Analyzer metering device

Abstract

The present invention relates to an analyzer metering device, belonging to the technical field of metering devices. The device comprises a pump, a valve, a mixing reactor and a connecting pipe; the pump, the valve and the mixing reactor are connected in series through the connecting pipe to form an integral series flow path, and the pump and the mixing reactor are respectively located at the head and tail ends of the series flow path; the series flow path has at least three normally open common channel ports and at least two pairs of single channel ports, each of which can be switched on and off, and the two single channel ports are connected in parallel to form a pair; the single channel ports are used to connect at least two samples externally; the valve and the connecting pipe connected in series between two adjacent common channel ports constitute a metering channel with a quantitative volume, and the series flow path has at least two sections of metering channels. The device can simultaneously inject more than two quantitative samples into the mixing reactor during the operation of the sample analyzer and facilitates the flushing of the samples.

Description

Technical Field

[0001] The invention relates to a metering device for an analyzer, belonging to the technical field of metering devices. Background Art

[0002] The metering device is an indispensable part of the analyzer equipment, and the performance of the metering device directly affects the performance of the analyzer. Traditional metering methods generally include peristaltic pumps, diaphragm metering pumps, pulse metering pumps, syringe metering pumps, etc., but these conventional metering methods are often difficult to measure when measuring trace reagents or measuring excessively large ratios (such as reagent 1: reagent 2 greater than 100:1), and the repeatability is poor when measuring large ratios.

[0003] Chinese patent 201010176350.5 automatic analyzer metering device can accurately measure multiple samples and large-ratio micro-samples. However, the device uses parallel pipelines for micro-metering, and it is inconvenient to flush the samples retained in the pipelines, and additional power and flushing agents are required; and only one quantitative sample can be injected into the mixing reactor one by one, and more than two quantitative samples cannot be injected into the mixing reactor at the same time. Summary of the invention

[0004] The technical problem to be solved by the present invention is to enable the metering device to simultaneously inject more than two quantitative samples into the mixing reactor during the operation of the sample analyzer and facilitate the flushing of the samples.

[0005] The technical solution proposed by the present invention to solve the above technical problems is: an analyzer metering device, including a pump, a valve, a mixing reactor and a connecting pipe; the pump, the valve and the mixing reactor are connected in series through the connecting pipe to form an integral series flow path, and the pump and the mixing reactor are respectively located at the head and tail ends of the series flow path; the series flow path has at least three normally open common channel ports and at least two pairs of single channel ports, each single channel port can be switched on and off, and two single channel ports are connected in parallel to each other to form a pair; the single channel ports are used to externally connect at least two samples; the valve and the connecting pipe connected in series between two adjacent common channel ports constitute a metering channel with a quantitative volume, and the series flow path has at least two sections of the metering channels.

[0006] The beneficial effects of the present invention are as follows: since the pump, mixing reactor and valve are connected in series through a connecting pipe to form an overall series flow path, more than two quantitative samples can be stored and injected into the mixing reactor at the same time on the entire series flow path, and the connecting pipes or containers (with quantitative volumes) and valves (with quantitative volumes) between the pump and the valve and between the valves are used as metering channels, and all samples are connected in series in the flow path entering the final reactor or mixing reactor, which can achieve single sample metering one by one and two or more samples metering and mixing at the same time. Moreover, the sample with a large dose is stored near the proximal end of the pump, and the sample with a large dose pushes the sample with a small dose into the mixing reactor first and enters the mixing reactor itself last, so that the sample with a small dose can be completely rinsed; the sample with a large dose has a large dose itself, so even if there is a trace amount of it remaining in the flow path, it will not affect the metering too much and can be ignored.

[0007] The first improvement of the above technical solution is: the pump adopts a dual pump in parallel, each pump can be switched on and off independently, the valve is at least two two-position three-way valves connected in series, the parallel interface of the dual pumps and the common interface of the two-position three-way valve constitute the common channel port, and the normally open interface and the normally closed interface of the two-position three-way valve constitute the single channel port.

[0008] Furthermore, the pump is a single pump, and the valve is at least three two-position three-way valves connected in series, the common interface of the two-position three-way valve constitutes the common channel port, and the normally open interface and the normally closed interface of the two-position three-way valve constitute the single channel port.

[0009] The second improvement of the above technical solution is: the pump adopts a parallel dual pump, each pump can be independently switched on and off, and the parallel interface of the dual pumps constitutes the common channel port; the valve is at least two multi-channel rotary valves with at least three channels; the middle channel port of every three adjacent channels of the multi-channel rotary valve constitutes the common channel port, and the other two channel ports constitute the single channel port.

[0010] The third improvement of the above technical solution is: the pump adopts a dual pump in parallel, each pump can be switched on and off independently, and the parallel interface of the dual pump constitutes the common channel port; the valve is at least two valve groups consisting of a tee and two stop valves connected to the tee in parallel, the port of the stop valve constitutes the single channel port, and the converging interface of the tee and the stop valve constitutes the common channel port.

[0011] Furthermore, the pump adopts a single pump; the valve is a valve group consisting of at least three valves consisting of a tee and two stop valves connected to the tee in parallel, the port of the stop valve constitutes the single channel port, and the converging interface of the tee and the stop valve constitutes the common channel port.

[0012] Furthermore, the mixing reactor is also connected with a direct discharge pipe.

[0013] Furthermore, an intermediate tube with a quantitative volume is connected between two adjacent single-channel ports in the series flow path; when the sample passes through the intermediate tube, the intermediate tube serves as a part of the metering channel.

[0014] Furthermore, there are four two-position three-way valves; wherein, the common channel port of the first two-position three-way valve is connected to the common channel port of the dual pumps, the two single channel ports of the second two-position three-way valve are respectively connected to the common channel port of the third two-position three-way valve and the common channel port of the fourth two-position three-way valve, the two single channel ports of the third two-position three-way valve are respectively connected to the two mixing reactors, one single channel port of the first two-position three-way valve is connected to the first sample, and the two single channel ports of the fourth two-position three-way valve are respectively connected to the second sample and the third sample.

[0015] Furthermore, a closed container with a quantitative volume is provided on the connecting pipe. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The analyzer metering device of the present invention will be further described below in conjunction with the accompanying drawings.

[0017] Figure 1 This is a control circuit diagram of the analyzer metering device in Example 1

[0018] Figure 2 This is a control circuit diagram of the analyzer metering device of Example 2

[0019] Figure 3 This is a control circuit diagram of the analyzer metering device of Example 3

[0020] Figure 4 This is a control circuit diagram of the analyzer metering device of the fourth embodiment.

[0021] Figure 5 This is a control circuit diagram of the first state of the analyzer metering device in Example 5

[0022] Figure 6 This is a control circuit diagram of the second state of the analyzer metering device in Example 5

[0023] Figure 7 This is a control circuit diagram of the third state of the analyzer metering device in Example 5

[0024] Figure 8 This is a control circuit diagram of the analyzer metering device of Example 6

[0025] Fig. 9 This is a control circuit diagram of the analyzer metering device of Example 7

[0026] Fig.10It is a control loop diagram of the analyzer metering device of Example 8. DETAILED DESCRIPTION

[0027] Embodiment 1

[0028] The analyzer metering device of this embodiment is as follows: Figure 1 As shown, it includes a pump Lp, a valve, a mixing reactor MIX and a connecting pipe. The valves are respectively a first two-position three-way valve H1 and a second two-position three-way valve H2 connected in series, and the pump Lp uses a pair of pumps P1 and P2 connected in parallel. The parallel interface of the two pumps P1 and P2 constitutes a common channel port COM0, the respective common interfaces of the first two-position three-way valve H1 and the second two-position three-way valve H2 constitute common channel ports COM1 and COM2 respectively, and the respective normally open interfaces and normally closed interfaces of the first two-position three-way valve H1 and the second two-position three-way valve H2 constitute single channel ports N01 and N02 for normally opening, and single channel ports NC1 and NC2 for normally closing. The connecting pipes include connecting pipes L1 and L2, and the pump Lp, the first two-position three-way valve H1, the second two-position three-way valve H2 and the mixing reactor MIX are connected in series through the connecting pipes to form an overall series flow path, and the pump Lp and the mixing reactor MIX are respectively located at the head and tail ends of the series flow path; wherein the common channel port COM0 of the pump Lp and the common channel port COM1 of the first two-position three-way valve H1 are connected through the connecting pipe L1 with a quantitative volume, the single channel port NC1 (or NO1) of the first two-position three-way valve H1 and the common channel port COM2 of the second two-position three-way valve H2 are connected through the connecting pipe L2 with a quantitative volume, and the single channel port NC2 (of course it can also be the single channel port N02) of the second two-position three-way valve H2 is connected to the mixing reactor MIX through a general connecting pipe.

[0029] The single-channel ports N01 and N02 (of course, they can also be single-channel ports NC1 and NC2, i.e., any single-channel port of the valve) of the first two-position three-way valve H1 and the second two-position three-way valve H2 are used to connect two samples SA1 and SA2 respectively. The channel between the adjacent common channel ports COM0 and COM1 (including the connecting pipe L1 in the series flow path and the first two-position three-way valve H1) constitutes the first section of the metering channel (denoted as V1) with a quantitative volume; the channel between the adjacent common channel ports COM1 and COM2 (including the first two-position three-way valve H1, the connecting pipe L2, and the second two-position three-way valve H2) constitutes the second section of the metering channel (denoted as V1) with a quantitative volume. In this way, the sample has two metering volumes V1 and V2 when metering.

[0030] When working, the pump Lp sucks at P1, the single-channel port NC1 of the first two-position three-way valve H1 and the single-channel port N02 of the second two-position three-way valve H2 are both opened, and the sample SA2 enters from the single-channel port N02 of the second two-position three-way valve H2 and is stored in "NO2-V2-V1-P1". After a while, the single-channel port NC1 is closed, and the sample SA1 enters from the single-channel port N01 of the first two-position three-way valve H1 and is stored in "NO1-V1-P1", and the SA2 previously stored in "V1-P1" is replaced by SA1. After a while, the suction of P1 of pump Lp stops, and then the single channel port NC1 of the first two-position three-way valve H1, the closed single channel port NC2 of the second two-position three-way valve H2, and the blowing of P2 of pump Lp are opened in sequence; at this time, SA1 and SA2 stored in "V1-V2" enter the mixing reactor MIX from the single channel port NC2 of the second two-position three-way valve H2 and mix or react in the mixing reactor MIX. Thus, SA1:SA2=V1:V2 is realized.

[0031] If the workflow is slightly changed, pump Lp's P1 sucks, the single-channel port NC1 of the first two-position three-way valve H1 is opened, and the sample SA2 enters from the single-channel port N02 of the second two-position three-way valve H2 in sequence and is stored in "NO2-V2-V1-P1". After a while, pump Lp's P1 sucks and stops, and then the single-channel port NC2 of the second two-position three-way valve H2 and pump Lp's P2 are opened in sequence; at this time, SA2 stored in "V1-V2" enters the mixing reactor MIX from the single-channel port NC2 of the second two-position three-way valve H2. After another moment, the single-channel port NC1 of the first two-position three-way valve H1, the single-channel port NC2 of the second two-position three-way valve H2 and pump Lp's P2 are closed for blowing, and then pump Lp's P1 sucks; at this time, the sample SA1 enters from the single-channel port N01 of the first two-position three-way valve H1 in sequence and is stored in "V1-P1". After a while, the suction of P1 of pump Lp stops, and then the single channel port NC1 of the first two-position three-way valve H1, the single channel port NC2 of the second two-position three-way valve H2 and the P2 of pump Lp are opened in sequence to blow; at this time, SA1 stored in "V1" enters the mixing reactor MIX from the single channel port NC2 of the second two-position three-way valve H2 and mixes or reacts with the previously added SA2 in the mixing reactor MIX. Thus, SA1: SA2 = V1: (V1 + V2) is realized.

[0032] Generally speaking, the dosage of SA1 is greater than that of SA2, that is, the sample SA1 with a large dosage is stored near the proximal end of the pump Lp, and the pump Lp drives the samples SA1 and SA2 in the flow path. The large-dose SA1 can completely flush the sample SA2 with a small dosage in the flow path and bring it into the mixing reactor MIX. Since the dosage of SA1 is large, even if there is a trace amount remaining in the flow path, it can be ignored.

[0033] When it is necessary to discharge the mixed liquid in the mixing reactor MIX, open the single channel port NC2 of the second two-position three-way valve H2, the single channel port NC1 of the first two-position three-way valve H1 and the P1 suction of the pump Lp in sequence, so that the liquid in the mixing reactor MIX is discharged through the "NC2-V2-V1-P1" channel in sequence.

[0034] Embodiment 2

[0035] This embodiment is a variation of the first embodiment. In addition to being the same as the first embodiment, the difference is that the parallel double pumps P1 and P2 of the pump Lp are replaced with Figure 2 The single pump shown is added with a two-position three-way valve. When the pump is needed to realize the blowing function during work, it is first sucked through P and NO0, and the liquid inside the pump body is replaced by air, so that the metering volume V1 of the sample ignores the influence of the pump Lp.

[0036] Embodiment 3

[0037] This embodiment is a variation of the first embodiment, and is the same as the first embodiment except that: Figure 3 As shown, a third two-position three-way valve H3 is added, connected in series to the second two-position three-way valve H2, and a connecting pipe L3 is added. In this way, the following can be achieved:

[0038] 1. The dosage of SA1 is V1; the dosage of SA2 can be V2 or V1+V2; the dosage of SA3 can be V3, V2+V3 or V1+V2+V3.

[0039] 2. If SA2 is air, it is also possible to achieve only SA1:SA3==V1:V2, and SA1 and SA2 are added to the mixing reactor MIX separately at different times.

[0040] Embodiment 4

[0041] This embodiment is a variation of the first embodiment, and is the same as the first embodiment except that: Figure 4 As shown, the first two-position three-way valve H1 is replaced by a three-way valve T1 and two stop valves D1 and D2, and the second two-position three-way valve H2 is replaced by another three-way valve T2 and another two stop valves D3 and D4. The ports of the stop valves D1, D2, D3, and D4 form a single channel port, the convergence interface of the three-way valve T1 and the stop valves D1 and D2 forms a common channel port, and the convergence interface of the three-way valve T2 and the stop valves D3 and D4 forms another common channel port.

[0042] Embodiment 5

[0043] This embodiment is a variation of the first embodiment, and is the same as the first embodiment except that: Figure 5 , Figure 6 and Figure 7 As shown, two multi-channel rotary valves X1 and X2 are used to replace the two-position three-way valves H1 and H2. In the figure, the channel port 5 of the rotary valves X1 and X2 is used as a common channel port, and the channel ports 4 and 6 are used as single channel ports respectively. Figure 5 It shows the state of the two samples SA1 and SA2 when they are mixed and discharged. Figure 6 The display shows the state when the sample SA2 is sucked in. Figure 7 The state when the sample SA1 is sucked is shown. The middle channel openings of every three adjacent channels of the multi-channel rotary valves X1 and X2 constitute a common channel opening, and the other two channel openings of the three adjacent channels constitute a single channel opening. The three adjacent channels can act as a two-position three-way valve. The moving plates of the multi-channel rotary valves X1 and X2 are switched left and right at a fixed angle, and the annular arc grooves on the moving plates enable the middle channel opening to be alternately connected and switched with the channel openings on both sides.

[0044] Embodiment 6

[0045] This embodiment is a variation of the second embodiment, and is different from the second embodiment in that: Figure 8 As shown, the mixing reactor MIX is connected to NO0 via a direct discharge pipe Lmix. Thus, when the mixing reactor MIX is empty, it is equivalent to the second embodiment. Figure 2 The effect of air AIR entering from the single channel port NO0 of the first two-position three-way valve H1 can be achieved, and the following can be achieved: when the mixed liquid in the mixing reactor MIX needs to be discharged, the P suction of the liquid flow driver Lp is opened, so that the liquid in the mixer MIX is directly discharged smoothly from the "MIX-Lmix-COM0-P suction" channel. And when the demand for sample SA1 or SA2 is large, a closed container with a quantitative volume can also be added to the connecting pipe L1 or L2.

[0046] Obviously, the direct discharge pipe Lmix can also be connected to the liquid flow driver Lp from other channel ports of the series flow path.

[0047] Embodiment 7

[0048] This embodiment is a variation of the third embodiment. In addition to being the same as the third embodiment, the difference is that: Fig. 9 As shown:

[0049] 1) The connecting pipe L2 is moved between the common channels COM2 and COM3 of the second two-position three-way valve H2 and the third two-position three-way valve H3, the connecting pipe L3 is removed, and an intermediate pipe LX is connected between the single channel port NC1 of the first two-position three-way valve H1 and the single channel port NO2 of the second two-position three-way valve H2. When SA2 quantitative sampling passes through LX, the channels between COM1-NC1-LX-NO2-COM2-L2-COM3 constitute a metering channel V2 with a quantitative volume; when SA2 quantitative sampling does not pass through LX but passes through Lmix, LX is empty, and the channels between "COM2-L2-COM3" constitute a metering channel V2 with a quantitative volume.

[0050] 2) A direct discharge pipe Lmix is ​​connected between the single channel port NC2 of the second two-position three-way valve H2 and the mixer Lp. This allows the liquid in the mixer MIX to be discharged from the "MIX-L2-NC2-Lmix-P1 suction" channel.

[0051] Embodiment 8

[0052] This embodiment is a variation of the third embodiment. In addition to being the same as the third embodiment, the difference is that: Fig.10 As shown:

[0053] A fourth two-position three-way valve H4 is added, the common channel port COM1 of the first two-position three-way valve H1 is connected to the common channel port COM0 of the dual pumps, the two single channel ports NC2 and NO2 of the second two-position three-way valve H2 are respectively connected to the common channel port COM3 of the third two-position three-way valve H3 and the common channel port COM4 of the fourth two-position three-way valve H4, the two single channel ports NC3 and NO3 of the third two-position three-way valve H3 are respectively connected to the two mixing reactors MIX1 and MIX2, the single channel port NO1 of the first two-position three-way valve H1 is connected to the first sample SA1, and the two single channel ports NC4 and NO4 of the fourth two-position three-way valve H4 are respectively connected to two samples (the second sample SA2 and the third sample SA3). In this way, two different mixed samples of SA1:SA2=SA1:SA3 can be stored in MIX1 and MIX2 respectively.

[0054] Obviously, this embodiment can also store two other mixed samples with different proportions.

[0055] The above description is only a preferred embodiment of the present invention, but the present invention is not limited thereto. All equivalent replacements or equivalent changes of the concepts and technical solutions according to the present invention should be included in the protection scope of the present invention.

Claims

1. An analyzer metering device, comprising a pump, a valve, a mixing reactor and a connecting pipe; characterized in that: The pump, valve and mixing reactor are connected in series through the connecting pipe to form an integral series flow path, and the pump and mixing reactor are respectively located at the head and tail ends of the series flow path; the series flow path has at least three normally open common channel ports and at least two pairs of single channel ports, each of which can be switched on and off, and two single channel ports are connected in parallel to form a pair; the single channel ports are used to externally connect at least two samples; the valve and connecting pipe connected in series between two adjacent common channel ports constitute a metering channel with a quantitative volume, and the series flow path has at least two sections of the metering channels.

2. The analyzer metering device according to claim 1, characterized in that: The pump adopts a double pump in parallel, each pump can be switched on and off independently, the valve is at least two two-position three-way valves connected in series, the parallel interface of the double pump and the common interface of the two-position three-way valve constitute the common channel port, and the normally open interface and the normally closed interface of the two-position three-way valve constitute the single channel port.

3. The analyzer metering device according to claim 1, characterized in that: The pump is a single pump, the valve is at least three two-position three-way valves connected in series, the common interface of the two-position three-way valve constitutes the common channel port, and the normally open interface and the normally closed interface of the two-position three-way valve constitute the single channel port.

4. The analyzer metering device according to claim 1, characterized in that: The pump adopts a double pump in parallel, each pump can be switched on and off independently, and the parallel interface of the double pump constitutes the common channel port; the valve is at least two multi-channel rotary valves with at least three channels; the middle channel ports of every three adjacent channels of the multi-channel rotary valve constitute the common channel port, and the other two channel ports constitute the single channel port.

5. The analyzer metering device according to claim 1, characterized in that: The pump adopts a double pump in parallel, each pump can be switched on and off independently, and the parallel interface of the double pump constitutes the common channel port; the valve is at least two valve groups consisting of a three-way valve and two stop valves connected to the three-way valve in parallel, the port of the stop valve constitutes the single channel port, and the converging interface of the three-way valve and the stop valve constitutes the common channel port.

6. The analyzer metering device according to claim 1, characterized in that: The pump is a single pump; the valve is a valve group consisting of at least three valves, including a tee and two stop valves connected in parallel to the tee, the ports of the stop valves constitute the single channel port, and the converging interface of the tee and the stop valves constitutes the common channel port.

7. The analyzer metering device according to any one of claims 1 to 6, characterized in that: The mixing reactor is also connected to a direct discharge pipe.

8. The analyzer metering device according to any one of claims 1 to 6, characterized in that: An intermediate tube with a quantitative volume is connected between two adjacent single-channel ports in the series flow path; when the sample passes through the intermediate tube, the intermediate tube serves as a part of the metering channel.

9. The analyzer metering device according to claim 2, characterized in that: There are four two-position three-way valves; wherein, the common channel port of the first two-position three-way valve is connected to the common channel port of the dual pumps, the two single channel ports of the second two-position three-way valve are respectively connected to the common channel port of the third two-position three-way valve and the common channel port of the fourth two-position three-way valve, the two single channel ports of the third two-position three-way valve are respectively connected to the two mixing reactors, one single channel port of the first two-position three-way valve is connected to the first sample, and the two single channel ports of the fourth two-position three-way valve are respectively connected to the second sample and the third sample.

10. The analyzer metering device according to any one of claims 1 to 6, characterized in that: A closed container with a quantitative volume is arranged on the connecting pipe.

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