Traditional Chinese medicine composition for psoriasis and preparation method thereof

Abstract

The invention relates to a traditional Chinese medicine composition for psoriasis and a preparation method thereof. The traditional Chinese medicine composition is prepared by two medicines of rhizoma smilacis glabrae and smilax china L.. The composition has an effect of expelling wind and detoxifying, and is mainly used for treating psoriasis. Compared with the prior art, the composition is advanced in technology, clinical pharmacodynamic test results of the composition is improved significantly, the bioavailability is high, and the composition has no any side effects.

Description

technical field

[0001] The invention relates to a traditional Chinese medicine composition for psoriasis and a preparation method thereof, belonging to the technical field of pharmacy. technical background

[0002] Psoriasis is a common skin disease that seriously affects the daily life and work of patients. At present, there are many Chinese patent medicines for the treatment of psoriasis, but most of them have unsatisfactory curative effect, low cure rate and easy recurrence. "Yinxie Granules" under the item WS3-B-2033-95 of the tenth volume of "Prescriptions of Traditional Chinese Medicine" issued by the Ministry of Standards is a pure Chinese medicine preparation. After years of clinical use, the drug has achieved certain results in the treatment of psoriasis. Curative effect; but in the clinical application, we found that its curative effect is not ideal, and there are defects such as low cure rate, easy recurrence, and rough craftsmanship; the granules contain sugar p...

Examples

Embodiment 1

[0113] Formula ratio:

[0114] Smilax 3375g Smilax 3375g;

[0115] The preparation method is as follows: the above two flavors and sarsaparilla are crushed into coarse powder, and percolated twice, the first time with 8 times the amount of 85% ethanol, and the second time with 8 times the amount of 60% ethanol for percolation, the percolation speed to 5ml / min, combine the above percolation liquids, decompress and recover ethanol (-0.08Mpa, 70°C) and concentrate to a clear paste with a relative density of 1.05-1.10 (60°C±1) for later use; Add water to decoct Smilax smilax three times, add 12 times the amount of water for the first time, decoct for 3 hours, add 10 times the amount of water for the second and third times, decoct for 2 hours respectively, combine the decoctions, filter, and concentrate the filtrate under reduced pressure ( -0.08MPa, 80°C) to a clear paste with a relative density of 1.05-1.10 (60°C±1), combine with the above clear paste, mix evenly, and spray dry ...

Embodiment 2

[0117] Formula ratio:

[0118] Smilax 3375g Smilax 3375g;

[0119] The preparation method is as follows: the above two flavors and sarsaparilla are crushed into coarse powder, and percolated twice, the first time with 8 times the amount of 85% ethanol, and the second time with 8 times the amount of 60% ethanol for percolation, the percolation speed to 5ml / min, combine the above percolation liquids, decompress and recover ethanol (-0.08Mpa, 70°C) and concentrate to a clear paste with a relative density of 1.05-1.10 (60°C±1) for later use; Add water to decoct Smilax smilax three times, add 12 times the amount of water for the first time, decoct for 3 hours, add 10 times the amount of water for the second and third times, decoct for 2 hours respectively, combine the decoctions, filter, and concentrate the filtrate under reduced pressure ( -0.08MPa, 80°C) to a clear paste with a relative density of 1.05-1.10 (60°C±1), combine with the above clear paste, mix evenly, and spray dry ...

Embodiment 3

[0121] Formula ratio:

[0122] Smilax 3375g Smilax 3375g;

[0123] The preparation method is as follows: the above two flavors and sarsaparilla are crushed into coarse powder, and percolated twice, the first time with 8 times the amount of 85% ethanol, and the second time with 8 times the amount of 60% ethanol for percolation, the percolation speed to 5ml / min, combine the above percolation liquids, decompress and recover ethanol (-0.08Mpa, 70°C) and concentrate to a clear paste with a relative density of 1.05-1.10 (60°C±1) for later use; Add water to decoct Smilax smilax three times, add 12 times the amount of water for the first time, decoct for 3 hours, add 10 times the amount of water for the second and third times, decoct for 2 hours respectively, combine the decoctions, filter, and concentrate the filtrate under reduced pressure ( -0.08MPa, 80°C) to a clear paste with a relative density of 1.05-1.10 (60°C±1), combine with the above clear paste, mix evenly, and spray dry ...

technical field

[0001] The invention relates to a traditional Chinese medicine composition for psoriasis and a preparation method thereof, belonging to the technical field of pharmacy. technical background

[0002] Psoriasis is a common skin disease that seriously affects the daily life and work of patients. At present, there are many Chinese patent medicines for the treatment of psoriasis, but most of them have unsatisfactory curative effect, low cure rate and easy recurrence. "Yinxie Granules" under the item WS3-B-2033-95 of the tenth volume of "Prescriptions of Traditional Chinese Medicine" issued by the Ministry of Standards is a pure Chinese medicine preparation. After years of clinical use, the drug has achieved certain results in the treatment of psoriasis. Curative effect; but in the clinical application, we found that its curative effect is not ideal, and there are defects such as low cure rate, easy recurrence, and rough craftsmanship; the granules contain sugar p...

Examples

Embodiment 1

[0113] Formula ratio:

[0114] Smilax 3375g Smilax 3375g;

[0115] The preparation method is as follows: the above two flavors and sarsaparilla are crushed into coarse powder, and percolated twice, the first time with 8 times the amount of 85% ethanol, and the second time with 8 times the amount of 60% ethanol for percolation, the percolation speed to 5ml / min, combine the above percolation liquids, decompress and recover ethanol (-0.08Mpa, 70°C) and concentrate to a clear paste with a relative density of 1.05-1.10 (60°C±1) for later use; Add water to decoct Smilax smilax three times, add 12 times the amount of water for the first time, decoct for 3 hours, add 10 times the amount of water for the second and third times, decoct for 2 hours respectively, combine the decoctions, filter, and concentrate the filtrate under reduced pressure ( -0.08MPa, 80°C) to a clear paste with a relative density of 1.05-1.10 (60°C±1), combine with the above clear paste, mix evenly, and spray dry ...

Embodiment 2

[0117] Formula ratio:

[0118] Smilax 3375g Smilax 3375g;

[0119] The preparation method is as follows: the above two flavors and sarsaparilla are crushed into coarse powder, and percolated twice, the first time with 8 times the amount of 85% ethanol, and the second time with 8 times the amount of 60% ethanol for percolation, the percolation speed to 5ml / min, combine the above percolation liquids, decompress and recover ethanol (-0.08Mpa, 70°C) and concentrate to a clear paste with a relative density of 1.05-1.10 (60°C±1) for later use; Add water to decoct Smilax smilax three times, add 12 times the amount of water for the first time, decoct for 3 hours, add 10 times the amount of water for the second and third times, decoct for 2 hours respectively, combine the decoctions, filter, and concentrate the filtrate under reduced pressure ( -0.08MPa, 80°C) to a clear paste with a relative density of 1.05-1.10 (60°C±1), combine with the above clear paste, mix evenly, and spray dry ...

Embodiment 3

[0121] Formula ratio:

[0122] Smilax 3375g Smilax 3375g;

[0123] The preparation method is as follows: the above two flavors and sarsaparilla are crushed into coarse powder, and percolated twice, the first time with 8 times the amount of 85% ethanol, and the second time with 8 times the amount of 60% ethanol for percolation, the percolation speed to 5ml / min, combine the above percolation liquids, decompress and recover ethanol (-0.08Mpa, 70°C) and concentrate to a clear paste with a relative density of 1.05-1.10 (60°C±1) for later use; Add water to decoct Smilax smilax three times, add 12 times the amount of water for the first time, decoct for 3 hours, add 10 times the amount of water for the second and third times, decoct for 2 hours respectively, combine the decoctions, filter, and concentrate the filtrate under reduced pressure ( -0.08MPa, 80°C) to a clear paste with a relative density of 1.05-1.10 (60°C±1), combine with the above clear paste, mix evenly, and spray dry ...

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