Medicine for treating bromhidrosis and preparation method thereof

Abstract

The invention discloses a medicine for treating bromhidrosis and a preparation method thereof.The medicine is prepared from water, silver nitrate, copper sulfate and alcohol, the silver nitrate, the copper sulfate and the alcohol are reasonably prepared according to the generation reasons of bromhidrosis, and substances generated through a high-temperature reaction can inhibit secretion of China glands for a long time and have a very strong bactericidal effect, so that the medicine can be used for treating bromhidrosis of bromhidrosis of bromhidrosis of bromhidrosis of bromhidrosis of bromhidrosis of bromhidrosis of bromhidrosis. Therefore, the bromhidrosis eliminating effect is achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of drugs, and in particular to a drug for treating underarm odor and a preparation method thereof. Background Art

[0002] Bromhidrosis, also known as "body odor", refers to a special pungent odor formed by the unsaturated fatty acids produced by the decomposition of apocrine sweat gland secretions by bacteria in the armpits. It is common in young and middle-aged people, and is more common in female patients, which seriously affects the patient's life and social life, causing a huge psychological burden. At present, the treatment methods for axillary odor include surgery, botulinum toxin type A and photoelectric therapy, but there are many disadvantages such as large trauma, long recovery time or high recurrence rate. Drugs are also used for treatment, but some drugs on the market are easy to cause allergies; some external ointments need to be used frequently, which makes them inconvenient to use; some are short-lived, easy to relapse, or have a long course of treatment; some drugs are colorful and easy to color clothes. Summary of the invention

[0003] Therefore, based on the above background, the present invention provides a medicine for treating axillary odor and a preparation method thereof, which has a short treatment course, a low recurrence rate, a low treatment frequency and a high patient compliance.

[0004] The technical solution of the present invention is:

[0005] A medicine for treating underarm odor, which is made from the following raw materials by weight:

[0006]

[0007] Preferably, it is made of the following raw materials by weight:

[0008]

[0009] Preferably, it is made of the following raw materials by weight:

[0010]

[0011] Preferably, the volume concentration of the alcohol is 95%.

[0012] Preferably, it is a spray.

[0013] Preferably, the preparation method comprises the following steps:

[0014] S1: Take water, silver nitrate, copper sulfate and alcohol according to the amount, and heat the water to 100℃;

[0015] S2: adding ethanol to water with condensation reflux;

[0016] S3: Then add silver nitrate and copper sulfate, stir until completely dissolved, cool and you can get the spray.

[0017] The beneficial effects achieved by the technical solution of the present invention are:

[0018] The generation of underarm odor is mostly due to the overdevelopment of the apocrine sweat glands in the armpits, which produces a large amount of fatty acids, which are decomposed by bacteria to produce an unpleasant odor. According to the causes of underarm odor, the present invention reasonably prepares silver nitrate, copper sulfate and alcohol. The substances generated by the high-temperature reaction can not only inhibit the secretion of the apocrine sweat glands for a long time, but also have a strong bactericidal effect, thereby achieving the effect of eliminating underarm odor. The treatment course is short, the frequency of use is low, the use is convenient, the patient compliance is high, and the recurrence rate is low. DETAILED DESCRIPTION

[0019] In order to make the objectives, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with its embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0020] Embodiment 1: A medicine for treating underarm odor, which is made from the following raw materials by weight:

[0021]

[0022] Embodiment 2: A medicine for treating underarm odor, which is made from the following raw materials by weight:

[0023]

[0024] The volume concentration of alcohol used in Example 1 and Example 2 is 95%.

[0025] Embodiments 1 and 2 can be made into sprays, and the preparation method thereof comprises the following steps:

[0026] S1: Take water, silver nitrate, copper sulfate and alcohol according to the amount, and heat the water to 100℃;

[0027] S2: adding ethanol to water with condensation reflux;

[0028] S3: Then add silver nitrate and copper sulfate, stir until completely dissolved, cool and you can get the spray.

[0029] When the spray used in Examples 1 and 2 is used, it is generally sprayed on the armpit after bathing. The frequency of use is low, generally once every 7-10 days, and once every half a month for mild body odor.

[0030] Clinical Cases:

[0031] The spray of the present invention has been used to treat 200 patients with underarm odor from Changhe Hospital from August 2022 to February 2024, including 80 males and 120 females, including 10 patients with mild underarm odor (strange smell in summer, there will be a strange smell when you smell it carefully, but the smell is not particularly serious), 40 patients with moderate underarm odor (generally in the process of close contact, you may smell an irritating smell, which may spread to a farther place in the hot summer), and 40 patients with severe underarm odor. (Generally, an obvious odor can be smelled within a range of three meters, and there will also be an odor inside the closet) 150 patients were treated with the spray of Example 1 of the present invention. After 25 days of treatment (during the treatment, the armpits were sprayed once on the first day and once after 10 days), the cure rate (= number of cured people * 100% / total number of people) reached 20%, and the effective rate ((number of cured people + effective number of people) / total number of people) reached 72%, among which the cure rate of patients with severe body odor was 15%, and the effective rate reached 85%.

[0032] The treatment efficacy criteria are:

[0033] Cure: 10 days after stopping the medication, there is no armpit odor and armpit sweating is significantly reduced;

[0034] Effective: 10 days after stopping the medication, armpit odor and armpit sweating were significantly reduced;

[0035] Ineffective: After stopping the medication for 10 days, the armpit odor remained or even worsened.

[0036] For the other patients who did not reach the cure standard, the spray of Example 1 was used to continue treatment, with the longest treatment time being 6 months. If the cure standard was reached in the middle, the drug was stopped, and the cure rate could reach 81.5%; none of the patients had allergic reactions during the treatment process, and 20 cured patients were randomly selected for follow-up two months later, and no recurrence occurred.

[0037] Typical cases:

[0038] Case 1: Mr. Li, male, 24 years old, had severe underarm odor. He visited the hospital in July 2004. After using the spray of Example 1 of the present invention for the first time, the odor was significantly reduced after taking a shower on the same day. He then used it every 7 days. After using it for 2 consecutive months, he reached the cure standard. He was revisited two years later and there was no recurrence.

[0039] Case 2: Zhou, female, 26 years old, severe underarm odor. After using the spray of the present invention in Example 1 in 2019, the odor was significantly reduced after taking a shower on the same day. After using it once every ten days, after continuous use for 3 months, the cure standard was achieved. After follow-up, there has been no recurrence so far.

[0040] Case 3: Min, male, 50 years old, had severe underarm odor. In the past, various underarm odor topical medicines were not ideal, and underarm odor surgery was also performed, but there was still odor. Later, the spray of Example 1 of the present invention was used for treatment, once every 7 days. After continuous treatment for nearly one and a half months, the patient was cured.

[0041] Comparative Example 1: A medicine for treating underarm odor, which is made from the following raw materials by weight:

[0042] Water 1000ml

[0043] Silver nitrate 200mg

[0044] Copper sulfate 1000mg.

[0045] Compared with Example 1, in this embodiment, alcohol is removed and replaced with water.

[0046] This comparative example is made into a spray, and its preparation method comprises the following steps:

[0047] S1: Take water, silver nitrate and copper sulfate according to the amount, wherein the water is heated to 100°C;

[0048] S2: Add silver nitrate and copper sulfate under condensation reflux, stir until completely dissolved, and cool to obtain a spray.

[0049] Comparative Example 2: A medicine for treating underarm odor, which is made from the following raw materials by weight:

[0050] 800ml water

[0051] Silver nitrate 1200mg

[0052] 200ml of alcohol.

[0053] In this embodiment, copper sulfate is removed and replaced with silver nitrate.

[0054] This comparative example is made into a spray, and its preparation method comprises the following steps:

[0055] S1: Take water, silver nitrate, copper sulfate and alcohol according to the amount, and heat the water to 100℃;

[0056] S2: adding ethanol to water with condensation reflux;

[0057] S3: Then add silver nitrate, stir until completely dissolved, and cool to obtain a spray.

[0058] In January 2023, 50 patients who visited Changhe Hospital for treatment of body odor were recruited, including 27 males and 23 females. All of them had moderate body odor. Before treatment, their opinions were sought and comparison examples 1 and 2 were used for treatment.

[0059] The above patients were randomly divided into two groups, 25 people in each group, namely control group 1 and control group 2.

[0060] Comparative Example 1 group was treated with the spray prepared in Comparative Example 1, and Comparative Example 2 group was treated with the spray prepared in Comparative Example 2. After 25 days (during the treatment, the armpits were sprayed once on the first day and once after 10 days), the cure rate of Comparative Example 1 group reached 4%, and the effective rate reached 56%; the cure rate of Comparative Example 2 group was 12%, and the effective rate reached 72%.

[0061] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A medicine for treating underarm odor, characterized in that: It is made from the following raw materials by weight:

2. A medicine for treating underarm odor according to claim 1, characterized in that: It is made from the following raw materials by weight:

3. A medicine for treating underarm odor according to claim 1, characterized in that: It is made from the following raw materials by weight:

4. A medicine for treating underarm odor according to any one of claims 1 to 3, characterized in that: The volume concentration of the alcohol is 95%.

5. A medicine for treating underarm odor according to any one of claims 1 to 4, characterized in that: It is a spray.

6. A medicine for treating underarm odor according to claim 6, characterized in that: The preparation method thereof comprises the following steps: S1: Take water, silver nitrate, copper sulfate and alcohol according to the amount, and heat the water to 100℃; S2: adding ethanol to water with condensation reflux; S3: Then add silver nitrate and copper sulfate, stir until completely dissolved, cool and you can get the spray.

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