Polypeptide medicine purification device

Abstract

The invention belongs to the technical field of polypeptide drug purification, and particularly relates to a polypeptide drug purification device which comprises a barrel, a cover plate is detachably fixed to the top of the barrel, and the polypeptide drug purification device further comprises a material distribution assembly, a material storage assembly and a purification assembly, and the material distribution assembly penetrates through the cover plate, extends into the barrel and is used for material distribution; the adsorption assembly is mounted in the inner cavity of the cylinder body and is used for adsorbing and purifying the materials; and the driving assembly is fixed to the top of the cover plate, the driving assembly is connected with the material distribution assembly, and the driving assembly is used for driving the material distribution assembly to rotate. The material distribution assembly is driven by the driving assembly to rotate, so that uniform material distribution on the upper side of the separation column is realized, materials can be uniformly distributed on the separation column during adsorption, the separation column is fully utilized for adsorption, eluent can be uniformly distributed on the separation column during elution, and the adsorption efficiency is improved. The sufficient contact between the eluent and the material adsorbed on the separation column is facilitated, so that the elution effect is improved.

Description

Technical Field

[0001] The invention relates to the technical field of polypeptide drug purification, in particular to a polypeptide drug purification device. Background Art

[0002] The working principle of the peptide drug purification device is mainly based on the differences in the physical, chemical or biological properties of peptides and other components, and the purification of peptide drugs is achieved through selective separation technology;

[0003] In actual use, the existing peptide drug purification device consists of an injection system, a separation column, and a collection system. The material is introduced into the purification device, and then the peptide drug is adsorbed by the separation column, and the impurities cannot be adsorbed, so they can be directly discharged to achieve purification and separation. After the purification is completed, the purified material obtained on the separation column can be removed by introducing an eluent. However, in actual use, whether the raw material is directed to the separation column or the eluent is directed to the ion column, the feed is not evenly distributed. The uneven feed distribution will cause some areas of the separation column to be over-utilized, while other areas are under-utilized, which will reduce the overall adsorption efficiency and elution efficiency. For this reason, a new technical solution needs to be designed to solve the problem. Summary of the invention

[0004] The purpose of the present invention is to provide a polypeptide drug purification device to solve the problems raised in the background technology.

[0005] To achieve the above object, the present invention provides the following technical solution: a polypeptide drug purification device, comprising a cylinder, a cover plate is detachably fixed on the top of the cylinder, and further comprising:

[0006] A cloth assembly, the cloth assembly passes through the cover plate and extends into the cylinder, and the cloth assembly is used for cloth distribution;

[0007] An adsorption component, which is installed in the inner cavity of the cylinder and is used for adsorption and purification of materials;

[0008] A driving assembly is fixed to the top of the cover plate, the driving assembly is connected to the cloth assembly, and the driving assembly is used to drive the cloth assembly to rotate.

[0009] By adopting the above technical scheme, during adsorption purification and separation, the material is guided into the cylinder through the cloth assembly, and the driving assembly drives the cloth assembly to rotate at a uniform speed, so that uniform distribution of material on the top of the adsorption assembly can be achieved, and then during adsorption, the material can be evenly distributed on the adsorption assembly, thereby fully utilizing the adsorption assembly for adsorption, and at the same time, during elution, the eluent is evenly guided to the elution assembly by the cloth assembly, so that the eluent can be evenly distributed on the adsorption assembly, which is beneficial to improving the sufficiency of the contact between the eluent and the material adsorbed on the adsorption assembly, thereby helping to improve the elution effect.

[0010] As a preferred embodiment of the present invention, the adsorption component comprises:

[0011] A mesh plate, the mesh plate is fixed to the lower side of the inner cavity of the cylinder, and a limiting rod is fixed at the middle of the top of the mesh plate;

[0012] The separation column has a plurality of separation columns, and the plurality of separation columns are mounted on the outer wall of the limiting rod. A spring is fixed to the tail end of the separation column, and the tail end of the spring is fixedly connected to the corresponding separation column and the mesh plate, and the spring is mounted on the outer wall of the limiting rod.

[0013] By adopting the above technical solution, the material to be purified can be adsorbed by the separation column after entering the cylinder, and the impurities in the material can be directly discharged from the cylinder.

[0014] As a preferred embodiment of the present invention, the cloth assembly comprises:

[0015] A hollow shaft, wherein the hollow shaft passes through the cover plate, and an outer wall of the hollow shaft is connected to a driving assembly;

[0016] A distribution pipe, both sides of the tail end of the hollow shaft are fixedly connected with distribution pipes, and a plurality of evenly distributed holes are opened at the bottom of the distribution pipe;

[0017] A feed pipe is connected to the hollow shaft through a rotary joint, and the outer end of the feed pipe is connected to a first feed pipe and a second feed pipe through a three-way valve.

[0018] By adopting the above technical solution, during adsorption, the material is introduced into the feed pipe through the first feed pipe, and then into the hollow shaft, and then the material will enter the distribution pipe, and then be discharged along the hole, and rotated under the drive of the driving component to achieve uniform distribution. Similarly, during elution, the eluent is introduced into the distribution pipe through the second feed pipe, and the liquid can be evenly distributed to the separation column under rotation.

[0019] As a preferred embodiment of the present invention, the driving assembly comprises:

[0020] A servo motor, wherein the servo motor is fixed to the top of the cover plate, and an outer end of a transmission shaft of the servo motor is fixedly connected to a first gear;

[0021] The second gear is fixedly sleeved on the outer wall of the hollow shaft, and the second gear is meshed with the first gear.

[0022] By adopting the above technical solution, the servo motor can drive the first gear to rotate, thereby driving the second gear to rotate, and further driving the hollow shaft to rotate.

[0023] As a preferred embodiment of the present invention, it also includes a toggle assembly, and the toggle assembly includes:

[0024] A toggle block, wherein the number of the toggle blocks is two, and the two toggle blocks are respectively installed on both sides of the tail end of the hollow shaft;

[0025] A sleeve, the sleeve is sleeved on the top outer wall of the limiting rod, and limiting blocks are fixed on both sides of the top of the separation column on the upper side, and the limiting blocks are inserted into the limiting grooves opened at the bottom of the sleeve;

[0026] A fixing plate is fixed to the top of the sleeve, and wedge blocks are fixed on both sides of the top of the fixing plate.

[0027] By adopting the above technical solution, when adsorbing the material, the sleeve, the fixed plate and the wedge block are first removed from the limit rod, and when eluting, the sleeve is installed. Then, during the rotation of the cloth component, the toggle block can be driven to rotate accordingly, so that the toggle block can impact the wedge block, and at the same time, the toggle block can apply pressure to the wedge block, so that the sleeve applies pressure to the separation column, so that the separation column compresses the spring, and when the toggle block is separated from the wedge block, the spring rebounds, so that the separation column produces an up and down amplitude, which is beneficial to further improve the contact effect between the eluent and the material on the separation column, and further help to further improve the elution effect.

[0028] Furthermore, by utilizing the limit block to limit the axial position between the sleeve and the separation column, and the separation column being movably sleeved on the limit rod and fixedly connected to the spring end, when the toggle block toggles the wedge block, not only can the separation column be made to oscillate up and down, but also the wedge block can be pushed axially, so that the separation column produces an axial motion trajectory, thereby twisting the spring, and then after being released, the separation column can also produce axial vibration, which is beneficial to further improve the contact effect between the eluent and the material on the separation column, and further helps to further improve the elution effect.

[0029] As a preferred embodiment of the present invention, a carrier plate is provided on the top of the toggle block, the carrier plate is fixedly connected to the tail end of the hollow shaft, a bolt passes through the top of the carrier plate, and the penetration point is rotatably connected by a bearing, a threaded hole is opened on the top of the toggle block, the bolt is inserted into the threaded hole and the thread is engaged.

[0030] As a preferred embodiment of the present invention, a vertical rod is fixed to one side of the bottom of the carrier plate, and the vertical rod is inserted into a slot provided at the top of the toggle block.

[0031] As a preferred embodiment of the present invention, the top of the cylinder is fixedly connected with a conduit, and the tail end of the first conduit is connected with a first discharge pipe and a second discharge pipe via a three-way valve.

[0032] Compared with the prior art, the present invention has the following beneficial effects:

[0033] The present invention drives the material distribution component to rotate through the driving component, thereby realizing uniform material distribution on the upper side of the separation column, and then during adsorption, the material can be evenly distributed on the separation column, thereby fully utilizing the separation column for adsorption, and at the same time, during elution, the eluent can be evenly distributed on the separation column, which is beneficial to the sufficient contact between the eluent and the material adsorbed on the separation column, thereby facilitating the improvement of the elution effect;

[0034] The cloth group can drive the toggle block to rotate during the rotation process, so that the toggle block can impact the wedge block, and at the same time, the toggle block can press the wedge block, so that the sleeve presses the separation column, so that the separation column compresses the spring, and the spring rebounds when the toggle block is separated from the wedge block, so that the separation column generates an up and down amplitude, which is conducive to further improving the contact effect between the eluent and the material on the separation column, and further helping to further improve the elution effect;

[0035] Axial limitation is achieved by using a limiting block between the sleeve and the separation column, and the separation column is movably sleeved on the limiting rod and fixedly connected to the spring end. Therefore, when the toggle block toggles the wedge block, not only can the separation column be made to oscillate up and down, but also the wedge block can be pushed axially, so that the separation column produces an axial motion trajectory, thereby twisting the spring, and then after release, the separation column can also produce axial vibration, which is beneficial to further improve the contact effect between the eluent and the material on the separation column, and further helps to further improve the elution effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] Other features, objects and advantages of the present invention will become more apparent from the detailed description of non-limiting embodiments made with reference to the following drawings:

[0037] Figure 1 This is a schematic diagram of the overall structure of a polypeptide drug purification device of the present invention;

[0038] Figure 2 It is a schematic cross-sectional view of a polypeptide drug purification device of the present invention;

[0039] Figure 3 It is a schematic diagram of the enlarged structure of A of a polypeptide drug purification device of the present invention;

[0040] Figure 4 It is a schematic diagram of the cross-sectional bottom view of a polypeptide drug purification device of the present invention;

[0041] Figure 5 It is a schematic diagram of the enlarged structure of B of a polypeptide drug purification device of the present invention;

[0042] Figure 6 This is a schematic diagram of the structure of an adsorption component of a polypeptide drug purification device of the present invention;

[0043] Figure 7 The present invention is a schematic diagram of the structure of a toggle block of a polypeptide drug purification device.

[0044] In the figure:

[0045] 1. Cylinder; 11. Cover plate; 12. Conduit; 13. First discharge pipe; 14. Second discharge pipe;

[0046] 2. Hollow shaft; 21. Rotary joint; 22. Feed pipe; 23. First feed pipe; 24. Second feed pipe; 25. Distribution pipe; 26. Hole;

[0047] 3. Separation column; 31. Screen plate; 32. Limit rod; 33. Casing; 34. Spring; 35. Limit block;

[0048] 4. Toggle block; 41. Carrier plate; 42. Bolt; 43. Vertical rod;

[0049] 5. Fixed plate; 51. Wedge block;

[0050] 6. servo motor; 61. first gear; 62. second gear. DETAILED DESCRIPTION

[0051] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0052] In the description of the present invention, it is necessary to understand that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship are based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0053] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "set" should be understood in a broad sense, for example, they can be fixedly connected or set, or detachably connected or set, or connected or set in one piece. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances. The models of electrical appliances provided in the present invention are only for reference, and different models of electrical appliances with the same functions can be replaced according to actual usage.

[0054] See also Figure 1-7 The present invention provides a technical solution: a polypeptide drug purification device, comprising a cylinder 1, a cover plate 11 is detachably fixed on the top of the cylinder 1, and further comprising:

[0055] A cloth assembly, which passes through the cover plate 11 and extends into the cylinder 1, and is used for cloth dispensing;

[0056] An adsorption component is installed in the inner cavity of the cylinder 1 and is used for adsorption and purification of materials;

[0057] A driving assembly, which is fixed to the top of the cover plate 11 and connected to the cloth assembly, and is used to drive the cloth assembly to rotate;

[0058] It should be understood that during adsorption purification and separation, the material is guided into the cylinder 1 by the cloth assembly, and the driving assembly drives the cloth assembly to rotate at a uniform speed, so that the material can be evenly distributed on the top of the adsorption assembly, and then during adsorption, the material can be evenly distributed on the adsorption assembly, thereby fully utilizing the adsorption assembly for adsorption, and at the same time, during elution, the eluent is evenly guided to the elution assembly by the cloth assembly, so that the eluent can be evenly distributed on the adsorption assembly, which is beneficial to improve the adequacy of the contact between the eluent and the material adsorbed on the adsorption assembly, thereby helping to improve the elution effect.

[0059] Furthermore, a conduit 12 is fixedly connected to the top of the cylinder 1, and the tail end of the first conduit 12 is connected to a first discharge pipe 13 and a second discharge pipe 14 through a three-way valve. The first discharge pipe 13 and the second discharge pipe 14 can be used to respectively discharge impurities discharged during adsorption and purified materials obtained after elution.

[0060] like Figure 1 and 2 , 6; the adsorption component includes:

[0061] The mesh plate 31 is fixed to the lower side of the inner cavity of the cylinder 1, and a limiting rod 32 is fixed at the middle of the top of the mesh plate 31;

[0062] Separation column 3, the number of separation columns 3 is multiple, and the multiple separation columns 3 are mounted on the outer wall of the limiting rod 32, and the tail end of the separation column 3 is fixed with a spring 34, the tail end of the spring 34 is fixedly connected to the corresponding separation column 3 and the mesh plate 31, and the spring 34 is mounted on the outer wall of the limiting rod 32;

[0063] It should be understood that after the material to be purified enters the cylinder 1 , it can be adsorbed by the separation column 3 , and the impurities in the material can be directly discharged from the cylinder 1 .

[0064] like Figure 1 , 2 As shown in , 3 and 5, the cloth component includes:

[0065] A hollow shaft 2, the hollow shaft 2 passes through the cover plate 11, and the outer wall of the hollow shaft 2 is connected to the driving assembly;

[0066] A distribution pipe 25, both sides of the rear end of the hollow shaft 2 are fixedly connected with a distribution pipe 25, and a plurality of evenly distributed holes 26 are opened at the bottom of the distribution pipe 25;

[0067] A feed pipe 22, the feed pipe 22 is connected to the hollow shaft 2 through a rotary joint 21, and the outer end of the feed pipe 22 is connected to a first feed pipe 23 and a second feed pipe 24 through a three-way valve;

[0068] It should be understood that during adsorption, the material is introduced into the feed pipe 22 through the first feed pipe 23, and then into the hollow shaft 2, and then the material will enter the distribution pipe 25, and then be discharged along the hole 26, and rotated under the drive of the driving component to achieve uniform distribution. Similarly, during elution, the eluent is introduced into the distribution pipe 25 using the second feed pipe 24, and the liquid can be evenly distributed to the separation column 3 during rotation.

[0069] like Figure 1 and 2 As shown; the drive assembly includes:

[0070] A servo motor 6, which is fixed to the top of the cover plate 11, and a first gear 61 is fixedly connected to the outer end of the transmission shaft of the servo motor 6;

[0071] A second gear 62, the second gear 62 is fixedly sleeved on the outer wall of the hollow shaft 2, and the second gear 62 is meshed with the first gear 61;

[0072] It should be understood that the servo motor 6 can drive the first gear 61 to rotate, thereby driving the second gear 62 to rotate, and further driving the hollow shaft 2 to rotate.

[0073] like Figure 1 and 2 , 3, 4, 5, 6, 7; and also includes a toggle assembly, the toggle assembly includes:

[0074] The toggle block 4 is two in number, and the two toggle blocks 4 are respectively installed on both sides of the tail end of the hollow shaft 2;

[0075] The sleeve 33 is sleeved on the top outer wall of the limiting rod 32, and the limiting blocks 35 are fixed on both sides of the top of the upper separation column 3, and the limiting blocks 35 are inserted into the limiting grooves opened at the bottom of the sleeve 33;

[0076] A fixing plate 5, the fixing plate 5 is fixed to the top of the sleeve 33, and wedge blocks 51 are fixed on both sides of the top of the fixing plate 5;

[0077] It should be understood that when adsorbing the material, the sleeve 33, the fixed plate 5 and the wedge block 51 are first removed from the limit rod 32. When eluting, the sleeve 33 is installed. Then, during the rotation of the cloth assembly, the toggle block 4 can be driven to rotate accordingly, so that the toggle block 4 can impact the wedge block 51. At the same time, the toggle block 4 can apply pressure to the wedge block 51, so that the sleeve 33 applies pressure to the separation column 3, so that the separation column 3 compresses the spring 34. When the toggle block 4 is separated from the wedge block 51, the spring 34 rebounds, causing the separation column 3 to produce an up and down amplitude, which is beneficial to further improve the contact effect between the eluent and the material on the separation column 3, and further help to further improve the elution effect.

[0078] Furthermore, the limiting block 35 is used to limit the axial position between the sleeve 33 and the separation column 3, and the separation column 3 is movably sleeved on the limiting rod 32 and fixedly connected to the end of the spring 34. Therefore, when the toggle block 4 toggles the wedge block 51, not only can the separation column 3 be made to vibrate up and down, but also the wedge block 51 can be pushed axially, so that the separation column 3 produces an axial motion trajectory, thereby twisting the spring 34, and then after being released, the separation column 3 can also produce an amplitude in the axial direction, which is beneficial to further improve the contact effect between the eluent and the material on the separation column 3, and further help to further improve the elution effect.

[0079] Furthermore, a carrier plate 41 is provided on the top of the toggle block 4, and the carrier plate 41 is fixedly connected to the tail end of the hollow shaft 2. A bolt 42 penetrates the top of the carrier plate 41, and the penetration is rotatably connected through a bearing. A threaded hole is opened on the top of the toggle block 4, and the bolt 42 is inserted into the threaded hole and the thread is engaged;

[0080] By rotating the bolt 42, the toggle block 4 can be adjusted to move up and down, thereby adjusting the stroke of the toggle block 4 on the wedge block 51, and then adjusting the amplitude of the separation column 3 after the toggle, thereby improving the adaptability and meeting the amplitude requirements when removing different materials, which is beneficial to improving the elution effect.

[0081] Furthermore, a vertical rod 43 is fixed to one side of the bottom of the carrier plate 41, and the vertical rod 43 is inserted into a slot provided at the top of the toggle block 4. When the bolt 42 drives the toggle block 4 to adjust the position, the vertical rod 43 can be used to limit the position to ensure the stability of the lifting.

[0082] This technical solution is a polypeptide drug purification device, and the specific work is as follows:

[0083] When adsorption is performed, the cover plate 11 is first opened, and the sleeve 33, the fixing plate 5 and the wedge block 51 are first removed from the limiting rod 32, and the material is guided into the cylinder 1 through the material distribution component, and the driving component drives the material distribution component to rotate at a uniform speed, so that the material can be evenly distributed on the top of the adsorption component, and then the material can be evenly distributed on the adsorption component during adsorption, so that the adsorption component can be fully utilized for adsorption. At the same time, during elution, the sleeve 33 is installed, and the eluent is evenly guided to the elution component by the material distribution component, so that the eluent can be evenly distributed on the adsorption component, which is beneficial to improve the adequacy of the contact between the eluent and the material adsorbed on the adsorption component, and thus is beneficial to improve the elution effect;

[0084] During the rotation of the cloth assembly, the toggle block 4 can be driven to rotate accordingly, so that the toggle block 4 can impact the wedge block 51, and at the same time, the toggle block 4 can press the wedge block 51, so that the sleeve 33 presses the separation column 3, so that the separation column 3 compresses the spring 34, and when the toggle block 4 is separated from the wedge block 51, the spring 34 rebounds, so that the separation column 3 generates an up and down amplitude, which is conducive to further improving the contact effect between the eluent and the material on the separation column 3, and further helping to further improve the elution effect;

[0085] The limiting block 35 is used to limit the axial position between the sleeve 33 and the separation column 3, and the separation column 3 is movably sleeved on the limiting rod 32 and fixedly connected to the end of the spring 34. Therefore, when the toggle block 4 toggles the wedge block 51, not only can the separation column 3 be made to vibrate up and down, but also the wedge block 51 can be pushed axially, so that the separation column 3 produces an axial motion trajectory, thereby twisting the spring 34, and then after being released, the separation column 3 can also produce an amplitude in the axial direction, which is beneficial to further improve the contact effect between the eluent and the material on the separation column 3, and further help to further improve the elution effect.

[0086] In addition, the components included in the polypeptide drug purification device of the present invention are all universal standard parts or components known to those skilled in the art, and their structures and principles can be known to those skilled in the art through technical manuals or conventional experimental methods. In the idle part of the device, all the above-mentioned electrical components, which refer to power elements, electrical components, and adapted monitoring computers and power supplies, are connected through wires. The specific connection means should refer to the following working principle, and the electrical connection between the electrical components is completed in a sequential working order. The detailed connection means are well-known technologies in the art. The following mainly introduces the working principle and process, and no longer explains the electrical control.

[0087] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It is obvious to those skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is defined by the attached claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention. Any figure mark in the claims should not be regarded as limiting the claims involved.

[0088] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A polypeptide drug purification device, comprising a cylinder (1), a cover plate (11) being detachably fixed to the top of the cylinder (1), characterized in that: Also includes: A cloth assembly, the cloth assembly passes through the cover plate (11) and extends into the cylinder (1), and the cloth assembly is used for cloth dispensing; An adsorption component, the adsorption component is installed in the inner cavity of the cylinder (1), and the adsorption component is used to perform adsorption purification on the material; A driving assembly is fixed to the top of the cover plate (11), the driving assembly is connected to the cloth assembly, and the driving assembly is used to drive the cloth assembly to rotate.

2. A polypeptide drug purification device according to claim 1, characterized in that: The adsorption assembly comprises: A mesh plate (31), wherein the mesh plate (31) is fixed to the lower side of the inner cavity of the cylinder (1), and a limiting rod (32) is fixed at the middle of the top of the mesh plate (31); A separation column (3), wherein the number of the separation columns (3) is multiple, and the multiple separation columns (3) are mounted on the outer wall of the limiting rod (32), and a spring (34) is fixed to the tail end of the separation column (3), and the tail end of the spring (34) is fixedly connected to the corresponding separation column (3) and the mesh plate (31), and the spring (34) is mounted on the outer wall of the limiting rod (32).

3. A polypeptide drug purification device according to claim 2, characterized in that: The cloth component comprises: A hollow shaft (2), wherein the hollow shaft (2) passes through the cover plate (11), and an outer wall of the hollow shaft (2) is connected to a driving assembly; A distribution tube (25), both sides of the tail end of the hollow shaft (2) are fixedly connected with a distribution tube (25), and a plurality of evenly distributed holes (26) are opened at the bottom of the distribution tube (25).

4. A polypeptide drug purification device according to claim 3, characterized in that: The driving assembly comprises: A servo motor (6), wherein the servo motor (6) is fixed to the top of the cover plate (11), and the outer end of the transmission shaft of the servo motor (6) is fixedly connected to a first gear (61); The second gear (62) is fixedly sleeved on the outer wall of the hollow shaft (2), and the second gear (62) is meshed with the first gear (61).

5. A polypeptide drug purification device according to claim 4, characterized in that: Also included is a toggle assembly, the toggle assembly comprising: A toggle block (4), wherein the number of the toggle blocks (4) is two, and the two toggle blocks (4) are respectively installed on both sides of the rear end of the hollow shaft (2); A sleeve (33), the sleeve (33) is sleeved on the top outer wall of the limiting rod (32), and limiting blocks (35) are fixed on both sides of the top of the separation column (3) on the upper side, and the limiting blocks (35) are inserted into the limiting grooves opened at the bottom of the sleeve (33); A fixing plate (5), wherein the fixing plate (5) is fixed to the top of the sleeve (33), and wedge blocks (51) are fixed to both sides of the top of the fixing plate (5).

6. A polypeptide drug purification device according to claim 5, characterized in that: A carrier plate (41) is arranged on the top of the toggle block (4), and the carrier plate (41) is fixedly connected to the rear end of the hollow shaft (2). A bolt (42) penetrates the top of the carrier plate (41), and the penetration point is rotatably connected via a bearing. A threaded hole is opened on the top of the toggle block (4), and the bolt (42) is inserted into the threaded hole and the thread is engaged.

7. A polypeptide drug purification device according to claim 6, characterized in that: A vertical rod (43) is fixed to one side of the bottom of the carrier plate (41), and the vertical rod (43) is inserted into a slot provided at the top of the toggle block (4).

8. A polypeptide drug purification device according to claim 7, characterized in that: The top of the cylinder (1) is fixedly connected to a conduit (12), and the tail end of the first conduit (12) is connected to a first discharge pipe (13) and a second discharge pipe (14) via a three-way valve.

9. A polypeptide drug purification device according to claim 8, characterized in that: The material distribution assembly further comprises a feed pipe (22), wherein the feed pipe (22) is connected to the hollow shaft (2) via a rotary joint (21), and the outer end of the feed pipe (22) is connected to a first feed pipe (23) and a second feed pipe (24) via a three-way valve.

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