A kind of pharmaceutical composition and its preparation method and application

Abstract

The invention provides a pharmaceutical composition and its preparation method and application, which belong to the field of medicine. The medicinal composition is a mixed extract of fennel fennel and thorn bean. The medicinal composition can suppress the allergic reaction of the body, suppress the local tissue edema and the enhancement of blood vessel permeability caused by allergic mediators. Simultaneously, the medicinal composition can obviously prolong the cough latency time, and has obvious inhibitory effect on the cough. In addition, the medicinal composition can also obviously promote the secretion ability of the tracheal mucous membrane, and has the obvious effect of stimulating the upper respiratory tract to shoot phlegm. It is thus suggested that the pharmaceutical composition can be used for preparing anti-allergic, antitussive, expectorant and other drugs, especially for the preparation of drugs for treating asthma and allergic rhinitis, and has broad application prospects.

Description

technical field

[0001] The present invention relates to the field of medicine, in particular to a pharmaceutical composition and its preparation method and application. Background technique

[0002] Asthma, also known as bronchial asthma, bronchial asthma is a chronic airway inflammation involving a variety of cells and cell components. This inflammation is often accompanied by increased airway responsiveness, resulting in recurrent wheezing, shortness of breath, chest tightness and / or Symptoms such as coughing mostly occur at night and / or in the early morning. Such symptoms are often accompanied by extensive and variable airflow obstruction, which can be reversed spontaneously or through treatment.

[0003] At present, in the process of treating allergic diseases such as asthma, hormonal antiallergic drugs are mostly used. During its long-term use, it is likely to cause side effects such as obesity, and it is prone to repeated illness and long treatment time. In view of t...

Examples

preparation example Construction

[0027] Further, the preparation method of the pharmaceutical composition comprises:

[0028] Mix the mixed medicinal materials formed by fennel and spinach and 70-100% ethanol solution according to the ratio of solid to liquid: 1:15-25, and reflux extraction for 2-4 times, each time for 0.5-1.5h, concentrate the obtained extract, dry Dry.

[0029] Preferably, the temperature of the reflux extraction is 60-80°C, or 65-75°C, or 70°C.

[0030] Preferably, the ratio of solid to liquid is 1:17-24, or 1:19-22, or 1:20.

[0031] Preferably, the concentration of the ethanol solution is 80-100%, or 90-100%, or 95%.

[0032] Preferably, extraction is performed 2 to 3 times, 0.8 to 1.2 hours each time; or 3 times, 1 hour each time.

[0033] This embodiment also provides a liquid preparation for treating asthma and allergic rhinitis, which is prepared by mixing the above pharmaceutical composition with sterile water to form a 5-500 g / L medicinal liquid and filtering it.

[0034] Prefe...

Embodiment 1

[0038] This embodiment provides a pharmaceutical composition, which comprises fennel fennel and Oxytropis falciparum at a mass ratio of 1:1.

[0039] The preparation method of this pharmaceutical composition comprises:

[0040] The fennel and Oxytropis falciparum were mixed according to the mass ratio of 1:1, and mixed with 95% ethanol according to the ratio of solid to liquid of 1:20, and refluxed and extracted at 70°C for 3 times, each time for 1h. The supernatant is recovered, concentrated, dried, and pulverized to obtain the obtained product.

Embodiment 2

[0042] The present embodiment provides a pharmaceutical composition, which comprises fennel and Oxytropis falciparum at a mass ratio of 1:5.

[0043] The preparation method of this pharmaceutical composition comprises:

[0044] Mix fennel and Oxytropis falciparum at a mass ratio of 1:5, and with absolute ethanol at a solid-to-liquid ratio of 1:15, and extract twice at 80°C under reflux, each time for 1.5h. The supernatant is recovered, concentrated, dried, and pulverized to obtain the obtained product.

technical field

[0001] The present invention relates to the field of medicine, in particular to a pharmaceutical composition and its preparation method and application. Background technique

[0002] Asthma, also known as bronchial asthma, bronchial asthma is a chronic airway inflammation involving a variety of cells and cell components. This inflammation is often accompanied by increased airway responsiveness, resulting in recurrent wheezing, shortness of breath, chest tightness and / or Symptoms such as coughing mostly occur at night and / or in the early morning. Such symptoms are often accompanied by extensive and variable airflow obstruction, which can be reversed spontaneously or through treatment.

[0003] At present, in the process of treating allergic diseases such as asthma, hormonal antiallergic drugs are mostly used. During its long-term use, it is likely to cause side effects such as obesity, and it is prone to repeated illness and long treatment time. In view of t...

Examples

preparation example Construction

[0027] Further, the preparation method of the pharmaceutical composition comprises:

[0028] Mix the mixed medicinal materials formed by fennel and spinach and 70-100% ethanol solution according to the ratio of solid to liquid: 1:15-25, and reflux extraction for 2-4 times, each time for 0.5-1.5h, concentrate the obtained extract, dry Dry.

[0029] Preferably, the temperature of the reflux extraction is 60-80°C, or 65-75°C, or 70°C.

[0030] Preferably, the ratio of solid to liquid is 1:17-24, or 1:19-22, or 1:20.

[0031] Preferably, the concentration of the ethanol solution is 80-100%, or 90-100%, or 95%.

[0032] Preferably, extraction is performed 2 to 3 times, 0.8 to 1.2 hours each time; or 3 times, 1 hour each time.

[0033] This embodiment also provides a liquid preparation for treating asthma and allergic rhinitis, which is prepared by mixing the above pharmaceutical composition with sterile water to form a 5-500 g / L medicinal liquid and filtering it.

[0034] Prefe...

Embodiment 1

[0038] This embodiment provides a pharmaceutical composition, which comprises fennel fennel and Oxytropis falciparum at a mass ratio of 1:1.

[0039] The preparation method of this pharmaceutical composition comprises:

[0040] The fennel and Oxytropis falciparum were mixed according to the mass ratio of 1:1, and mixed with 95% ethanol according to the ratio of solid to liquid of 1:20, and refluxed and extracted at 70°C for 3 times, each time for 1h. The supernatant is recovered, concentrated, dried, and pulverized to obtain the obtained product.

Embodiment 2

[0042] The present embodiment provides a pharmaceutical composition, which comprises fennel and Oxytropis falciparum at a mass ratio of 1:5.

[0043] The preparation method of this pharmaceutical composition comprises:

[0044] Mix fennel and Oxytropis falciparum at a mass ratio of 1:5, and with absolute ethanol at a solid-to-liquid ratio of 1:15, and extract twice at 80°C under reflux, each time for 1.5h. The supernatant is recovered, concentrated, dried, and pulverized to obtain the obtained product.

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