Controlled-release metronidazole membrane for teeth

Abstract

A metronidazole dental slow-release drug film is characterized in that the composition includes: metronidazole standard substance, sodium carboxymethylcellulose, polyvinyl alcohol-124; its ratio is: metronidazole 10.71 1%, carboxy Sodium methylcellulose 28.58%, polyvinyl alcohol-124 42.85%, starch 17.86%. It solves the problems of oral tablet metronidazole in the treatment of periodontal disease, large dose of medicine, poor medical effect, and large side effects, and is widely suitable for the use of periodontal disease patients.

Description

technical field

[0001] The invention relates to the field of preparations of medical drugs, in particular to a preparation method of a metronidazole dental slow-release film. Background technique

[0002] At present, in drug treatment of periodontal disease, it is mainly completed by taking metronidazole tablet orally. Its disadvantages are that the dosage of the drug is large, the concentration of the drug in the local periodontal area is low, the medical effect is poor, and it is highly irritating to the gastrointestinal tract. Contents of the invention

[0003] In order to solve the problems of large dosage, poor medical effect and large side effects of oral metronidazole in the treatment of periodontal disease, the present invention invents an absorbable metronidazole drug film using polymer material as a slow-release carrier.

[0004] The technical solution of the present invention is a metronidazole sustained-release dental film, the composition of which includes: ...

Examples

Embodiment 1

[0010] Example 1, take 10.71 grams of metronidazole, 28.58 grams of sodium carboxymethylcellulose, 42.85 grams of polyvinyl alcohol-124, and 17.86 grams of starch. First soak 42.85 grams of polyvinyl alcohol-124 and 28.58 grams of sodium carboxymethyl cellulose for 10 hours to dissolve respectively, and grind 10.71 grams of metronidazole and 17.86 grams of starch with water, then mix the above-mentioned 42.85 grams of polyvinyl alcohol-124, 28.58 gram carboxymethylcellulose sodium, 10.71 gram metronidazole, and 17.86 gram starch gelatinous liquid are mixed and stirred evenly; then add preservatives and sodium saccharin, dilute with distilled water to form an easy-to-apply paste, and spread it on a flat board. Thin layer, dry naturally to form a film.

Embodiment 2

[0011] Example 2, take 21.42 grams of metronidazole, 57.16 grams of sodium carboxymethylcellulose, 85.70 grams of polyvinyl alcohol-124, and 35.72 grams of starch. First soak 85.70 grams of polyvinyl alcohol-124 and 57.16 grams of sodium carboxymethyl cellulose for 14 hours to dissolve, and grind 21.42 grams of metronidazole and 35.72 grams of starch with water, then mix the above-mentioned 85.70 grams of polyvinyl alcohol-124, 57.16 gram carboxymethyl cellulose sodium, 21.42 gram metronidazole, 35.72 gram starch colloidal solution, mix and stir evenly; then add preservatives, saccharin sodium, dilute with distilled water and reconcile into a paste that is easy to smear, spread out on a flat board Thin layer, dry naturally to form a film.

technical field

[0001] The invention relates to the field of preparations of medical drugs, in particular to a preparation method of a metronidazole dental slow-release film. Background technique

[0002] At present, in drug treatment of periodontal disease, it is mainly completed by taking metronidazole tablet orally. Its disadvantages are that the dosage of the drug is large, the concentration of the drug in the local periodontal area is low, the medical effect is poor, and it is highly irritating to the gastrointestinal tract. Contents of the invention

[0003] In order to solve the problems of large dosage, poor medical effect and large side effects of oral metronidazole in the treatment of periodontal disease, the present invention invents an absorbable metronidazole drug film using polymer material as a slow-release carrier.

[0004] The technical solution of the present invention is a metronidazole sustained-release dental film, the composition of which includes: ...

Examples

Embodiment 1

[0010] Example 1, take 10.71 grams of metronidazole, 28.58 grams of sodium carboxymethylcellulose, 42.85 grams of polyvinyl alcohol-124, and 17.86 grams of starch. First soak 42.85 grams of polyvinyl alcohol-124 and 28.58 grams of sodium carboxymethyl cellulose for 10 hours to dissolve respectively, and grind 10.71 grams of metronidazole and 17.86 grams of starch with water, then mix the above-mentioned 42.85 grams of polyvinyl alcohol-124, 28.58 gram carboxymethylcellulose sodium, 10.71 gram metronidazole, and 17.86 gram starch gelatinous liquid are mixed and stirred evenly; then add preservatives and sodium saccharin, dilute with distilled water to form an easy-to-apply paste, and spread it on a flat board. Thin layer, dry naturally to form a film.

Embodiment 2

[0011] Example 2, take 21.42 grams of metronidazole, 57.16 grams of sodium carboxymethylcellulose, 85.70 grams of polyvinyl alcohol-124, and 35.72 grams of starch. First soak 85.70 grams of polyvinyl alcohol-124 and 57.16 grams of sodium carboxymethyl cellulose for 14 hours to dissolve, and grind 21.42 grams of metronidazole and 35.72 grams of starch with water, then mix the above-mentioned 85.70 grams of polyvinyl alcohol-124, 57.16 gram carboxymethyl cellulose sodium, 21.42 gram metronidazole, 35.72 gram starch colloidal solution, mix and stir evenly; then add preservatives, saccharin sodium, dilute with distilled water and reconcile into a paste that is easy to smear, spread out on a flat board Thin layer, dry naturally to form a film.