A controllable and degradable calcium phosphate bone cement and its preparation method

Abstract

The invention discloses a calcium phosphate bone cement degradable under regulation. The calcium phosphate bone cement is prepared from the following raw materials: a liquid-phase agent and a solid-phase powder. The liquid-phase agent is a common calcium phosphate bone cement liquid-phase agent or a mixed liquid of a two-dimensional black phosphorus nano-material dispersion liquid and the common calcium phosphate bone cement liquid-phase agent, wherein the two-dimensional black phosphorus nano-material dispersion liquid is a mixed liquid of a two-dimensional black phosphorus nano-material anddeionized water. The solid-phase powder is a mixture of a temperature-sensitive oxygen-produced compound and a calcium phosphate bone cement solid-phase powder, wherein the temperature-sensitive oxygen-produced compound is a sodium percarbonate-wax microsphere composite suface-coated with a gelatin layer, and the sodium percarbonate-wax microsphere composite is a sodium percarbonate microsphere composite coated with a wax layer. The invention also discloses a preparation method for the above-mentioned calcium phosphate bone cement degradable under regulation. The calcium phosphate bone cementprepared in the invention can be accelerated in degradation rate through both heat treatment and near-infrared light treatment, and is good in safety and suitable for mass production.

Description

technical field

[0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an adjustable and degradable calcium phosphate bone cement and a preparation method thereof. Background technique

[0002] Calcium phosphate bone cement is a biomedical material that can not only help the repair and reconstruction of human hard tissues, but also serve as a carrier for drug release. Calcium phosphate bone cement has the advantages of easy preparation and arbitrary shaping. Compared with other bone cements, it has better biocompatibility, does not generate heat during solidification and crystallization, and has higher safety. However, the in vivo degradation rate of the existing calcium phosphate bone cement is relatively slow, which hinders the regeneration and reconstruction of human bone tissue to a certain extent, and it is impossible to realize the controllable degradation of calcium phosphate bone cement in vitro. At present, there a...

Examples

Embodiment 1

[0044] A controllable and degradable calcium phosphate bone cement, the raw materials of which include liquid-phase agent and solid-phase powder.

[0045] The liquid phase agent is a mixed solution of a two-dimensional black phosphorus nanomaterial dispersion liquid with a volume ratio of 1:9 and a common calcium phosphate bone cement liquid phase agent, and the two-dimensional black phosphorus nanomaterial dispersion liquid is a two-dimensional black phosphorus nanomaterial dispersion liquid. The mixed solution of the material and deionized water, the mass fraction of the two-dimensional black phosphorus nanomaterial dispersion in the two-dimensional black phosphorus nanomaterial dispersion is 2%.

[0046] The solid-phase powder is a mixture of a temperature-sensitive oxygen-generating compound and an ordinary calcium phosphate bone cement solid-phase powder, wherein the mass fraction of the temperature-sensitive oxygen-generating compound in the solid-phase powder is 5%; the ...

Embodiment 2

[0048] This example is based on Example 1, with the only difference that: the liquid phase agent is a common calcium phosphate bone cement liquid phase agent.

Embodiment 3

[0050] A controllable and degradable calcium phosphate bone cement, the raw materials of which include liquid-phase agent and solid-phase powder.

[0051] The liquid phase agent is a mixed solution of a two-dimensional black phosphorus nanomaterial dispersion liquid with a volume ratio of 1:9 and a common calcium phosphate bone cement liquid phase agent, and the two-dimensional black phosphorus nanomaterial dispersion liquid is a two-dimensional black phosphorus nanomaterial dispersion liquid. The mixed solution of the material and deionized water, the mass fraction of the two-dimensional black phosphorus nanomaterial dispersion in the two-dimensional black phosphorus nanomaterial dispersion liquid is 0.01%.

[0052] The solid-phase powder is a mixture of a temperature-sensitive oxygen-generating compound and an ordinary calcium phosphate bone cement solid-phase powder, wherein the mass fraction of the temperature-sensitive oxygen-generating compound in the solid-phase powder is ...

technical field

[0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an adjustable and degradable calcium phosphate bone cement and a preparation method thereof. Background technique

[0002] Calcium phosphate bone cement is a biomedical material that can not only help the repair and reconstruction of human hard tissues, but also serve as a carrier for drug release. Calcium phosphate bone cement has the advantages of easy preparation and arbitrary shaping. Compared with other bone cements, it has better biocompatibility, does not generate heat during solidification and crystallization, and has higher safety. However, the in vivo degradation rate of the existing calcium phosphate bone cement is relatively slow, which hinders the regeneration and reconstruction of human bone tissue to a certain extent, and it is impossible to realize the controllable degradation of calcium phosphate bone cement in vitro. At present, there a...

Examples

Embodiment 1

[0044] A controllable and degradable calcium phosphate bone cement, the raw materials of which include liquid-phase agent and solid-phase powder.

[0045] The liquid phase agent is a mixed solution of a two-dimensional black phosphorus nanomaterial dispersion liquid with a volume ratio of 1:9 and a common calcium phosphate bone cement liquid phase agent, and the two-dimensional black phosphorus nanomaterial dispersion liquid is a two-dimensional black phosphorus nanomaterial dispersion liquid. The mixed solution of the material and deionized water, the mass fraction of the two-dimensional black phosphorus nanomaterial dispersion in the two-dimensional black phosphorus nanomaterial dispersion is 2%.

[0046] The solid-phase powder is a mixture of a temperature-sensitive oxygen-generating compound and an ordinary calcium phosphate bone cement solid-phase powder, wherein the mass fraction of the temperature-sensitive oxygen-generating compound in the solid-phase powder is 5%; the ...

Embodiment 2

[0048] This example is based on Example 1, with the only difference that: the liquid phase agent is a common calcium phosphate bone cement liquid phase agent.

Embodiment 3

[0050] A controllable and degradable calcium phosphate bone cement, the raw materials of which include liquid-phase agent and solid-phase powder.

[0051] The liquid phase agent is a mixed solution of a two-dimensional black phosphorus nanomaterial dispersion liquid with a volume ratio of 1:9 and a common calcium phosphate bone cement liquid phase agent, and the two-dimensional black phosphorus nanomaterial dispersion liquid is a two-dimensional black phosphorus nanomaterial dispersion liquid. The mixed solution of the material and deionized water, the mass fraction of the two-dimensional black phosphorus nanomaterial dispersion in the two-dimensional black phosphorus nanomaterial dispersion liquid is 0.01%.

[0052] The solid-phase powder is a mixture of a temperature-sensitive oxygen-generating compound and an ordinary calcium phosphate bone cement solid-phase powder, wherein the mass fraction of the temperature-sensitive oxygen-generating compound in the solid-phase powder is ...

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