Oral spray gel for relieving thirst and preparation method thereof

Abstract

The invention relates to oral spray gel for relieving thirst and a preparation method of the oral spray gel, belongs to the technical field of foods, and solves at least one of the problems of more adverse reactions, limited use, short adhesion time on oral mucosa and the like of thirst relieving products in the prior art. The oral spray gel for relieving thirst is prepared from a gel matrix and a salivation promoting raw material, wherein the gel matrix comprises konjac glucomannan and gellan gum, and the salivation promoting raw materials comprise an acidulant and a herbal salivation promoting component. According to the invention, the edible raw materials with the effect of promoting the production of body fluid to quench thirst and the gel matrix with strong adhesive force are screened aiming at the demand of relieving thirst feeling of a patient in a water-forbidden period before and after an operation, so that long-time adhesion to oral mucosa and the effect of promoting the production of body fluid to quench thirst are realized.

Description

Technical Field

[0001] The invention relates to the technical field of food, and in particular to an oral spray gel for relieving thirst and a preparation method thereof. Background Art

[0002] The human body often experiences thirst symptoms when the body does not drink enough water or when the patient is fasting before and after surgery. The existing products for relieving thirst are mainly artificial saliva, and the general formula of artificial saliva is syrup, distilled water, and pilocarpine (or cevimeline). Among them, pilocarpine (or cevimeline) is a cholinergic drug that can promote saliva secretion. However, it has many adverse reactions and can cause nausea, muscle tremors, headaches, abdominal pain, etc. Therefore, the use of pilocarpine (or cevimeline) is limited. Patients with congestive heart disease, narrow-angle glaucoma, moderate / severe asthma, pregnant women, lactating women, etc. should use it with caution. This type of product is not suitable as a common food to relieve thirst, and cannot be used during the fasting period before and after surgery.

[0003] At the same time, from the perspective of preparation form, artificial saliva is a syrup solution, which adheres to the oral mucosa for a short time. Most artificial saliva is swallowed quickly, which affects the effect of promoting salivation and quenching thirst. Gel is a preparation form with great potential in adhesion. However, the existing gel products applied to the oral mucosa are mainly used to protect tooth extraction wounds or oral ulcer wounds. Their efficacy is prominent in antibacterial or anti-inflammatory effects. Lysozyme, chlorhexidine or dexamethasone are often added, and they lack the targeted effect of relieving thirst. Summary of the invention

[0004] In view of the above analysis, the embodiments of the present invention aim to provide an oral spray gel for relieving thirst and a preparation method thereof, so as to solve at least one of the problems of existing thirst relieving products, such as many adverse reactions, limited use, and short adhesion time on the oral mucosa.

[0005] On the one hand, an embodiment of the present invention provides an oral spray gel for relieving thirst, comprising: a gel matrix and fluid-producing raw materials; wherein the gel matrix comprises konjac glucomannan and gellan gum, and the fluid-producing raw materials comprise an acidulant and a herbal fluid-producing ingredient.

[0006] Furthermore, the herbal ingredients for promoting body fluid production include at least three of: black plum, hawthorn, mint, licorice and watermelon.

[0007] Further, the acidulant includes citric acid and / or tartaric acid.

[0008] Furthermore, by mass, the herbal ingredients for promoting body fluid include: at least three of: 22 to 28 parts of black plum, 16 to 24 parts of hawthorn, 8 to 12 parts of mint, 8 to 12 parts of licorice, and 18 to 22 parts of watermelon; the acidulants include: 1 to 3 parts of citric acid and / or 1 to 2 parts of tartaric acid.

[0009] Further, by mass, the black plum is 25 parts of black plum, the hawthorn is 20 parts, the mint is 10 parts, the licorice is 10 parts, the watermelon is 20 parts, the citric acid is 2 parts, and the tartaric acid is 1 part.

[0010] Furthermore, the gel matrix comprises, by mass, 4 to 8 parts of konjac glucomannan and 1 to 2 parts of gellan gum.

[0011] Further, the gel matrix comprises, by mass, 8 parts of konjac glucomannan and 2 parts of gellan gum.

[0012] Furthermore, the oral spray gel further comprises tannin to enhance the adhesion of the oral spray gel.

[0013] Furthermore, the amount of tannin added does not exceed 2 parts.

[0014] On the other hand, an embodiment of the present invention provides a method for preparing an oral spray gel for relieving thirst, which is used to prepare the gel of the above embodiment, comprising: mixing and homogenizing the acidulant, the herbal fluid-inducing component, konjac glucomannan and gellan gum, and heating at a predetermined temperature to dissolve and mix the components uniformly to obtain a gel-like mixed solution; wherein the herbal fluid-inducing components are all in liquid form; and allowing the gel-like mixed solution to stand at room temperature until a gel-like semi-fluid is formed to obtain an oral spray gel for relieving thirst.

[0015] Compared with the prior art, the oral spray gel for relieving thirst of the present invention can achieve at least one of the following beneficial effects:

[0016] 1. The present invention adopts edible raw materials such as herbal fluid-generating ingredients and sour agents as fluid-generating ingredients to achieve the effect of promoting fluid and quenching thirst, and has no side effects and adverse reactions to the human body, and is suitable for different types of people; and the thirst-relieving product is made into a gel, so that it can adhere to the oral mucosa for a long time, and achieve the sustained release of fluid-generating ingredients, thereby maximizing the fluid-generating and thirst-quenching effect of the oral spray gel, and can meet the needs of relieving thirst when the human body is short of water or during water fasting before and after surgery.

[0017] 2. The konjac glucomannan and gellan gum in the oral spray gel of the present invention act synergistically to form a film on and adhere to the oral mucosa, prolonging the action time of the fluid-producing raw materials in the oral cavity, and better releasing the flavor of the sour agent and the herbal fluid-producing ingredients to stimulate saliva secretion, thereby better exerting its fluid-producing and thirst-quenching effect.

[0018] 3. The present invention can enhance the adhesion of the oral spray gel by adding tannin to the oral spray gel, thereby prolonging the residence time of the oral spray gel in the oral cavity and prolonging the action time of the body fluid-producing raw materials in the gel in the oral cavity, so as to give full play to the body fluid-producing raw materials' thirst-quenching effect, improve the thirst-quenching effect, and reduce the number of times users use it.

[0019] In the present invention, the above-mentioned technical solutions can also be combined with each other to achieve more preferred combination solutions. Other features and advantages of the present invention will be described in the subsequent description, and some advantages can become obvious from the description, or can be understood by practicing the present invention. The purpose and other advantages of the present invention can be realized and obtained through the contents particularly pointed out in the description and the drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The drawings are only for the purpose of illustrating particular embodiments and are not to be considered limiting of the present invention. Like reference symbols denote like components throughout the drawings.

[0021] Figure 1 This is a comparison chart of the saliva flow rates of test subjects after using the oral spray gels of Examples 1 to 5 of the present invention.

[0022] Figure 2 This is a comparison chart of the viscosities of the oral spray gels of Examples 5 to 9 of the present invention.

[0023] Figure 3 This is a comparison chart of the residence time of the oral spray gels of Examples 5, 10 to 13 of the present invention in the oral cavity. DETAILED DESCRIPTION

[0024] The preferred embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings, wherein the accompanying drawings constitute a part of this application and are used together with the embodiments of the present invention to illustrate the principles of the present invention, but are not used to limit the scope of the present invention.

[0025] The embodiment of the present invention provides an oral spray gel for relieving thirst, which comprises: a gel matrix and a fluid-inducing raw material, wherein the gel matrix comprises konjac glucomannan and gellan gum, and the fluid-inducing raw material comprises an acidulant and a herbal fluid-inducing component.

[0026] The embodiments of the present invention use edible raw materials such as herbal fluid-producing ingredients and sour agents as fluid-producing ingredients to achieve the effect of promoting fluid production and quenching thirst, and have no side effects and adverse reactions to the human body, and are suitable for different types of people; and the present invention uses a gel matrix with strong adhesion to make the fluid-producing product into a gel state, so that it can adhere to the oral mucosa for a long time, achieve the sustained release of fluid-producing ingredients, thereby maximizing the fluid-producing and thirst-quenching effect of the fluid-producing product, and can meet the needs of relieving thirst when the human body is short of water or during water fasting before and after surgery.

[0027] Furthermore, the embodiments of the present invention use a composition of konjac glucomannan and gellan gum as a gel matrix, so that the oral gel for promoting body fluid production has greater viscosity and stronger adhesion, and can achieve its adhesion to the oral mucosa for a longer period of time.

[0028] Among them, konjac glucomannan is a typical pseudoplastic fluid with natural film-forming properties. Its mechanical properties and barrier properties are superior to those of traditional gel matrices. Konjac glucomannan, as a high-molecular soluble dietary fiber, can easily produce a sense of fullness after consumption, and is particularly suitable for use when food and water are insufficient.

[0029] Gellan gum is a new type of microbial gum, and its gelling properties are much better than traditional gel matrices such as xanthan gum, and the formed gel is rich in juice. Compared with traditional matrices such as carrageenan and agar, it has obvious advantages in flavor release. The application of gellan gum in the present invention can better reflect the thirst-quenching effect of base materials such as acidulants and herbal fluid-inducing ingredients.

[0030] The konjac glucomannan and gellan gum in the oral spray gel of the embodiment of the present invention act synergistically, so that the gel can form a film and adhere to the oral mucosa, prolong the action time of the fluid-producing raw materials in the oral cavity, and better release the flavor of the sour agent and the herbal fluid-producing ingredients to stimulate saliva secretion, thereby better exerting its fluid-producing and thirst-quenching effect.

[0031] In some embodiments, the gellan gum may be high acyl gellan gum (HAGG) having a molecular weight of 2×10 6 Dalton. High acyl gellan gum has a relatively high viscosity and can form a soft, elastic gel, improving the adhesion of the gel.

[0032] In some embodiments, the herbal salivation ingredients include at least three of black plum, hawthorn, mint, licorice and watermelon, which are used to provide a sour, fruity or cool taste to stimulate oral saliva secretion, relieve thirst, and improve the taste of the oral spray gel to increase the acceptance of the gel by the user.

[0033] In some embodiments, the sour agent includes citric acid and / or tartaric acid to provide more sour taste to stimulate saliva secretion and further relieve thirst.

[0034] In some embodiments, among the raw materials for promoting body fluid, the herbal ingredients for promoting body fluid include, by mass: at least three of: 22 to 28 parts of black plum, 16 to 24 parts of hawthorn, 8 to 12 parts of mint, 8 to 12 parts of licorice, and 18 to 22 parts of watermelon; the acidulants include: 1 to 3 parts of citric acid and / or 1 to 2 parts of tartaric acid.

[0035] The embodiments of the present invention use a large amount of herbal ingredients such as black plum, hawthorn, mint, licorice, watermelon, etc., which not only have no side effects and will not cause adverse reactions, but also can enrich the taste of the gel, make the gel taste better, and make it easier for people to accept it; at the same time, a very small amount of acidulants such as citric acid and tartaric acid are added to add a certain sour taste to the gel, while stimulating saliva secretion, avoiding excessive acidulants that cause the gel to be too acidic, which is difficult for people to accept.

[0036] Preferably, by mass, the herbal ingredients for promoting body fluid include: at least three of 25 parts of black plum, 20 parts of hawthorn, 10 parts of mint, 10 parts of licorice, and 20 parts of watermelon; the acidulant includes: 2 parts of citric acid and / or 1 part of tartaric acid.

[0037] Further preferably, the ingredients for promoting the production of body fluids include: 25 parts of black plum, 20 parts of hawthorn, 10 parts of mint, 10 parts of licorice and 20 parts of watermelon; and the acidulants include: 2 parts of citric acid and 1 part of tartaric acid.

[0038] The embodiments of the present invention increase the saliva flow rate of the user after use by adjusting the content of each component, thereby optimizing the thirst-quenching effect of the gel.

[0039] In some embodiments, the gel matrix includes 4 to 8 parts of konjac glucomannan and 1 to 2 parts of gellan gum by weight. The embodiments of the present invention increase the viscosity of the gel at physiological temperature by adjusting the content of konjac glucomannan and gellan gum, so that the gel has greater adhesion in the oral cavity, thereby prolonging the adhesion time of the gel on the oral mucosa.

[0040] Preferably, the gel matrix comprises 8 parts of konjac glucomannan and 2 parts of gellan gum by mass. The embodiment of the present invention uses more konjac glucomannan and less gellan gum, and increases the concentration of the gel matrix to optimize the viscosity and adhesion of the gel, so that the residence time of the gel in the oral cavity is optimal.

[0041] In some embodiments, the oral spray gel further comprises: tannin. In the embodiments of the present invention, by adding tannin to the oral spray gel, the adhesion of the gel can be enhanced, thereby prolonging the residence time of the oral spray gel in the oral cavity, prolonging the action time of the fluid-producing raw materials in the gel in the oral cavity, so as to give full play to the fluid-producing raw materials' thirst-quenching effect, improve the thirst-quenching effect, and reduce the number of uses.

[0042] In some embodiments, the amount of tannin added to the oral spray gel does not exceed 2 parts, which can enhance the adhesion of the gel while avoiding the bitterness of the tannin caused by excessive tannin affecting the taste of the oral spray gel. At the same time, the sour and fruity flavors of black plum, hawthorn, licorice, watermelon, etc. can mask the bitterness of the tannin, thereby avoiding the user's acceptance of the oral spray gel from being reduced.

[0043] Aiming at the demand of relieving thirst during the period of water abstinence in patients with insufficient drinking water or before and after surgery, the present invention selects food raw materials with thirst-quenching effects and a gel matrix with strong adhesion, thereby achieving long-term adhesion to the oral mucosa and thirst-quenching effects.

[0044] By using the oral spray gel of the present invention, the saliva flow rate of the user can reach more than 1 mL / min, and can reach up to about 1.8 mL / min; and the gel has strong adhesion, so that the retention time in the oral cavity reaches more than 20 minutes, and can stay for up to 35 minutes.

[0045] On the other hand, an embodiment of the present invention further provides a method for preparing an oral spray gel for relieving thirst, which is used to prepare the gel in the above embodiment, and the method comprises the following steps:

[0046] The acidulant, the herbal fluid-inducing component, konjac glucomannan and gellan gum are mixed and homogenized, and heated at a predetermined temperature to dissolve and mix the components uniformly to obtain a gel-like mixed solution; wherein the herbal fluid-inducing component is in liquid form;

[0047] The jelly-like mixed solution is allowed to stand at room temperature until a gel-like semifluid is formed to obtain an oral spray gel.

[0048] It should be noted that the herbal saliva-producing ingredients are all in liquid form, for example, fruit juice or extract, including black plum juice, hawthorn juice, watermelon juice, mint water extract, and licorice water extract; citric acid and tartaric acid are in powder form.

[0049] When the gel is prepared by the method of the embodiment of the present invention, the powdered acidulant, the liquid herbal salivation component and the gel matrix are mixed and homogenized according to the mass ratio of each component in the gel of the above embodiment, and the fluidity of the gel matrix is ​​improved by heating to facilitate the dissolution and uniform distribution of the acidulant and the herbal salivation component in the gel matrix, thereby obtaining a uniform gel-like mixed solution; after the gel-like mixed solution is left to stand and cool at room temperature, the fluidity of the mixed solution gradually decreases due to the decrease in temperature, and finally a gel-like semi-fluid is formed.

[0050] During the preparation process, the mixture is stirred while being heated so that the components are evenly dispersed and dissolved to obtain a uniform gel-like mixed solution.

[0051] In some embodiments, the heated jelly-like mixed solution contains a large number of obvious bubbles, and the container of the jelly-like mixed solution can be tapped or shaken to remove the bubbles.

[0052] In some embodiments, the predetermined temperature during the heating process is 70-90° C., and the heating time is 20-40 minutes. Preferably, the heating temperature is 80° C., and the heating time is 30 minutes.

[0053] The preparation method of the present invention can obtain the oral gel for promoting body fluid production by heating and dissolving each component. The preparation method is simple and efficient, does not require complicated equipment, and has low cost.

[0054] The oral spray gel for relieving thirst and the preparation method thereof of the present invention are further described below with reference to specific examples.

[0055] Example 1

[0056] The oral spray gel of this embodiment comprises: 1 part of tartaric acid, 25 parts of black plum, 20 parts of hawthorn, 10 parts of mint, 10 parts of licorice, 20 parts of watermelon, 8 parts of konjac glucomannan, 2 parts of high acyl gellan gum, and 2 parts of tannin. The high acyl gellan gum is commercially available high acyl gellan gum with a molecular weight of 2×10 6 Dalton.

[0057] Preparation method of oral spray gel:

[0058] Weigh each component according to the above formula, mix the components homogeneously, and heat in a water bath at 80°C for 30 minutes, stirring while heating to dissolve each component and stir evenly. After heating, place the obtained gel-like mixed solution in a clean container, where a large number of obvious bubbles can be seen. Tap the bottom of the container to remove the bubbles, and then let it stand at room temperature for 12 hours to allow the mixed solution to form a gel-like semi-fluid.

[0059] Example 2

[0060] The oral spray gel of this embodiment comprises: 2 parts of citric acid, 25 parts of black plum, 20 parts of hawthorn, 10 parts of mint, 10 parts of licorice, 20 parts of watermelon, 8 parts of konjac glucomannan, 2 parts of high acyl gellan gum, and 2 parts of tannin.

[0061] Example 3

[0062] The oral spray gel of this embodiment comprises: 2 parts of citric acid, 1 part of tartaric acid, 10 parts of mint, 10 parts of licorice, 20 parts of watermelon, 8 parts of konjac glucomannan, 2 parts of high acyl gellan gum, and 2 parts of tannin.

[0063] Example 4

[0064] The oral spray gel of this embodiment comprises: 2 parts of citric acid, 1 part of tartaric acid, 25 parts of black plum, 20 parts of hawthorn, 20 parts of watermelon, 8 parts of konjac glucomannan, 2 parts of high acyl gellan gum, and 2 parts of tannin.

[0065] Example 5

[0066] The oral spray gel of this embodiment comprises: 2 parts of citric acid, 1 part of tartaric acid, 25 parts of black plum, 20 parts of hawthorn, 10 parts of mint, 10 parts of licorice, 20 parts of watermelon, 8 parts of konjac glucomannan, 2 parts of high acyl gellan gum, and 2 parts of tannin.

[0067] The oral spray gels in Examples 1 to 5 have different formulas of saliva-producing raw materials, but the contents of gel matrix and tannin components are the same. The oral spray gels in Examples 1 to 5 are sequentially placed on the front of the tongue dorsum of 12 subjects, 4 drops each time, and the subjects roll back the tip of their tongues to collect saliva secreted by the subjects by spitting, and each subject collects for 10 minutes each time to obtain the average saliva flow rate of the subjects after using the oral spray gels in Examples 1 to 5; and the 12 subjects respectively perform acceptance scores on the oral spray gels in Examples 1 to 5.

[0068] The average saliva flow rate and acceptance score of each embodiment are shown in Table 1 and Figure 1 According to Table 1 and Figure 1 It can be seen that after using the oral spray gel of each embodiment, the saliva flow rate can mostly reach 1 mL / min, and the subjects have good acceptance of the gel, with an acceptance score of more than 7 points; among them, the saliva flow rate after using the oral gel of Example 5 is the largest, reaching 1.49 mL / min, and its thirst-quenching effect is the best, and its acceptance score also reaches the highest 9 points.

[0069] Table 1 Average salivary flow rate and acceptability score after using oral spray gel

[0070] type Saliva flow rate mL / min Acceptability score Example 1 1.16 7 Example 2 1.01 8 Example 3 1.19 8 Example 4 0.87 7 Example 5 1.49 9

[0071] Example 6

[0072] The oral spray gel of this embodiment comprises: 2 parts of citric acid, 1 part of tartaric acid, 25 parts of black plum, 20 parts of hawthorn, 10 parts of mint, 10 parts of licorice, 20 parts of watermelon, 4 parts of konjac glucomannan, 1 part of high acyl gellan gum, and 2 parts of tannin.

[0073] Example 7

[0074] The oral spray gel of this embodiment comprises: 2 parts of citric acid, 1 part of tartaric acid, 25 parts of black plum, 20 parts of hawthorn, 10 parts of mint, 10 parts of licorice, 20 parts of watermelon, 6 parts of konjac glucomannan, 1 part of high acyl gellan gum, and 2 parts of tannin.

[0075] Example 8

[0076] The oral spray gel of this embodiment comprises: 2 parts of citric acid, 1 part of tartaric acid, 25 parts of black plum, 20 parts of hawthorn, 10 parts of mint, 10 parts of licorice, 20 parts of watermelon, 4 parts of konjac glucomannan, 2 parts of high acyl gellan gum, and 2 parts of tannin.

[0077] Example 9

[0078] The oral spray gel of this embodiment comprises: 2 parts of citric acid, 1 part of tartaric acid, 25 parts of black plum, 20 parts of hawthorn, 10 parts of mint, 10 parts of licorice, 20 parts of watermelon, 6 parts of konjac glucomannan, 2 parts of high acyl gellan gum, and 2 parts of tannin.

[0079] The formula of the spray gels in Examples 5 to 9 is the same, but the proportion and concentration of the gel matrix are different. The viscosity of the oral spray gels in Examples 5 to 9 at 25°C and 37°C is measured respectively, as shown in Tables 2 and Figure 2 shown.

[0080] As shown in Table 2 and Figure 2 As shown, at the physiological temperature of 37°C, the viscosity of the gel is above 0.9 Pa·s, and the high viscosity enables the gel to adhere to the oral mucosa for a long time.

[0081] Among them, the oral spray gels in Examples 5, 8, and 9 have a relatively high viscosity at physiological temperature, which can prolong the adhesion time of the gel in the oral cavity to a certain extent, and achieve the sustained release of the salivation raw materials in the oral cavity; while the oral spray gels in Examples 5 to 7 have a relatively low viscosity at room temperature, have a certain fluidity, and are easy to fill and produce.

[0082] In addition, the oral spray gel for promoting body fluid production in Example 5 has a relatively low viscosity at room temperature, which facilitates the formation of a spray for spraying in the oral cavity, and has a relatively high viscosity at 37° C., which allows for rapid film formation and adhesion in the oral cavity, thereby prolonging the adhesion time and improving the thirst-quenching effect of the gel.

[0083] Table 2 Viscosity of the oral spray gel of each example at 25°C and 37°C

[0084]

[0085] Example 10

[0086] The oral spray gel of this embodiment comprises: 2 parts of citric acid, 1 part of tartaric acid, 25 parts of black plum, 20 parts of hawthorn, 10 parts of mint, 10 parts of licorice, 20 parts of watermelon, 6 parts of konjac glucomannan, 2 parts of high acyl gellan gum, and no tannin.

[0087] Embodiment 11

[0088] The oral spray gel of this embodiment comprises: 2 parts of citric acid, 1 part of tartaric acid, 25 parts of black plum, 20 parts of hawthorn, 10 parts of mint, 10 parts of licorice, 20 parts of watermelon, 6 parts of konjac glucomannan, 2 parts of high acyl gellan gum, and 0.5 part of tannin.

[0089] Example 12

[0090] The oral spray gel of this embodiment comprises: 2 parts of citric acid, 1 part of tartaric acid, 25 parts of black plum, 20 parts of hawthorn, 10 parts of mint, 10 parts of licorice, 20 parts of watermelon, 6 parts of konjac glucomannan, 2 parts of high acyl gellan gum, and 1 part of tannin.

[0091] Embodiment 13

[0092] The oral spray gel of this embodiment comprises: 2 parts of citric acid, 1 part of tartaric acid, 25 parts of black plum, 20 parts of hawthorn, 10 parts of mint, 10 parts of licorice, 20 parts of watermelon, 6 parts of konjac glucomannan, 2 parts of high acyl gellan gum, and 1.5 parts of tannin.

[0093] The tannin content of the gel in Examples 10 to 13 and Example 5 was different, and the other components and contents were the same. 12 subjects used the oral spray gel in Examples 5 and 10 to 13 in turn, and the subjects swallowed voluntarily. The duration of sour taste in the oral cavity and the number of swallowings were collected, as shown in Tables 3 and Figure 3 shown.

[0094] Table 3 The residence time of oral spray gel in the oral cavity and the number of swallowing times of the subjects

[0095] type Residence time / min Swallowing times Example 10 20 106 Embodiment 11 20 111 Example 12 24 127 Embodiment 13 31 138 Example 5 35 149

[0096] Among them, when no tannin is added, the residence time of the gel can reach 20 minutes, and the subjects swallowed it more than 100 times. Compared with traditional products, the gel can adhere to the oral cavity for a longer time, so that the salivation effect can be fully exerted. With the increase of tannin added, the residence time of the oral spray gel in the subject's mouth gradually becomes longer, up to more than 30 minutes, and the number of swallowing times of the subjects also increases accordingly, up to more than 140 times, thereby prolonging the action time of the salivation raw materials in the oral cavity and fully exerting the salivation effect of the gel.

[0097] Comparative Example 1

[0098] The oral spray gel in this comparative example adopts a blank spray gel, wherein 6 parts of konjac glucomannan and 2 parts of gellan gum are contained, and no raw materials for promoting body fluid production are contained.

[0099] 26 subjects were randomly divided into two groups, the control group used the blank oral spray gel in Comparative Example 1, and the experimental group used the oral spray gel in Example 5. The subjects spit saliva into a test tube every 60 seconds and collected it for 10 minutes. The total amount of saliva of the subjects was less than 1 mL, which was abnormal and was excluded. The average saliva flow rate of the control group and the experimental group was obtained, as shown in Table 4. Among them, the saliva flow rate of the experimental group was much greater than that of the control group, indicating that the oral spray gel in Example 5 has an excellent effect of promoting body fluid.

[0100] Table 4 Saliva flow rate of subjects after using oral spray gel

[0101] Group Saliva flow rate mL / min Control group (Comparative example 1) 0.81 Experimental group (Example 5) 1.82

[0102] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily conceived by any technician familiar with the technical field within the technical scope disclosed by the present invention should be covered within the protection scope of the present invention.

Claims

1. An oral spray gel for relieving thirst, characterized in that: include: A gel matrix and raw materials for promoting body fluid; wherein the gel matrix comprises konjac glucomannan and gellan gum, and the raw materials for promoting body fluid comprise acidulants and herbal ingredients for promoting body fluid.

2. The gel according to claim 1, characterized in that The herbal ingredients for promoting body fluid production include at least three of black plum, hawthorn, mint, liquorice and watermelon.

3. The gel according to claim 2, characterized in that The acidulant includes citric acid and / or tartaric acid.

4. The gel according to claim 3, characterized in that The herbal ingredients for promoting body fluids include, by weight, at least three of: 22 to 28 parts of black plum, 16 to 24 parts of hawthorn, 8 to 12 parts of mint, 8 to 12 parts of liquorice, and 18 to 22 parts of watermelon; The acidulant comprises: 1 to 3 parts of citric acid and / or 1 to 2 parts of tartaric acid.

5. The gel according to claim 4, characterized in that By mass, the black plum comprises 25 parts of black plum, hawthorn comprises 20 parts of peppermint, 10 parts of licorice, 20 parts of watermelon, 2 parts of citric acid and 1 part of tartaric acid.

6. The gel according to claim 4, characterized in that The gel matrix comprises, by mass, 4 to 8 parts of konjac glucomannan and 1 to 2 parts of gellan gum.

7. The gel according to claim 6, characterized in that The gel matrix comprises, by mass, 8 parts of konjac glucomannan and 2 parts of gellan gum.

8. The gel according to any one of claims 1 to 7, characterized in that Also includes: Tannins are used to enhance the adhesion of the oral spray gel.

9. The gel according to claim 8, characterized in that The added amount of the tannin does not exceed 2 parts.

10. A method for preparing an oral spray gel for relieving thirst, for preparing the gel according to any one of claims 1 to 9, characterized in that: include: The acidulant, the herbal fluid-inducing ingredients, konjac glucomannan and gellan gum are mixed and homogenized, and heated at a predetermined temperature to dissolve and mix the ingredients uniformly to obtain a gel-like mixed solution; wherein the herbal fluid-inducing ingredients are all in liquid form; The jelly-like mixed solution is allowed to stand at room temperature until a gel-like semifluid is formed, thereby obtaining the oral spray gel for relieving thirst.

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