A kind of preparation method and application of emulsion polymerized salicylic acid molecularly imprinted membrane

Abstract

The invention relates to a preparation method and an application of an emulsion polymerization salicylic acid molecularly imprinted membrane, which belongs to the technical field of material preparation. The invention particularly provides a new method for preparing a salicylic acid molecularly imprinted membrane (MIM) through a water-in-oil emulsion polymerization method with polypropylene microfiltration membrane as a substrate, impurity-salicylic acid(SA) in aspirin as a template molecule, methacrylic acid (MAA) or 4-vinyl pyridine (4-VP) as a functional monomer, span 80 as an emulsifier, toluene as a continuous phase, ethylene glycol di(methacrylic acid) ester (EGDMA) as a crosslinking agent and azobisisobutyronitrile (AIBN) as an initiator, and the selective recognition performance of the prepared molecularly imprinted membrane is researched by a selective permeation experiment. As shown in the result, the salicylic acid molecularly imprinted membrane obtained by the preparation method has excellent salicylic acid molecule recognition performance.

Description

technical field

[0001] The invention belongs to the field of material preparation, and relates to a preparation method of a salicylic acid molecularly imprinted membrane, in particular to a new method for preparing a molecularly imprinted membrane by using an emulsion polymerization method. Background technique

[0002] Aspirin, also known as acetylsalicylic acid, is an antipyretic and analgesic with a long history. It is used to treat colds, fever, headache, toothache, joint pain, rheumatism, and to prevent and treat ischemic heart disease and angina. , cardiopulmonary infarction, and cerebral thrombosis are also effective in angioplasty and bypass grafting. Aspirin is usually obtained by esterification of salicylic acid and acetic anhydride. Therefore, the by-product salicylic acid is often produced in the product, and aspirin is easily hydrolyzed to produce salicylic acid during storage. Some data show that if the concentration of salicylic acid in aspirin exceeds the s...

Examples

Embodiment 1

[0033] (1) Mix 2 mmol of methacrylic acid (MAA), 5 mmol of ethylene glycol di(methacrylate) (EGDMA), and 0.2 g of Span 80 into 60 mL of toluene. (The concentration of MAA is 33.3 mmol L -1 , the concentration of EGDMA is 83.3 mmol L -1 , the concentration of Span 80 is 3.33 g L -1 ).

[0034] (2) Add 0.018 g salicylic acid (SA) into 10 mL deionized water (the concentration of SA is 1.8 g L -1 ), then add this solution to the above (1) and mix it with ultrasound for 15 minutes to form a water-in-oil emulsion, then add 0.0140 g of azoisobutyronitrile (AIBN) into the water-in-oil emulsion, keep it at room temperature for 30 minutes after ultrasonication for 5 minutes The upper organic layer was then removed to concentrate the emulsion.

[0035] (3) Take 100 mg PP film in a beaker containing 10 mL of acetone for 15 min, take it out to dry at room temperature, place it in a watch glass, add an appropriate amount of oleic acid to the watch glass to infiltrate the film surface, a...

Embodiment 2

[0045] (1) Mix 4 mmol 4-vinylpyridine (4-VP), 10 mmol ethylene glycol di(methacrylate) (EGDMA), and 0.6 g Span 80 into 60 mL toluene. (The concentration of 4-VP is 66.7 mmol L -1 , the concentration of EGDMA is 166.7 mmol L -1 , the concentration of Span 80 is 10.0 g L -1 ).

[0046] (2) Add 0.054 g salicylic acid (SA) into 30 mL deionized water (the concentration of SA is 1.8 g L -1 ), then add this solution to the above (1) and mix with ultrasound for 15 minutes to form a water-in-oil emulsion, then add 0.043 g of azoisobutyronitrile (AIBN) into the water-in-oil emulsion, keep it at room temperature for 30 minutes after ultrasonication for 5 minutes The upper organic layer was then removed to concentrate the emulsion.

[0047] (3) Take 120 mg PP film in a beaker containing 12 mL of acetone for 15 min, take it out to dry at room temperature, place it in a watch glass, add an appropriate amount of oleic acid to the watch glass to infiltrate the film surface, and then immer...

technical field

[0001] The invention belongs to the field of material preparation, and relates to a preparation method of a salicylic acid molecularly imprinted membrane, in particular to a new method for preparing a molecularly imprinted membrane by using an emulsion polymerization method. Background technique

[0002] Aspirin, also known as acetylsalicylic acid, is an antipyretic and analgesic with a long history. It is used to treat colds, fever, headache, toothache, joint pain, rheumatism, and to prevent and treat ischemic heart disease and angina. , cardiopulmonary infarction, and cerebral thrombosis are also effective in angioplasty and bypass grafting. Aspirin is usually obtained by esterification of salicylic acid and acetic anhydride. Therefore, the by-product salicylic acid is often produced in the product, and aspirin is easily hydrolyzed to produce salicylic acid during storage. Some data show that if the concentration of salicylic acid in aspirin exceeds the s...

Examples

Embodiment 1

[0033] (1) Mix 2 mmol of methacrylic acid (MAA), 5 mmol of ethylene glycol di(methacrylate) (EGDMA), and 0.2 g of Span 80 into 60 mL of toluene. (The concentration of MAA is 33.3 mmol L -1 , the concentration of EGDMA is 83.3 mmol L -1 , the concentration of Span 80 is 3.33 g L -1 ).

[0034] (2) Add 0.018 g salicylic acid (SA) into 10 mL deionized water (the concentration of SA is 1.8 g L -1 ), then add this solution to the above (1) and mix it with ultrasound for 15 minutes to form a water-in-oil emulsion, then add 0.0140 g of azoisobutyronitrile (AIBN) into the water-in-oil emulsion, keep it at room temperature for 30 minutes after ultrasonication for 5 minutes The upper organic layer was then removed to concentrate the emulsion.

[0035] (3) Take 100 mg PP film in a beaker containing 10 mL of acetone for 15 min, take it out to dry at room temperature, place it in a watch glass, add an appropriate amount of oleic acid to the watch glass to infiltrate the film surface, a...

Embodiment 2

[0045] (1) Mix 4 mmol 4-vinylpyridine (4-VP), 10 mmol ethylene glycol di(methacrylate) (EGDMA), and 0.6 g Span 80 into 60 mL toluene. (The concentration of 4-VP is 66.7 mmol L -1 , the concentration of EGDMA is 166.7 mmol L -1 , the concentration of Span 80 is 10.0 g L -1 ).

[0046] (2) Add 0.054 g salicylic acid (SA) into 30 mL deionized water (the concentration of SA is 1.8 g L -1 ), then add this solution to the above (1) and mix with ultrasound for 15 minutes to form a water-in-oil emulsion, then add 0.043 g of azoisobutyronitrile (AIBN) into the water-in-oil emulsion, keep it at room temperature for 30 minutes after ultrasonication for 5 minutes The upper organic layer was then removed to concentrate the emulsion.

[0047] (3) Take 120 mg PP film in a beaker containing 12 mL of acetone for 15 min, take it out to dry at room temperature, place it in a watch glass, add an appropriate amount of oleic acid to the watch glass to infiltrate the film surface, and then immer...

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