Application of calycosin to preparation of drugs for preventing, relieving and/or treating hyperuricemia

A technology of calycosin and hyperuricemia, which is applied in the field of medicine, can solve the problems of limited treatment effect of hyperuricemia, achieve the effect of alleviating liver atrophy and significant curative effect

CN111202728APending Publication Date: 2020-05-29CHINA PHARM UNIV
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Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2020-05-29

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Abstract

The invention belongs to the field of medicine, and aims at exploring an active compound for treating hyperuricemia. Experimental researches find that calycosin has certain treating effect for hyperuricemia. The medicinal composition is definitely a monomeric compound; and meanwhile, animal experiments indicate that the compound has a relatively strong function of reducing the contents of uric acid (UA), blood urea nitrogen (BUN), creatinine (SCr) and xanthine oxidase (XOD) in mice. Hyperuricemia animal models are utilized to prove that calycosin is remarkable in effect of treating hyperuricemia.
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Description

Technical field

[0001] The invention relates to the field of medical technology, and to be precise, the application of mullein, especially the application in the treatment of hyperuricemia. Background technique

[0002] Hyperuricemia is a metabolic disease in which uric acid production increases and excretion decreases due to the disorder of purine metabolism. This disease is easy to precipitate and deposit urate crystals in the body, leading to gout, and inducing many major diseases such as myocardial infarction, coronary heart disease, diabetes, hyperlipidemia, metabolic syndrome and chronic kidney disease.

[0003] my country’s economy is developing rapidly, and people’s eating habits have also changed dramatically. The number of patients with hyperuricemia caused by poor eating habits is also increasing year by year. According to reports, there are about 120 million patients suffering from hyperuricemia in my country, accounting for about 10% of the total number of people in m...

Examples

Embodiment Construction

[0040] The following embodiments may enable those skilled in the art to understand the present invention more comprehensively, but do not limit the present invention in any way. If specific conditions are not indicated in the examples, it shall be carried out in accordance with conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used without the manufacturer's indication are all conventional products that can be purchased commercially.

[0041] Experimental animals: Kunming mice, SPF grade 20±2g, male.

[0042] Experimental drugs: potassium oxazinate (brand: aladdin, product number: P137112), allopurinol (brand: aladdin, product number: A105386), verbasil (Shanghai Shifeng Biological Products Co., Ltd.), fangchi, astragalus, licorice, Atractylodes.

[0043] Experimental model: mouse hyperuricemia model.

[0044] Experimental method: Kunming mice were randomly divided into groups and numbered, each with 7 mice, namely the normal group, t...