Traditional Chinese medicine formula for conditioning female endocrine dyscrasia

Abstract

The invention discloses a traditional Chinese medicine formula for conditioning female endocrine dyscrasia. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: Chinese angelica, white paeony root and the like, and has a definite range and a preferable formula. The preparation method comprises the following steps: washing, drying, crushing, sieving, decocting twice with water, combining, filtering and concentrating to obtain an extract, and preparing into various dosage forms such as powder. The radix bupleuri and the like have the effects of soothing the liver and regulating qi, the poria cocos and the like have the effects of tonifying the spleen, the glossy privet fruit and the like have the effects of nourishing the liver and the kidney, the moutan bark and the like have the effects of clearing heat, and the gentiana apiata and the like have the abundant effects of comprehensively coping with etiology and symptoms. The accurate dosage range can be adjusted according to individual differences, the dissolution rate of effective components can be improved by medicinal material pretreatment and a unique water decoction process, complete extraction is ensured, and concentration and dosage form diversification meet different requirements. The formula has scientificity, pertinence and reasonability from composition to preparation, and a safe, effective and diversified traditional Chinese medicine scheme is provided for treatment of female endocrine dyscrasia.

Description

Technical Field

[0001] The invention relates to a traditional Chinese medicine formula for regulating female endocrine disorders. Background Art

[0002] Female endocrine disorders are one of the common health problems of modern women. The series of symptoms caused by them seriously affect women's quality of life and physical and mental health. In the field of modern medicine, the treatment of female endocrine disorders mainly adopts means such as hormone replacement therapy. For example, for endocrine disorders caused by low estrogen levels, exogenous estrogen is often used for supplementation. However, this treatment method has many disadvantages. Long-term use of hormone replacement therapy may increase the risk of patients suffering from diseases such as breast cancer and endometrial cancer, and is prone to cause adverse reactions such as weight gain, edema, nausea, and vomiting. At the same time, hormone replacement therapy is often only aimed at regulating hormone levels. It has limited effect on improving the overall body function disorders associated with endocrine disorders, such as mood swings and breast pain caused by liver depression and qi stagnation, and complex symptoms such as hot flashes, night sweats, and insomnia caused by liver and kidney yin deficiency. It is difficult to fundamentally regulate the body's endocrine balance, and once the medication is stopped, the recurrence rate is high.

[0003] Traditional Chinese medicine has a long history and rich experience in the treatment of female endocrine disorders. According to traditional Chinese medicine theory, female endocrine disorders are closely related to qi and blood disorders and organ dysfunction. For example, liver dysfunction, spleen dysfunction, and kidney yin deficiency can all lead to endocrine abnormalities. However, some existing Chinese medicine prescriptions have the problem of relatively single formula composition when treating female endocrine disorders. Some prescriptions only focus on replenishing blood and activating blood circulation, while ignoring comprehensive conditioning in many aspects such as soothing the liver and regulating qi, strengthening the spleen and tonifying the kidney, clearing away heat and removing dampness. For example, although some traditional prescriptions for regulating menstruation can improve the symptoms of irregular menstruation, they are not effective in treating skin problems such as acne and chloasma caused by endocrine disorders, as well as systemic symptoms such as mood and sleep. In terms of the dosage of medicinal materials, there is a lack of precise design, which cannot adapt well to the individual differences of different patients, which may lead to inaccurate dosage, affect the efficacy or produce adverse reactions. In terms of preparation technology, the extraction methods of some traditional Chinese medicine prescriptions are relatively simple and crude, and the dissolution characteristics of the active ingredients of different medicinal materials are not fully considered, resulting in incomplete extraction of the active ingredients of the medicine, which reduces the quality and efficacy of the medicine. In addition, the dosage form is relatively single, mostly traditional decoctions, which are inconvenient to take and difficult to meet the diverse medication needs of modern patients, especially for female patients with a fast pace of life and long-term conditioning. Compliance is poor.

[0004] In summary, the current treatment of female endocrine disorders, whether it is modern medicine hormone replacement therapy or some existing traditional Chinese medicine treatment methods, has certain limitations. Therefore, it is of great practical significance to develop a traditional Chinese medicine formula with scientific and reasonable formula, precise dosage of medicinal materials, perfect preparation process and diverse dosage forms for the treatment of female endocrine disorders. Summary of the invention

[0005] The purpose of the present invention is to provide a Chinese medicine formula for regulating female endocrine disorders to solve the problems raised in the above background technology.

[0006] To solve the above technical problems, the technical solution provided by the present invention is: a traditional Chinese medicine formula for regulating female endocrine disorders, composed of the following raw materials in parts by weight: 10-20 parts of angelica sinensis, 12-25 parts of white peony root, 15-30 parts of rehmannia root, 8-15 parts of chuanxiong, 15-30 parts of motherwort, 8-15 parts of rose, 6-12 parts of bupleurum, 10-20 parts of cyperus rotundus, 6-18 parts of jujube herb, 8-24 parts of zedoaria, 5-25 parts of verbena, 10-30 parts of involucral herb, 11-23 parts of silver edge jade, 12-24 parts of fish eye grass, 12-25 parts of poria, 10-20 parts of atractylodes, 10-20 parts of glossy privet, 10-20 parts of eclipta prostrata, 10-20 parts of wolfberry, 8-15 parts of peony bark, and 6-12 parts of gardenia.

[0007] Preferably, a traditional Chinese medicine formula for regulating female endocrine disorders is composed of the following raw materials in parts by weight: 10 parts of Angelica sinensis, 12 parts of white peony root, 15 parts of Rehmannia root, 8 parts of Chuanxiong, 15 parts of Leonurus japonicus, 8 parts of Rosa chinensis, 6 parts of Bupleurum chinense, 10 parts of Cyperus rotundus, 6 parts of Herba Coptidis, 8 parts of Eupatorium fortunei, 5 parts of Verbena officinalis, 10 parts of Herba Lycopodii, 11 parts of Herba Cibotii, 12 parts of Herba Eupatorii, 12 parts of Poria, 10 parts of Atractylodes macrocephala, 10 parts of Fructus Ligustri Lucidi, 10 parts of Herba Ecliptae, 10 parts of Lycium barbarum, 8 parts of Cortex Moutan, and 6 parts of Gardenia jasminoides.

[0008] Preferably, a traditional Chinese medicine formula for regulating female endocrine disorders is composed of the following raw materials in parts by weight: 13 parts of angelica, 16 parts of white peony root, 20 parts of rehmannia root, 10 parts of chuanxiong, 20 parts of motherwort, 10 parts of rose, 8 parts of bupleurum, 13 parts of cyperus, 10 parts of jujube, 14 parts of zedoaria, 12 parts of verbena, 18 parts of truncatum, 15 parts of jasmine, 16 parts of fish eye grass, 16 parts of poria, 13 parts of atractylodes, 13 parts of glossy privet, 13 parts of eclipta, 13 parts of wolfberry, 10 parts of peony bark, and 8 parts of gardenia.

[0009] Preferably, a traditional Chinese medicine formula for regulating female endocrine disorders is composed of the following raw materials in parts by weight: 15 parts of Angelica sinensis, 20 parts of white peony root, 25 parts of Rehmannia root, 12 parts of Chuanxiong, 25 parts of Leonurus japonicus, 12 parts of Rosa chinensis, 10 parts of Bupleurum chinense, 15 parts of Cyperus rotundus, 14 parts of Herba Cortex Pogostemonis, 18 parts of Zedoariae, 18 parts of Verbena officinalis, 20 parts of Herba Cyperi Truncatum, 18 parts of Jasmine sinensis, 20 parts of Herba Eupatorii, 20 parts of Poria, 15 parts of Atractylodes macrocephala, 15 parts of Fructus Ligustri Lucidi, 15 parts of Herba Ecliptae, 15 parts of Lycium barbarum, 12 parts of Paeonia suffruticosa, and 10 parts of Gardenia jasminoides.

[0010] Preferably, a traditional Chinese medicine formula for regulating female endocrine disorders is composed of the following raw materials in parts by weight: 18 parts of Angelica sinensis, 23 parts of white peony root, 28 parts of Rehmannia glutinosa, 14 parts of Chuanxiong, 28 parts of Leonurus japonicus, 14 parts of Rosa chinensis, 11 parts of Bupleurum chinense, 18 parts of Cyperus rotundus, 16 parts of Herba Codonopsis pilosulae, 22 parts of Eupatorium fortunei, 22 parts of Verbena officinalis, 25 parts of Herba Cyperi truncatulae, 21 parts of Codonopsis pilosulae, 22 parts of Herba Eupatorii, 23 parts of Poria, 18 parts of Atractylodes macrocephala, 18 parts of Fructus Ligustri Lucidi, 18 parts of Herba Ecliptae, 18 parts of Lycium barbarum, 14 parts of Paeonia suffruticosa, and 11 parts of Gardenia jasminoides.

[0011] Preferably, a traditional Chinese medicine formula for regulating female endocrine disorders is composed of the following raw materials in parts by weight: 20 parts of Angelica sinensis, 25 parts of white peony root, 30 parts of Rehmannia glutinosa, 15 parts of Chuanxiong, 30 parts of Leonurus japonicus, 15 parts of Rosa chinensis, 12 parts of Bupleurum chinense, 20 parts of Cyperus rotundus, 18 parts of Herba Juelicis grandiflorae, 24 parts of Eupatorium fortunei, 25 parts of Verbena officinalis, 30 parts of Herba Coptidis Truncatum, 23 parts of Jasmine sinensis, 24 parts of Herba Eupatorii, 25 parts of Poria, 20 parts of Atractylodes macrocephala, 20 parts of Fructus Ligustri Lucidi, 20 parts of Herba Ecliptae, 20 parts of Lycium barbarum, 15 parts of Paeonia suffruticosa, and 12 parts of Gardenia jasminoides.

[0012] Preferably, the above-mentioned Chinese medicine formula for regulating female endocrine disorders is prepared by:

[0013] 1) Weigh each raw material drug by weight, wash, dry, crush, and pass through a 200-300 sieve to obtain a medicinal powder for later use;

[0014] 2) Mix the medicinal material powders and decoct them in water twice. For the first decoction, add 8-10 times the amount of water and decoct for 2-4 hours. For the second decoction, add 6-8 times the amount of water and decoct for 1-2 hours. Combine the two decoctions and filter. Concentrate the filtrate under reduced pressure. When the relative density is 1.1-1.2 at 50° C., an extract is obtained.

[0015] 3) drying the extract obtained in step 2) and preparing it into powder, pills, tablets or capsules.

[0016] The advantages of the present invention are as follows:

[0017] Synergistic effect of multiple medicinal materials: This Chinese medicine formula contains multiple Chinese medicinal materials, such as the Siwu Decoction composed of Angelica sinensis, White Peony Root, Rehmannia Glutinosa, and Chuanxiong. It is a classic basic formula for blood-tonifying and menstruation-regulating, which can effectively regulate the female menstrual cycle, nourish blood and activate blood circulation, and improve the symptoms of endocrine disorders caused by blood deficiency and blood stasis. Motherwort promotes blood circulation and removes blood stasis, regulates menstruation and promotes diuresis, and rose soothes the liver and relieves depression, promotes blood circulation and regulates menstruation. They work synergistically with the Siwu Decoction, significantly enhancing the regulatory effect on the female reproductive system, helping to restore normal menstrual patterns and relieve problems such as dysmenorrhea and amenorrhea.

[0018] Bupleurum and Cyperus rotundus can soothe the liver and regulate qi, making the liver qi smooth and blood flowing. They have a good effect on improving endocrine disorders caused by liver depression and qi stagnation, such as mood swings and breast pain. Poria and Atractylodes macrocephala can strengthen the spleen and replenish qi. A healthy spleen can activate qi and blood biochemical metabolism, which can provide the body with sufficient qi and blood nourishment. At the same time, they can prevent other tonic herbs from hindering the spleen, ensure the normal transportation and transformation function of the spleen and stomach, and make the drugs better absorbed and utilized.

[0019] Ligustrum lucidum, Eclipta prostrata, and Lycium barbarum nourish the yin of the liver and kidneys. They target endocrine disorders of liver and kidney yin deficiency and can regulate symptoms such as hot flashes, night sweats, insomnia, and weakness in the waist and knees caused by liver and kidney deficiency, fundamentally regulating the balance of the endocrine axis. Peony bark clears heat and cools blood, promotes blood circulation and removes blood stasis, while Gardenia clears heat and purges fire. Both can clear the stagnant heat in the body caused by stagnation of qi and blood, improve skin problems such as acne and chloasma caused by endocrine disorders, and restore skin to a smooth and clean state. Herbs such as Herba julibrissin, Herba zedoariae, Verbena officinalis, Herba truncatulae, Herba scutellariae, and Herba scutellariae further enrich the efficacy of the formula, either enhancing the power of promoting blood circulation and removing blood stasis, or assisting in clearing heat, promoting dampness, and detoxifying, and comprehensively regulating the complex causes and diverse symptoms of female endocrine disorders.

[0020] Accurate dosage range of medicinal materials: The weight of each medicinal material in the formula has been carefully designed, with a clear range to choose from, and multiple preferred specific formulas are given. This design can not only adapt to the individual differences of different patients, but also ensure the effectiveness and safety of the formula. For example, the dosage of angelica is between 10-20 parts, and the dosage can be flexibly adjusted according to the degree of blood deficiency of the patient. For those with more severe blood deficiency, an amount close to 20 parts can be used to enhance the blood-tonifying effect; for patients with more sensitive constitutions or weak spleen and stomach, an amount of about 10 parts can be selected to avoid excessive nourishment. Similarly, other medicinal materials such as bupleurum are between 6-12 parts, which can be formulated according to the severity of the patient's liver depression, so that the formula is more in line with the patient's actual condition and achieves precise treatment.

[0021] Pretreatment of medicinal materials: First, wash, dry, crush and pass each raw material through a 200-300 sieve to obtain medicinal powder. This step can not only remove impurities and microorganisms on the surface of the medicinal materials to ensure the purity of the medicine, but also make the medicinal particles uniform and small, increase the contact area between the medicinal materials and the solvent, which is beneficial to the subsequent decoction and extraction process, and improve the dissolution rate of the active ingredients, thereby enhancing the efficacy of the medicine.

[0022] Water decoction process: The method of water decoction is adopted twice. For the first time, 8-10 times the amount of water is added and the decoction is performed for 2-4 hours. For the second time, 6-8 times the amount of water is added and the decoction is performed for 1-2 hours. This process design of step-by-step decoction with different water volume and time fully considers the dissolution characteristics of the active ingredients in different medicinal materials. For some medicinal materials with hard texture and difficult to dissolve active ingredients, their active ingredients can be fully extracted in the first decoction with a longer time and a larger amount of water; and the second decoction can further extract the active ingredients in the remaining medicinal materials, making the extraction of the medicine more complete. For example, rhizome medicinal materials such as Rehmannia glutinosa can better release their tonic ingredients in the first decoction, while medicinal materials containing volatile ingredients such as mint can reduce the loss of active ingredients under the relatively mild decoction conditions of the second time, thereby ensuring the maximum extraction of active ingredients of various medicinal materials in the formula and improving the quality and efficacy of the medicine.

[0023] Concentration and diversification of dosage forms: After combining the two decoctions and filtering, the filtrate is concentrated under reduced pressure to an extract with a relative density of 1.1-1.2 at 50°C. This control of the degree of concentration is not only conducive to the preparation of subsequent dosage forms, but also ensures that the concentration of the active ingredients of the drug is appropriate. After drying, the extract can be made into a variety of dosage forms such as powders, pills, tablets or capsules, which meet the medication needs and preferences of different patients. Powders are easy to take and easy to absorb, suitable for some patients with dysphagia or who need a quick effect; pills have a mild and lasting effect, suitable for chronic conditioning; tablets and capsules are easy to carry and store, with accurate dosage, suitable for patients in modern fast-paced life, and improve patients' medication compliance.

[0024] In summary, this traditional Chinese medicine formula for regulating female endocrine disorders has significant advantages of scientificity, pertinence and rationality in terms of formula composition and preparation method, and provides a safe, effective and diversified traditional Chinese medicine solution for the treatment of female endocrine disorders. DETAILED DESCRIPTION

[0025] For the purpose of the following detailed description, it should be understood that the present invention may adopt various alternative changes and step sequences, unless expressly specified to the contrary. In addition, except in any operating examples, or otherwise indicated, all numbers representing the amount of ingredients used in the specification and claims should be understood to be modified by the term "about" in all cases. Therefore, unless otherwise indicated, the numerical parameters set forth in the following specification and the attached claims are approximate values ​​that vary according to the desired performance to be obtained by the present invention. At least it is not intended to limit the application of the doctrine of equivalents to the scope of the claims, and each numerical parameter should at least be interpreted according to the number of reported significant figures and by applying ordinary rounding techniques.

[0026] Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the invention are approximations, the numerical values ​​set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements.

[0027] In addition, it should be understood that any numerical range described herein is intended to include all subranges subsumed therein. For example, a range of "1 to 10" is intended to include all subranges between (and including) the stated minimum value of 1 and the stated maximum value of 10, i.e., having a minimum value equal to or greater than 1 and a maximum value equal to or less than 10.

[0028] Example 1

[0029] A traditional Chinese medicine formula for regulating female endocrine disorders, consisting of the following raw materials in parts by weight: 10 parts of angelica sinensis, 12 parts of white peony root, 15 parts of rehmannia root, 8 parts of ligusticum chuanxiong, 15 parts of motherwort, 8 parts of rose, 6 parts of bupleurum, 10 parts of cyperus rotundus, 6 parts of jujube herb, 8 parts of zedoaria, 5 parts of verbena, 10 parts of truncatum truncatum, 11 parts of pyracantha, 12 parts of fish eye grass, 12 parts of tuckahoe, 10 parts of atractylodes macrocephala, 10 parts of glossy privet fruit, 10 parts of eclipta prostrata, 10 parts of wolfberry, 8 parts of peony bark, and 6 parts of gardenia.

[0030] Preferably, the above-mentioned Chinese medicine formula for regulating female endocrine disorders is prepared by:

[0031] 1) Weigh each raw material drug by weight, wash, dry, crush, and pass through a 200-300 sieve to obtain a medicinal powder for later use;

[0032] 2) Mix the medicinal material powders and decoct them in water twice. For the first decoction, add 8-10 times the amount of water and decoct for 2-4 hours. For the second decoction, add 6-8 times the amount of water and decoct for 1-2 hours. Combine the two decoctions and filter. Concentrate the filtrate under reduced pressure. When the relative density is 1.1-1.2 at 50° C., an extract is obtained.

[0033] 3) drying the extract obtained in step 2) to prepare a powder.

[0034] Example 2

[0035] A traditional Chinese medicine formula for regulating female endocrine disorders, comprising the following raw materials in parts by weight: 13 parts of angelica sinensis, 16 parts of white peony root, 20 parts of rehmannia root, 10 parts of ligusticum chuanxiong, 20 parts of motherwort, 10 parts of rose, 8 parts of bupleurum, 13 parts of cyperus rotundus, 10 parts of jujube herb, 14 parts of zedoaria, 12 parts of verbena, 18 parts of truncatum truncatum, 15 parts of emerald green, 16 parts of fish eye grass, 16 parts of tuckahoe, 13 parts of atractylodes macrocephala, 13 parts of glossy privet fruit, 13 parts of eclipta prostrata, 13 parts of wolfberry, 10 parts of moutan bark, and 8 parts of gardenia.

[0036] Preferably, the above-mentioned Chinese medicine formula for regulating female endocrine disorders is prepared by:

[0037] 1) Weigh each raw material drug by weight, wash, dry, crush, and pass through a 200-300 sieve to obtain a medicinal powder for later use;

[0038] 2) Mix the medicinal material powders and decoct them in water twice. For the first decoction, add 8-10 times the amount of water and decoct for 2-4 hours. For the second decoction, add 6-8 times the amount of water and decoct for 1-2 hours. Combine the two decoctions and filter. Concentrate the filtrate under reduced pressure. When the relative density is 1.1-1.2 at 50° C., an extract is obtained.

[0039] 3) drying the extract obtained in step 2) and preparing it into pills.

[0040] Example 3

[0041] A Chinese medicine formula for regulating female endocrine disorders, composed of the following raw materials in parts by weight: 15 parts of angelica, 20 parts of white peony root, 25 parts of Rehmannia root, 12 parts of Chuanxiong, 25 parts of Leonurus japonicus, 12 parts of Rosa chinensis, 10 parts of Bupleurum, 15 parts of Cyperus rotundus, 14 parts of Herba jujubae, 18 parts of Zedoariae, 18 parts of Verbena officinalis, 20 parts of Herba truncatulae, 18 parts of Cnidium officinale, 20 parts of Herba scutellariae, 20 parts of Poria, 15 parts of Atractylodes macrocephalae, 15 parts of Fructus Ligustri Lucidi, 15 parts of Herba Ecliptae, 15 parts of Lycium barbarum, 12 parts of Paeonia suffruticosae, and 10 parts of Gardenia jasminoides. Preferably, the above Chinese medicine formula for regulating female endocrine disorders is prepared by the following method:

[0042] 1) Weigh each raw material drug by weight, wash, dry, crush, and pass through a 200-300 sieve to obtain a medicinal powder for later use;

[0043] 2) Mix the medicinal material powders and decoct them in water twice. For the first decoction, add 8-10 times the amount of water and decoct for 2-4 hours. For the second decoction, add 6-8 times the amount of water and decoct for 1-2 hours. Combine the two decoctions and filter. Concentrate the filtrate under reduced pressure. When the relative density is 1.1-1.2 at 50° C., an extract is obtained.

[0044] 3) drying the extract obtained in step 2) and preparing tablets.

[0045] Example 4

[0046] A Chinese medicine formula for regulating female endocrine disorders, composed of the following raw materials in parts by weight: 18 parts of angelica, 23 parts of white peony root, 28 parts of Rehmannia root, 14 parts of Chuanxiong, 28 parts of Leonurus japonicus, 14 parts of Rosa chinensis, 11 parts of Bupleurum, 18 parts of Cyperus rotundus, 16 parts of Herba jujubae, 22 parts of Herba zedoariae, 22 parts of Verbena officinalis, 25 parts of Herba truncatulae, 21 parts of Herba scutellariae, 22 parts of Herba scutellariae, 23 parts of Poria, 18 parts of Atractylodes macrocephalae, 18 parts of Fructus Ligustri Lucidi, 18 parts of Herba Ecliptae, 18 parts of Lycium barbarum, 14 parts of Cortex Moutan, and 11 parts of Gardenia jasminoides. Preferably, the above-mentioned Chinese medicine formula for regulating female endocrine disorders is prepared by the following method:

[0047] 1) Weigh each raw material drug by weight, wash, dry, crush, and pass through a 200-300 sieve to obtain a medicinal powder for later use;

[0048] 2) Mix the medicinal material powders and decoct them in water twice. For the first decoction, add 8-10 times the amount of water and decoct for 2-4 hours. For the second decoction, add 6-8 times the amount of water and decoct for 1-2 hours. Combine the two decoctions and filter. Concentrate the filtrate under reduced pressure. When the relative density is 1.1-1.2 at 50° C., an extract is obtained.

[0049] 3) drying the extract obtained in step 2) to prepare capsules.

[0050] Example 5

[0051] A traditional Chinese medicine formula for regulating female endocrine disorders, consisting of the following raw materials in parts by weight: 20 parts of angelica sinensis, 25 parts of white peony root, 30 parts of rehmannia root, 15 parts of ligusticum chuanxiong, 30 parts of motherwort, 15 parts of rose, 12 parts of bupleurum, 20 parts of cyperus rotundus, 18 parts of jujube herb, 24 parts of zedoaria, 25 parts of verbena, 30 parts of truncatum truncatum, 23 parts of pyracantha, 24 parts of fish eye grass, 25 parts of tuckahoe, 20 parts of atractylodes macrocephala, 20 parts of glossy privet fruit, 20 parts of eclipta prostrata, 20 parts of wolfberry, 15 parts of moutan bark, and 12 parts of gardenia.

[0052] Preferably, the above-mentioned Chinese medicine formula for regulating female endocrine disorders is prepared by:

[0053] 1) Weigh each raw material drug by weight, wash, dry, crush, and pass through a 200-300 sieve to obtain a medicinal powder for later use;

[0054] 2) Mix the medicinal material powders and decoct them in water twice. For the first decoction, add 8-10 times the amount of water and decoct for 2-4 hours. For the second decoction, add 6-8 times the amount of water and decoct for 1-2 hours. Combine the two decoctions and filter. Concentrate the filtrate under reduced pressure. When the relative density is 1.1-1.2 at 50° C., an extract is obtained.

[0055] 3) drying the extract obtained in step 2) and preparing it into powder, pills, tablets or capsules.

[0056] The following are six cases of using the Chinese medicine formula of the present invention to treat female endocrine disorders:

[0057] Case 1

[0058] Patient Information:

[0059] Name: Ms. Zhao

[0060] Age: 28

[0061] Symptoms: irregular menstruation, shortened cycle, increased menstrual flow, accompanied by a large number of blood clots, and menstruation extended to 8-10 days. Often feel dizzy and weak, pale face, pale lips and nails.

[0062] Diagnosis: Endocrine disorders due to blood deficiency and blood stasis

[0063] Treatment process: The formula of Example 1 was used. The powder was prepared according to the preparation method and taken three times a day, 4 capsules each time, for three consecutive months.

[0064] Treatment results:

[0065] After taking it for one month, the menstrual flow began to decrease, blood clots decreased, and the menstrual period was shortened to 6-7 days. After two months, the dizziness and fatigue symptoms were alleviated, and the complexion became slightly rosy. After three months, the menstrual cycle returned to normal, 28-30 days, the menstrual flow was normal, there were no obvious blood clots, the menstrual period was 5-6 days, the color of the lips and nails improved, and the physical condition improved significantly.

[0066] Case 2

[0067] Patient Information:

[0068] Name: Ms. Qian

[0069] Age: 35

[0070] Symptoms: delayed menstruation, often every 2-3 months, scanty and light-colored menstruation, accompanied by depression, anxiety, breast pain, and fullness in the ribs.

[0071] Diagnosis: Endocrine disorders due to liver depression and qi stagnation

[0072] Treatment process: The formula of Example 2 was used to make pills, each pill was 6 grams, three times a day, 1 pill each time, and taken continuously for four months.

[0073] Treatment results:

[0074] After two months of treatment, her mood improved, her anxiety was reduced, and her breast tenderness and flank distension were relieved. After three months, her menstrual cycle was shortened to 40-50 days, and her menstrual flow increased slightly. After four months, her menstrual cycle basically returned to normal, 30-35 days, her menstrual flow was normal, her mood was stable, and her breast and flank discomfort symptoms disappeared.

[0075] Case 3

[0076] Patient Information:

[0077] Name: Ms. Sun

[0078] Age: 40

[0079] Symptoms: Menstrual disorders, sometimes early, sometimes late, sometimes more, sometimes less, accompanied by hot flashes, night sweats, insomnia, sore waist and knees, memory loss, and worsening of facial chloasma.

[0080] Diagnosis: Endocrine disorders due to liver and kidney yin deficiency

[0081] Treatment process: The formulation of Example 3 was used to prepare tablets, each tablet was 0.5 grams, three times a day, 6 tablets each time, for five consecutive months.

[0082] Treatment results:

[0083] After three months of taking it, the hot flashes and night sweats were relieved, the sleep quality was improved, the symptoms of sore waist and knees and memory loss were improved, and the color of chloasma became lighter. After five months, the menstrual cycle tended to be regular, the menstrual flow was stable, the symptoms of hot flashes and night sweats, insomnia and other symptoms basically disappeared, the chloasma was significantly reduced, and the overall mental state was good.

[0084] Case 4

[0085] Patient Information:

[0086] Name: Ms. Li

[0087] Age: 26

[0088] Symptoms: long-term dysmenorrhea, severe pain, need to take painkillers to relieve, menstrual cycle is basically normal, but the menstrual flow is small, dark color, with small blood clots. At the same time, there is acne, mainly distributed on the forehead and chin, and the skin is greasy.

[0089] Diagnosis: Endocrine disorders of Qi stagnation, blood stasis and damp-heat type

[0090] Treatment process: The formulation of Example 4 was used to prepare capsules, which were taken three times a day, 5 grams each time, with warm water for three consecutive months.

[0091] Treatment results:

[0092] After taking it for one and a half months, the degree of dysmenorrhea was alleviated, no painkillers were needed, the menstrual flow increased, the blood clots decreased, the oily skin condition improved, and the acne decreased. After three months, the dysmenorrhea basically disappeared, the color of menstruation was normal, the menstrual flow was normal, the acne basically subsided, and the skin returned to normal.

[0093] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A Chinese medicine formula for regulating female endocrine disorders, characterized in that: The invention is composed of the following raw materials in parts by weight: 10-20 parts of angelica sinensis, 12-25 parts of white peony root, 15-30 parts of rehmannia root, 8-15 parts of ligusticum chuanxiong, 15-30 parts of motherwort, 8-15 parts of rose, 6-12 parts of bupleurum, 10-20 parts of cyperus rotundus, 6-18 parts of iris herb, 8-24 parts of zedoaria, 5-25 parts of verbena, 10-30 parts of truncatum truncatum, 11-23 parts of pyracantha, 12-24 parts of fisheye grass, 12-25 parts of poria, 10-20 parts of atractylodes macrocephala, 10-20 parts of glossy privet fruit, 10-20 parts of eclipta prostrata, 10-20 parts of wolfberry, 8-15 parts of moutan bark and 6-12 parts of gardenia.

2. A Chinese medicine formula for treating female endocrine disorders according to claim 1, characterized in that: The drug composition is composed of the following raw materials in parts by weight: 10 parts of angelica sinensis, 12 parts of white peony root, 15 parts of rehmannia root, 8 parts of chuanxiong, 15 parts of motherwort, 8 parts of rose, 6 parts of bupleurum, 10 parts of cyperus rotundus, 6 parts of jujube herb, 8 parts of zedoaria, 5 parts of verbena, 10 parts of truncatum truncatum, 11 parts of pyracantha, 12 parts of fisheye grass, 12 parts of poria, 10 parts of atractylodes, 10 parts of glossy privet, 10 parts of eclipta prostrata, 10 parts of wolfberry, 8 parts of peony bark, and 6 parts of gardenia.

3. A Chinese medicine formula for treating female endocrine disorders according to claim 1, characterized in that: The drug composition is composed of the following raw materials in parts by weight: 13 parts of angelica sinensis, 16 parts of white peony root, 20 parts of rehmannia root, 10 parts of ligusticum chuanxiong, 20 parts of motherwort, 10 parts of rose, 8 parts of bupleurum, 13 parts of cyperus rotundus, 10 parts of jujube herb, 14 parts of zedoaria, 12 parts of verbena, 18 parts of truncatum truncatum, 15 parts of pyracantha, 16 parts of fisheye grass, 16 parts of poria, 13 parts of atractylodes, 13 parts of glossy privet, 13 parts of eclipta prostrata, 13 parts of wolfberry, 10 parts of peony bark, and 8 parts of gardenia.

4. A Chinese medicine formula for treating female endocrine disorders according to claim 1, characterized in that: The drug composition is composed of the following raw materials in parts by weight: 15 parts of angelica sinensis, 20 parts of white peony root, 25 parts of rehmannia root, 12 parts of ligusticum chuanxiong, 25 parts of motherwort, 12 parts of rose, 10 parts of bupleurum, 15 parts of cyperus rotundus, 14 parts of jujube herb, 18 parts of zedoaria, 18 parts of verbena, 20 parts of truncatum truncatum, 18 parts of silver edge emerald, 20 parts of fish eye grass, 20 parts of poria, 15 parts of atractylodes, 15 parts of glossy privet, 15 parts of eclipta herb, 15 parts of wolfberry, 12 parts of peony bark, and 10 parts of gardenia.

5. A Chinese medicine formula for treating female endocrine disorders according to claim 1, characterized in that: The drug composition is composed of the following raw materials in parts by weight: 18 parts of angelica sinensis, 23 parts of white peony root, 28 parts of rehmannia root, 14 parts of ligusticum chuanxiong, 28 parts of motherwort, 14 parts of rose, 11 parts of bupleurum, 18 parts of cyperus rotundus, 16 parts of cornus officinalis, 22 parts of zedoaria, 22 parts of verbena, 25 parts of truncatum truncatum, 21 parts of pyracantha, 22 parts of fisheye grass, 23 parts of poria, 18 parts of atractylodes, 18 parts of glossy privet, 18 parts of eclipta prostrata, 18 parts of wolfberry, 14 parts of moutan bark, and 11 parts of gardenia.

6. A Chinese medicine formula for treating female endocrine disorders according to claim 1, characterized in that: The drug composition is composed of the following raw materials in parts by weight: 20 parts of angelica sinensis, 25 parts of white peony root, 30 parts of rehmannia root, 15 parts of ligusticum chuanxiong, 30 parts of motherwort, 15 parts of rose, 12 parts of bupleurum, 20 parts of cyperus rotundus, 18 parts of jujube herb, 24 parts of zedoaria, 25 parts of verbena, 30 parts of truncatum truncatum, 23 parts of jasmine, 24 parts of fisheye grass, 25 parts of poria, 20 parts of atractylodes macrocephala, 20 parts of glossy privet fruit, 20 parts of eclipta prostrata, 20 parts of wolfberry, 15 parts of moutan bark, and 12 parts of gardenia.

7. A Chinese medicine formula for treating female endocrine disorders according to any one of claims 1 to 6, characterized in that: Its preparation method is: 1) Weigh each raw material drug by weight, wash, dry, crush, and pass through a 200-300 sieve to obtain a medicinal powder for later use; 2) Mix the medicinal material powders and decoct them in water twice. For the first decoction, add 8-10 times the amount of water and decoct for 2-4 hours. For the second decoction, add 6-8 times the amount of water and decoct for 1-2 hours. Combine the two decoctions and filter. Concentrate the filtrate under reduced pressure. When the relative density is 1.1-1.2 at 50° C., an extract is obtained. 3) drying the extract obtained in step 2) and preparing it into powder, pills, tablets or capsules.