Aromatic Chinese herbal medicine composition for relieving female climacteric insomnia as well as preparation method and application of aromatic Chinese herbal medicine composition

Abstract

The invention discloses an aromatic Chinese herbal medicine composition for relieving female climacteric insomnia and a preparation method and application thereof. The aromatic Chinese herbal medicine composition consists of albizia flower, lavender, rose, rhizoma atractylodis, white chrysanthemum, wormwood, angelica sinensis, ligusticum wallichii, cinnamon and rhizoma acori graminei. Ten aromatic Chinese herbal medicines are selected according to influence factors and symptoms of insomnia of climacteric women, insomnia is improved by adopting aromatherapy, the potential of multiple Chinese herbal medicine aromatherapy as a natural therapy for relieving insomnia symptoms is highlighted, and non-invasive and convenient multiple aromatic Chinese herbal medicine inhalation therapy has excellent tolerance. The application range of aromatic Chinese herbal medicine and aromatherapy is expanded, and understanding and application of the traditional Chinese medicine principle in modern medical practice are promoted.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and more specifically, relates to an aromatic Chinese herbal medicine composition for relieving female menopausal insomnia, and a preparation method and application thereof. Background Art

[0002] Women in menopause (45-59 years old) are more likely to suffer from perimenopausal syndrome and sleep disorders due to the combined influence of ovarian dysfunction, decreased estrogen secretion, hyperpituitarism, increased pituitary gonadotropin, physiological factors of natural aging, emotional fluctuations (anxiety, depression), psychological factors such as excessive stress, and changes in family environment, social roles, interpersonal relationships, etc. Among them, insomnia in menopausal women is mainly manifested as difficulty falling asleep, easy awakening, early awakening, inability to fall asleep again after waking up, dreaminess and easy startle, etc. In severe cases, it is also accompanied by gastrointestinal discomfort, hot flashes, palpitations, irritability, blurred vision, inattention and other symptoms; it can also cause negative emotions such as anxiety and depression; affect cognitive functions such as attention and memory; weaken the body's immune system, increase the risk of infection, and even lead to cardiovascular diseases such as hypertension and heart disease, as well as endocrine diseases such as diabetes and obesity. It is estimated that the incidence rate of menopausal women in Western countries is as high as 35%, while the incidence rate in China is as high as 56%. Menopause is the period with the highest incidence of insomnia among women of all ages. Therefore, paying attention to sleep problems in menopausal women and alleviating their symptoms is an important part of menopausal women's health care.

[0003] At present, Western medicine often uses oral sedative hypnotics and anti-anxiety and anti-depressant drugs to relieve insomnia. Although it can improve symptoms, it only treats the symptoms and not the root cause. It is easy to produce tolerance, dependence, and side effects such as movement and memory disorders. Long-term use may even cause sequelae such as mental disorders. Traditional Chinese medicine believes that the onset of insomnia is closely related to liver and kidney deficiency and restlessness, and is also related to spleen and stomach dysfunction. Therefore, oral Chinese herbal decoctions, acupuncture, massage, etc. are often used to treat insomnia, which can treat both the symptoms and the root cause without obvious toxic and side effects, showing unique advantages in the treatment of insomnia. However, due to the bitter taste of Chinese herbal decoctions, painful acupuncture, and long-term massage, more and more menopausal women prefer to choose non-invasive complementary and alternative medical therapies, such as aromatherapy. Western medicine aromatherapy often uses aromatic essential oils to act on the human body through inhalation, massage, bathing, etc. to relieve insomnia symptoms. Studies have shown that some essential oils are phototoxic, sensitizing, and irritating, which will inevitably cause potential risks to the recipients, and there are certain safety hazards in the use of burning them at night. Chinese medicine aromatherapy often uses aromatic Chinese herbs to improve sleep disorders by inhalation. It has a long history and high safety. The effect of this method in relieving insomnia has been confirmed in many randomized controlled studies. For example, Chinese patent CN113813349A discloses a depression-relieving and calming sachet, and Chinese patent CN105615443A discloses a medicated pillow for improving sleep. Currently disclosed aromatic Chinese herbal medicines can be classified according to their medicinal properties and efficacy, such as aromatic warming and unblocking, aromatic resuscitation and aromatic dehumidifying Chinese herbal medicines. Specifically, aromatic warming and unblocking medicines have the effects of warming the kidney and assisting yang, warming the meridians and activating blood circulation, which help to relieve the visceral disorders related to insomnia; aromatic resuscitation medicines have the effects of calming the mind and refreshing the spirit, which help to relieve insomnia symptoms and negative emotions related to insomnia; aromatic dehumidifying medicines have the effects of invigorating the spleen and appetizing, which help to relieve gastrointestinal discomfort related to insomnia. However, insomnia in menopausal women is caused by a variety of physical and psychological changes such as the decrease in estrogen and progesterone levels in menopausal women. Unlike conventional insomnia, the existing aromatic Chinese herbal medicines and aromatherapy for conventional insomnia have poor efficacy on insomnia in menopausal women. Therefore, it is very necessary to provide an aromatic Chinese herbal medicine composition for improving the symptoms of insomnia in women during menopause. Summary of the invention

[0004] The purpose of the present invention is to overcome the above defects and shortcomings in the prior art and provide an aromatic Chinese herbal medicine composition for relieving menopausal insomnia in women.

[0005] The second object of the present invention is to provide a method for preparing the aromatic Chinese herbal medicine composition.

[0006] The third object of the present invention is to provide an application of the aromatic Chinese herbal medicine composition.

[0007] The fourth object of the present invention is to provide a product comprising the aromatic Chinese herbal composition.

[0008] The above-mentioned object of the present invention is achieved through the following technical solutions:

[0009] The invention provides an aromatic Chinese herbal medicine composition for relieving female menopausal insomnia. The Chinese herbal medicine composition consists of flos julibrissin, lavender, rose, atractylodes, white chrysanthemum, wormwood, angelica, ligusticum chuanxiong, cinnamon bark and calamus.

[0010] Studies have shown that the mechanisms of insomnia in menopausal women mainly include decreased estrogen levels, decreased secretion of 5-hydroxytryptamine and melatonin, depression, and dysfunction of the temperature control center. At the same time, the disorder of inflammatory genes and the increase of reactive oxygen are important causes of insomnia and cardiovascular diseases related to insomnia. Therefore, the hormone regulation, mood relief, temperature regulation, anti-inflammatory and antioxidant effects of Chinese herbal medicine are of great significance to improving insomnia and related symptoms in menopausal women. Modern pharmacological studies have shown that the quercetin and white chrysanthemum water extracts in the flowers of Albizzia can play a sedative, hypnotic and anti-anxiety role by mediating the 5-hydroxytryptamine system; ethylene oxide in roses and lavender and wormwood volatile oil have a hypnotic effect; Atractylodes can inhibit the excitability of neurons and thus play a hypnotic role; cinnamon has the effects of nourishing the heart, activating the spleen and calming; angelica, Chuanxiong and Acorus calamus have the effects of inhibiting inflammatory factors, protecting nerve cells, anti-inflammatory, antioxidant and immunomodulatory. Related studies have shown that inhalation therapy can directly act on the limbic system through the olfactory pathway to regulate emotions, hormones and the autonomic nervous system to improve sleep. Therefore, the present invention uses traditional Chinese medicine as a theoretical basis, and selects 10 kinds of aromatic Chinese herbal medicines for the influencing factors and symptoms of insomnia, including albizzia julibrissin, lavender, rose, and calamus, which have the effects of soothing the liver and relieving depression, calming the mind and settling the mind, wormwood, angelica, cinnamon, and chuanxiong, which have the effects of warming the kidney and assisting yang, activating blood circulation and promoting qi, and atractylodes and white chrysanthemum, which have the effects of regulating the spleen and stomach, clearing away heat and detoxifying. The aromatic properties of the above 10 kinds of aromatic Chinese herbal medicines can be used to adopt aromatherapy to directly act on the limbic system through the olfactory pathway to regulate emotions, hormones and the autonomic nervous system to improve insomnia.

[0011] Albizzia julibrissin is the flower bud of the leguminous plant Albizzia julibrissin. It is sweet, mild, aromatic, and belongs to the heart and lung meridians. Its traditional effects include relieving depression and calming the mind, promoting blood circulation and reducing swelling. It is often used to treat depression, restlessness, insomnia, forgetfulness, dreaminess, and falls and injuries. Modern studies have shown that the main components of Albizzia julibrissin, such as flavonoids, polysaccharides, and volatile oils, have pharmacological activities such as anti-depression, anti-anxiety, sedative and hypnotic, liver protection, immunomodulatory, and antioxidant. The present invention uses Albizzia julibrissin as the main component of the menopausal women's sleep-aiding sachet, with the intention of taking its aromatic medicinal properties, the traditional effects of relieving depression and calming the mind, promoting blood circulation and beautifying the face, and the modern effects of sedative and hypnotic, anti-depression, immunomodulatory, and antioxidant, to improve the resistance of menopausal women and relieve the low mood and insomnia symptoms related to insomnia.

[0012] Lavender is the dried aerial part of Lavandula angustifolia of the Lamiaceae family. It is sweet, flat, aromatic, and enters the liver and heart meridians. It has traditional effects of soothing nerves, sedation and hypnosis, and is commonly used in the treatment of neurasthenia, insomnia, anxiety, depression, headaches, etc. Modern studies have shown that linalool, lavandinol, and 8-cineoleol contained in its volatile oil have antibacterial, anti-inflammatory, antianxiety, antioxidant, and sleep-improving pharmacological activities. The present invention takes lavender as the main component of the menopausal female sleep-aiding sachet, intending to take its aromatic medicinal properties, the traditional effects of soothing nerves, sedation and hypnosis, and the modern effects of antibacterial, anti-inflammatory, antianxiety, antioxidant, and sleep-improving, improve the resistance of menopausal women and alleviate the depression and insomnia symptoms associated with insomnia.

[0013] Rose is the dried flower bud of the shrub rose of the Rosaceae family. It is warm, sweet, slightly bitter, aromatic, and belongs to the liver and stomach meridians. The traditional effects include promoting qi and relieving depression, promoting blood circulation and relieving pain. It is commonly used for the treatment of liver and stomach pain, vomiting blood and hemoptysis, irregular menstruation, dysentery, mastitis, etc.; modern studies have shown that rutin and anthocyanins in rose have anti-inflammatory, antiviral, hypnotic, anticancer, lipid-lowering, anti-aging, vision-enhancing and other pharmacological activities. The present invention takes rose as the main component of the menopausal female sleep-aiding sachet, which is intended to take its aromatic medicinal properties, the traditional effects of promoting qi and relieving depression, promoting blood circulation, and the modern effects of anti-inflammatory, antiviral, hypnotic, and anti-aging, improve the resistance of menopausal women and alleviate the depression and insomnia symptoms related to insomnia.

[0014] Atractylodes lancea is the rhizome of Atractylodes lancea of ​​the Asteraceae family. It is pungent, bitter, warm and aromatic, and is used in the spleen, stomach and liver meridians. The traditional effects include drying dampness and strengthening the spleen, dispelling wind and removing dampness, relieving the symptoms of diaphoresis and improving eyesight. It is commonly used for the treatment of sweat-dampness and spleen stagnation, heaviness of limbs, phlegm and fluid retention, edema, dry eyes and the like. Modern studies have shown that β-eudesmol and atractylodesine in Atractylodes lancea have anti-inflammatory, antioxidant, antibacterial, immunomodulatory, sedative, liver-protecting, hypoglycemic and anti-tumor pharmacological activities. The present invention takes Atractylodes lancea as the main component of the menopausal female sleep-aiding sachet, and intends to take its aromatic medicinal properties, the traditional effects of drying dampness and strengthening the spleen, dispelling wind and removing dampness, and improving eyesight, and the modern effects of anti-inflammatory, antibacterial, immunomodulatory, sedative and liver-protecting, and improves the resistance of menopausal women and alleviates gastrointestinal discomfort, eye discomfort and insomnia symptoms related to insomnia.

[0015] White chrysanthemum is the flower of the chrysanthemum of the Asteraceae family. It is slightly cold, bitter, pungent, and aromatic, and belongs to the lung and liver meridians. The traditional effects include soothing the liver, clearing away heat and detoxifying, nourishing yin and moistening dryness, and improving eyesight. It is commonly used in the treatment of carbuncle, erysipelas, eczema, dermatitis, colds, sore throat, headache, dizziness, etc.; modern studies have shown that it has sedative, antibacterial, antipyretic, body resistance enhancement, blood pressure lowering, anti-tumor, and antioxidant effects. The present invention takes white chrysanthemum as the main component of the menopausal female sleep-aiding sachet, which is intended to take its aromatic medicinal properties, the traditional effects of clearing away heat and detoxifying, and improving eyesight, and the modern effects of antibacterial, body resistance enhancement, sedative, and antipyretic, so as to improve the resistance of menopausal women and relieve the hot flashes, eye discomfort, and insomnia symptoms associated with insomnia.

[0016] Mugwort is a leaf of a herbaceous plant of the Asteraceae family. It is warm, pungent, and aromatic. It belongs to the liver, spleen, and kidney meridians. Its traditional effects include warming the meridians and dispelling cold, relieving pain, removing dampness and relieving itching. It is often used to treat irregular menstruation, indigestion, headaches, etc. Modern studies have shown that its volatile oil has anti-inflammatory, antioxidant, sedative, immunity-enhancing, and liver-protecting effects. The present invention uses mugwort as the main component of the menopausal female sleep-aiding sachet, intending to take its aromatic medicinal properties, the traditional effects of warming the kidney and assisting yang, warming the meridians and dispelling cold, and the modern effects of anti-inflammatory, antioxidant, antibacterial, sedative, and immunity-enhancing, thereby improving the resistance of menopausal women and relieving insomnia symptoms.

[0017] Angelica sinensis is the root of the herbaceous plant Angelica sinensis of the Umbelliferae family. It is pungent, sweet, warm and aromatic, and enters the liver, spleen and heart meridians. The traditional effects include nourishing blood, promoting blood circulation and relieving pain, regulating blood and menstruation, and moistening the intestines and relieving constipation. It is often used to treat insomnia, dreaminess, dizziness, forgetfulness, weak pulse, oligomenorrhea, dysmenorrhea, uterine fibroids and other gynecological diseases caused by deficiency of both heart and spleen, deficiency of both qi and blood, and malnutrition of meridians; modern studies have shown that its volatile oil has analgesic, anti-inflammatory and antibacterial effects. The present invention uses Angelica sinensis as the main ingredient of the sleeping sachet for menopausal women, with the intention of taking its aromatic medicinal properties, the traditional effects of nourishing blood, regulating blood and menstruation, and the modern effects of anti-inflammatory, antibacterial and sedative, to improve the resistance of menopausal women and relieve insomnia symptoms.

[0018] Cinnamon is the dry bark of the cinnamon bark, an evergreen tree of the Lauraceae family. It is pungent, sweet, hot, aromatic, and enters the kidney, spleen, liver, and heart meridians. The traditional effects include warming the kidney and spleen, replenishing fire and assisting yang, guiding fire back to the origin, dispelling cold and relieving pain. It is commonly used for the treatment of dysmenorrhea, pain in the waist and knees, frequent urination at night, and dizziness due to yang deficiency. Modern studies have shown that it has pharmacological activities such as vasodilation, anti-oxidation, anti-inflammatory, antibacterial, and sedative. The present invention takes cinnamon as the main ingredient of the menopausal female sleep-aiding sachet, which is intended to take its aromatic medicinal properties, the traditional effects of warming the kidney and spleen, replenishing fire and assisting yang, and the modern effects of anti-inflammatory, antibacterial, and sedative, to improve the resistance of menopausal women and relieve insomnia symptoms.

[0019] Chuanxiong is the rhizome of the herbaceous plant Chuanxiong of the Umbelliferae family. It is pungent, warm and aromatic, and enters the liver, gallbladder and pericardium meridians. It has traditional effects of promoting blood circulation and qi, dispersing wind and relieving pain. It is often used together with angelica and wormwood leaves, and is often used for the treatment of dysmenorrhea, amenorrhea, limb numbness, headache, arteriosclerosis and hypertension. Modern studies have shown that the polysaccharides in Chuanxiong have pharmacological activities such as enhancing immunity, anti-inflammatory, anti-oxidation, cardiotonic, vasodilation and sedation. The present invention takes Chuanxiong as the main component of the menopausal female sleep-aiding sachet, which is intended to take its aromatic medicinal properties, the traditional effects of promoting blood circulation and qi, and the modern effects of sedation, anti-inflammatory, antibacterial and enhancing immunity, so as to improve the resistance of menopausal women and relieve insomnia symptoms.

[0020] Acorus calamus is the dried rhizome of Acorus calamus, a plant of the Araceae family. It is warm, pungent, aromatic, and enters the heart, spleen, and stomach meridians. Traditional effects include calming the mind and improving intelligence, resolving phlegm and opening the mind, removing dampness and stimulating appetite, and it is commonly used in the treatment of confusion, insomnia, dementia, tinnitus, etc. Modern studies have shown that volatile oil of Acorus calamus can regulate neurotransmitters, promote the production of 5-hydroxytryptamine, and has pharmacological effects such as anti-oxidation and anti-inflammatory. The present invention takes Acorus calamus as the main ingredient of the menopausal female sleep-aiding sachet, and intends to take its aromatic medicinal properties, the traditional effects of calming the mind and improving intelligence, resolving phlegm and opening the mind, removing dampness and stimulating appetite, and the modern hormone regulation and anti-inflammatory effects, improve the resistance of menopausal women and relieve gastrointestinal discomfort and insomnia symptoms related to insomnia.

[0021] Specifically, the combination of Albizzia julibrissin with Acorus calamus, lavender and rose can significantly enhance the effect of calming the nerves and relieving depression, helping menopausal women to better relieve anxiety and improve sleep quality; the combination of white chrysanthemum and Atractylodes can enhance the effect of calming the liver and improving eyesight, which helps to better relieve eye fatigue; the combination of Acorus calamus and Atractylodes can enhance the effect of drying dampness and strengthening the spleen, removing dampness and stimulating appetite, which helps to relieve the gastrointestinal discomfort of menopausal women; mugwort and cinnamon can warm the kidney and assist yang, warm the meridians and dredge the meridians, improve blood circulation, and help to exert the effect of angelica and Chuanxiong in promoting blood circulation, so that the overall qi and blood flow more smoothly, which is conducive to better improving the yang deficiency constitution of menopausal women, enhancing immunity, relieving weakness, and then helping to obtain a higher sleep quality. At the same time, the combination of multiple Chinese herbal medicines can better adapt to individual differences in constitution and smell preferences, and help prevent tolerance problems caused by long-term use of a single Chinese herbal medicine, and ultimately improve the use effect of the sachet. In addition, the present invention also takes into account the potential problem that the warming properties of Chuanxiong, cinnamon and angelica easily lead to overheating in the body and the drying effect of Atractylodes lancea easily leads to dryness. Therefore, the slightly cold medicinal properties and traditional heat-clearing effects of white chrysanthemum are neutralized with the warming properties of Chinese herbal medicines such as Chuanxiong, cinnamon and angelica to avoid oral ulcers, constipation and the like caused by overheating in the body; the moisturizing effect of white chrysanthemum is balanced with the drying effect of Atractylodes lancea to reduce the side effect of dryness. The results of the present invention show that the Chinese herbal medicine sachet made of the above-mentioned composition formula can effectively improve the insomnia symptoms of menopausal women, improve sleep quality, and relieve the symptoms of perimenopausal syndrome without obvious side effects.

[0022] Furthermore, the aromatic Chinese herbal composition is composed of the following components in parts by weight: 10-15 parts of julibrissin flowers, 10-15 parts of lavender, 10-15 parts of roses, 10-15 parts of atractylodes, 10-15 parts of white chrysanthemum, 10-15 parts of mugwort, 10-15 parts of angelica, 6-8 parts of cinnamon, 6-8 parts of chuanxiong, and 4-6 parts of calamus.

[0023] Furthermore, the aromatic Chinese herbal composition is composed of the following components in parts by weight: 11-14 parts of julibrissin flowers, 11-14 parts of lavender, 11-14 parts of roses, 11-14 parts of atractylodes, 11-14 parts of white chrysanthemum, 11-14 parts of mugwort, 11-14 parts of angelica, 6.5-7.5 parts of cinnamon, 6.5-7.5 parts of chuanxiong, and 4.5-5.5 parts of calamus.

[0024] Furthermore, the Chinese herbal composition is composed of the following components in parts by weight: 11-13 parts of julibrissin flowers, 11-13 parts of lavender, 11-13 parts of roses, 11-13 parts of atractylodes, 11-13 parts of white chrysanthemum, 11-13 parts of mugwort, 11-13 parts of angelica, 6.5-7.5 parts of cinnamon, 6.5-7.5 parts of ligusticum, and 4.5-5.5 parts of calamus.

[0025] Preferably, the Chinese herbal composition is composed of the following components in parts by weight: 12 parts of julibrissin flowers, 12 parts of lavender, 12 parts of roses, 12 parts of atractylodes, 12 parts of white chrysanthemum, 12 parts of mugwort, 12 parts of angelica, 7 parts of cinnamon, 7 parts of chuanxiong, and 5 parts of calamus.

[0026] The present invention provides a method for preparing the above aromatic Chinese herbal medicine composition, wherein julibrissin, lavender, rose, atractylodes, white chrysanthemum, wormwood, angelica, chuanxiong, cinnamon and calamus are ground into powder respectively, and the corresponding weight portions of Chinese herbal medicine powder are weighed and mixed. The sachet made of powdered aromatic Chinese herbal medicine can utilize the aromatic smell and volatility of the Chinese herbal medicine to be absorbed and penetrated into the human body through channels, acupuncture points and mucous membranes, from the outside to the inside, and circulate throughout the body through the qi and blood channels, so as to relax muscles and soothe emotions, thereby improving sleep quality, and the safety is relatively high.

[0027] The present invention also provides an application of the aromatic Chinese herbal medicine composition in preparing a product for alleviating female menopausal insomnia.

[0028] The present invention also provides an application of the aromatic Chinese herbal medicine composition in preparing a product for alleviating perimenopausal syndrome caused by menopausal insomnia in women.

[0029] Therefore, the present invention also provides a product for alleviating female menopausal insomnia, wherein the product contains the aromatic Chinese herbal medicine composition.

[0030] Furthermore, the product is a sachet or a medicinal pillow.

[0031] Preferably, the product is a sachet.

[0032] Preferably, the product is a sachet in which the aromatic Chinese herbal composition is packed into a non-woven medicine bag, which is then packed into a mesh linen bag.

[0033] Compared with the prior art, the present invention has the following beneficial effects:

[0034] The present invention provides an aromatic Chinese herbal composition for relieving female menopausal insomnia, and the Chinese herbal composition is composed of Flos Albiziae, Lavender, Rose, Atractylodes, White Chrysanthemum, Artemisia, Angelica, Rhizoma Chuanxiong, Cinnamon, and Acorus Calamus. The present invention selects 10 aromatic Chinese herbal medicines according to the influencing factors and symptoms of menopausal female insomnia, intervenes in menopausal insomnia women, and shows that the sachet can effectively improve the insomnia symptoms of menopausal women, improve sleep quality, and relieve perimenopausal syndrome symptoms, highlighting the potential of multiple Chinese herbal aromatherapy as a natural therapy for relieving female menopausal insomnia symptoms, and the non-invasive and convenient multiple aromatic Chinese herbal inhalation therapy has excellent tolerability. The present invention expands the application scope of aromatic Chinese herbal medicines and aromatherapy, promotes the understanding and application of Chinese medicine principles in modern medical practice, and actively promotes the inheritance and development of medical culture. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 The invention relates to a sachet comprising the aromatic Chinese herbal medicine composition of the invention.

[0036] Figure 2 This is a line graph of PSQI scores for the two groups at different time points.

[0037] Figure 3 It is a line graph of GCS scores of two groups at different time points. DETAILED DESCRIPTION

[0038] The present invention is further described below in conjunction with the accompanying drawings and specific examples, but the examples do not limit the present invention in any form. Unless otherwise specified, the reagents, methods and equipment used in the present invention are conventional reagents, methods and equipment in the art.

[0039] Unless otherwise specified, the reagents and materials used in the following examples are commercially available.

[0040] Example 1

[0041] Take 12g of Albizzia julibrissin, 12g of lavender, 12g of rose, 12g of Atractylodes lancea, 12g of white chrysanthemum, 12g of mugwort, 12g of Chinese angelica, 7g of cinnamon, 7g of Chuanxiong, 5g of Acorus calamus, put the Chinese herbal medicine powder into a non-woven medicine bag with a specification of 12cmx16cm, and then put it into a mesh linen bag with a specification of 13c×18cm. The dosage of each sachet is 103g. The finished product is as follows Figure 1 shown.

[0042] Example 2

[0043] Take 15g of julibrissin, 15g of lavender, 15g of rose, 15g of atractylodes, 15g of white chrysanthemum, 15g of mugwort, 15g of angelica, 8g of cinnamon, 8g of chuanxiong, and 6g of calamus. Put the herbal powder into a non-woven medicine bag with a specification of 12cmx16cm, and then put it into a mesh linen bag with a specification of 13c×18cm. The dosage of each sachet is 127g.

[0044] Example 3

[0045] Take 10g of julibrissin flower, 10g of lavender, 10g of rose, 10g of atractylodes, 10g of white chrysanthemum, 10g of mugwort, 10g of angelica, 6g of cinnamon, 6g of chuanxiong, and 4g of calamus. Put the herbal powder into a non-woven medicine bag with a specification of 12cmx16cm, and then put it into a mesh linen bag with a specification of 13c×18cm. The dosage of each sachet is 86g.

[0046] Example 4

[0047] Take 11g of julibrissin flower, 11g of lavender, 11g of rose, 11g of atractylodes, 11g of white chrysanthemum, 11g of mugwort, 11g of angelica, 6.5g of cinnamon, 6.5g of chuanxiong, and 4.5g of calamus. Put the herbal powder into a non-woven medicine bag with a specification of 12cmx16cm, and then put it into a mesh linen bag with a specification of 13c×18cm. The dosage of each sachet is 94.5g.

[0048] Example 5

[0049] Take 14g of julibrissin, 14g of lavender, 14g of rose, 14g of atractylodes, 14g of white chrysanthemum, 14g of mugwort, 14g of angelica, 7.5g of cinnamon, 7.5g of chuanxiong, and 5.5g of calamus. Put the herbal powder into a non-woven medicine bag with a specification of 12cmx16cm, and then put it into a mesh linen bag with a specification of 13c×18cm. The dosage of each sachet is 118.5g.

[0050] Example 6

[0051] Take 13g of julibrissin, 13g of lavender, 13g of rose, 13g of atractylodes, 13g of white chrysanthemum, 13g of mugwort, 13g of angelica, 7.5g of cinnamon, 7.5g of chuanxiong, and 5.5g of calamus. Put the herbal powder into a non-woven medicine bag with a specification of 12cmx16cm, and then put it into a mesh linen bag with a specification of 13c×18cm. The dosage of each sachet is 111.5g.

[0052] Example 7

[0053] Take 12g of julibrissin, 12g of lavender, 12g of rose, 13g of atractylodes, 13g of white chrysanthemum, 13g of mugwort, 13g of angelica, 7.5g of cinnamon, 7.5g of chuanxiong, and 5.5g of calamus. Put the herbal powder into a non-woven medicine bag with a specification of 12cmx16cm, and then put it into a mesh linen bag with a specification of 13c×18cm. The dosage of each sachet is 108.5g.

[0054] Test Example 1

[0055] To exclude the influence of food, other people's perfume smell, etc. on the smell of the sachet, hang the sachet on the side wall at a height of about 30 cm from the nose when sleeping at night. The intervention time is 8 hours from 23:00 to 07:00 the next morning. The next morning, put them into a sealed bag with a size of 16cm×24cm for storage, and put two bags of food desiccant in the sealed bag to prevent the aroma from quickly dispersing, the effective ingredients from volatilizing, moisture or contamination by other objects. In order to ensure the function and effect of each sachet, the sachet is replaced every 3 weeks.

[0056] The present invention uses the sachets and placebos in Examples 1 to 7 to intervene in 112 subjects for 9 weeks using the above method, and evaluates them using the Pittsburgh Sleep Quality Index (PSQI) and the Greene Climacteric Scale (GCS). The herbal ingredients and dosages of the placebo sachet group are: 15g of Poria cocos, 15g of Angelica dahurica, 15g of Pueraria root, 20g of Plantago, 20g of Pumice stone, and 18g of Roselle. The total dosage of the placebo sachet is 103g, which is consistent with the dosage of the sachet in Example 1.

[0057] The therapeutic results of the sachet in Example 1 are as follows Figure 2 As shown, the intervention effect of the aromatic Chinese herbal sachet of the present invention is significantly better than that of the placebo. The sachet can effectively improve the insomnia symptoms of menopausal women and improve the sleep quality, highlighting the potential of multiple Chinese herbal aromatherapy as a natural therapy for relieving insomnia symptoms, and the non-invasive and convenient multiple aromatic Chinese herbal inhalation therapy has excellent tolerability.

[0058] The therapeutic results of the sachet in Example 1 are as follows Figure 3 As shown, the aromatic Chinese herbal sachet of the present invention can effectively relieve the symptoms of perimenopausal syndrome in female menopause without obvious side effects.

[0059] At the same time, compared with Examples 2 to 7, Example 1 has the best therapeutic effect in improving female menopausal insomnia and relieving perimenopausal syndrome, among which, the effects of Example 7, Example 6, Example 4, Example 5, Example 3, and Example 2 are lower than those of Example 1, but the therapeutic effects are still significantly higher than those of the placebo. The above results show that the sachets of Examples 1 to 7 of the present invention can improve female menopausal insomnia and relieve perimenopausal syndrome.

[0060] Comparative Example 1

[0061] Take Chuanxiong, Atractylodes, Chinese Angelica, Cinnamon, Mugwort, Lavender, and Rose and grind them into powder. Take the following weights of each component respectively: 7g Chuanxiong, 12g Atractylodes, 12g Chinese Angelica, 7g Cinnamon, 12g Mugwort, 12g Lavender, and 12g Rose. Put them into the sachet bag and mix them evenly. Seal the mouth to prevent the powder from leaking out. Compared with Example 1, the Chinese herbal medicine sachet lacks Flos Albiziae, Flos Chrysanthemi, and Acorus Calamus, and the aromatic characteristics of the Chinese herbal medicine sachet are weakened. Because the warm properties of Chuanxiong, Cinnamon, and Chinese Angelica are prone to cause overheating in the body and the potential problem of drying caused by the drying effect of Atractylodes, so lacking Flos Albiziae, Flos Chrysanthemi, and Acorus Calamus may cause oral ulcers, constipation, dryness, etc. caused by overheating in the body, and at the same time, compared with Example 1, it will also affect the sleep quality, and the sleep improvement effect is not as good as that of Example 1.

[0062] Comparative Example 2

[0063] Rose, lavender, chrysanthemum, albizzia, angelica, chuanxiong, and calamus are ground into powder, and the following weights of each component are taken respectively: 12g of rose, 12g of lavender, 12g of chrysanthemum, 12g of albizzia, 12g of angelica, 7g of chuanxiong, and 5g of calamus are put into a sachet bag and mixed evenly, and the mouth is sealed to prevent the powder from leaking out. Compared with Example 1, the Chinese herbal medicine sachet lacks atractylodes, wormwood, and cinnamon. Because the combination of Atractylodes lancea and Acorus calamus can enhance the effects of drying dampness and strengthening the spleen, removing dampness and stimulating appetite, which helps to better relieve gastrointestinal discomfort in menopausal women; the combination of Atractylodes lancea and Chrysanthemum can enhance the effect of calming the liver and improving eyesight, which helps to better relieve eye fatigue; Artemisia argyi and cinnamon can warm the kidney and assist yang, warm the meridians and dredge the meridians, improve blood circulation, and are more conducive to the effect of angelica and Chuanxiong in promoting blood circulation, so that the overall qi and blood flow more smoothly, which is conducive to better improving the yang deficiency constitution of menopausal women, enhancing immunity, and alleviating weakness, and then helping to obtain higher sleep quality. Therefore, the lack of Atractylodes lancea, Artemisia argyi, and Cinnamon in Comparative Example 2 is significantly weaker than that in Example 1 in the treatment of insomnia.

[0064] Comparative Example 3

[0065] Take angelica, lavender, calamus, chuanxiong, wormwood, rose, albizzia, chrysanthemum and grind them into powder, take the following weights of each component respectively: angelica 12g, lavender 12g, calamus 5g, chuanxiong 7g, wormwood 12g, rose 12g, albizzia 12g, chrysanthemum 12g, put them into a sachet bag and mix them evenly, and seal the mouth to prevent the powder from leaking out. Compared with Example 1, the Chinese herbal medicine sachet lacks atractylodes and cinnamon. Because the combination of Atractylodes lancea and Acorus calamus can enhance the effects of drying dampness and strengthening the spleen, removing dampness and stimulating appetite, it helps to better relieve gastrointestinal discomfort in menopausal women; the combination of Atractylodes lancea and White Chrysanthemum can enhance the effect of calming the liver and improving eyesight, which helps to better relieve eye fatigue; Cinnamon can warm the meridians and improve blood circulation, and is more conducive to the effect of Angelica sinensis and Chuanxiong in promoting blood circulation, so that the overall qi and blood flow is smoother, which is conducive to better improving the yang deficiency constitution of menopausal women, enhancing immunity, and relieving weakness, and then helping to obtain higher sleep quality. Therefore, the lack of Atractylodes lancea and Cinnamon in Comparative Example 3 is significantly weaker than that in Example 1 in the treatment of insomnia.

[0066] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.

Claims

1. An aromatic Chinese herbal medicine composition for relieving insomnia in women during menopause, characterized in that: The Chinese herbal medicine composition consists of julibrissin, lavender, rose, atractylodes, white chrysanthemum, wormwood, angelica, ligusticum chuanxiong, cinnamon bark and calamus.

2. The aromatic Chinese herbal medicine composition according to claim 1, characterized in that: The Chinese herbal medicine composition is composed of the following components in parts by weight: 10-15 parts of julibrissin flowers, 10-15 parts of lavender, 10-15 parts of roses, 10-15 parts of atractylodes, 10-15 parts of white chrysanthemums, 10-15 parts of wormwood, 10-15 parts of angelica, 6-8 parts of cinnamon, 6-8 parts of ligusticum chuanxiong, and 4-6 parts of calamus.

3. The aromatic Chinese herbal medicine composition according to claim 1, characterized in that: The Chinese herbal medicine composition consists of the following components in parts by weight: 11-14 parts of julibrissin flowers, 11-14 parts of lavender, 11-14 parts of roses, 11-14 parts of atractylodes, 11-14 parts of white chrysanthemums, 11-14 parts of wormwood, 11-14 parts of angelica, 6.5-7.5 parts of cinnamon, 6.5-7.5 parts of ligusticum chuanxiong, and 4.5-5.5 parts of calamus.

4. The aromatic Chinese herbal medicine composition according to claim 1, characterized in that: The Chinese herbal medicine composition consists of the following components in parts by weight: 11-13 parts of julibrissin flowers, 11-13 parts of lavender, 11-13 parts of roses, 11-13 parts of atractylodes, 11-13 parts of white chrysanthemums, 11-13 parts of wormwood, 11-13 parts of angelica, 6.5-7.5 parts of cinnamon, 6.5-7.5 parts of ligusticum chuanxiong, and 4.5-5.5 parts of calamus.

5. The aromatic Chinese herbal medicine composition according to claim 1, characterized in that: The Chinese herbal medicine composition is composed of the following components in parts by weight: 12 parts of julibrissin flowers, 12 parts of lavender, 12 parts of roses, 12 parts of atractylodes, 12 parts of white chrysanthemums, 12 parts of wormwood, 12 parts of angelica, 7 parts of cinnamon, 7 parts of ligusticum chuanxiong and 5 parts of calamus.

6. The method for preparing the aromatic Chinese herbal medicine composition according to any one of claims 1 to 5, characterized in that: Grind julibrissin flower, lavender, rose, atractylodes, white chrysanthemum, wormwood, angelica, ligusticum chuanxiong, cinnamon bark and calamus into powder respectively, weigh corresponding weight portions of Chinese herbal medicine powder and mix them.

7. Use of the aromatic Chinese herbal medicine composition according to any one of claims 1 to 5 in the preparation of a product for alleviating menopausal insomnia in women.

8. Use of the aromatic Chinese herbal medicine composition according to any one of claims 1 to 5 in the preparation of a product for alleviating perimenopausal syndrome caused by menopausal insomnia in women.

9. A product for alleviating insomnia during menopause in women, characterized in that: The product contains the aromatic Chinese herbal medicine composition according to any one of claims 1 to 5.

10. The product according to claim 9, characterized in that: The product is a sachet or a medicine pillow.

Images