High-voltage electric composite hydrogel for wound skin repair and preparation method thereof

Abstract

This application provides a high-voltage electrochemical composite hydrogel for wound skin repair and its preparation method. The high-voltage electrochemical composite hydrogel is prepared by using hydroxyethyl cellulose and acrylamide monomers as raw materials to form an interpenetrating network structure. Polyvinylidene fluoride (PVDF) and ZnO nanowires are used as piezoelectric materials, and are formed by interweaving PVDF and ZnO nanowires within the hydrogel. This high-voltage electrochemical composite hydrogel significantly improves the crystallization orientation and polarization efficiency of PVDF through mechanical stretching and polarization, resulting in an order-of-magnitude improvement in the piezoelectric properties of the composite hydrogel. Simultaneously, it retains the excellent flexibility and biocompatibility of the hydrogel, showing broad application prospects in flexible sensors, self-powered devices, and human-computer interfaces.

Description

Technical Field

[0001] This invention belongs to the field of piezoelectric hydrogel technology, and relates to a high-voltage composite hydrogel for wound skin repair and its preparation method. Background Technology

[0002] Piezoelectric materials are crystalline materials that exhibit a voltage between their two ends when subjected to pressure. They enable the direct conversion of mechanical energy into electrical energy and are core components of sensors, actuators, and energy harvesters.

[0003] Piezoelectric materials include inorganic and organic piezoelectric materials. Inorganic piezoelectric materials further include piezoelectric crystals and piezoelectric ceramics, while organic piezoelectric materials are also known as piezoelectric polymers. Inorganic piezoelectric materials exhibit excellent properties, but they suffer from inherent defects such as hardness, brittleness, and poor biocompatibility, making it difficult to meet the requirements of modern flexible electronic devices for material flexibility, stretchability, and biosafety. The composite of organic piezoelectric materials such as polyvinylidene fluoride (PVDF) with flexible matrices can solve these problems. PVDF possesses excellent piezoelectricity, chemical stability, and processability, but its piezoelectric activity mainly originates from the β phase in its crystal structure. During conventional solution casting or melt processing, PVDF easily forms a thermodynamically stable non-piezoelectric α phase, resulting in the final composite material's piezoelectric properties falling far short of theoretical values. To increase the β phase content of PVDF, polarization treatment using a high-voltage electric field is typically required. However, in disordered polymer networks, the movement of molecular chain segments is severely restricted, making it difficult for dipoles to turn, resulting in low polarization efficiency. This requires extremely high electric fields (>10 kV / mm) and long processing times, and breakdown is prone to occur.

[0004] Hydrogels are soft materials with high water content and good biocompatibility, making them ideal substrates for constructing next-generation flexible electronic devices. Introducing PVDF into hydrogel systems holds promise for obtaining composite materials that combine high piezoelectricity and excellent biomechanical properties. However, most PVDF-hydrogel composites involve simple physical blending, and the strong binding effect of the hydrogel network on the PVDF molecular chains makes the polarization process more difficult. Therefore, efficiently inducing the formation of a highly oriented β phase in PVDF within a hydrogel matrix is ​​a key technological bottleneck for improving its macroscopic piezoelectric properties. Summary of the Invention

[0005] The purpose of this invention is to provide a high-voltage electrostatic composite hydrogel for wound skin repair and its preparation method, so as to solve the problems of low piezoelectric phase orientation and insufficient piezoelectric performance of existing piezoelectric hydrogels.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: This application provides a high-voltage electrochemical composite hydrogel for wound skin repair, the preparation method of which includes: ZnO nanowires were added to deionized water and ultrasonically dispersed. Then, hydroxyethyl cellulose aqueous solution, polyvinylidene fluoride solution, acrylamide monomer, crosslinking agent, plasticizer and initiator were added. The mixture was reacted at 50-60℃ and ultrasonically treated to obtain hydrogel precursor solution. The hydrogel precursor solution is transferred into a mold and dried to form a composite hydrogel. The composite hydrogel was subjected to multiple uniaxial stretching and polarization processes to obtain a high-voltage composite hydrogel.

[0007] The present invention has the following beneficial effects: (1) In this application, hydrogels with interpenetrating network structures are prepared using hydroxyethyl cellulose and acrylamide monomers as raw materials, and polyvinylidene fluoride and ZnO nanowires are used as piezoelectric materials. Polyvinylidene fluoride and ZnO nanowires are interspersed in the hydrogel to form a high-voltage composite hydrogel.

[0008] (2) Hydroxyethyl cellulose provides excellent hydrophilicity and biocompatibility; the crosslinking of acrylamide monomer and crosslinking agent enables the high-voltage electrochemical composite hydrogel to have good mechanical strength and shape retention; the use of plasticizer can improve the flexibility and freeze resistance of the high-voltage electrochemical composite hydrogel. The synergistic effect of each component ensures that the high-voltage electrochemical composite hydrogel has excellent comprehensive properties in addition to its high voltage electrochemical properties.

[0009] (3) In this application, the transformation of polyvinylidene fluoride from the non-piezoelectric α phase to the high-piezoelectric β phase is effectively induced by mechanical stretching. It can also make the molecular chains of polyvinylidene fluoride highly oriented along the stretching direction, thereby increasing the piezoelectric coefficient of the high-piezoelectric composite hydrogel by 5-10 times.

[0010] (4) ZnO nanowires are grown in situ in the hydrogel network structure to form ZnO piezoelectric crystals, which are tightly bonded to the polymer chains of the hydrogel network structure. When the high-voltage electrochemical composite hydrogel is subjected to external deformation or extrusion, the ZnO piezoelectric crystals can undergo piezoelectric polarization, generate electrical signals, and improve the piezoelectric properties of the high-voltage electrochemical composite hydrogel.

[0011] (5) The preparation method in this application is simple, the reaction conditions are mild, and it is easy to scale up production. It has broad application prospects in the fields of flexible sensors, self-powered devices and human-computer interaction interfaces. Attached Figure Description

[0012] Figure 1 This is a sample morphology image of the high-voltage electrochemical composite hydrogel prepared in Example 1 of this application; Figure 2 These are SEM images of the high-voltage electrochemical composite hydrogel prepared in Example 1 of this application at different magnifications; Figure 3The measured figures show the flexibility and tensile properties of the high-voltage electrochemical composite hydrogel prepared in Example 1 of this application. Figure 4 This is an adhesion test diagram of the high-voltage electrochemical composite hydrogel prepared in Example 1 of this application; Figure 5 This is a test image of the high-voltage electro-composite hydrogel prepared in Example 1 of this application for wearable application. Figure 6 The piezoelectric properties of the piezoelectric composite hydrogel prepared in Example 1 of this application and the piezoelectric composite hydrogel prepared in Comparative Examples 1-4 are measured under different degrees of stretching. Detailed Implementation

[0013] This application provides a high-voltage electrochemical composite hydrogel for wound skin repair, the preparation method of which includes: S01: ZnO nanowires are added to deionized water and ultrasonically dispersed. Then, hydroxyethyl cellulose aqueous solution, polyvinylidene fluoride solution, acrylamide monomer, crosslinking agent, plasticizer and initiator are added. The mixture is reacted at 50-60℃ and ultrasonically treated to obtain hydrogel precursor solution.

[0014] Hydroxyethyl cellulose with a molecular weight of 300,000-1,500,000 is added to deionized water and heated and stirred at 50-60°C until completely dissolved, forming a 1-5 wt% hydroxyethyl cellulose aqueous solution. Polyvinylidene fluoride (PVDF) is added to N,N-dimethylformamide and stirred at room temperature until completely dissolved, forming a 3-6 wt% PVDF solution. ZnO nanowires are added to deionized water and ultrasonically treated at a power of 200-500 W for 10-30 minutes to uniformly disperse the ZnO nanowires in the deionized water, forming a ZnO nanowire solution.

[0015] Under ultrasonic conditions, an aqueous solution of hydroxyethyl cellulose, a solution of polyvinylidene fluoride, acrylamide monomer, a crosslinking agent, a plasticizer, and an initiator are added to a ZnO nanowire solution, and the mixture is stirred at 50-60°C to obtain a hydrogel precursor solution. Mixing the components under ultrasonic and heating conditions ensures uniform dispersion, increases the contact frequency between components, improves the reaction rate, and reduces product aggregation.

[0016] In this application, ZnO nanowires are a one-dimensional nanomaterial with a hexagonal prismatic single-crystal structure. Under the action of an initiator and a crosslinking agent, hydroxyethyl cellulose, polyvinylidene fluoride, and acrylamide monomers undergo a crosslinking reaction to form a hydrogel network structure. During the formation of the hydrogel network structure, ZnO nanowires grow in situ within the hydrogel network structure to form ZnO piezoelectric crystals, which are tightly bonded to the polymer chains of the hydrogel network structure. When the piezoelectric composite hydrogel is subjected to external deformation or compression, the ZnO piezoelectric crystals can undergo piezoelectric polarization, generating an electrical signal and improving the piezoelectric properties of the piezoelectric composite hydrogel.

[0017] In this application, the crosslinking agent includes one or more of aluminum chloride hexahydrate, calcium chloride, or aluminum citrate; the plasticizer includes one or more of glycerol, ethylene glycol, or polyethylene glycol; and the initiator is one or more of ammonium persulfate, potassium persulfate, or azobisisobutyronitrile.

[0018] According to the weight parts, the amounts of each component are as follows: 0.5-1 parts ZnO nanowires, 1 part hydroxyethyl cellulose, 0.08-0.12 parts polyvinylidene fluoride, 0.8-1.2 parts acrylamide monomer, 0.08-0.12 parts crosslinking agent, 0.8-1.2 parts plasticizer and 0.006-0.008 parts initiator.

[0019] S02: Transfer the hydrogel precursor solution into a mold and dry it at 60-80℃ for 4-8 hours to form a composite hydrogel.

[0020] S03: The composite hydrogel is subjected to multiple uniaxial stretching polarizations to obtain a high-voltage composite hydrogel.

[0021] The dried composite hydrogel is cut and fixed on the clamp of a tensile polarization device. The composite hydrogel is stretched 50-100 times at a constant rate and held in a stretched state to form a piezoelectric composite hydrogel. Multiple uniaxial mechanical stretchings not only transform the polyvinylidene fluoride (PVDF) segments in the hydrogel network structure from the non-piezoelectric α-phase to the piezoelectric β-phase, but also enable the PVDF molecular chains and fillers to be highly oriented along the stretching direction. In this application, the uniaxial tensile polarization strain applied to the composite hydrogel is 100-400%.

[0022] The technical solution of the present invention will be further explained and described below through specific embodiments.

[0023] Example 1 This application provides a high-voltage electrochemical composite hydrogel for wound skin repair, and the preparation method of the high-voltage electrochemical composite hydrogel includes: S101: 0.5g of hydroxyethyl cellulose (HFC) with a molecular weight of 900,000 was added to 9.5mL of deionized water and heated and stirred at 55°C until no particulate matter remained in the solution, forming a colorless, transparent 5wt% hydroxyethyl cellulose aqueous solution. 0.1g of polyvinylidene fluoride (PVDF) was added to 2g of N,N-dimethylformamide and stirred at room temperature until completely dissolved, forming a 4.76wt% PVDF solution. ZnO nanowires were added to deionized water and sonicated at 400W for 20min to form a ZnO nanowire solution. Under sonication, 10g of hydroxyethyl cellulose aqueous solution, 1.2g of PVDF solution, 8g of acrylamide monomer, 0.5g of aluminum chloride hexahydrate, 8g of glycerol, and 0.07g of ammonium persulfate were added to 10g of ZnO nanowire solution and stirred at 55°C to obtain a hydrogel precursor solution.

[0024] S102: Using a pipette, spread 15g of hydrogel precursor solution evenly in a glass culture dish with a diameter of 9cm, dry at 75℃ for 8h, and demold after cooling to room temperature to obtain a composite hydrogel dry film with a thickness of about 0.2mm.

[0025] S103: After cutting the dry composite hydrogel film, fix it on the fixture of the stretching polarization device, and stretch the composite hydrogel to 3 times its original length at a constant rate. At this time, the uniaxial tensile polarization strain is 200%. Maintain the stretching state and repeat the stretching 80 times to form a high-voltage composite hydrogel.

[0026] Example 2 This application provides a high-voltage electrochemical composite hydrogel for wound skin repair, and the preparation method of the high-voltage electrochemical composite hydrogel includes: S201: Add 0.5g of hydroxyethyl cellulose (HFC) with a molecular weight of 300,000 to 49.5mL of deionized water. Heat and stir at 50℃ until no particulate matter remains in the solution, forming a colorless, transparent 1wt% hydroxyethyl cellulose aqueous solution. Add 0.1g of polyvinylidene fluoride (PVDF) to 3.23g of N,N-dimethylformamide (NDM), and stir at room temperature until completely dissolved, forming a 3wt% PVDF solution. Add ZnO nanowires to deionized water and sonicate at 200W for 30min to form a ZnO nanowire solution. Under sonication conditions, add 10g of hydroxyethyl cellulose aqueous solution, 0.8g of PVDF solution, 8g of acrylamide monomer, 0.8g of calcium chloride, 8g of ethylene glycol, and 0.06g of potassium persulfate to 5g of ZnO nanowire solution. Stir and react at 50℃ to obtain a hydrogel precursor solution.

[0027] S202: Using a pipette, spread 10g of hydrogel precursor solution evenly in a glass culture dish with a diameter of 9cm, dry at 60℃ for 7h, and demold after cooling to room temperature to obtain a composite hydrogel dry film with a thickness of about 0.2mm.

[0028] S203: After cutting the dry composite hydrogel film, fix it on the fixture of the stretching polarization device, and stretch the composite hydrogel to 4 times its original length at a constant rate. At this time, the uniaxial tensile polarization strain is 300%. Maintain the stretching state and repeat the stretching 50 times to form a high-voltage composite hydrogel.

[0029] Example 3 This application provides a high-voltage electrochemical composite hydrogel for wound skin repair, and the preparation method of the high-voltage electrochemical composite hydrogel includes: S301: Add 0.5g of hydroxyethyl cellulose (HFC) with a molecular weight of 1.5 million to 9.5mL of deionized water. Heat and stir at 60℃ until no particulate matter remains in the solution, forming a colorless, transparent 5wt% hydroxyethyl cellulose aqueous solution. Add 0.1g of polyvinylidene fluoride (PVDF) to 1.57g of N,N-dimethylformamide (NDM), and stir at room temperature until completely dissolved, forming a 6wt% PVDF solution. Add ZnO nanowires to deionized water and sonicate at 500W for 10min to form a ZnO nanowire solution. Under sonication conditions, add 10g of hydroxyethyl cellulose aqueous solution, 1.2g of PVDF solution, 12g of acrylamide monomer, 1.2g of aluminum citrate, 12g of ethylene glycol, and 0.08g of azobisisobutyronitrile (AIOBR) to 8g of ZnO nanowire solution. Stir and react at 60℃ to obtain a hydrogel precursor solution.

[0030] S302: Using a pipette, spread 10g of hydrogel precursor solution evenly in a glass culture dish with a diameter of 9cm, dry at 80℃ for 4h, and demold after cooling to room temperature to obtain a composite hydrogel dry film with a thickness of about 0.15mm.

[0031] S303: After cutting the dry composite hydrogel film, fix it on the fixture of the stretching polarization device, and stretch the composite hydrogel to twice its original length at a constant rate. At this time, the uniaxial tensile polarization strain is 100%. Maintain the stretching state and repeat the stretching 90 times to form a high-voltage composite hydrogel.

[0032] Example 4 This application provides a high-voltage electrochemical composite hydrogel for wound skin repair, and the preparation method of the high-voltage electrochemical composite hydrogel includes: S401: Add 0.5g of hydroxyethyl cellulose (HFC) with a molecular weight of 500,000 to 24.5mL of deionized water. Heat and stir at 55℃ until no particulate matter remains in the solution, forming a colorless, transparent 2wt% hydroxyethyl cellulose aqueous solution. Add 0.1g of polyvinylidene fluoride (PVDF) to 1.9g of N,N-dimethylformamide (NDM), and stir at room temperature until completely dissolved, forming a 5wt% PVDF solution. Add ZnO nanowires to deionized water and sonicate at 300W for 15min to form a ZnO nanowire solution. Under sonication, add 10g of hydroxyethyl cellulose aqueous solution, 1.0g of PVDF solution, 9g of acrylamide monomer, 0.9g of aluminum chloride hexahydrate, 10g of glycerol, and 0.065g of potassium persulfate to 6g of ZnO nanowire solution. Stir and react at 50-60℃ to obtain a hydrogel precursor solution.

[0033] S402: Using a pipette, spread 15g of hydrogel precursor solution evenly in a glass culture dish with a diameter of 9cm, dry at 70℃ for 5h, and demold after cooling to room temperature to obtain a composite hydrogel dry film with a thickness of about 0.2mm.

[0034] S403: After cutting the dry composite hydrogel film, fix it on the fixture of the stretching polarization device, and stretch the composite hydrogel to 5 times its original length at a constant rate. At this time, the uniaxial tensile polarization strain is 400%. Maintain the stretching state and repeat the stretching 60 times to form a high-voltage composite hydrogel.

[0035] Example 5 This application provides a high-voltage electrochemical composite hydrogel for wound skin repair, and the preparation method of the high-voltage electrochemical composite hydrogel includes: S501: Add 0.5g of hydroxyethyl cellulose (HFC) with a molecular weight of 1.2 million to 24.5mL of deionized water. Heat and stir at 55°C until no particulate matter remains in the solution, forming a colorless, transparent 2wt% hydroxyethyl cellulose aqueous solution. Add 0.1g of polyvinylidene fluoride (PVDF) to 1.9g of N,N-dimethylformamide (NDM), and stir at room temperature until completely dissolved, forming a 5wt% PVDF solution. Add ZnO nanowires to deionized water and sonicate at 400W for 15min to form a ZnO nanowire solution. Under sonication conditions, add 10g of hydroxyethyl cellulose aqueous solution, 1.1g of PVDF solution, 12g of acrylamide monomer, 0.8g of calcium chloride, 10g of polyethylene glycol, and 0.08g of azobisisobutyronitrile (AIOBR) to 5g of ZnO nanowire solution, and stir at 55°C to obtain a hydrogel precursor solution.

[0036] S502: Using a pipette, spread 15g of hydrogel precursor solution evenly in a glass culture dish with a diameter of 9cm, dry at 65℃ for 6h, and demold after cooling to room temperature to obtain a composite hydrogel dry film with a thickness of about 0.2mm.

[0037] S503: After cutting the dry composite hydrogel film, fix it on the fixture of the stretching polarization device, and stretch the composite hydrogel to 3 times its original length at a constant rate. At this time, the uniaxial tensile polarization strain is 200%. Maintain the stretching state and repeat the stretching 70 times to form a high-voltage composite hydrogel.

[0038] Comparative Example 1 This application provides a piezoelectric composite hydrogel as a comparative example. The preparation method of the piezoelectric composite hydrogel is the same as that in Example 1, except that polyvinylidene fluoride is not added.

[0039] Comparative Example 2 This application provides a piezoelectric composite hydrogel as a comparative example. The preparation method of the piezoelectric composite hydrogel is the same as that in Example 1, except that ZnO nanowires are not added.

[0040] Comparative Example 3 This application provides a piezoelectric composite hydrogel as a comparative example. The preparation method of the piezoelectric composite hydrogel is the same as that in Example 1, except that polyvinylidene fluoride and ZnO nanowires are not added.

[0041] Comparative Example 4 This application provides a piezoelectric composite hydrogel as a comparative example. The preparation method of the piezoelectric composite hydrogel is the same as that in Example 1, except that step S103 is not performed.

[0042] This application presents the high-voltage electrochemical composite hydrogel prepared in Example 1, and analyzes its morphology, SEM, flexibility, tensile properties, adhesion, and wearable application properties to obtain the following results. Figure 1-5 Meanwhile, this application tested the piezoelectric properties of the piezoelectric composite hydrogels prepared in Example 1 and Comparative Example 1 under different degrees of stretching, and obtained the results. Figure 6 .

[0043] From the appendix Figure 1 , 2 As can be seen, the high-voltage electrochemical composite hydrogel prepared in Example 1 of this application has a semi-transparent thin film appearance and a three-dimensional network structure inside, with ZnO nanowires distributed in the three-dimensional network structure.

[0044] From the appendix Figure 3 , 4As can be seen, the high-voltage electrochemical composite hydrogel prepared in Example 1 of this application has good flexibility and tensile properties, and the tensile length can reach 5 times its own length; the high-voltage electrochemical composite hydrogel has the least adhesion to leather and the greatest adhesion to glass, so it will not stick to clothing when used as a wound skin repair material.

[0045] From the appendix Figure 5 As can be seen, the composite hydrogel sensor exhibits broad adaptability to movements in multiple parts of the body. The fluctuation of the voltage curve visually presents the "motion-signal" conversion process, fully verifying the piezoelectric properties and sensing sensitivity of the material. The combined presentation of "motion scenario + voltage signal + wearing form" vividly demonstrates the application potential of this composite hydrogel in the field of flexible electronics, namely, using the piezoelectric effect to convert biomechanical motion into resolvable electrical signals, empowering the fields of health monitoring and energy harvesting.

[0046] From the appendix Figure 6 As can be seen, with the increase of the stretching distance, the piezoelectric coefficient d33 value of the high-voltage electrostatic composite hydrogel prepared in Example 1 of this application reaches 125 pc / N, while the piezoelectric coefficient d33 value of the piezoelectric composite hydrogel prepared in Comparative Example 1 is 0.2 pc / N, which is much smaller than the piezoelectric coefficient of the high-voltage electrostatic composite hydrogel in Example 1. This indicates that the addition of polyvinylidene fluoride and ZnO nanowires, as well as mechanical stretching polarization, can significantly improve the piezoelectric properties of the composite hydrogel.

[0047] The above description is merely a preferred embodiment of this application and is not intended to limit this application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A method for preparing a high-voltage electrochemical composite hydrogel for wound skin repair, characterized in that, include: ZnO nanowires were added to deionized water and then ultrasonically dispersed. Hydroxyethyl cellulose aqueous solution, polyvinylidene fluoride solution, acrylamide monomer, crosslinking agent, plasticizer and initiator were added under ultrasonic conditions, and the mixture was reacted at 50-60℃ to obtain a hydrogel precursor solution. The hydrogel precursor solution is transferred into a mold and dried to form a composite hydrogel. The composite hydrogel was subjected to multiple uniaxial stretching and polarization processes to obtain a high-voltage composite hydrogel.

2. The method for preparing the high-voltage electrochemical composite hydrogel for wound skin repair according to claim 1, characterized in that, According to the weight parts, the amounts of each component are as follows: 0.5-1 parts ZnO nanowires, 1 part hydroxyethyl cellulose, 0.08-0.12 parts polyvinylidene fluoride, 0.8-1.2 parts acrylamide monomer, 0.08-0.12 parts crosslinking agent, 0.8-1.2 parts plasticizer and 0.006-0.008 parts initiator.

3. The method for preparing the high-voltage electrochemical composite hydrogel for wound skin repair according to claim 1, characterized in that, The preparation of the hydroxyethyl cellulose aqueous solution includes: adding hydroxyethyl cellulose to deionized water, heating and stirring at 50-60°C until completely dissolved to form a hydroxyethyl cellulose aqueous solution.

4. The method for preparing the high-voltage electrochemical composite hydrogel for wound skin repair according to claim 1, characterized in that, The preparation of the polyvinylidene fluoride solution includes: adding polyvinylidene fluoride to N,N-dimethylformamide and stirring at room temperature until completely dissolved to form a polyvinylidene fluoride solution.

5. The method for preparing the high-voltage electrochemical composite hydrogel for wound skin repair according to claim 1, characterized in that, The concentration of the hydroxyethyl cellulose aqueous solution is 1-5 wt%, and the molecular weight is 300,000-1,500,000; the concentration of the polyvinylidene fluoride solution is 3-6 wt%.

6. The method for preparing the high-voltage electrochemical composite hydrogel for wound skin repair according to claim 1, characterized in that, The crosslinking agent includes one or more of aluminum chloride hexahydrate, calcium chloride, or aluminum citrate; the plasticizer includes one or more of glycerol, ethylene glycol, or polyethylene glycol; and the initiator is one or more of ammonium persulfate, potassium persulfate, or azobisisobutyronitrile.

7. The method for preparing the high-voltage electrochemical composite hydrogel for wound skin repair according to claim 1, characterized in that, The drying temperature is 60-80℃ and the drying time is 4-8 hours.

8. The method for preparing the high-voltage electrochemical composite hydrogel for wound skin repair according to claim 1, characterized in that, The ultrasonic power is 200-500W, and the ultrasonic time is 10-30min.

9. The method for preparing the high-voltage electrochemical composite hydrogel for wound skin repair according to claim 1, characterized in that, The strain of the uniaxial tensile polarization is 100-400%.

10. A high-voltage electrochemical composite hydrogel for wound skin repair prepared by the preparation method according to any one of claims 1-9.

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