Production technique of pharmaceutical gelatin

Abstract

The invention relates to a production technique of a gelatin, particularly a production technique of a pharmaceutical gelatin, which comprises the following steps: pretreatment technique, degelatinizing, filtering, ion exchange, film concentration, plate drying, sterilization, gumming, drying, pulverization and inspection to obtain the finished product. The invention is characterized in that the pretreatment technique adopts an alkali-hydrogen peroxide-acid composite process and combines with the subsequent techniques to constitute an acid-alkali-hydrogen peroxide three-element process for producing the high-quality gelatin. The jelly strength and viscosity of the first three gelatins extracted in the degelatinizing process are obviously improved as compared with the single acid process or alkali process. The skin material treatment time is greatly shortened as compared with the alkali process. Besides, the alkali treatment is performed at normal temperature, thereby saving the energy and water on the premise of ensuring the high quality of the product.

Description

technical field

[0001] The invention relates to a production method of gelatin, in particular to a production process of medicinal gelatin. Background technique

[0002] Generally speaking, gelatin can be divided into two categories: animal glue and leather glue. Among them, animal glue refers to the glue made from collagen-containing tissues such as animal skin, bone, tendon, horn core, and scale after purification and primary hydrolysis. It can be derived from traditional pigs, cattle, fish, It can also be derived from other mammals such as sheep, horses, and camels. Moreover, the quality of the gelatin produced from the skin corners of different animal sources and different parts of the same animal source is not the same. Therefore, gelatin can be divided into industrial gelatin, edible gelatin, medicinal gelatin and photographic gelatin. kind.

[0003] The main composition of gelatin is a mixture of 18 amino acid polypeptide molecules with the same composition and a w...

Examples

Embodiment 1

[0031] In this embodiment, 1 kg of pigskin (the collagen content of which is measured to be 256.4 g) is used for processing through the pretreatment process of the present invention, including the following steps:

[0032] (a) Skin cutting: use a leather cutter to cut the leather into strips, and transfer it to the washing tank with a delivery pump;

[0033] (b) Alkali treatment: add water to the leather, add 1.0% liquid caustic soda sodium hydroxide, and soak for 2 hours;

[0034] (c) Hydrogen peroxide pretreatment: add hydrogen peroxide with a concentration of 10% to the lye in (b) to treat the raw skin,

[0035] Soak at room temperature for 6 days;

[0036] (d) Separation: Use a separation system to separate skin water and recover liquid alkali;

[0037] (e) Water washing: wash the leather in the washing tank until the pH value of the solution is 6.5;

[0038] (f) Pickling: Add sulfuric acid to make the pH of the solution reach 2.1, and the soaking time is 18 hours;

[...

Embodiment 2

[0052] In this embodiment, 1 kg of cowhide (278.2 g of collagen content was measured) was used to carry out the process through the pretreatment process of the present invention.

[0053] row processing, including the following steps:

[0054] (a) Skin cutting: use a leather cutter to cut the leather into strips, and transfer it to the washing tank with a delivery pump;

[0055] (b) Alkali treatment: Add water to the leather, add 0.8% liquid caustic soda sodium hydroxide, and soak for 2 hours;

[0056] (c) Hydrogen peroxide pretreatment: add hydrogen peroxide with a concentration of 5% to the lye in (b) to treat the raw skin,

[0057] Soak at room temperature for 8 days;

[0058] (d) Separation: Use a separation system to separate skin water and recover liquid alkali;

[0059] (e) Water washing: wash the leather in the washing tank until the pH value of the solution is 7.2;

[0060] (f) Pickling: add sulfuric acid to make the pH of the solution reach 2.4, and the soaking t...

Embodiment 3

[0067] In this embodiment, 1 kg of cowhide (278.2 g of collagen content was measured) was used to carry out the process through the pretreatment process of the present invention.

[0068] row processing, including the following steps:

[0069] (a) Skin cutting: use a leather cutter to cut the leather into strips, and transfer it to the washing tank with a delivery pump;

[0070] (b) Alkali treatment: add water to the leather, add 0.9% liquid caustic soda sodium hydroxide, and soak for 2 hours;

[0071] (c) Hydrogen peroxide pretreatment: add hydrogen peroxide with a concentration of 20% to the lye in (b) to treat the raw skin,

[0072] Soak for 5 days at room temperature;

[0073] (d) Separation: Use a separation system to separate skin water and recover liquid alkali;

[0074] (e) Water washing: wash the leather in the washing tank until the pH value of the solution is 6.8;

[0075] (f) Pickling: Add sulfuric acid to make the pH of the solution reach 1.8, and the soaking ...

technical field

[0001] The invention relates to a production method of gelatin, in particular to a production process of medicinal gelatin. Background technique

[0002] Generally speaking, gelatin can be divided into two categories: animal glue and leather glue. Among them, animal glue refers to the glue made from collagen-containing tissues such as animal skin, bone, tendon, horn core, and scale after purification and primary hydrolysis. It can be derived from traditional pigs, cattle, fish, It can also be derived from other mammals such as sheep, horses, and camels. Moreover, the quality of the gelatin produced from the skin corners of different animal sources and different parts of the same animal source is not the same. Therefore, gelatin can be divided into industrial gelatin, edible gelatin, medicinal gelatin and photographic gelatin. kind.

[0003] The main composition of gelatin is a mixture of 18 amino acid polypeptide molecules with the same composition and a w...

Examples

Embodiment 1

[0031] In this embodiment, 1 kg of pigskin (the collagen content of which is measured to be 256.4 g) is used for processing through the pretreatment process of the present invention, including the following steps:

[0032] (a) Skin cutting: use a leather cutter to cut the leather into strips, and transfer it to the washing tank with a delivery pump;

[0033] (b) Alkali treatment: add water to the leather, add 1.0% liquid caustic soda sodium hydroxide, and soak for 2 hours;

[0034] (c) Hydrogen peroxide pretreatment: add hydrogen peroxide with a concentration of 10% to the lye in (b) to treat the raw skin,

[0035] Soak at room temperature for 6 days;

[0036] (d) Separation: Use a separation system to separate skin water and recover liquid alkali;

[0037] (e) Water washing: wash the leather in the washing tank until the pH value of the solution is 6.5;

[0038] (f) Pickling: Add sulfuric acid to make the pH of the solution reach 2.1, and the soaking time is 18 hours;

[...

Embodiment 2

[0052] In this embodiment, 1 kg of cowhide (278.2 g of collagen content was measured) was used to carry out the process through the pretreatment process of the present invention.

[0053] row processing, including the following steps:

[0054] (a) Skin cutting: use a leather cutter to cut the leather into strips, and transfer it to the washing tank with a delivery pump;

[0055] (b) Alkali treatment: Add water to the leather, add 0.8% liquid caustic soda sodium hydroxide, and soak for 2 hours;

[0056] (c) Hydrogen peroxide pretreatment: add hydrogen peroxide with a concentration of 5% to the lye in (b) to treat the raw skin,

[0057] Soak at room temperature for 8 days;

[0058] (d) Separation: Use a separation system to separate skin water and recover liquid alkali;

[0059] (e) Water washing: wash the leather in the washing tank until the pH value of the solution is 7.2;

[0060] (f) Pickling: add sulfuric acid to make the pH of the solution reach 2.4, and the soaking t...

Embodiment 3

[0067] In this embodiment, 1 kg of cowhide (278.2 g of collagen content was measured) was used to carry out the process through the pretreatment process of the present invention.

[0068] row processing, including the following steps:

[0069] (a) Skin cutting: use a leather cutter to cut the leather into strips, and transfer it to the washing tank with a delivery pump;

[0070] (b) Alkali treatment: add water to the leather, add 0.9% liquid caustic soda sodium hydroxide, and soak for 2 hours;

[0071] (c) Hydrogen peroxide pretreatment: add hydrogen peroxide with a concentration of 20% to the lye in (b) to treat the raw skin,

[0072] Soak for 5 days at room temperature;

[0073] (d) Separation: Use a separation system to separate skin water and recover liquid alkali;

[0074] (e) Water washing: wash the leather in the washing tank until the pH value of the solution is 6.8;

[0075] (f) Pickling: Add sulfuric acid to make the pH of the solution reach 1.8, and the soaking ...

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