Oral composition for treating allergic rhinitis

Abstract

The invention relates to a pharmaceutical composition, in particular to an oral composition for treating allergic rhinitis, which takes magnolia flower and baical skullcap root as monarch drugs, dahurian angelica root, divaricate saposhnikovia root, szechuan lovage rhizome, milkvetch root and Indian buead as ministerial drugs, liquoric root as a guide and the balance as adjuvant drugs. Comprising the following components: 2-3 parts of biond magnolia flower, 2-3 parts of angelica dahurica, 3-5 parts of fructus forsythiae, 3-5 parts of fried burdock, 2-3 parts of divaricate saposhnikovia root, 3-5 parts of dandelion, 3-5 parts of astragalus membranaceus, 3-5 parts of scutellaria baicalensis, 3-5 parts of poria cocos, 3-5 parts of bighead atractylodes rhizome, 10-15 parts of coix seed, 2-3 parts of ligusticum wallichii, 2-3 parts of radix scrophulariae The traditional Chinese medicine preparation for treating wind-heat invading lung and spleen qi weakness type allergic rhinitis has the effects of dispelling wind, clearing lung, dredging nasal orifices and replenishing qi to invigorate the spleen, the symptoms of patients are relieved, and the living quality of vast child patients is improved.

Description

Technical Field

[0001] The invention relates to a pharmaceutical composition, in particular to an oral composition for treating allergic rhinitis. Background Art

[0002] Allergic rhinitis, also known as allergic rhinitis, refers to a type I allergic disease of the nasal mucosa that occurs when susceptible individuals come into contact with allergens, under the influence of immunoglobulins and immune-active cells, and is mainly mediated by specific IgE, with symptoms such as paroxysmal sneezing, clear watery nasal discharge, nasal congestion, and nasal itching. It is a major nasal disease that affects children's physical and mental health, academic performance, and quality of life, with a high prevalence and a great social impact.

[0003] Allergic rhinitis in children is a common clinical disease that can occur all year round and can occur in children aged 1 to 18 years. The global estimated incidence of allergic rhinitis in children aged 6-7 is 8.5%, and in children aged 13-14 is 14.6%. Although the lesions mainly manifest in the nose, they often induce a variety of complications, such as otitis media, sinusitis, asthma, pharyngitis, adenoid hypertrophy, etc., and are also prone to co-occurrence of diseases such as ADHD and tic disorders. It seriously affects children's physical and mental health, academic performance and quality of life. Therefore, the continuously rising incidence of allergic rhinitis in children is not only a medical problem, but also a social problem.

[0004] The main pathogenesis of allergic rhinitis is the imbalance of type 1 T helper cell (T helper type 1 cell, Th1) / type 2 T helper cell (T helper type 2 cell, Th2) cell differentiation. The cytokines produced by them affect the regulatory pathway of IgE production, leading to the occurrence of the disease. In genetically susceptible individuals, IL-4 initiates a positive feedback mechanism to cause Th2 to overreact, causing differentiation to shift toward Th2, leading to the occurrence of allergic rhinitis. IFN-γ is released by Th1 cells to inhibit the mRNA expression and protein synthesis of IL-4, inhibiting the differentiation of Th2 cells. Therefore, the expression levels of IFN-γ and IL-4 are key factors in regulating the balance of Th1 / Th2. Once the expression is abnormal, it will lead to an imbalance of Th1 / Th2, triggering a chronic inflammatory reaction of the nasal mucosa mediated by IgE, which is mainly based on the Th2 immune response of the nasal mucosa, causing the occurrence of allergic rhinitis, and symptoms such as sneezing, watery runny nose, nasal congestion, and itchy eyes.

[0005] Before the child develops symptoms of allergic rhinitis, he or she first undergoes an allergen sensitization process. When the body comes into contact with the allergen again, it can stimulate an IgE-mediated allergic inflammatory response. The whole process has an immediate phase reaction stage (acute allergic symptoms can appear within minutes) and a delayed phase reaction stage (reaches a peak within 6-9 hours after contact with the allergen, and then gradually subsides. During this period, inflammatory cells infiltrating the nasal mucosa can stimulate an immediate phase reaction again, causing repeated symptoms). This is also the reason why allergic rhinitis is prone to rapid and repeated attacks.

[0006] At present, nasal corticosteroids and antihistamines are the core of the treatment of allergic rhinitis and are the first-line clinical treatment drugs. Nasal corticosteroids include mometasone furoate, fluticasone propionate, triamcinolone acetonide, etc. Corticosteroids have a direct inhibitory effect on the functions of various cells involved in inflammatory reactions, and can effectively reduce the number of antigen-presenting cells, mast cells, basophils and eosinophils in the nasal mucosa. However, while relieving nasal symptoms (especially nasal congestion), there are also some defects, and long-term use of doctors and patients still has concerns about adverse drug reactions. Antihistamines: including cetirizine hydrochloride, loratadine, etc. Antihistamine H1 receptor antagonists block the binding of histamine to H1 receptors by competitively binding to H1 receptors, thereby inhibiting histamine from exerting its biological effects and achieving the purpose of controlling the symptoms of allergic rhinitis, but they are poor at controlling the prolonged symptoms caused by continuous antigen exposure. Leukotriene receptor antagonists: such as montelukast sodium. Leukotrienes play an important role in both the immediate and delayed phases of allergic inflammatory reactions. The mechanism of action of anti-leukotrienes therapy may be to inhibit the production, activation and infiltration of histamine-producing inflammatory cells (mast cells and basophils).

[0007] Traditional Chinese medicine has accumulated rich clinical practice experience in the treatment of allergic rhinitis. The successful intervention and low cost of traditional Chinese medicine have shown that traditional Chinese medicine has advantages in the prevention and treatment of allergic rhinitis.

[0008] Chinese doctors of all dynasties have discussed the etiology and pathogenesis of allergic rhinitis. In summary, it is mainly caused by cold, heat and physical weakness. Overall, its pathogenesis is mainly due to external wind-cold or wind-heat invading the lungs on the basis of physical weakness, resulting in poor lung qi. The nose is the orifice of the lungs, resulting in poor nasal orifices. The condition is a mixture of deficiency and excess, and the disease recurs repeatedly. The basis of the pathogenesis of allergic rhinitis is that wind-heat invades the lungs. In terms of treatment, the first thing to do is to examine the symptoms and find the cause, distinguish between cold and heat, and make a comprehensive judgment based on the clarity of the nasal mucus, the color of the nasal mucus, the amount of nasal mucus, the thickness of the tongue coating, the color of the tongue, and the red and purple of the fingerprints (if the nasal mucosa is pale, the nasal mucus is clear and thin, the tongue is light, the coating is white, and the fingerprints are red, it is cold; if the nasal mucosa is red and swollen, the mucus is turbid and sticky, the tongue is red, the coating is thick and greasy, and the fingerprints are purple, it is hot). In the acute stage of allergic rhinitis, the main treatment is to treat the symptoms. For those who are affected by wind and cold before phlegm is formed, the method is to dispel wind and resolve the exterior, and to clear the lungs and dissipate cold; for those who are affected by wind and heat, the method is to dispel wind and resolve the exterior, and to clear the lungs and clear heat. In the stage where phlegm has formed, the prescription should be selected according to the cold and hot nature of the phlegm. For cold phlegm, the method is to warm the lungs and resolve phlegm, and to clear the nasal orifices; for hot phlegm, the method is to clear heat and resolve phlegm, and to clear the nasal orifices. In the remission period of allergic rhinitis, the main treatment is to strengthen the body's health, starting with the lungs, spleen, and kidneys, and to ensure that the prescription and medication are "tailored to the individual". Children in the remission period have been ill for a long time, and their qi is weak and the defense is not solid, their spleen is weak and it is difficult to produce gold, and their yin is deficient and the lungs are not moistened and nourished. Therefore, it is necessary to replenish qi and nourish yin, strengthen the body's health and eliminate wind to treat the root cause. The prescription is Yupingfeng Powder or Shashen Maidong Decoction with modifications.

[0009] Traditional Chinese Medicine's understanding of allergic rhinitis: The nose is the orifice of the lungs, and relies on the nourishment of the lung qi and the ancestral qi. Children's lungs are often insufficient, and the defensive surface is not solid, which makes them easy to be affected by external evils. The nose is the external orifice of the lungs, and when external evils invade, the nose is the first to be affected. Among the six evils, wind evil is the main cause of disease. "Wind is the leader of all diseases." Clinically, allergic rhinitis may be different from cold to hot, but it is always caused by wind evil. If the lung qi is weak, the nose will be blocked and the breath will be short. If it is strong, the chest will be full and the breath will be raised. The patency of the nasal orifice depends on the transportation and transformation of the spleen and stomach. If the spleen and stomach are healthy, the essence of water and grain can be transported up through the spleen qi to moisten the nasal orifice. Otherwise, it is easy to develop allergic rhinitis. The kidney is the foundation of yin and yang in the body. If the kidney qi is sufficient and the kidney yang is abundant, the nasal orifice will be smooth, the sense of smell will be sharp, and the breathing will be smooth.

[0010] From the above discussion, it can be seen that the main pathogenesis of allergic rhinitis with wind-heat invading the lungs and spleen deficiency is deficiency of the root and excess of the symptoms. The root deficiency is mainly spleen deficiency, and the excess of the symptoms is mainly wind-heat invading the lungs. Spleen deficiency leads to insufficient qi and blood, lung qi is also weak, qi deficiency and weak defense of the surface, which makes it easy to be susceptible to wind-heat, and wind-heat easily invades the lungs. Therefore, the treatment should focus on dispersing wind and clearing the lungs, unblocking the nasal orifices, and invigorating qi and strengthening the spleen.

[0011] Traditional Chinese medicine has accumulated relatively rich clinical practice experience in the treatment of allergic rhinitis. The successful intervention and low cost of traditional Chinese medicine have shown that traditional Chinese medicine has obvious advantages in the field of prevention and treatment of allergic rhinitis.

[0012] After searching the "New National Traditional Chinese Medicines", it is found that traditional Chinese medicines with rhinitis as the main treatment purpose are relatively common, and there are more varieties of oral dosage forms. The representative finished products are listed as follows: (1) Tongqiao rhinitis tablets Z22021280 Composition: It is composed of Atractylodes macrocephala, Angelica dahurica, Mentha, Xanthium sibiricum, Saposhnikovia divaricata, Astragalus membranaceus, Magnolia officinalis, etc. Efficacy: dissipate wind and strengthen the exterior, clear the lungs and open the orifices. Used for acute rhinitis of lung qi deficiency and wind evil type, chronic rhinitis, allergic rhinitis, sinusitis and other nasal diseases.

[0013] (2) Tongqiao Rhinitis Granules Z10980073 Composition: Atractylodes macrocephala, Angelica dahurica, mint, Xanthium sibiricum, Saposhnikovia divaricata, Astragalus membranaceus, Magnolia officinalis, etc. Efficacy: dispel wind and reduce inflammation, clear the nasal passages. Used for sinusitis, nasal congestion, runny nose, forehead headache, rhinitis, sinusitis and allergic rhinitis.

[0014] (3) Biyankang Tablets Z20023063 Ingredients: Patchouli, Xanthium sibiricum, Goosegrass, Ephedra, Wild Chrysanthemum, Angelica, Scutellaria, Pig Gallbladder Powder, Peppermint Oil, Chlorpheniramine Maleate.

[0015] Efficacy: clearing away heat and detoxifying, promoting lung function and opening the orifices, reducing swelling and relieving pain. Used for acute and chronic rhinitis and allergic rhinitis caused by wind evil in the lungs.

[0016] (4) Xinqin Granules Z10950088 Composition: It is composed of Astragalus, Atractylodes, Saposhnikovia, Asarum, Schizonepeta, Cassia twig, Angelica dahurica, Acorus calamus, Xanthium sibiricum, Scutellaria baicalensis, etc.

[0017] Efficacy: replenishes qi and strengthens the exterior, dispels wind and clears the orifices. It is used for nasal itching, sneezing, runny nose, and susceptibility to colds caused by insufficient lung qi and external wind evil; and for allergic rhinitis with the above symptoms.

[0018] (5) Biyuan Tongqiao Granule Z20030071 Composition: It is composed of magnolia, stir-fried Xanthium sibiricum, ephedra, angelica dahurica, mint, Ligusticum chuanxiong, scutellaria baicalensis, forsythia suspensa, wild chrysanthemum, Radix Trichosanthis, Rehmannia glutinosa, Salvia miltiorrhiza, Poria cocos, and licorice.

[0019] Efficacy: dispel wind and heat, promote lung function and clear the orifices. Used for acute sinusitis (acute sinusitis) which is caused by external pathogens invading the lungs. Symptoms include: tenderness in the forehead or zygomatic region, nasal congestion, sticky white or yellow runny nose, headache, fever, thin yellow or white fur, and floating pulse.

[0020] (6) Xinyi Biyan Pills Z44020046 Composition: It is composed of magnolia, mint, perilla leaves, licorice, patchouli, Xanthium sibiricum, goose not eating grass, isatis root, angelica dahurica, siler, houttuynia cordata, chrysanthemum, etc.

[0021] Efficacy: dispel wind, clear away heat, and detoxify. Mainly used to treat rhinitis.

[0022] Chinese patent publication number CN104398711A discloses a Chinese medicine composition for treating allergic rhinitis in children. The active ingredients contained in the Chinese medicine composition are prepared by the following raw material drug proportions by weight: 2-4 parts of honey-roasted ephedra, 2-4 parts of cassia twig, 3-9 parts of magnolia, 3-9 parts of xanthium sibiricum, 3-9 parts of schisandra chinensis, 3-9 parts of black plum, 3-9 parts of arisaema cinerea, and 5-15 parts of cynanchum wilfordii. The preparation method and application of the above medicine are also disclosed. The Chinese medicine composition has the effects of promoting lung function, benefiting the orifices, eliminating wind and resolving phlegm. Clinical studies have confirmed that the Chinese medicine composition has a significant therapeutic effect on treating allergic rhinitis in children. It can not only improve the symptoms of children with allergic rhinitis, but also improve the atopic constitution of children to a certain extent. It is an ideal medicine for treating allergic rhinitis in children.

[0023] Analysis of the prescription drugs of the above varieties shows that most of them are suitable for adults, and are symptomatic treatments mainly for clearing the lungs and relieving nasal symptoms. However, there are very few Chinese patent medicines with clear pharmacological effects on the market for the treatment of children's rhinitis. Even rarer are Chinese patent medicines that treat both the symptoms and the root causes by mainly clearing the nasal passages, invigorating qi and strengthening the spleen. Summary of the invention

[0024] The present invention aims to provide an oral composition for treating allergic rhinitis, which is particularly suitable for children.

[0025] The present invention provides an oral composition for treating allergic rhinitis, comprising, by weight: 2-3 parts of magnolia, 2-3 parts of angelica dahurica, 3-5 parts of forsythia, 3-5 parts of stir-fried burdock seeds, 2-3 parts of siler, 3-5 parts of dandelion, 3-5 parts of astragalus, 3-5 parts of scutellaria baicalensis, 3-5 parts of poria, 3-5 parts of atractylodes, 10-15 parts of coix seed, 2-3 parts of chuanxiong, 2-3 parts of scrophularia, and 1-2 parts of licorice.

[0026] The composition of the present invention can be prepared according to the preparation method of traditional Chinese medicine preparations.

[0027] This Chinese medicine oral composition has the effects of dispelling wind and clearing the lungs, clearing the nasal passages, and invigorating qi and strengthening the spleen. It is used for allergic rhinitis of the type of wind-heat attacking the lungs and spleen deficiency, with symptoms of nasal congestion, runny nose, nasal itching, sneezing, accompanied by poor appetite, pale face, sweating, susceptibility to colds, red tongue, white fur, thin pulse; enlarged inferior turbinate, edema of nasal mucosa.

[0028] The prescription mechanism of the present invention: At present, the treatment of allergic rhinitis is mainly symptomatic treatment and symptom relief. At the same time, try to avoid contact with allergens, pay attention to rest, avoid cold, keep indoor air circulation, avoid secondary bacterial infection, etc. Drug treatment can be used to relieve symptoms.

[0029] This syndrome is caused by wind-heat invading the lungs and spleen deficiency. The treatment method is mainly to dispel wind and clear the lungs, clear the nasal passages, and invigorate qi and strengthen the spleen. The prescription uses magnolia and scutellaria as the main drugs. Magnolia is pungent in taste and warm in nature. The pungent taste can penetrate the heat of the muscles and dispel wind evil, and the warm taste can dissolve the muscles and disperse the surface. It is an important drug for treating nasal diseases. Scutellaria is bitter in taste and cold in nature. It has the functions of clearing heat and drying dampness, purging fire and detoxifying, and can also help magnolia to dispel stagnant heat. Angelica dahurica, Saposhnikovia divaricata, Chuanxiong, Astragalus membranaceus, and Poria cocos are the assistant drugs. Among them, Angelica dahurica dispels wind and relieves the surface, clears the nasal passages; Saposhnikovia divaricata dispels wind and relieves the surface; Chuanxiong promotes qi and activates blood circulation, dispels wind and relieves pain; Astragalus membranaceus invigorates qi and raises yang, invigorates qi and consolidates the surface, and promotes diuresis and reduces swelling; Poria cocos invigorates the spleen, promotes diuresis and eliminates dampness. The five help the main drugs to dispel wind evil and invigorate qi and strengthen the spleen. Forsythia clears away heat and detoxifies, dissipates wind-heat; stir-fried burdock seeds dissipate wind-heat, clear the lungs and relieve sore throat; dandelion clears heat and detoxifies, eliminates carbuncles and resolves nodules; Scrophularia clears heat and cools blood, nourishes yin and reduces fire, dissipates nodules and resolves nodules; Coix seeds remove dampness and strengthen the spleen, relax muscles and eliminate numbness, clear away heat and discharge pus; Atractylodes macrocephala consolidates the exterior and stops sweating, replenishes qi and strengthens the spleen, dries dampness and promotes diuresis, and the above are all adjuvants. Licorice clears heat and detoxifies, moistens the lungs and relieves cough, and is a guiding drug that leads the drug into the lungs. All the drugs are used together to achieve the effects of dispersing wind and clearing the lungs, clearing the nasal passages, and replenishing qi and strengthening the spleen. Among them, Xinyi: pungent and warm. Enters the lung and stomach meridians. Functions: dispel wind evil and clear the nasal passages. Used for wind evil exogenous infection, nasal congestion and runny nose. This herb is pungent and warm, especially good at dispersing wind evil and clearing the nasal passages, and is an important medicine for treating rhinitis. "New Compendium of Materia Medica" says: "Xinyi, clears the passages and goes up to the brain, (treats) nasal congestion and sinusitis, has no other use, just keep it for future use. Moreover, if pungent and dispersing things are used too much, the true qi will be damaged, so it can be used temporarily but not for a long time." It is often used with Xanthium sibiricum, Angelica dahurica, etc., such as Xanthium sibiricum powder. Modern pharmacological studies have shown that Xinyi has the effects of shrinking nasal mucosal blood vessels, promoting the absorption of mucosal secretions, and reducing inflammation. It also has antibacterial, analgesic, antihypertensive and anti-allergic effects.

[0030] Scutellaria baicalensis: bitter in taste, cold in nature. Enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. It has the effects of clearing away heat and dampness, purging fire and detoxifying, stopping bleeding, and calming the fetus. It is mainly used to treat damp-heat, summer heat, chest tightness and nausea, damp-heat fullness, diarrhea, jaundice, lung heat cough, high fever and thirst, blood heat vomiting and bleeding, carbuncle, sore, and restless fetus. "Compendium of Materia Medica Volume 13": "It treats wind-heat, damp-heat, headache, running pig heat pain, fire cough and lung atrophy, fishy throat, and various blood loss." "Southern Yunnan Materia Medica": "It goes up to purge lung fire, goes down to purge bladder fire, men have five kinds of stranguria, women have sudden metrorrhagia, regulate menstruation and clear heat, fetal heat and restlessness, clear fetal heat, and eliminate the six meridians of real fire and heat." Modern pharmacological research shows that Scutellaria baicalensis has anti-inflammatory, anti-allergic and anti-microbial effects: Scutellaria baicalensis has a wide antibacterial spectrum, and has inhibitory effects on Shigella dysenteriae, diphtheria, Pseudomonas aeruginosa, Staphylococcus, Streptococcus, Pneumococcus and meningococcus in vitro. The decoction is used as a laryngeal spray, which is also effective for meningitis carriers. Even Staphylococcus aureus, which has developed resistance to antibiotics such as penicillin, is still sensitive to Scutellaria baicalensis. It also has antipyretic, antihypertensive, diuretic, choleretic and antispasmodic effects.

[0031] Angelica dahurica: pungent, warm in nature. Enters the lung, spleen, and stomach meridians. It has the effects of dispersing wind and relieving exterior symptoms, opening the orifices to relieve pain, and relieving itching. It is used for headaches, toothaches, rheumatic pain, sinusitis, leucorrhea, sores, carbuncles, and swelling. "Yao Xing Lun" says: "It treats heart and abdomen blood stabbing pain, removes wind evil, treats women's uterine bleeding and vomiting, improves eyesight, stops tears, treats women's bleeding, waist and abdominal pain; it can erode pus." "Rihuazi Materia Medica" says: "It treats red eyes and pterygium, and repairs abortion and slipping, breaks up old blood, replenishes new blood, breast abscesses, back hair, scrofula, intestinal wind, hemorrhoids and fistulas, discharges pus, sores, scabies, relieves pain and promotes tissue regeneration, and removes facial wrinkles and scars." "Yunnan Materia Medica" says: "It removes wandering wind from the skin, stops stomach cold abdominal pain and cold pain, and cold and dampness pain all over the body." "Compendium of Materia Medica": "It can treat sinusitis, epistaxis, toothache, pain in the brow bone, constipation due to wind in the large intestine, blood in urine, dizziness due to blood wind in women, nausea and vomiting; it can also treat arsenic poisoning, snake bites, and wounds caused by knives, arrows, and metal." Modern pharmacological studies have found that angelica dahurica coumarin has multiple pharmacological activities such as antihypertensive, anticoagulant, antimicrobial, antiviral, anticancer, and antioxidant, and also has obvious antipyretic and analgesic effects.

[0032] Saposhnikovia divaricata: pungent, sweet, slightly warm. It enters the bladder, spleen, and liver meridians. It has the effects of dispelling wind, relieving symptoms, relieving pain, and overcoming dampness. "Shennong's Herbal Classic": "It is used to treat strong wind, dizziness, aversion to wind, wind evil, blindness, wind all over the body, pain and numbness in the joints, and fullness and fullness." "Famous Doctors' Records": "Pain in the ribs, wind in the head and face, cramps in the limbs, spasms in the breasts and wounds." "Ben Cao Meng Sheng": "It can cure all pains in the body, and it is also a moisturizer among wind medicines. It is generally used to treat wind and dispel dampness." Modern pharmacological studies have found that Saposhnikovia divaricata has 1. Analgesic effect: The active ingredients in Saposhnikovia divaricata can inhibit the excitement of pain nerves and relieve pain. 2. Anti-inflammatory effect: The chemical components in Saposhnikovia divaricata have the effect of inhibiting inflammatory reactions and the production of cytokines, and can effectively relieve inflammatory symptoms. 3. Antibacterial effect: The ingredients in Saposhnikovia divaricata can inhibit the growth and reproduction of a variety of bacteria, and have an auxiliary therapeutic effect on a variety of infections. 4. Antipyretic effect: The ingredients in Saposhnikovia divaricata can lower body temperature by regulating the central nervous system.

[0033] Astragalus: sweet, slightly warm; it enters the spleen and lung meridians. It has the effects of invigorating qi and raising yang, consolidating the exterior and stopping sweating, discharging pus and promoting muscle growth, and promoting diuresis and reducing swelling. "Rihuazi Bencao": "Astragalus helps qi and strengthens bones, grows flesh and replenishes blood, breaks cancer addiction, treats li disease, thinness, intestinal wind, metrorrhagia, leucorrhea...all diseases before and after, uneven menstruation, thirst, phlegm and cough". "Bencao Huiyan": "Astragalus is a medicine for nourishing the lungs and spleen, strengthening the defense and restraining sweat, and expelling wind and transporting poisons". Modern pharmacological studies have found that low doses of total astragalus saponins can aggravate heart failure, while medium and large doses have anti-heart failure effects, and have an enhancing effect on the contraction and relaxation of the myocardium without increasing the oxygen consumption of the myocardium. Astragalus can significantly increase the total number of white blood cells in the blood and promote the phagocytic function and bactericidal ability of neutrophils and macrophages. Astragalus can significantly enhance cellular immunity and promote lymphocyte transformation caused by PHA and PWM (Pokeweed). Astragalus polysaccharide can increase the hematocrit of normal rats and increase the number of red blood cells. For rats or mice with blood deficiency syndrome, astragalus and astragalus polysaccharide can increase the hematocrit or hemoglobin content. Astragalus can also prevent and treat the decrease in the total number of peripheral blood leukocytes and bone marrow nucleated cells in mice caused by radiation, and can promote the differentiation and proliferation of hematopoietic stem cells.

[0034] Poria: sweet and mild in taste, neutral in nature. Heart, spleen, and lung meridians. It has the effect of strengthening the spleen, promoting water and removing dampness. It can treat urination problems, edema, phlegm and cough, vomiting, diarrhea, spermatorrhea, stranguria, palpitations, and forgetfulness. "Ben Jing": "It can treat chest and flank qi reversal, worry, anger, fear, palpitations, heart pain, cold and heat, fullness, cough, dry mouth and tongue, and promote urination." "Ben Cao Yan Yi": "Poria, Fu Shen, have many functions of moving water, and can benefit the heart and spleen." "Shi Bu Zhai Medical Book": "Poria - taste, is the main medicine for treating phlegm. The root of phlegm is water, and Poria can move water. The movement of phlegm is dampness, and Poria can also move dampness." Modern pharmacological research has found that Poria has the following effects: diuresis, antibacterial, preventive effect on ulcers, and can reduce gastric acid and blood sugar.

[0035] Chuanxiong: pungent, warm. Enters the liver, gallbladder, and pericardium meridians. Has the effects of promoting qi and blood circulation, dispelling wind and relieving pain. Indications: soothe nerves, treat headaches caused by wind in the head, abdominal pain caused by masses, stabbing pain in the chest and ribs, swelling and pain caused by falls, headaches, and rheumatic pain. "Ben Jing": "It is used for stroke entering the brain, headaches, cold arthritis, muscle spasms, wounds, and blood stasis in women." "Ben Cao Yan Yi": "This medicine is the most used by people today. It is indispensable for treating wind in the head and face, but it must be supplemented with other medicines." Modern pharmacological studies have found that Chuanxiong has the effects of contracting the myocardium, dilating blood vessels, lowering blood pressure, resisting myocardial ischemia, resisting cerebral ischemia, inhibiting platelet aggregation, resisting thrombosis, sedation, and analgesia; Chuanxiongzine has a certain inhibitory effect on the contraction of guinea pig isolated tracheal strips caused by leukotrienes C4 and D4, histamine, PGF1a, etc., and has a preventive and therapeutic effect on the onset of asthma.

[0036] Forsythia: bitter, slightly cold; enters the lung, heart, and gallbladder meridians. It has the effects of clearing away heat and detoxifying, and dispersing wind-heat. Indications: Treat wind-heat colds, sore throat, fever, restlessness, thirst, macules, pyretic stranguria, carbuncle, scrofula, and erysipelas. "Medical Records of Chinese and Western Medicines" states: "Forsythia has the power of ascending, floating, and dispersing, circulates qi and blood, treats blood stagnation and qi accumulation in the twelve meridians, and is an important medicine for sores. It can penetrate the muscles and relieve the symptoms, clear away heat and expel wind, and is also an important medicine for treating wind-heat. It also has the ability to expel poison, and is also an important medicine for expelling rashes." Modern pharmacological studies have found that Forsythia has antibacterial, antifungal, and antiviral effects. Forsythia decoction has inhibitory effects on Staphylococcus aureus, Streptococcus, Pneumococcus, as well as dysentery, typhoid, paratyphoid, diphtheria, Escherichia coli, Proteus, plague, human tuberculosis and other bacteria in vitro; Forsythia phenol (i.e. forsythia glycoside) has a strong inhibitory effect on Staphylococcus aureus and Shigella dysenteriae.

[0037] Fried burdock seeds: bitter and pungent, cool, enter the lung meridian and stomach meridian. It has the effect of dispersing wind-heat, clearing the lungs and relieving sore throat. It is mainly used to treat wind-heat cough, sore throat, macules that do not clear, itchy rashes, carbuncles and sores. "Famous Doctors' Other Records": "It is mainly used to improve eyesight, tonify the middle, and eliminate wind damage." "Ben Cao Jing Shu": "Evil is a poison that disperses wind, removes heat and detoxifies. Pungent can disperse knots, bitter can relieve heat, and when heat knots are dispersed, the internal organs are clear, so it improves eyesight and tonifies the middle. Where the wind hurts, the defensive qi must be blocked, and blockage will cause fever. Pungent and cool dispersal will make the surface qi harmonious, and the wind will have nowhere to stay. ... Therefore, it is used for urticaria and smallpox, and it is particularly effective." Modern pharmacological studies have found that fried burdock seeds have the effect of preventing measles and scarlet fever. It has a good preventive and therapeutic effect on rashes and acne. It can be used to treat lower blood pressure and prevent and treat acne, rectal cancer, and lung cancer. It protects the kidneys, prevents urinary retention, lowers blood sugar and delays aging.

[0038] Dandelion: bitter, sweet, cold in nature. Enters the liver and stomach meridians. It has the effects of clearing away heat and detoxifying, eliminating carbuncle and dispersing knots, and promoting diuresis and relieving stranguria. It is mainly used to treat carbuncle swelling and poison, breast carbuncle, scrofula, red eyes, sore throat, lung carbuncle, intestinal carbuncle, damp-heat jaundice, and hot stranguria. "Ben Cao Jing Shu" says: "Dandelion tastes sweet and flat, and is non-toxic. It should be an important medicine for entering the liver and stomach, relieving heat and cooling blood. Mastitis belongs to the liver meridian. After women's menstruation, the liver meridian is in charge, so it is used to treat breast carbuncle swelling and milk poison in women, and it is suitable to produce warm food." "Compendium of Materia Medica" states: "Dandelion is cool in nature and can treat all sores, carbuncles, swelling, heat and toxicity. It can be taken orally or applied to treat breast abscesses, swelling and lumps, and is particularly effective. Fresh dandelions can be mashed and taken as warm juice, while dried dandelions can be decocted and taken. It can also be used alone to treat all diseases, and it is indispensable in decoction prescriptions." Modern pharmacological studies have found that dandelions have antioxidant, hypoglycemic, hypolipidemic, anti-inflammatory and antibacterial effects.

[0039] Scrophularia: Sweet, bitter, salty, slightly cold. Enters the lung, stomach, and kidney meridians. It has the effects of clearing heat and cooling blood, nourishing yin and reducing fire, and detoxifying and dispersing stagnation. It is mainly used to treat febrile diseases that damage yin, red tongue and thirst, fever and rashes, constipation caused by damage to body fluid, bone steaming and cough, red eyes, sore throat, scrofula, diphtheria, carbuncle, ulcers and ulcers. "Ben Jing": "It is used to treat cold and heat accumulation in the abdomen, postpartum diseases in women, replenish kidney qi, and make people's eyes clear." "Ben Cao Pin Hui Jing Yao·Volume 10": "It eliminates swelling in the throat and drains fire without roots." "Compendium of Materia Medica·Volume 12": "It nourishes yin and reduces fire, removes rashes and toxicity, benefits the throat, and relieves urinary blood stasis." Modern pharmacological studies have found that Scrophularia has antibacterial, antihypertensive, and cardiotonic effects.

[0040] Coix seed: sweet, light, cool in nature. It enters the spleen, stomach, and lung meridians. It has the effects of removing dampness and strengthening the spleen, relaxing muscles and removing numbness, clearing away heat and discharging pus. It is mainly used to treat edema, beriberi, dysuria, spleen deficiency diarrhea, dampness and stiffness, lung abscess, intestinal abscess, and warts. "Ben Jing": "It is mainly used for muscle spasm, inability to bend and stretch, rheumatism, and lowering qi." "Compendium of Materia Medica Volume 23": "Coix seed is a Yangming medicine that can strengthen the spleen and benefit the stomach. If it is weak, it can replenish its mother, so it is used for lung abscess and lung abscess. Diseases of muscles and bones are based on treating Yangming, so it is used for stiffness, stiffness, and rheumatism. Earth can overcome water and remove dampness, so it is used for diarrhea and edema." Modern pharmacological studies have found that coix seed has anti-tumor, analgesic and anti-inflammatory, regulates sugar and lipid metabolism, enhances immunity, lowers blood pressure, anti-oxidation, anti-aging, and whitening effects.

[0041] Atractylodes macrocephala: bitter and sweet, warm in nature. It enters the spleen and stomach meridians. It has the effects of strengthening the exterior and stopping sweating, replenishing qi and strengthening the spleen, drying dampness and promoting diuresis. It is mainly used to treat spleen deficiency, poor appetite, abdominal distension and diarrhea, phlegm and fluid, palpitations, edema, spontaneous sweating, and restless fetal movement. "Famous Doctors' Explosion" says: "It is used to treat strong wind in the body and face, wind dizziness and headache, tears in the eyes, eliminate phlegm and water, expel wind and water swelling between the skin, eliminate the urgent fullness under the heart and cholera vomiting and diarrhea, promote blood circulation between the waist and navel, benefit body fluids, warm the stomach and digest food, and improve appetite." Modern pharmacological research has found that Atractylodes macrocephala has diuretic, antibacterial, anti-aging, anti-tumor and other effects. It also has certain effects on the nervous system, uterine smooth muscle, gastrointestinal motility, and has immune regulation function.

[0042] Licorice: sweet, neutral in nature. It enters the heart, lung, spleen, and stomach meridians. It has the effects of tonifying the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving pain, and harmonizing various medicines. "Ben Jing": "It controls the cold and heat evil spirits of the five internal organs, strengthens tendons and bones, grows muscles, doubles strength, cleans swelling, and detoxifies." "Tujing Bencao": "Licorice can detoxify Baiyao, and is the key to all medicines." Modern pharmacological studies have found that licorice has anti-inflammatory, anti-tumor, antibacterial, antiviral, antioxidant and immunomodulatory effects, and has a good therapeutic effect on cardiovascular and cerebrovascular diseases, diabetes, and liver diseases.

[0043] The invention provides application of the oral composition in medicine for treating allergic rhinitis.

[0044] Long-term clinical application shows that the oral composition of the present invention has no toxic side effects on the patient's diet and excretion function and has a certain safety. Since the drug is a pure Chinese medicine preparation and does not contain sugar components, diabetic patients can also take it with confidence. The present invention uses traditional Chinese medicine syndrome differentiation and treatment, combined with a large amount of clinical experience, to form this prescription.

[0045] The present invention is a Chinese medicine preparation developed by inheriting the traditional Chinese medicine theory and putting the long-term treatment experience into clinical application, which has the effects of dispelling wind and clearing the lungs, clearing the nasal passages, and invigorating qi and strengthening the spleen, and is used for allergic rhinitis of the type of wind-heat attacking the lungs and spleen deficiency. The symptoms include nasal congestion, runny nose, nasal itching, sneezing, accompanied by poor appetite, pale face, sweating, easy to catch cold; red tongue, white fur, thin pulse; hypertrophy of the inferior turbinate, edema of the nasal mucosa. It alleviates the symptoms of patients and improves the quality of life of the majority of children. DETAILED DESCRIPTION

[0046] Provided is an oral composition formulation for treating allergic rhinitis, comprising: 6g magnolia, 6g angelica root, 10g forsythia, 10g fried burdock seeds Saposhnikovia 6g, Taraxacum mongolicum 10g, Astragalus 10g, Scutellaria baicalensis 10g Poria 10g Atractylodes 10g Coix seeds 30g Chuanxiong 6g Scrophularia 6g Licorice 2g The oral Chinese medicine prepared by the above prescription can be made into Chinese patent medicines such as decoctions, granules, pills, etc.

[0047] Lord: Scutellaria baicalensis, Magnolia officinalis Minister: Angelica dahurica, Saposhnikovia divaricata, Astragalus membranaceus, Poria cocos, Chuanxiong Adjuvants: Forsythia suspensa, fried burdock seeds, dandelion, Scrophularia ningpoensis, Coix seeds, Atractylodes macrocephala Made by: Licorice 1. The efficacy of the medicinal flavor: Scutellaria: clears away heat and dampness, purges fire and detoxifies Xinyi: dispel wind and cold, clear the nasal passages Angelica dahurica: dispel wind and relieve symptoms, relieve pain and itching Fangfeng: dispel wind, relieve symptoms, relieve pain, and eliminate dampness Astragalus: replenishes qi and raises yang, strengthens the exterior and stops sweating, discharges pus and promotes tissue regeneration, promotes diuresis and reduces swelling Poria: Strengthens the spleen, promotes diuresis and eliminates dampness Chuanxiong: promotes qi and blood circulation, dispels wind and relieves pain Forsythia: clearing away heat and detoxifying, dispersing wind-heat Stir-fried burdock seeds: dispel wind-heat, clear the lungs and relieve sore throat Dandelion: clears away heat, detoxifies, eliminates carbuncle and relieves lumps Scrophularia: clearing heat and cooling blood, nourishing yin and reducing fire, detoxifying and dispersing stagnation Coix seeds: promote dampness and invigorate the spleen, relax muscles and eliminate numbness, clear away heat and discharge pus Atractylodes macrocephala: Strengthens the exterior and stops sweating, replenishes qi and strengthens the spleen, dries dampness and promotes diuresis Licorice: clears away heat and detoxifies, moistens the lungs and relieves cough 2. Explanation of the prescription: Soothes wind and clears the lungs, clears the nasal passages, replenishes qi and strengthens the spleen 3. Indications: Nasal symptoms such as nasal congestion, runny nose, nasal itching, sneezing, etc. caused by allergic rhinitis or respiratory tract infection.

[0048] The oral Chinese medicine composition of this embodiment is prepared into a granule dosage form or a decoction piece, which is portable and easy to take. As shown in Table 1 below, each Chinese medicine is prepared into a granule dosage form or a decoction piece: The clinical efficacy is very significant. Over the years, it has been widely used in clinical practice, with positive efficacy and reputation, and is worthy of promotion, laying a solid foundation for the clinical treatment of allergic rhinitis. The present invention uses TCM syndrome differentiation and treatment, combines modern pharmacological research with many years of clinical experience, and adopts traditional Chinese medicine therapy to alleviate patient symptoms and improve clinical efficacy, etc., and has accumulated rich experience. And in the long-term clinical practice process, continuous optimization and adjustment, closely following the core pathological links of such diseases, has formed this prescription. This prescription has been used clinically for many years, and patients generally reflect that it has a good effect after taking it, has no side effects, and is deeply favored by patients.

[0049] The obtained medicine has the functions of dispelling wind and clearing lungs, clearing nasal passages, invigorating qi and strengthening spleen. It is used to treat allergic rhinitis in children with wind-heat attacking lungs and spleen deficiency. This preparation not only has a wide range of applications and good efficacy, but also closely matches the pathogenesis of the disease, increases the selectivity of patients, and meets the needs of a large number of clinical patients. This prescription has outstanding efficacy, safety and reliability in clinical use, and there are many successful cases. Clinical efficacy: The efficacy standard is formulated with reference to the "Guidelines for Clinical Research of New Chinese Medicines (Trial)". Cured: Clinical symptoms such as nasal itching, nasal congestion, sneezing and runny nose disappear, and the two inferior nasal conchas are not edematous and the color is normal; Significantly effective: Clinical symptoms such as nasal itching, nasal congestion, sneezing and runny nose are significantly alleviated, and there is still mild edema of the nasal concha; Improved: Clinical symptoms such as nasal itching, nasal congestion, sneezing and runny nose have improved, but there are occasional attacks, and there is still edema of the inferior nasal concha; Ineffective: Clinical symptoms such as nasal itching, nasal congestion, sneezing and runny nose have not improved or have worsened.

[0050] The present invention is generally used for a course of treatment of 2 weeks, and the total effective rate of the above prescription for child patients is more than 95%, and no side effects occur.

[0051] The prescriptions and efficacy of 142 children from 2018 to 2023 are shown in Table 2: The traditional Chinese medicine prepared by the invention has good curative effect on allergic rhinitis, and the selection of corresponding traditional Chinese medicine for prevention and treatment can achieve remarkable effect.

Claims

1. An oral composition for treating allergic rhinitis, comprising magnolia bud and scutellaria baicalensis as main drugs, angelica dahurica, saposhnikovia divaricata, ligusticum chuanxiong, astragalus membranaceus and tuckahoe as assistant drugs, liquorice as a messenger, and others as adjuvant drugs, and comprising the following components by weight: 2-3 parts of magnolia, 2-3 parts of angelica dahurica, 3-5 parts of forsythia, 3-5 parts of stir-fried burdock seeds, 2-3 parts of siler, 3-5 parts of dandelion, 3-5 parts of astragalus, 3-5 parts of scutellaria baicalensis, 3-5 parts of poria, 3-5 parts of atractylodes, 10-15 parts of coix seed, 2-3 parts of chuanxiong, 2-3 parts of scrophularia, and 1-2 parts of licorice.

2. The oral composition for treating allergic rhinitis according to claim 1, characterized in that: It is composed of the following components: 6g of magnolia, 6g of angelica dahurica, 10g of forsythia, 10g of stir-fried burdock seed, 6g of siler, 10g of dandelion, 10g of astragalus, 10g of scutellaria, 10g of poria, 10g of atractylodes, 30g of coix seed, 6g of chuanxiong, 6g of scrophularia, and 2g of liquorice.

3. A method for preparing an oral composition for treating allergic rhinitis according to claim 1 or 2, characterized in that: Firstly, each component is prepared into granules or powders, and then prepared into decoctions, granules, powders or pills according to the formula.

4. Use of the oral composition according to claim 1 or 2 in medicine for treating allergic rhinitis.

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