Dioscorea nipponica effective components for treating acute gouty arthritis and extracting method thereof

Abstract

The invention discloses an extract of dioscorea nipponica effective components for treating acute gouty arthritis and an extracting method thereof. The extract is prepared by the following steps of: crushing the dioscorea nipponica, then using water for decoction, extracting, collecting water decoction liquid and filtering; or using 10-95% ethanol to conduct extracting after crushing the dioscorea nipponica, then collecting ethanol extraction and recycling the ethanol. The dioscorea nipponica effective components for treating acute gouty arthritis are rich in active ingredients and have pharmacological actions of lowering uric acid, anti-inflammation and analgesia. The effective components not only can relieve inflammatory reactions of swelling thermal pain in acute stage, but also can lower uric acid level in blood aiming at pathogenesis, treat the primary and the secondary aspects simultaneously for gout and can be used for preparing medicaments with good curative effects for preventing and treating acute gouty arthritis safely and reliably. The extracting technology of the effective components is simple, does not need high-temperature or high-pressure or special equipment, and has safety, easy operation and low cost.

Description

technical field

[0001] The invention relates to an effective part of a traditional Chinese medicine, in particular to an effective part of pangolinus for treating acute gouty arthritis. The method for extracting the effective part of the invention belongs to the field of traditional Chinese medicine for treating gouty arthritis. Background technique

[0002] Studies have shown that the prevalence of gout is rising rapidly in both developed and developing countries. The first symptom of gout is acute gouty arthritis. If it is not properly treated, it will not only bring great pain to the patient, but also easily lead to serious consequences such as joint deformity, kidney stones, and kidney damage. Therefore, acute gouty arthritis has become a threat to human health. A serious disease for which there is still no cure. Therefore, there is an urgent need to find effective Chinese medicines for the prevention and treatment of acute gouty arthritis, so as to control the occurren...

Examples

Embodiment 1

[0016] Cut 1000g of dried roots and rhizomes of Pangosia chinensis, crush them, soak for 30 minutes, add 6 times the weight of water, and decoct for 1 hour to obtain a decoction; the decoction is concentrated to 1g / ml on an AB-8 macroporous adsorption resin column, and used Elute with distilled water until colorless, collect the eluate to obtain component I; then elute with 30% ethanol until colorless, collect the eluate to obtain component II; recover ethanol, and then elute with 50% ethanol until no color, collect the eluate, recover ethanol to obtain component III; then elute with 70% ethanol until colorless, collect the eluate, recover ethanol to obtain component IV.

Embodiment 2

[0018] Slice 1000g of dried roots and rhizomes of Pangosia chinensis, crush them, soak for 30 minutes, add 8 times the weight of water, decoct for 1 hour, decoct twice, combine the decoctions to obtain a decoction; concentrate the decoction to 2g / ml D101 Type macroporous adsorption resin column, eluted with 6 times of distilled water, discarded the eluent, then eluted with 8 times of 30% ethanol, collected the eluate, recovered ethanol, obtained component II, and then eluted with 50% ethanol until colorless, collect the eluent, recover ethanol, and obtain component III; then elute with 70% ethanol until colorless, collect the eluent, recover ethanol, and obtain component IV.

Embodiment 3

[0020] Cut 1000 g of dried roots and rhizomes of Pangosia chinensis, crush them, add 3 times the weight of 70% ethanol, reflux extraction 4 times, combine the extracts, recover the ethanol, and obtain the effective part extract of Pangosia pangolins (component V).

technical field

[0001] The invention relates to an effective part of a traditional Chinese medicine, in particular to an effective part of pangolinus for treating acute gouty arthritis. The method for extracting the effective part of the invention belongs to the field of traditional Chinese medicine for treating gouty arthritis. Background technique

[0002] Studies have shown that the prevalence of gout is rising rapidly in both developed and developing countries. The first symptom of gout is acute gouty arthritis. If it is not properly treated, it will not only bring great pain to the patient, but also easily lead to serious consequences such as joint deformity, kidney stones, and kidney damage. Therefore, acute gouty arthritis has become a threat to human health. A serious disease for which there is still no cure. Therefore, there is an urgent need to find effective Chinese medicines for the prevention and treatment of acute gouty arthritis, so as to control the occurren...

Examples

Embodiment 1

[0016] Cut 1000g of dried roots and rhizomes of Pangosia chinensis, crush them, soak for 30 minutes, add 6 times the weight of water, and decoct for 1 hour to obtain a decoction; the decoction is concentrated to 1g / ml on an AB-8 macroporous adsorption resin column, and used Elute with distilled water until colorless, collect the eluate to obtain component I; then elute with 30% ethanol until colorless, collect the eluate to obtain component II; recover ethanol, and then elute with 50% ethanol until no color, collect the eluate, recover ethanol to obtain component III; then elute with 70% ethanol until colorless, collect the eluate, recover ethanol to obtain component IV.

Embodiment 2

[0018] Slice 1000g of dried roots and rhizomes of Pangosia chinensis, crush them, soak for 30 minutes, add 8 times the weight of water, decoct for 1 hour, decoct twice, combine the decoctions to obtain a decoction; concentrate the decoction to 2g / ml D101 Type macroporous adsorption resin column, eluted with 6 times of distilled water, discarded the eluent, then eluted with 8 times of 30% ethanol, collected the eluate, recovered ethanol, obtained component II, and then eluted with 50% ethanol until colorless, collect the eluent, recover ethanol, and obtain component III; then elute with 70% ethanol until colorless, collect the eluent, recover ethanol, and obtain component IV.

Embodiment 3

[0020] Cut 1000 g of dried roots and rhizomes of Pangosia chinensis, crush them, add 3 times the weight of 70% ethanol, reflux extraction 4 times, combine the extracts, recover the ethanol, and obtain the effective part extract of Pangosia pangolins (component V).

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