Melanoidin-like sunscreen cream and preparation method thereof

Abstract

The invention provides melanoidin sunscreen cream and a preparation method thereof, and belongs to the technical field of cosmetics. The melanoidin sunscreen cream provided by the invention is prepared from the following raw materials in parts by weight: 4-6 parts of melanoidin, 42 parts of deionized water, 6-8 parts of glycerol, 1-2 parts of allantoin, 35-37 parts of an oil phase, 4-6 parts of an emulsifier, 2-3 parts of octadecanol and 1-2 parts of a preservative. The melanin-like sunscreen cream has a wider absorption wave band for ultraviolet rays, and can achieve a better sunscreen effect; the food-sourced melanoidins are high in safety performance, have the effects of resisting oxidation, resisting skin aging and the like, and can better protect the skin; besides, the melanoidins have good water solubility, can ensure that the skin feeling of the product is fresh and breathable, have the characteristics of simple components and good sunscreen effect, enable consumers to have better experience in the aspect of sunscreen, and have wide application prospects.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, and in particular to a melanoidin sunscreen and a preparation method thereof. Background Art

[0002] Ultraviolet (UV) is the general term for radiation with a wavelength of 10 to 400nm in the electromagnetic spectrum. More than 95% of the ultraviolet rays that the skin is exposed to on a daily basis are UVA (315 to 400nm), which can penetrate the epidermis and attack the dermis, causing severe damage to the collagen and elastin in the skin, causing the skin to become loose, wrinkled, and have microvessels, which can cause premature aging of the skin. At the same time, it can activate tyrosinase, leading to the formation and deposition of melanin, making the skin darker and less shiny. Most of UVB (280 to 315nm) will be absorbed by the ozone layer, and less than 2% can reach the earth's surface, but it will oxidize the lipid layer, dry the skin, and cause symptoms such as acute dermatitis (i.e. sunburn), and even induce skin cancer.

[0003] At present, sunscreens are mainly divided into physical sunscreen and chemical sunscreen. Among them, physical sunscreen is achieved by the reflection, refraction or scattering of ultraviolet rays by zinc oxide and titanium dioxide, so that ultraviolet rays cannot directly contact human skin, thereby achieving the effect of sunscreen. However, the safety of zinc oxide and titanium dioxide is not high, and they feel greasy when applied. They only have a certain blocking effect on UVA, and the effect on UVB segment is not obvious. Chemical sunscreen uses ultraviolet absorbers such as ethylhexyl salicylate, diethylaminohydroxybenzoyl hexyl benzoate, and drometrizole trisiloxane to achieve sunscreen by absorbing harmful ultraviolet rays. However, a chemical sunscreen only targets the UVA or UVB area, and the chemical molecules will be absorbed by the skin, and then eliminated by human metabolism, and will cause certain irritation and damage to the skin. Therefore, it is of great practical value to develop sunscreens with good safety performance and excellent sunscreen effect. Summary of the invention

[0004] The invention provides a melanoidin sunscreen and a preparation method thereof. The obtained sunscreen has excellent sunscreen effect and feels refreshing, breathable and non-greasy on the skin.

[0005] The present invention provides a melanoidin sunscreen, which is prepared from the following raw materials in parts by weight:

[0006] 4-6 parts of melanoidin, 42 parts of deionized water, 6-8 parts of glycerin, 1-2 parts of allantoin, 35-37 parts of oil phase, 4-6 parts of emulsifier, 2-3 parts of octadecyl alcohol, and 1-2 parts of preservative.

[0007] Furthermore, the oil phase includes at least one of liquid paraffin, lanolin or stearic acid.

[0008] Furthermore, the emulsifier includes at least one of Tween-80 and glyceryl monostearate.

[0009] Furthermore, the preservatives are methyl parahydroxybenzoate and propyl parahydroxybenzoate, wherein the mass ratio of methyl parahydroxybenzoate to propyl parahydroxybenzoate is 1:1.

[0010] An embodiment of the present invention further provides a method for preparing any of the above-mentioned melanoidin sunscreens, comprising the following steps:

[0011] (a) placing the oil phase, octadecyl alcohol, and part of the emulsifier in a water bath at 75-85° C. to obtain a first mixture;

[0012] (b) mixing melanoidin, deionized water, glycerin, allantoin, and remaining emulsifier to obtain a second mixture;

[0013] (c) adding the second mixture to the first mixture, stirring at 75-85° C., cooling to 45-55° C., adding a preservative and homogenizing to obtain a melanoidin sunscreen.

[0014] Furthermore, in step (c), stirring is performed at a rotation speed of 800 to 1300 r / min.

[0015] Furthermore, in step (c), the stirring time is 5 to 10 minutes.

[0016] Furthermore, in step (c), the homogenization time is 30 to 50 minutes.

[0017] The present invention has the following advantages:

[0018] The present invention selects melanoidin as the main component of sunscreen, and the obtained sunscreen can not only resist ultraviolet radiation, reduce free radicals generated in skin tissue, reduce the production of melanin, achieve excellent sunscreen effect, but also has the effects of anti-oxidation and cell aging. In addition, the obtained sunscreen feels refreshing, breathable and non-greasy. The present invention simplifies the product formula, refines the production process, avoids too many allergens, improves the safety of the product, reduces the production cost, and meets the current consumer demand. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The accompanying drawings constituting a part of the present invention are used to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the accompanying drawings:

[0020] Figure 1 The ultraviolet absorption spectra of Example 1 and Comparative Example 1 of the present invention are shown;

[0021] Figure 2The UV absorption spectra of commercially available sunscreens of Example 1 and Comparative Example 2 of the present invention are shown. DETAILED DESCRIPTION

[0022] The following embodiments of the technical solution of the present invention are described in detail in conjunction with the embodiments. The following embodiments are only used to more clearly illustrate the technical solution of the present invention, and are therefore only used as examples, and cannot be used to limit the protection scope of the present invention.

[0023] It should be noted that, unless otherwise specified, the technical terms or scientific terms used in this application should have the common meanings understood by those skilled in the art to which the present invention belongs.

[0024] An embodiment of the present invention provides a melanoidin sunscreen, which is prepared from the following raw materials in parts by weight:

[0025] 4-6 parts of melanoidin, 42 parts of deionized water, 6-8 parts of glycerin, 1-2 parts of allantoin, 35-37 parts of oil phase, 4-6 parts of emulsifier, 2-3 parts of octadecyl alcohol, and 1-2 parts of preservative.

[0026] In the prior art, melanoidin is a polymeric, brown-colored macromolecular substance generated by the Maillard reaction and is mainly used in the field of food preparation technology.

[0027] The inventor of the present application has found through research that melanoidin has strong anti-ultraviolet ability. The ultraviolet absorption spectrum shows that melanoidin has a wide ultraviolet absorption range, including three sections of UVA, UVB and UVC, and has a good absorption value at 280-400nm. It can effectively act on the ultraviolet range that affects the skin and achieve excellent sun protection effect.

[0028] In addition, melanoidin has strong antioxidant properties. One of the main physiological functions of melanoidin is strong antioxidant activity. The antioxidant activity of melanoidin is much stronger than that of δ-tocopherol, the highest in the tocopherol family, and can resist cell aging and oxidation.

[0029] In addition, the use of food-derived water-soluble melanoidin improves the skin feel of the product. Food-derived melanoidin is a water-soluble weakly acidic polymer substance, and the water-soluble melanoidin makes the skin feel of the present invention refreshing, breathable, and non-greasy. At the same time, healthy human skin will be weakly acidic, so the use of weakly acidic products can make the human skin in the best state to absorb nutrients, and the skin is elastic and shiny.

[0030] In the sunscreen provided in the embodiment of the present invention, melanoidin has multiple functions such as sun protection, anti-oxidation, and anti-aging. The overall formula is simple in ingredients, and is free of fragrances and pigments, thereby avoiding excessive allergens and being safer.

[0031] In one embodiment of the present invention, the oil phase includes at least one of liquid paraffin, lanolin or stearic acid.

[0032] In one embodiment of the present invention, the emulsifier includes at least one of Tween-80 and glyceryl monostearate.

[0033] In one embodiment of the present invention, the preservatives are methyl parahydroxybenzoate and propyl parahydroxybenzoate, wherein the mass ratio of methyl parahydroxybenzoate to propyl parahydroxybenzoate is 1:1.

[0034] An embodiment of the present invention further provides a method for preparing any of the above-mentioned melanoidin sunscreens, comprising the following steps:

[0035] (a) placing the oil phase, octadecyl alcohol, and part of the emulsifier in a water bath at 75-85° C. to obtain a first mixture;

[0036] (b) mixing melanoidin, deionized water, glycerin, allantoin, and remaining emulsifier to obtain a second mixture;

[0037] (c) adding the second mixture to the first mixture, stirring at 75-85° C., cooling to 45-55° C., adding a preservative and homogenizing to obtain a melanoidin sunscreen.

[0038] In the prior art, most sunscreens are in the form of water-in-oil, which makes the skin feel greasy and easily causes pores to be clogged, etc. The preparation method of the melanoidin sunscreen proposed in the embodiment of the present invention, considering that the melanoidin sunscreen is easily soluble in water but not easily soluble in oil, the inventor adopts the above method to prepare the melanoidin sunscreen in the form of water-in-oil, and the obtained sunscreen feels refreshing, breathable, and non-greasy, effectively solving the problem of pore clogging.

[0039] The process of the invention is convenient to produce and can reduce the cost of enterprises. It meets the current consumer demand for simplified skin care and has broad market prospects.

[0040] In one embodiment of the present invention, in step (c), stirring is performed at a rotation speed of 800 to 1300 r / min.

[0041] In one embodiment of the present invention, in step (c), the stirring time is 5 to 10 minutes.

[0042] In one embodiment of the present invention, in step (c), the homogenization time is 30 to 50 minutes.

[0043] In one embodiment of the present invention, in step (a), the amount of emulsifier added may be 1 / 5 to 4 / 5, and the remaining emulsifier is added in step (b).

[0044] The present invention will be described in detail below with reference to embodiments.

[0045] Example 1A preparation method of melanoidin sunscreen

[0046] This type of black essence sunscreen includes the following raw materials in parts by weight:

[0047] 5 parts of melanoidin, 42 parts of deionized water, 7 parts of glycerin, 1.5 parts of allantoin, 5 parts of emulsifier, 36 parts of oil phase, 3 parts of octadecanol, 2 parts of preservative; wherein,

[0048] The emulsifier is a mixture of Tween-80 and glyceryl monostearate in a mass ratio of 1:4;

[0049] The oil phase is a mixture of liquid paraffin, lanolin and stearic acid in a mass ratio of 9:1:1;

[0050] The preservative is a mixture of methylparaben and propylparaben in a mass ratio of 1:1;

[0051] The preparation method comprises the following steps:

[0052] (a) placing liquid paraffin, lanolin, stearic acid, stearyl alcohol, and glyceryl monostearate in a water bath at 80° C. to obtain a first mixture;

[0053] (b) mixing melanoidin, deionized water, glycerol, allantoin and Tween-80 to obtain a second mixture;

[0054] (c) adding the second mixture to the first mixture, stirring at 80° C. and 1025 r / min for 7 min, cooling to 50° C., adding a preservative, and stirring and mixing for 40 min to obtain the above-mentioned melanoidin sunscreen.

[0055] Example 2 A preparation method of melanoidin sunscreen

[0056] Same as Example 1, except that the weight portion of melanoidin is 4 parts.

[0057] Example 3 A preparation method of melanoidin sunscreen

[0058] Same as Example 1, except that the weight portion of melanoidin is 6 parts.

[0059] Example 4 A preparation method of melanoidin sunscreen

[0060] Same as Example 2-1, except that the stirring was performed at a rotation speed of 1025 r / min for 5 min.

[0061] Example 5 A preparation method of melanoidin sunscreen

[0062] Same as Example 2-1, except that the stirring was performed at a rotation speed of 1025 r / min for 10 min.

[0063] Example 6 A preparation method of melanoidin sunscreen

[0064] The same as Example 1, except that the stirring was performed at 75° C. and at a rotation speed of 1025 r / min for 7 min.

[0065] Example 7 A preparation method of melanoidin sunscreen

[0066] The same as Example 1, except that the stirring was performed at 85° C. and at a rotation speed of 1025 r / min for 7 min.

[0067] Example 8 A preparation method of melanoidin sunscreen

[0068] The preparation steps are the same as those in Example 1, except that the homogenization speed is 800 r / min.

[0069] Example 9 A preparation method of melanoidin sunscreen

[0070] The preparation steps are the same as those in Example 1, except that the homogenization speed is 1200 r / min.

[0071] Comparative Example 1

[0072] Same as Example 1, except that the weight portion of melanoidin is 0 parts.

[0073] Comparative Example 2

[0074] There are currently commercially available water-in-oil sunscreens.

[0075] Test example The melanoidin sunscreen obtained by the present invention was tested, and the specific testing method is as follows:

[0076] 1Performance Test

[0077] 1.1 Sunscreen performance test

[0078] Test steps: dilute the prepared melanoidin sunscreen, pour the prepared solution into a 1cm*1cm*5cm quartz colorimetric cell, measure the absorbance value in the wavelength range of 200-700nm in a debugged UV-visible spectrophotometer, and scan. Obtain the required absorbance data based on the UV-visible absorbance spectrum, and then calculate the SPF value according to the following formula. And obtain the PA value of the sunscreen based on the long-wave UV transmittance of the measured sample. The relationship between transmittance and PA value is shown in Table 1.

[0079] Table 1 PA value and long-wave ultraviolet transmittance correspondence table

[0080] PA value Long wave ultraviolet transmittance / (%) PA+ 50％-25％ PA++ 25％-12.5％ PA+++ Less than 12.5%

[0081] 1.2 Stability Assessment

[0082] The stability of the melanoidin sunscreen was tested by centrifugation test, pH value test, freeze-thaw test, and room temperature sample test. The specific implementation is as follows:

[0083] Centrifugation experiment: Take 10g of sample, put it into a centrifuge tube with a scale, centrifuge at 2500r / min for 0.5h, and observe whether there is stratification.

[0084] pH value determination: Prepare the cream into a 0.5 g / mL suspension in a water bath at 50°C-55°C, and measure the pH value after cooling. If the pH value is within the range of 6.59-50.03, it meets the pH value requirements of the emulsion dosage form of skin care product safety regulations.

[0085] Freeze-thaw test: Place the prepared sample at -5°C for 24 hours and then thaw it at room temperature, and observe whether oil-water separation occurs in the sample after freeze-thaw.

[0086] Room temperature sample inspection: Place the samples at room temperature to inspect their consistency, water loss, pH, color uniformity, and the presence of mildew and oil-water separation.

[0087] The stability evaluation criteria are shown in Table 2.

[0088] Table 2 Stability evaluation index

[0089]

[0090] 1.3 Sensory evaluation

[0091] The sensory scoring criteria are shown in Table 3.

[0092] Table 3 Sensory evaluation indexes

[0093]

[0094]

[0095] The above test method was used to evaluate the performance of the melanoidin sunscreen prepared in Example 1, Example 2, and Example 3 of the present invention. The results are shown in Table 4.

[0096] As shown in Table 4, considering the comprehensive sun protection ability and sensory evaluation index, the product is the best when the weight portion of the melanoidin in Example 1 is 5 parts.

[0097] Table 4 Comparative evaluation of raw materials by weight of melanin

[0098] Group Number of raw materials SPF PA Sensory evaluation Example 1 5 40 +++ 9 Example 2 4 35 ++ 9 Example 3 6 45 +++ 7 Comparative Example 1 0 0 0 9

[0099] The melanoidin in Comparative Example 1 was removed, and the ultraviolet absorption spectrum was compared with that of Example 1. The results are as follows: Figure 1 The ultraviolet absorption spectrum shows that melanoidin has a wide ultraviolet absorption range, covering three segments of UVA, UVB and UVC, and has a good absorption value at 280-400nm. It can effectively act on the ultraviolet range that affects the skin and achieve excellent sun protection effect.

[0100] The above test method was used to evaluate the performance of the melanoidin sunscreen prepared in Example 1, Example 4, and Example 5 of the present invention. The results are shown in Table 5.

[0101] As shown in Table 5, considering the sunscreen stability and sensory evaluation indicators, the product with an emulsification time of 7 minutes in Example 1 is the best, indicating that an emulsification time of 7 minutes is the best condition for preparing melanoidin sunscreen.

[0102] Table 5 Comparison of emulsification time of preparation conditions of melanin sunscreen

[0103]

[0104] The above-mentioned test method was used to evaluate the performance of the melanoidin sunscreen prepared in Examples 1, 6 and 7 of the present invention. The results are shown in Table 6.

[0105] As shown in Table 6, considering the sunscreen stability and sensory evaluation indicators, the product in Example 1 with an emulsification time of 80°C is the best, indicating that an emulsification time of 80°C is the best condition for preparing melanoidin sunscreen.

[0106] Table 6 Comparison of emulsification temperature of preparation conditions of melanin sunscreen

[0107]

[0108] The above-mentioned test method was used to evaluate the performance of the melanoidin sunscreen prepared in Example 1, Example 8, and Example 9 of the present invention. The results are shown in Table 7.

[0109] As shown in Table 7, considering the sunscreen stability and sensory evaluation indicators, the product obtained under the condition of a homogenizing speed of 1025 r / min in Example 1 is the best, indicating that a homogenizing speed of 1025 r / min is the optimal homogenizing speed for preparing melanoidin sunscreen.

[0110] Table 7 Comparison of homogenization speed of preparation conditions of black essence sunscreen

[0111]

[0112] The sensory evaluation was conducted on the commercially available water-in-oil type sunscreen of comparative example 2 and the oil-in-water product of example 1. The difference indexes are shown in Table 8.

[0113] As shown in Table 8, the wettability, i.e., the degree of moisture, of the sunscreen of the present invention is higher than that of commercially available products, and has the advantages of being refreshing, breathable, and easy to absorb.

[0114] Table 8 Sensory evaluation of commercially available sunscreen and Example 1

[0115] Spreadability Wettability Moisturizing Provocative Heavy Absorbency Commercial sunscreen 9 7 4 7 5 7 Melanoid sunscreen 8 8 2 8 3 8

[0116] The existing commercially available sunscreen and Example 1 were subjected to ultraviolet absorption spectrum analysis, and the results are shown in Figure 2 .

[0117] like Figure 2 As shown, the sunscreen of the present invention has stronger ultraviolet absorption ability and better sun protection effect.

[0118] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A melanoidin sunscreen, characterized in that: Prepared from the following raw materials in parts by weight: 4-6 parts of melanoidin, 42 parts of deionized water, 6-8 parts of glycerin, 1-2 parts of allantoin, 35-37 parts of oil phase, 4-6 parts of emulsifier, 2-3 parts of octadecyl alcohol, and 1-2 parts of preservative.

2. The melanoidin sunscreen according to claim 1, characterized in that The oil phase includes at least one of liquid paraffin, lanolin or stearic acid.

3. The melanoidin sunscreen according to claim 1, characterized in that The emulsifier includes at least one of Tween-80 and glyceryl monostearate.

4. The melanoidin sunscreen according to claim 1, characterized in that The preservatives are methyl parahydroxybenzoate and propyl parahydroxybenzoate, wherein the mass ratio of methyl parahydroxybenzoate to propyl parahydroxybenzoate is 1:

1.

5. The method for preparing the melanoidin sunscreen according to any one of claims 1 to 4, characterized in that: The steps include: (a) placing the oil phase, octadecyl alcohol, and part of the emulsifier in a water bath at 75-85° C. to obtain a first mixture; (b) mixing melanoidin, deionized water, glycerin, allantoin, and remaining emulsifier to obtain a second mixture; (c) adding the second mixture to the first mixture, stirring at 75-85° C., cooling to 45-55° C., adding a preservative and homogenizing to obtain a melanoidin sunscreen.

6. The preparation method according to claim 5, characterized in that: In step (c), stirring is carried out at a rotation speed of 800 to 1300 r / min.

7. The preparation method according to claim 5, characterized in that: In step (c), the stirring time is 5 to 10 minutes.

8. The preparation method according to claim 5, characterized in that: In step (c), the homogenization time is 30 to 50 minutes.

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