A kind of preparation method of dendrimer modified magnetic nanocrystalline cellulose surface imprinted polymer

Abstract

The invention relates to the field of food science. Aiming at the problems of irregular polymer shape, few effective binding sites and slow mass transfer speed in the traditional polymer imprinting technology of the prior art, a dendrimer-modified magnetic The preparation method of nanocrystalline cellulose surface-imprinted polymers includes four preparation steps: (1) activation of magnetic Fe 3 o 4 Nanoparticles, Alkylated Magnetic Fe 3 o 4 Nanoparticles; (2) Synthesis of magnetic nanocrystalline cellulose; (3) Grafting dendrimers; (4) Preparation of magnetic nanocrystalline cellulose surface imprinted polymers modified by dendrimers. The present invention combines nanomaterials with surface imprinting technology, which can effectively realize the regular structure of dendritic polymers, and the obtained surface imprinted polymers have a large specific surface area, high adsorption rate, strong adsorption capacity and pore capacity , the molecular surface can provide abundant imprinting sites, and the imprinted polymer can realize rapid separation and improve the imprinting efficiency.

Description

technical field

[0001] The invention relates to the field of food science, in particular to a preparation method of dendrimer-modified magnetic nanocrystalline cellulose surface imprinted polymer. Background technique

[0002] Molecular imprinting technology is a technology for preparing polymers with specific recognition properties for target molecules, and surface molecular imprinting is one of the current research focuses in the field of molecular imprinting technology. The surface molecular imprinting method is based on the original preparation method of molecular imprinting technology, a newly emerging method of forming imprinted polymers from polymers. The shortcomings of embedding too deep and not easy to elute, using the surface imprinting method to effectively reduce embedding, and it is easy to elute the imprinted molecules.

[0003] Patent No. CN2013107390846, the title of the patent is "A Preparation Method of Magnetic Zinc Ion Surface Imprinted Polymer", the me...

Examples

Embodiment 1

[0033] A method for preparing dendrimer-modified magnetic nanocrystalline cellulose surface imprinted polymers, the specific preparation steps are as follows:

[0034] (1) Activated magnetic Fe 3 o 4 Nanoparticles: Add 3-propyltrimethoxysilane to deionized water, raise the temperature to 40°C, add magnetic Fe 3 o 4 Nanoparticles, stirring and constant temperature reaction for 35min, magnetic separation, and drying to obtain alkylated magnetic Fe 3 o 4 nanoparticles;

[0035] (2) Synthesis of magnetic nanocrystalline cellulose: nanocrystalline cellulose and methylene succinic acid are added in the aqueous solution of acetic acid, stirred and dissolved to obtain a mixed solution, the mass ratio of nanocrystalline cellulose and methylene succinic acid is 1 :5; Alkylated magnetic Fe 3 o 4 Add the nanoparticles into the mixed solution, raise the temperature to 48°C, add the initiator diisopropyl peroxydicarbonate, react at a constant temperature for 43 minutes, and magnetica...

Embodiment 2

[0039] The difference from Example 1 is that a method for preparing a dendrimer-modified magnetic nanocrystalline cellulose surface imprinted polymer, the specific preparation steps are as follows:

[0040] (1) Activated magnetic Fe 3 o 4 Nanoparticles: Add 3-propyltrimethoxysilane to deionized water, heat up to 35°C, add magnetic Fe 3 o 4 Nanoparticles, stirred and reacted at constant temperature for 30-40min, magnetically separated, and dried to obtain alkylated magnetic Fe 3 o 4 nanoparticles;

[0041] (2) Synthesis of magnetic nanocrystalline cellulose: nanocrystalline cellulose and methylene succinic acid are added in the aqueous solution of acetic acid, stirred and dissolved to obtain a mixed solution, the mass ratio of nanocrystalline cellulose and methylene succinic acid is 1 :4; Alkylated magnetic Fe 3 o 4 Add the nanoparticles into the mixed solution, raise the temperature to 45°C, add the initiator diisopropyl peroxydicarbonate, react at a constant temperatur...

Embodiment 3

[0045] The difference from Example 1 is that a method for preparing a dendrimer-modified magnetic nanocrystalline cellulose surface imprinted polymer, the specific preparation steps are as follows:

[0046] (1) Activated magnetic Fe 3 o 4 Nanoparticles: Add 3-propyltrimethoxysilane to deionized water, heat up to 45°C, add magnetic Fe 3 o 4 Nanoparticles, stirred and reacted at constant temperature for 40 minutes, magnetically separated, and dried to obtain alkylated magnetic Fe 3 o 4 nanoparticles;

[0047] (2) Synthesis of magnetic nanocrystalline cellulose: nanocrystalline cellulose and methylene succinic acid are added in the aqueous solution of acetic acid, stirred and dissolved to obtain a mixed solution, the mass ratio of nanocrystalline cellulose and methylene succinic acid is 1 :6; Alkylated magnetic Fe 3 o 4 Add the nanoparticles into the mixed solution, raise the temperature to 50°C, add the initiator diisopropyl peroxydicarbonate, react at a constant temperat...

technical field

[0001] The invention relates to the field of food science, in particular to a preparation method of dendrimer-modified magnetic nanocrystalline cellulose surface imprinted polymer. Background technique

[0002] Molecular imprinting technology is a technology for preparing polymers with specific recognition properties for target molecules, and surface molecular imprinting is one of the current research focuses in the field of molecular imprinting technology. The surface molecular imprinting method is based on the original preparation method of molecular imprinting technology, a newly emerging method of forming imprinted polymers from polymers. The shortcomings of embedding too deep and not easy to elute, using the surface imprinting method to effectively reduce embedding, and it is easy to elute the imprinted molecules.

[0003] Patent No. CN2013107390846, the title of the patent is "A Preparation Method of Magnetic Zinc Ion Surface Imprinted Polymer", the me...

Examples

Embodiment 1

[0033] A method for preparing dendrimer-modified magnetic nanocrystalline cellulose surface imprinted polymers, the specific preparation steps are as follows:

[0034] (1) Activated magnetic Fe 3 o 4 Nanoparticles: Add 3-propyltrimethoxysilane to deionized water, raise the temperature to 40°C, add magnetic Fe 3 o 4 Nanoparticles, stirring and constant temperature reaction for 35min, magnetic separation, and drying to obtain alkylated magnetic Fe 3 o 4 nanoparticles;

[0035] (2) Synthesis of magnetic nanocrystalline cellulose: nanocrystalline cellulose and methylene succinic acid are added in the aqueous solution of acetic acid, stirred and dissolved to obtain a mixed solution, the mass ratio of nanocrystalline cellulose and methylene succinic acid is 1 :5; Alkylated magnetic Fe 3 o 4 Add the nanoparticles into the mixed solution, raise the temperature to 48°C, add the initiator diisopropyl peroxydicarbonate, react at a constant temperature for 43 minutes, and magnetica...

Embodiment 2

[0039] The difference from Example 1 is that a method for preparing a dendrimer-modified magnetic nanocrystalline cellulose surface imprinted polymer, the specific preparation steps are as follows:

[0040] (1) Activated magnetic Fe 3 o 4 Nanoparticles: Add 3-propyltrimethoxysilane to deionized water, heat up to 35°C, add magnetic Fe 3 o 4 Nanoparticles, stirred and reacted at constant temperature for 30-40min, magnetically separated, and dried to obtain alkylated magnetic Fe 3 o 4 nanoparticles;

[0041] (2) Synthesis of magnetic nanocrystalline cellulose: nanocrystalline cellulose and methylene succinic acid are added in the aqueous solution of acetic acid, stirred and dissolved to obtain a mixed solution, the mass ratio of nanocrystalline cellulose and methylene succinic acid is 1 :4; Alkylated magnetic Fe 3 o 4 Add the nanoparticles into the mixed solution, raise the temperature to 45°C, add the initiator diisopropyl peroxydicarbonate, react at a constant temperatur...

Embodiment 3

[0045] The difference from Example 1 is that a method for preparing a dendrimer-modified magnetic nanocrystalline cellulose surface imprinted polymer, the specific preparation steps are as follows:

[0046] (1) Activated magnetic Fe 3 o 4 Nanoparticles: Add 3-propyltrimethoxysilane to deionized water, heat up to 45°C, add magnetic Fe 3 o 4 Nanoparticles, stirred and reacted at constant temperature for 40 minutes, magnetically separated, and dried to obtain alkylated magnetic Fe 3 o 4 nanoparticles;

[0047] (2) Synthesis of magnetic nanocrystalline cellulose: nanocrystalline cellulose and methylene succinic acid are added in the aqueous solution of acetic acid, stirred and dissolved to obtain a mixed solution, the mass ratio of nanocrystalline cellulose and methylene succinic acid is 1 :6; Alkylated magnetic Fe 3 o 4 Add the nanoparticles into the mixed solution, raise the temperature to 50°C, add the initiator diisopropyl peroxydicarbonate, react at a constant temperat...

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