus 25-28 parts, bitter kudzu root 25-28 parts, Uncaria rhynchophylla 25-28 parts, chuanxiong 25-28 parts, selfheal 11-13 parts, salvia miltiorrhiza 22-25 parts, gastrodia 11-13 parts, safflower 11-13 parts; further preferably including the following weight parts of raw materials: orientalis 30 parts, hawthorn 30 parts, tuckahoe 30 parts, persimmon leaf 15 parts, mulberry leaf 15 parts, mulberry linterus 30 parts, bitter kudzu root 30 parts, Uncaria rhynchophylla 30 parts, chuanxiong 30 parts, selfheal 10 parts, salvia miltiorrhiza 30 parts, gastrodia 10 parts, safflower 10 parts. The Chinese medicine of the present invention can be purchased through conventional channels.

[0018] In the present invention, the herb is also known as Ruyihua, has a sweet and light taste, is cold in nature, and enters the kidney and bladder meridians. It has the effects of promoting diuresis and dispelling dampness, relieving heat, clearing turbidity and reducing lipids. It is used for urinary dysfunction, edema, diarrhea, oliguria, phlegm and fluid dizziness, hot stranguria, and hyperlipidemia.

[0019] Hawthorn is sour and sweet, slightly warm in nature, and enters the spleen, stomach, and liver meridians. It has the effects of helping digestion and strengthening the stomach, promoting qi and dispersing blood stasis, clearing turbidity and reducing fat; it is used for meat stagnation, stomach fullness, heart and abdomen pain, chest pain, hernia pain, and hyperlipidemia.

[0020] Poria cocos is sweet and light in taste, neutral in nature, and enters the heart, lung, spleen, and kidney meridians. It has the effects of promoting diuresis and eliminating dampness, strengthening the spleen, and calming the mind; it is used for edema, oliguria, phlegm and fluid, palpitations, spleen deficiency, poor appetite, loose stools, restlessness, palpitations, and insomnia.

[0021] Persimmon leaf, also known as persimmon leaf, is bitter, cold in nature, and belongs to the lung meridian. It has the effects of relieving cough and asthma, promoting body fluid and relieving thirst, and promoting blood circulation and stopping bleeding. It is used for cough and asthma, thirst, various internal bleeding, and ecthyma.

[0022] Mulberry leaves are bitter and sweet, cold in nature, and enter the lung and liver meridians. They have the effects of dispersing wind-heat, clearing the lungs and moistening dryness, calming the liver and improving eyesight, cooling blood and stopping bleeding. Mulberry leaves also contain active substances that can promote vasodilation, thereby playing a role in lowering blood pressure.

[0023] Phellinus igniarius, slightly bitter in taste, cold in nature, enters the liver and kidney meridians. It has the functions of promoting blood circulation, stopping bleeding, transforming fluid, and stopping diarrhea; it is used for metrorrhagia, hematuria, rectal prolapse and bleeding, leucorrhea, amenorrhea, accumulation of lumps, drinking habit, and diarrhea due to spleen deficiency.

[0024] Pueraria root, pungent, bitter, neutral in nature, enters the lung and stomach meridians. It has the effects of clearing away heat and clearing rashes, promoting body fluid and quenching thirst; it is used for colds and fever, measles that do not clear up, thirst, vomiting blood, and mouth sores.

[0025] Uncaria rhynchophylla, sweet in taste, cool in nature, enters the liver and pericardium meridians. It has the effects of calming wind and relieving convulsions, clearing away heat and calming the liver; it is used for internal liver wind movement, convulsions, headaches and dizziness.

[0026] Chuanxiong is mainly used for promoting blood circulation and qi, dispelling wind and relieving pain, and is suitable for treating heart vessel stasis, chest and flank pain, injuries from falls, headache, rheumatism, and arthralgia, etc. In the Chinese medicine composition of the present invention, Chuanxiong has a slight sedative and blood pressure lowering effect.

[0027] Prunella vulgaris is pungent, bitter and cold in nature. It enters the liver and gallbladder meridians. It has the effects of clearing the liver and purging fire, improving eyesight, dispersing stagnation and reducing swelling. In the Chinese medicine composition of the present invention, Prunella vulgaris can effectively dilate blood vessels, increase blood flow in blood vessels, thereby reducing the pressure of blood on blood vessels and lowering blood pressure.

[0028] Danshen, bitter, slightly cold, enters the heart and liver meridians. It has the effects of promoting blood circulation and removing blood stasis, relieving pain, clearing the heart and eliminating vexation, cooling blood and eliminating carbuncle; it is used for chest pain, abdominal pain, accumulation of symptoms, heat arthralgia, restlessness and insomnia, irregular menstruation, dysmenorrhea, amenorrhea, sores and swelling.

[0029] Gastrodia elata is sweet and neutral in nature. It enters the liver meridian. It has the effects of calming wind and stopping spasms, calming liver yang, and dispelling wind and unblocking collaterals. Gastrodia elata can relieve symptoms such as internal liver wind movement, dizziness, and muscle and bone pain. At the same time, in the Chinese medicine composition of the present invention, Gastrodia elata has the effects of reducing vascular resistance and promoting blood circulation, and can reduce blood pressure to a certain extent.

[0030] Safflower, pungent in taste, warm in nature, enters the heart and liver meridians. It has the effects of promoting blood circulation and menstruation, dispersing blood stasis and relieving pain; it is used for chest pain, abdominal pain due to blood stasis, stabbing pain in the chest and ribs, injuries from falls, and swelling and pain in sores.

[0031] The Chinese medicine composition of the invention is scientifically compatible, and the drugs work together to achieve the effect of lowering blood pressure. It has high medication safety, significant efficacy, short treatment course and low adverse reaction rate.

[0032] The present invention also provides a method for preparing the Chinese medicine composition, which preferably comprises the following steps:

[0033] The Chinese medicine composition is weighed according to the weight portion, mixed, decocted for 20 to 50 minutes, and the medicinal liquid and the medicinal residue are collected by filtration; the collected medicinal residue is decocted again for 30 to 60 minutes, and the medicinal liquid is collected by filtration; the medicinal liquids collected twice are combined to obtain the Chinese medicine composition. More preferably, the Chinese medicine composition is weighed according to the weight portion, mixed, decocted for 30 minutes, and the medicinal liquid and the medicinal residue are collected by filtration; the collected medicinal residue is decocted again for 40 minutes, and the medicinal liquid is collected by filtration; the medicinal liquids collected twice are combined to obtain the Chinese medicine composition. In the present invention, as an operative method, during the decocting process, the weight ratio of the Chinese medicine composition to water is preferably 1:2 to 5; more preferably 1:3.

[0034] In the present invention, after the water boils during the decoction process, the decoction is switched to low heat for slow decoction. The present invention adopts low heat for slow decoction to effectively promote the dissolution of effective ingredients in traditional Chinese medicine.

[0035] The present invention also provides an application of the traditional Chinese medicine composition in preparing a drug for treating blood pressure.

[0036] In the present invention, the dosage form of the drug preferably includes pills, powders, solutions or granules. In the present invention, the drug is added with pharmaceutically acceptable pharmaceutical adjuvants to prepare clinically acceptable pills, powders, solutions or granules.

[0037] In the present invention, the method for preparing the pills preferably comprises the following steps: grinding the medicinal material into fine powder, sieving, and adding auxiliary materials to form pills. In the present invention, the auxiliary material in the pill preparation process is preferably honey. In the present invention, the fine Chinese medicine powder and honey are preferably mixed in a weight ratio of 2 to 3:1 to prepare the pills.

[0038] In the present invention, the preparation method of the powder comprises the following steps: mixing the medicinal materials uniformly, crushing them into powder, and sieving.

[0039] In the present invention, the mesh size of the sieving is preferably 100 to 120 meshes.

[0040] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0041] The experimental methods in the following examples are conventional methods unless otherwise specified. The experimental materials used in the following examples are commercially available products unless otherwise specified.

[0042] Example 1

[0043] A traditional Chinese medicine composition for treating hypertension, comprising the following raw materials in parts by weight: 30 parts of oriental rhizome, 30 parts of hawthorn, 30 parts of tuckahoe, 15 parts of persimmon leaf, 15 parts of mulberry leaf, 30 parts of phellinus linteus, 30 parts of kudzu root, 30 parts of Uncaria rhynchophylla, 30 parts of ligusticum chuanxiong, 10 parts of selfheal, 30 parts of salvia miltiorrhiza, 10 parts of gastrodia elata, and 10 parts of safflower;

[0044] The preparation method of the above-mentioned traditional Chinese medicine composition comprises the following steps: weighing the traditional Chinese medicine composition according to the weight portion and mixing, decocting for 30 minutes, filtering and collecting the medicinal liquid and the medicinal residue; decocting the collected medicinal residue again for 40 minutes, filtering and collecting the medicinal liquid; and combining the medicinal liquids collected twice.

[0045] Example 2

[0046] A traditional Chinese medicine composition for treating hypertension, comprising the following raw materials in parts by weight: 20 parts of oriental rhizome, 20 parts of hawthorn, 20 parts of tuckahoe, 10 parts of persimmon leaf, 10 parts of mulberry leaf, 20 parts of phellinus linteus, 20 parts of kudzu root, 20 parts of Uncaria rhynchophylla, 20 parts of ligusticum chuanxiong, 15 parts of selfheal, 20 parts of salvia miltiorrhiza, 15 parts of gastrodia elata, and 15 parts of safflower;

[0047] The preparation method of the above-mentioned traditional Chinese medicine composition comprises the following steps: weighing the traditional Chinese medicine composition according to the weight portion and mixing, decocting for 50 minutes, filtering and collecting the medicinal liquid and the medicinal residue; decocting the collected medicinal residue again for 30 minutes, filtering and collecting the medicinal liquid; and combining the medicinal liquids collected twice.

[0048] Example 3

[0049] A traditional Chinese medicine composition for treating hypertension, comprising the following raw materials in parts by weight: 25 parts of oriental rhizome, 25 parts of hawthorn, 25 parts of tuckahoe, 12 parts of persimmon leaf, 12 parts of mulberry leaf, 25 parts of phellinus linteus, 25 parts of kudzu root, 25 parts of Uncaria rhynchophylla, 25 parts of ligusticum chuanxiong, 12 parts of selfheal, 25 parts of salvia miltiorrhiza, 12 parts of gastrodia elata, and 12 parts of safflower;

[0050] The preparation method of the above-mentioned traditional Chinese medicine composition comprises the following steps: weighing the traditional Chinese medicine composition according to the weight portion and mixing, decocting for 20 minutes, filtering and collecting the medicinal liquid and the medicinal residue; decocting the collected medicinal residue again for 60 minutes, filtering and collecting the medicinal liquid; and combining the medicinal liquids collected twice.

[0051] Example 4

[0052] A pill for treating hypertension, comprising the following raw materials in parts by weight: 30 parts of oriental rhizome, 30 parts of hawthorn, 30 parts of tuckahoe, 15 parts of persimmon leaf, 15 parts of mulberry leaf, 30 parts of phellinus linteus, 30 parts of kudzu root, 30 parts of Uncaria rhynchophylla, 30 parts of ligusticum chuanxiong, 10 parts of selfheal, 30 parts of salvia miltiorrhiza, 10 parts of gastrodia elata, and 10 parts of safflower;

[0053] The preparation method of the pills comprises the following steps: grinding the medicinal materials into fine powder, passing through a 120-mesh sieve, and adding honey to form pills; wherein the fine powder of the Chinese medicinal materials and the honey are mixed at a weight ratio of 2.5:1.

[0054] Example 5

[0055] A powder for treating hypertension, comprising the following raw materials in parts by weight: 30 parts of oriental rhizome, 30 parts of hawthorn, 30 parts of tuckahoe, 15 parts of persimmon leaf, 15 parts of mulberry leaf, 30 parts of phellinus linteus, 30 parts of kudzu root, 30 parts of Uncaria rhynchophylla, 30 parts of ligusticum chuanxiong, 10 parts of selfheal, 30 parts of salvia miltiorrhiza, 10 parts of gastrodia elata, and 10 parts of safflower;

[0056] The preparation method of the powder comprises the following steps: mixing the medicinal materials uniformly, crushing them into powder, and passing through a 100-mesh sieve.

[0057] Test Example 1

[0058] 1. Experimental subjects

[0059] (1) Inclusion criteria: The diagnosis is based on the results of blood pressure measurements in the clinic. If the systolic blood pressure is ≥140 mmHg and / or the diastolic blood pressure is 90 mmHg at the first visit, it is recommended to recheck twice within 4 weeks. If the above diagnostic thresholds are reached on three different days, the diagnosis can be confirmed.

[0060] (2) Exclusion criteria: patients with severe heart, liver, or kidney dysfunction, malignant tumors, pregnant or lactating women, those who are allergic to Chinese medicine ingredients, and those who have used drugs that affect blood pressure in the past month.

[0061] 140 patients with hypertension who met the above criteria were selected and randomly divided into a treatment group and a control group, with 70 patients in each group, aged 30 to 70 years old. There was no statistically significant difference in age, gender and general information between the two groups.

[0062] 2. Experimental Grouping

[0063] (1) Chinese medicine treatment group: The Chinese medicine liquid was obtained according to the preparation method and prescription ratio of Example 1, and 200 mL of the Chinese medicine liquid was taken twice a day, on an empty stomach in the morning or before or after dinner, for a course of 1 month.

[0064] (2) Western medicine control group: The conventional antihypertensive drug nifedipine controlled-release tablets were used and taken as prescribed by the doctor for a course of 1 month.

[0065] 3. Efficacy evaluation criteria: in accordance with the blood pressure efficacy evaluation criteria (Guidelines for Clinical Research of New Chinese Medicines, 2002 edition).

[0066] Marked effect: ① The systolic blood pressure drops by more than 10 mmHg and reaches the normal range; ② The diastolic blood pressure has not dropped to the normal range but has dropped by 20 mmHg or more. Achieving one of the above two conditions is considered markedly effective;

[0067] Effective: ① The diastolic blood pressure drops by less than 10 mmHg, but has reached the normal range; ② The diastolic blood pressure drops by 10-19 mmHg compared with before treatment, but has not reached the normal range; ③ The systolic blood pressure drops by more than 30 mmHg compared with before treatment. If any one of the above three items is met, it is considered effective.

[0068] Invalid: If any of the validity criteria are not met, the application will be invalid.

[0069] 4. Observation indicators

[0070] (1) Main indicators: Measure the patient's blood pressure before and after treatment, including systolic and diastolic blood pressure, once a week.

[0071] (2) Secondary indicators: symptom improvement, such as the relief of hypertension-related symptoms such as headache, dizziness, palpitations, and fatigue, were evaluated by questionnaire survey and divided into three levels: significantly improved, improved, and no improvement.

[0072] (3) Adverse reactions: Record adverse reactions experienced by patients during treatment, such as gastrointestinal discomfort, allergic reactions, etc.

[0073] 5. Data Analysis

[0074] Statistical methods were used to analyze the various indicators of the two groups of patients. The differences in blood pressure control between the Chinese medicine treatment group and the Western medicine control group were compared to evaluate the efficacy of Chinese medicine preparations. At the same time, the incidence of adverse reactions was analyzed to evaluate the safety of the drugs.

[0075] Table 1 Comparison of the therapeutic effects of the Chinese medicine treatment group and the Western medicine control group on hypertension

[0076] Group Number of cases Number of people with significant effect Effective number of people Invalid number of people Total Effectiveness Treatment Group 70 40 25 5 92.86％ Control group 70 31 20 19 72.86％

[0077] Table 2 Statistical comparison of blood pressure changes before and after the Chinese medicine treatment group and the Western medicine control group

[0078]

[0079] According to the records in Tables 1 and 2, after a period of drug treatment, the therapeutic efficacy of the Chinese medicine composition of the present invention reaches more than 92%, while the antihypertensive drug therapeutic efficacy of the control group is 72.86%. The Chinese medicine treatment group of the present invention is significantly better than the control group.

[0080] At the same time, when using the Chinese medicine composition of the present invention, the proportion of patients with significantly improved symptoms of headache, dizziness, palpitations, and fatigue were 85.7%, 80.0%, 77.1%, and 71.4%, respectively; in the control group, the proportion of patients with significantly improved corresponding symptoms was 60.6%, 57.6%, 51.5%, and 48.5%, respectively. The symptom improvement in the treatment group was significantly better than that in the control group (p<0.05). When using the Chinese medicine composition of the present invention, 5 patients had gastrointestinal discomfort and 1 patient had an allergic reaction; in the control group, 8 patients had gastrointestinal discomfort, 2 patients had dizziness, and 3 patients had fatigue. It can be seen that the incidence of adverse reactions in the Chinese medicine treatment group of the present invention is significantly lower than that in the control group (p<0.05). It can be seen that the Chinese medicine composition of the present invention has a significant therapeutic effect on hypertension, small side effects, and a low adverse reaction rate.

[0081] Typical cases:

[0082] 1. Patient Qi, 76 years old, farmer. The patient has had hypertension for more than ten years, with high blood pressure at irregular frequencies, sometimes reaching 180-190 mmHg. In 2019, he only took the drug in Example 1, about 200 ml at a time, twice a day. After taking it for one month, his blood pressure has been stable and normal since then.

[0083] 2. Patient Liang had hypertension for three years before taking this medicine, with frequent headaches and dizziness. After taking the medicine of Example 1 twice a day, about 200 ml each time, for more than 20 consecutive days, it has been three years since today without recurrence.

[0084] 3. Patient Li, female, 76 years old, farmer. Before taking this medicine, she had hypertension for eight years and also suffered from coronary heart disease. She often felt chest tightness and headache from time to time. After taking the medicine of Example 1 twice a day, about 200 ml each time, for more than a month of treatment, there has been no recurrence for five years since today.

[0085] 4. Patient Yuan, female, age 44. She had hypertension for three or four years before taking this medicine. She had taken other treatment drugs before, but the symptoms did not stop. After taking the medicine of Example 1 twice a day, about 200 ml each time, for about 20 days of treatment, there has been no recurrence for 2 years.

[0086] 5. Patient Liu, female, 54 years old. She had hypertension for five years before taking this medicine. She had taken antihypertensive drugs (unknown details) in the meantime, and her blood pressure was not well controlled. She took the medicine of Example 1 twice a day, about 200 ml each time. After about one month of treatment, there was no recurrence so far.

[0087] 6. Patient Lei had hypertension for two years before taking the drug due to frequent work stress, irregular work and rest, etc. After taking the drug of Example 1 twice a day, about 200 ml each time, for about a month of treatment, there has been no recurrence so far.

[0088] 7. Patient Wei experienced dizziness and fatigue without obvious cause, which worsened after activity. He was later diagnosed with hypertension and took antihypertensive drugs on his own, but the effect was not good. After taking the drug in Example 1 for less than a month, his blood pressure stabilized and has not recurred to date.

[0089] 8. Patient Jiang, male, 45 years old, farmer. He had hypertension for six years before taking this medicine due to long-term drinking. He then started taking the medicine in Example 1, twice a day, and reduced drinking during the period. After about one month of treatment, his blood pressure became normal and stable, and there has been no recurrence so far.

[0090] 9. Patient Wei, male, went to see a doctor due to frequent headaches and dizziness and was found to have hypertension. He also took other antihypertensive drugs in the meantime, but the control effect was not good. Later, he insisted on taking it twice a day, about 200 ml each time. After one month of continuous taking the drug in Example 1, his blood pressure has been stable and normal since then.

[0091] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating hypertension, It is characterized in that The Chinese medicine composition comprises the following raw materials in parts by weight: 20-30 parts of Alisma orientalis, 20-30 parts of hawthorn, 20-30 parts of Poria, 10-15 parts of persimmon leaves, 10-15 parts of mulberry leaves, 20-30 parts of mulberry linterus, 20-30 parts of Pueraria lobata, 20-30 parts of Uncaria rhynchophylla, 20-30 parts of Chuanxiong, 10-15 parts of Prunella vulgaris, 20-30 parts of Salvia miltiorrhiza, 10-15 parts of Gastrodia elata, and 10-15 parts of Carthamus tinctorius.

2. A method for preparing the Chinese medicine composition according to claim 1, It is characterized in that The steps include: Weigh the Chinese medicine composition according to the weight portion, mix them, decoct for 20 to 50 minutes, filter and collect the medicinal liquid and the medicinal residue; decoct the collected medicinal residue again for 30 to 60 minutes, and filter and collect the medicinal liquid; Combine the two collected solutions.

3. The preparation method according to claim 2, It is characterized in that During the cooking process, after the water boils, turn to low heat and simmer.

4. Use of the Chinese medicine composition according to claim 1 in the preparation of antihypertensive drugs.

5. The use according to claim 4, It is characterized in that The dosage form of the drug includes pills, powders, solutions or granules.

6. The use according to claim 4, It is characterized in that The preparation method of the pills comprises the following steps: grinding the medicinal materials into fine powder, sieving, adding auxiliary materials and making the powder into pills.

7. The use according to claim 4, It is characterized in that The preparation method of the powder comprises the following steps: mixing the medicinal materials uniformly, crushing them into powder, and sieving.

8. The use according to claim 6 or 7, It is characterized in that The mesh number of the sieving is 100 to 120 meshes.

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