Cordyceps sinensis tablet and preparation method thereof

Abstract

The invention belongs to the technical field of cordyceps sinensis processing, and particularly relates to cordyceps sinensis tablets and a preparation method thereof, and the cordyceps sinensis tablets comprise the following components in percentage by mass: 90-97% of whole cordyceps sinensis and 3-10% of colloidal silicon dioxide. The preparation method comprises the steps of crushing, mixing, granulating, drying, tabletting and drying when the colloidal silicon dioxide is internally added, and comprises the steps of crushing, granulating, drying and mixing, tabletting and drying when the colloidal silicon dioxide is externally added. By improving a conventional tablet preparation process, the nutrition and unique flavor of the cordyceps sinensis are reserved to the maximum extent, only a small amount of filler is added, the technical effects that the proportion of the cordyceps sinensis is larger than or equal to 90% and the hardness is ideal are achieved, the process is simple, the finished product yield is high, the product quality is good, the production cost is low, and industrial large-scale production is easy to achieve.

Description

Technical Field

[0001] The invention belongs to the technical field of cordyceps processing, and particularly relates to a cordyceps tablet and a preparation method thereof. Background Art

[0002] Cordyceps sinensis is a complex of the fruiting bodies and larval corpses of the ergot fungus Cordyceps sinensis parasitizing the larvae of the bat moth family insects. In my country, the health-preserving value of Cordyceps sinensis has long been recognized by ancient medical scientists. As early as in the ancient pharmacopoeias such as "Compendium of Materia Medica", there were detailed records of Cordyceps sinensis. Traditional Chinese medicine believes that Cordyceps sinensis is sweet and warm in nature, and belongs to the lung and kidney meridians. It has the effects of benefiting the lungs and kidneys, replenishing the essence, stopping bleeding and reducing phlegm. It is often used to treat symptoms such as soreness of the waist and knees, impotence and premature ejaculation, and excessive phlegm and wheezing. Cordyceps sinensis is a precious and nourishing Chinese medicinal material with many beneficial ingredients for the human body. The traditional and common way of eating it is to use Cordyceps sinensis to make soup, tea or cooking, but the high-temperature heating process can easily cause the loss of some nutrients in Cordyceps sinensis, and it is inconvenient to take and cannot be taken at any time. If Cordyceps sinensis is developed into tablets, it will effectively avoid the loss of nutrients and improve its convenience.

[0003] It is reported that Cordyceps sinensis contains 10.84% ​​water, 25.32% crude protein, 18.55% crude fiber, 28.9% carbohydrates, 4.1% ash, 8.4% fat, and various amino acids, ergosterol and its oxides, D-mannitol, stearic acid, uracil, adenine, hypoxanthine and 3'-deoxyadenosine (cordycepin) and other ingredients. The sugar alcohol components are mainly mannitol, and the nucleosides are uracil, adenine, and adenine nucleoside. It also contains trace elements and vitamins B12, B1, vitamin C, etc. Since Cordyceps sinensis has a complex composition and is rich in cellulose and oils, it poses a great challenge to the preparation of tablets. The tablets pressed from Cordyceps sinensis powder are prone to low hardness, loose tablets, scattered tablets, and cracked tablets. The technical means that have been publicly disclosed to solve the compressibility of Cordyceps sinensis tablets are basically divided into the following two types:

[0004] The first method is to use Cordyceps powder for tableting without adding auxiliary materials, but it usually requires complex processes such as leaching, extraction, freeze-drying, and ball milling to remove the cellulose and oil components in Cordyceps that affect compressibility. Although this technical means can obtain a product with ideal hardness, the process is complicated and the production cost is high. It is difficult to industrialize production and the loss of nutrients cannot be avoided.

[0005] The second method is to improve the compressibility of the particles by adding excipients with better compressibility or materials with stronger adhesion through conventional tablet preparation technology. This technology only processes the Cordyceps sinensis in a simple way and can relatively completely retain the nutritional components of the Cordyceps sinensis itself. However, due to the complexity of the Cordyceps sinensis components, it is often necessary to add a large amount of excipients with different functions to achieve the ideal tablet hardness. The large amount of excipients added will dilute the effective ingredients and different types of excipients may have compatibility reactions with Cordyceps sinensis. Therefore, the amount and type of excipients should be reduced as much as possible.

[0006] CN113616611A discloses a method for preparing CS-4 tablets containing fermented Cordyceps sinensis powder, wherein the amount of Cordyceps sinensis powder in the prescription is controlled at 80%, different adhesives are used for granulation and molding, and auxiliary materials such as fillers, lubricants and absorbents are added to achieve ideal appearance, hardness and disintegration time.

[0007] The invention has many types of auxiliary materials and the dosage is large. The proportion of Cordyceps mycelium powder can only reach about 80%. When taking this product, more ineffective ingredients will be ingested. At the same time, fermented Cordyceps powder and Cordyceps whole grass powder are essentially different in composition, form and structure. Compared with fermented Cordyceps powder, Cordyceps whole grass powder is more complex in composition and has a higher proportion of cellulose, and is more difficult to press into tablets.

[0008] CN110575442A discloses a fermented cordyceps sinensis powder tablet, which is composed of 80-95% fermented cordyceps sinensis powder, 0-15% filler, 0-5% binder, 1-10% disintegrant, 1-10% adsorbent and 0.1-5% lubricant, and the total percentage of the filler, binder, disintegrant, adsorbent and lubricant is 5-20%; the above raw materials and auxiliary materials are first prepared into a solution for standby use, the fermented cordyceps sinensis powder and the filler are placed in a boiling drying granulator, the binder solution is sprayed into the granules, the granulated granules are then added with disintegrant, adsorbent and lubricant to mix evenly, and the tablet is obtained. The invention uses many kinds of auxiliary materials, which are not conducive to human absorption, and the cordyceps is soft in texture and the powder after crushing is relatively fluffy, and the one-step granulation process needs to keep the material in a good fluidized state in the fluidized bed, which will cause part of the material to be lost due to the discharge of airflow, resulting in a low material yield and increased material input cost, which is not conducive to industrial production.

[0009] In summary, the existing Cordyceps sinensis tablet preparation technology still has problems such as complex preparation process, high production cost, high dosage and variety of auxiliary materials, low material yield, and difficulty in industrial production. Summary of the invention

[0010] In order to solve the above technical problems, the present invention provides a cordyceps sinensis tablet and a preparation method thereof.

[0011] The present invention is implemented by providing a cordyceps sinensis tablet, which comprises the following components by mass percentage: 90-97% of the whole cordyceps sinensis and 3-10% of colloidal silicon dioxide.

[0012] Preferably, the tablet comprises the following components by mass percentage: 93-96% of whole Cordyceps sinensis and 4-7% of colloidal silicon dioxide.

[0013] More preferably, the tablets are prepared by wet granulation, and the amount of water added during the granulation process is 34-60% of the total amount of the material.

[0014] Further preferably, the tablets are granulated by wet method, and the particle size distribution of the prepared wet granules after drying is: ≥50% by mass of the dry granules of the material have a sieved particle size of ≥75 μm and ≤10% by mass of the dry granules of the material have a sieved particle size of ≥355 μm, and the water content of the dry granules of the material is 1-5%.

[0015] More preferably, during the tablet preparation process, the drying temperature of the Cordyceps sinensis tablet is 50-65°C.

[0016] The present invention provides a method for preparing a cordyceps sinensis tablet, comprising the following steps:

[0017] 1) Grinding: The cleaned and dried whole Cordyceps sinensis is subjected to low-temperature ultrafine grinding to obtain whole Cordyceps sinensis powder;

[0018] 2) Mixing: weighing the whole herb powder of Cordyceps sinensis and colloidal silicon dioxide or only the whole herb powder of Cordyceps sinensis according to a certain proportion, and granulating the mixture by a granulator;

[0019] 3) Granulation: Using a wet granulator, set the stirring speed to 150-250 rpm, the cutting blade speed to 1000-2000 rpm, and the atomization pressure to 0.5-1.5 bar, and evenly mix the material prepared in step 2) with purified water accounting for 34-60% of the total material, so that the mixture of Cordyceps sinensis whole herb powder and colloidal silicon dioxide or the Cordyceps sinensis whole herb powder material forms wet granules;

[0020] 4) Drying: drying the wet granules of the mixture of Cordyceps sinensis whole grass powder and colloidal silicon dioxide or drying the wet granules of Cordyceps sinensis whole grass powder and adding them together with the colloidal silicon dioxide weighed in proportion into a mixer and mixing them evenly;

[0021] 5) Tableting: using a rotary tablet press to perform tableting, setting the main pressing interval to 2.0-3.0 mm, and pressing the granules in step 4) into plain tablets;

[0022] 6) Drying: Drying the plain tablets to obtain Cordyceps sinensis whole herb tablets.

[0023] Preferably, in step 1) of the above method, the D of Cordyceps sinensis powder is 90 ≤130μm.

[0024] Preferably, in step 4) of the above method, the drying temperature is 50-65° C., and the drying is performed until the moisture content is reduced to 1.0-5.0%.

[0025] Preferably, in step 6) of the above method, the drying condition is drying at 50-65° C. for 10-20 hours.

[0026] Preferably, the above method further comprises packaging: packaging the dried whole cordyceps sinensis tablets in aluminum-plastic blister plates.

[0027] Compared with the prior art, the advantages of the present invention are:

[0028] The present invention improves the composition and preparation process of conventional tablets, crushes, granulates, compresses and dries the whole Cordyceps sinensis, retains the nutrition and unique flavor of Cordyceps sinensis to the greatest extent, and only adds a small amount of filler, which can achieve the technical effect of Cordyceps sinensis accounting for ≥ 90% and ideal hardness. Compared with the existing preparation process, the present invention has a high proportion of whole Cordyceps sinensis, a small amount and type of auxiliary materials, a simple process, a high yield of finished products, excellent product quality, low production cost and easy industrial mass production. DETAILED DESCRIPTION

[0029] The present invention is further explained below in conjunction with specific implementation schemes, but is not intended to limit the protection scope of the present invention.

[0030] The invention improves the fluidity of the whole cordyceps sinensis powder by adding a small amount of colloidal silicon dioxide. At the same time, the colloidal silicon dioxide has a large surface area and can absorb part of the oil of the cordyceps sinensis, thereby improving the compressibility of the cordyceps sinensis powder.

[0031] Example 1: Add 10.0% microcrystalline cellulose PH101 to prepare Cordyceps sinensis whole grass tablets with a content of 90.0%.

[0032] 243 mg of the whole Cordyceps sinensis after washing and drying was subjected to low temperature ultrafine grinding to obtain D 90Cordyceps sinensis whole grass micropowder of ≤130μm; premix the Cordyceps sinensis whole grass micropowder and 27mg microcrystalline cellulose PH101, and then pass through a 0.5mm screen granulator to sieve the granules, and then transfer to a fixed hopper mixer to mix for 10-20min to obtain a mixed material. The mixed material is put into a wet granulator, and the stirring speed is set to 150-250rpm, the cutting knife speed is set to 1000-2000rpm, and the atomization pressure is set to 0.5-1.5bar. After spraying a certain proportion of purified water to the total amount of the input material, granulation is obtained to obtain a wet granular material, and the wet granular material is dried in a 50-65℃ oven until the moisture content of the granules is reduced to 2%-4%, and the dried granules are tableted to obtain plain tablets, and finally the plain tablets are dried in a 60℃ oven for 10-20h to obtain Cordyceps sinensis whole grass tablets, which are then packaged into finished products.

[0033] Example 2: 10.0% lactose was added to prepare Cordyceps sinensis whole herb tablets with a content of 90.0%.

[0034] Compared with Example 1, the difference is that microcrystalline cellulose PH101 is replaced by lactose.

[0035] Example 3: 10.0% anhydrous calcium hydrogen phosphate was added to prepare Cordyceps sinensis whole herb tablets with a content of 90.0%.

[0036] Compared with Example 1, the difference is that microcrystalline cellulose PH101 is replaced by anhydrous calcium hydrogen phosphate.

[0037] Example 4: Adding 10% pregelatinized starch to prepare Cordyceps sinensis whole grass tablets with a content of 90.0%.

[0038] Compared with Example 1, the difference is that microcrystalline cellulose PH101 is replaced by pregelatinized starch.

[0039] Example 5: Preparation of Cordyceps sinensis whole herb tablets with a content of 90.0% by adding 10.0% colloidal silicon dioxide.

[0040] Compared with Example 1, the difference lies in that microcrystalline cellulose PH101 is replaced by colloidal silicon dioxide.

[0041] Comparative Example 1: Preparation of Cordyceps sinensis whole-herb tablets containing 100% of the total content by wet granulation.

[0042] The whole Cordyceps sinensis that had been washed and dried was subjected to low temperature ultrafine grinding to obtain D 90≤130μm Cordyceps micropowder; sieve the Cordyceps micropowder through a granulator with a 0.5mm screen. Put the granulated Cordyceps micropowder into a wet granulator, set the stirring speed to 150-250rpm, the cutting knife speed to 1000-2000rpm, and the atomization pressure to 0.5-1.5bar, spray a certain proportion of purified water to the total amount of the input material, and then granulate to obtain wet granular material, dry the wet granular material in a 50-65℃ oven until the granular moisture content meets 2%-4% of dry granules, then press the dry granules to obtain plain tablets, and finally dry the plain tablets in a 60℃ oven for 10-20h to obtain Cordyceps whole grass tablets, which are then packaged into finished products.

[0043] The following data were measured on the tablets prepared in Examples 1, 2, 3, 4, 5 and Comparative Example 1. The results are shown in Table 1:

[0044] Table 1

[0045]

[0046] The experimental results show that:

[0047] (1) The data results of Comparative Example 1 show that the hardness of the whole Cordyceps sinensis powder after tableting is low, the friability is unqualified, and the particle fluidity is poor, making it difficult to industrialize production.

[0048] (2) The above examples investigate the effect of microcrystalline cellulose, lactose, pregelatinized starch and anhydrous calcium hydrogen phosphate on improving tablet compressibility. It can be seen that when the drug content of Cordyceps sinensis reaches more than 90%, the effect of the four excipients on hardness is relatively weak. The present invention also investigates other fillers besides the above four excipients, such as cyclodextrin, mannitol, silicified microcrystalline cellulose, calcium phosphate, light magnesium carbonate, compressible sucrose, etc., which cannot achieve good hardness.

[0049] (3) The experimental results show that colloidal silicon dioxide has a great influence on the preparation of tablets. It can not only greatly improve the fluidity of the granules after granulation, but also greatly improve the compressibility of the granules, thereby achieving the technical effect of stable process and high product quality.

[0050] Example 6: Preparation of Cordyceps sinensis whole herb tablets with a content of 93.5% by adding 6.5% colloidal silicon dioxide.

[0051] Compared with Example 5, the difference is that the amount of colloidal silicon dioxide added is 6.5%, that is, the amount of Cordyceps sinensis whole grass powder added is 252.45 mg, and the amount of colloidal silicon dioxide added is 17.55 mg.

[0052] Example 7: Preparation of Cordyceps sinensis whole herb tablets with a content of 97.0% by adding 3.0% colloidal silicon dioxide.

[0053] Compared with Example 5, the difference is that the amount of colloidal silicon dioxide added is 3.0%, that is, the amount of Cordyceps sinensis whole herb powder added is 261.90 mg, and the amount of colloidal silicon dioxide added is 8.10 mg.

[0054] Example 8: Preparation of Cordyceps sinensis whole herb tablets with a content of 90% by adding 10% colloidal silicon dioxide.

[0055] The whole Cordyceps sinensis that had been washed and dried was subjected to low temperature ultrafine grinding to obtain D 90 Cordyceps sinensis powder of ≤130μm; the Cordyceps sinensis powder is sieved through a granulator with a 0.5mm screen, the granulated material is put into a wet granulator, the stirring speed is set to 150-250rpm, the cutting knife speed is 1000-2000rpm, the atomization pressure is 0.5-1.5bar, and a certain proportion of purified water accounting for the total amount of the input material is sprayed into the granulator to obtain a wet granular material, the wet granular material is dried in a 50-65℃ oven until the moisture content of the granules is reduced to 2-4%, and the dried granules and colloidal silicon dioxide are added to a fixed hopper mixer and mixed for 10-20min to obtain a total mixed material. The total mixed material is tableted to obtain a plain tablet, and finally the plain tablet is dried in a 60℃ oven for 10-20h to obtain a whole Cordyceps sinensis tablet, which is then packaged into a finished product.

[0056] To further explain here, the so-called internally added colloidal silicon dioxide means that the colloidal silicon dioxide and the cordyceps powder are wet granulated at the same time; the externally added colloidal silicon dioxide means that the colloidal silicon dioxide is evenly mixed with the dry granules of the cordyceps after granulation.

[0057] 1. Product performance test.

[0058] The tablets prepared in Examples 5, 6, 7, 8 and Comparative Example 1 were tested for the following data, and the results are shown in Table 2.

[0059] Table 2

[0060]

[0061] The experimental results show that:

[0062] (1) Through the data analysis of Examples 5, 6, 7 and Comparative Example 1, as the amount of colloidal silicon dioxide added decreases, the tablet hardness shows a downward trend. When the amount of colloidal silicon dioxide added reaches 3%, the tablet hardness is still greater than 50N, which has a good hardness effect; when no colloidal silicon dioxide is added, the tablet hardness drops sharply, which does not meet the tablet hardness requirements during product transportation.

[0063] (2) Colloidal silicon dioxide is commonly used by mixing it with granules before tableting to improve their fluidity. However, the data of Examples 5 and 8 show that the conventional external mixing method does not improve the tablet hardness as much as the internal addition method of granulating colloidal silicon dioxide and Cordyceps sinensis powder together.

[0064] 2. Stability test.

[0065] The samples of Examples 5, 6 and 7 were packaged with PVC and blank aluminum foil and placed in a 40°C high temperature stability box. The stability of the samples was investigated for 5, 10, 20 and 30 days. The results are shown in Table 3.

[0066] Table 3

[0067]

[0068] The results show that the appearance of the samples of Examples 5, 6 and 7 slightly darkened during the stability process, the hardness changed slightly, and the adenosine content did not change significantly, indicating the good stability of the product.

[0069] Examples 9-12: Investigation of the effects of different amounts of water added on the flowability and compressibility of Cordyceps sinensis whole herb tablet particles.

[0070] The whole Cordyceps sinensis that had been washed and dried was subjected to low temperature ultrafine grinding to obtain D 90 ≤130μm Cordyceps micropowder; 92% Cordyceps micropowder and 8% colloidal silicon dioxide are pre-mixed and sieved through a granulator with a 0.5mm screen, and then transferred to a fixed hopper mixer for mixing for 15 minutes to obtain a mixed material. The mixed material is put into a wet granulator, and the stirring speed is set to 150-250rpm, the cutting knife speed is 1000-2000rpm, and the atomization pressure is 0.5-1.5bar. Purified water in different proportions is sprayed according to Table 4 and granulated to obtain wet granular materials. The wet granular materials are dried in a 60℃ oven for ≥2h until the moisture content of the particles is less than 2%-4%, and the dried particles are tableted to obtain plain tablets. Finally, the plain tablets are dried in a 60℃ oven for 15h to obtain Cordyceps whole grass tablets, which are then packaged into finished products.

[0071] Table 4

[0072]

[0073] Note: [1] Purified water will be removed during the drying process and is not included in the total amount of the recipe.

[0074] [2] Purified water ratio: the ratio of purified water to the total weight of wet granulation material.

[0075] 1. Powder properties and compressibility data of particles

[0076] The dried particles of Examples 9, 10, 11, and 12 were collected and the particle size was tested by an intelligent powder property tester (manufacturer: Dandong Better Instrument Co., Ltd., model BT-1001). The following sieves with different apertures were installed in an oscillator from bottom to top. 10 g of the sample was poured into the largest sieve, and the oscillation was repeated 500 times. The powder properties of the particles were measured as shown in Table 5 below:

[0077] Table 5

[0078]

[0079] The dried granules of Examples 9, 10, 11 and 12 were collected for tableting. The parameters after tableting and the quality of the final product are shown in Table 6:

[0080] Table 6

[0081]

[0082]

[0083] The experimental results show that: in the wet granulation process, the amount of water added is the key factor for the powder to grow into granules. For the whole Cordyceps sinensis powder, the increase in the amount of water added will accelerate the outflow of the Cordyceps components, resulting in a darker color of the final granules. When the amount of water added is small, the color of the Cordyceps granules is light yellow. When the amount of water added reaches a certain level, the color of the Cordyceps gradually deepens to brown. Therefore, the amount of water added is also a key factor affecting the uneven color of the final tablets.

[0084] After experimental investigation, when the amount of water added is 30%, the particle size of the wet granulation particles is smaller, the fluidity of the particles is poor, and the material feeding is not smooth during tableting, and the feeding speed needs to be increased, which is not conducive to tableting and easily leads to large fluctuations in tablet weight; when the amount of water added is greater than 60%, the particle size of the wet granulation particles is larger, the particles are harder and have low compressibility, the main pressure is larger, the hardness of the dried tablets is low, and the uneven color of the particles leads to uneven color on the surface of the final tablets with obvious pitting.

[0085] The present invention finds that when the sieved particle size of the granulated particles satisfies: ≥50% by mass of the particles have a sieved particle size ≥75 μm and ≤10% by mass of the particles have a sieved particle size ≥355 μm, the particles have good fluidity and compressibility. Preferably, 65% by mass of the particles have a sieved particle size ≥75 μm and the particle ratio ≤8% by mass of the particles have a sieved particle size ≥355 μm, the particles have excellent fluidity and compressibility.

[0086] Example 13: Investigation of the effect of drying process after tableting on the hardness of plain tablets.

[0087] Drying the tablets after tableting is a key process for further improving the hardness of the tablets. The key reason for this step is that the particles are broken after tableting, and the moisture inside the particles migrates to the surface of the particles through drying to increase the adhesion between the particles, thereby improving the hardness of the tablets.

[0088] The washed and dried Cordyceps sinensis was ultra-finely pulverized at low temperature to obtain D 90 ≤130μm Cordyceps micropowder; 92% Cordyceps micropowder and 8% colloidal silicon dioxide are pre-mixed and sieved through a 0.5mm sieve granulator, and then transferred to a fixed hopper mixer for mixing for 15 minutes to obtain a mixed material. The mixed material is put into a wet granulator, and the stirring speed is set to 150-250rpm, the cutting knife speed is 1000-2000rpm, and the atomization pressure is 0.5-1.5bar. After spraying 45% purified water, granulation is performed for 60s to obtain a wet granular material. The wet granular material is dried in a 60℃ oven until the granule moisture is as low as 2%-4%. The dried granules are pressed into tablets to obtain plain tablets. Finally, the plain tablets are dried in 50℃, 60℃, and 65℃ ovens for 5, 10, 15, and 20 hours, respectively, to obtain Cordyceps sinensis whole grass tablets. The test data is shown in Table 7 below.

[0089] Table 7

[0090]

[0091] The experimental results show that the drying time of the plain tablets has a great influence on the hardness. The hardness of the plain tablets can be significantly improved through this process. At the same time, the degree of drying is positively correlated with the hardness, but when the drying reaches a certain degree, the hardness changes little. According to experimental investigations, when the drying temperature is 50-65℃, the hardness of the plain tablets dried for 10-20 hours is relatively high, which meets the transportation requirements of ordinary tablets.

[0092] Example 14: Investigate the yield of preparation of Cordyceps sinensis whole herb tablets.

[0093] Since the whole herb ingredients of Cordyceps sinensis are complex and have poor compressibility, the existing technology often requires deep processing such as extraction and ball milling of Cordyceps sinensis, which leads to the loss of some effective ingredients, or adopts complex processes such as one-step granulation or multiple tableting, which leads to large material loss. Therefore, the whole herb Cordyceps sinensis tablets prepared by the existing technology often have a relatively low final yield, which increases the investment in Cordyceps sinensis raw materials. This technology adopts a wet granulation process, accurately controls each process, and minimizes the loss of materials. The data of Examples 5, 6, 7, 9, 10, 11, and 12 are collected to compare the qualified finished product amount with the theoretical finished product amount, and the statistical qualified finished product yield is shown in Table 8 below:

[0094] Table 8

[0095] Example Yield of qualified finished products (mass ratio) Example 5 92.3％ Example 6 90.5％ Example 7 92.6％ Example 9 93.1％ Example 10 91.1％ Embodiment 11 90.3％ Example 12 90.4％

[0096] Experimental results show that: the present invention adopts a tablet preparation process of wet granulation, and uses the whole Cordyceps sinensis without any extraction and deep processing of the Cordyceps sinensis, which can minimize the loss of the Cordyceps sinensis raw material, and at the same time, each process is simple to operate with low loss, and the overall qualified finished product yield can be maintained at more than 90%, which is suitable for industrial production; for expensive Chinese medicinal materials such as Cordyceps sinensis, a high yield means a reduction in material costs, and at the same time, the process stability is better and the process reproducibility is better.

Claims

1. A Cordyceps sinensis tablet, characterized in that: The invention comprises the following components by mass percentage: 90-97% of whole cordyceps sinensis and 3-10% of colloidal silicon dioxide.

2. The cordyceps sinensis tablet according to claim 1, characterized in that: The invention comprises the following components by mass percentage: 93-96% of whole cordyceps sinensis and 4-7% of colloidal silicon dioxide.

3. The cordyceps sinensis tablet according to claim 1 or 2, characterized in that: The wet granulation method is adopted, and the amount of water added during the granulation process is 34-60% of the total amount of the material.

4. The cordyceps sinensis tablet according to claim 1 or 2, characterized in that: The wet granules prepared by wet granulation have a particle size distribution after drying: ≥50% by mass of the dry granules have a sieve particle size of ≥75 μm and ≤10% by mass of the dry granules have a sieve particle size of ≥355 μm, and the moisture content of the dry granules is 1-5%.

5. The cordyceps sinensis tablet according to claim 1 or 2, characterized in that: During the preparation process, the drying temperature of the Cordyceps sinensis tablets is 50-65°C.

6. A method for preparing Cordyceps sinensis tablets, characterized in that: The following steps are involved: 1) Grinding: The cleaned and dried whole Cordyceps sinensis is subjected to low-temperature ultrafine grinding to obtain whole Cordyceps sinensis powder; 2) Mixing: weighing the whole herb powder of Cordyceps sinensis and colloidal silicon dioxide or only the whole herb powder of Cordyceps sinensis according to a certain proportion, and granulating the mixture by a granulator; 3) Granulation: Using a wet granulator, set the stirring speed to 150-250 rpm, the cutting blade speed to 1000-2000 rpm, and the atomization pressure to 0.5-1.5 bar, and evenly mix the material prepared in step 2) with purified water accounting for 34-60% of the total material, so that the mixture of Cordyceps sinensis whole herb powder and colloidal silicon dioxide or the Cordyceps sinensis whole herb powder material forms wet granules; 4) Drying: drying the wet granules of the mixture of Cordyceps sinensis whole grass powder and colloidal silicon dioxide or drying the wet granules of Cordyceps sinensis whole grass powder and adding them together with the colloidal silicon dioxide weighed in proportion into a mixer and mixing them evenly; 5) Tableting: using a rotary tablet press to perform tableting, setting the main pressing interval to 2.0-3.0 mm, and pressing the granules in step 4) into plain tablets; 6) Drying: Drying the plain tablets to obtain Cordyceps sinensis whole herb tablets.

7. The method for preparing a cordyceps sinensis tablet according to claim 6, characterized in that: In the step 1), the D 90 ≤130μm.

8. The method for preparing a cordyceps sinensis tablet according to claim 6, characterized in that: In the step 4), the drying temperature is 50-65° C., and the drying is performed until the moisture content is reduced to 1.0-5.0%.

9. The method for preparing a Cordyceps sinensis tablet according to claim 6, characterized in that: In the step 6), the drying condition is drying at 50-65° C. for 10-20 hours.

10. The method for preparing a cordyceps sinensis tablet according to claim 6, characterized in that: The method also includes packaging: the dried cordyceps sinensis whole-herb tablets are packaged in aluminum-plastic blister plates.

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