A kind of pharmaceutical composition for treating pelvic floor achalasia type constipation and preparation method thereof

Abstract

The invention discloses a pharmaceutical composition for treating pelvic floor achalasia constipation and a preparation method thereof. The pharmaceutical composition mainly uses pharmaceutically acceptable osmotic laxatives and anxiolytics, wherein the osmotic laxatives and anxiolytics The weight ratio of the drugs is 2-8:1, and the drug combination of the pharmaceutical composition has a significant synergistic effect. Through the specific drug ratio, the toxic and side effects of the two drugs on the human body are significantly reduced, and the anal muscles, especially the sphincter, are significantly reduced. The pressure can reduce the maximum spontaneous systolic pressure of the anorectum and the resting pressure of the anorectum, improve the curative effect of the pharmaceutical composition, and has broad medical application prospects.

Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating pelvic floor achalasia type constipation and a preparation method thereof. Background technique

[0002] Constipation is one of the most common gastrointestinal symptoms clinically. It often manifests as strained defecation, decreased frequency of defecation, induration or dry ball of defecation, feeling of incomplete defecation, anorectal blockage, and even assisted defecation with manipulation. Chronic constipation has been underestimated by people for quite a long time in the past. In recent years, the prevalence of constipation has gradually increased, and studies have shown that it is closely related to acute cardiovascular and cerebrovascular diseases, dementia, and colorectal cancer. More and more attention.

[0003] The Rome II standard was introduced in 2000, and the international concept of constipation uses the Ro...

Examples

Embodiment 1

[0037] The preparation of embodiment 1 compound tablet

[0038]

[0039] Preparation process: mix buspirone, polyethylene glycol 4000 and microcrystalline cellulose, add 6% PVP ethanol solution to the mixture, and pass through a 20-mesh sieve to granulate. The wet granules are dried at 50°C. After drying, the granules are passed through a 20-mesh sieve for granulation, and the fine powder in the dry granules is sifted out, mixed with magnesium stearate, and then mixed with the dry granules, and pressed into tablets to obtain the product.

Embodiment 2

[0040] The preparation of embodiment 2 compound suppositories

[0041]

[0042]

[0043] Preparation process: Take Tween and mix it with glycerin in a vessel, stir evenly, add the prescribed amount of paroxetine and lactulose, continue to stir evenly, pour into the plug mold coated with lubricant until it slightly overflows the mold mouth, cool, and solidify Finally, the overflow part is cut off, demoulding, quality inspection, and packaging.

Embodiment 3

[0044] The preparation of embodiment 3 dispersible tablets

[0045]

[0046] Preparation process: Weigh and mix citalopram and polyethylene glycol 5000 according to the prescription quantity, use microcrystalline cellulose as filler, polyvinylpyrrolidone as disintegrant, 60% ethanol solution as binder, and micronized silica gel as flow aid , using a fluidized bed to granulate in one step, and then compressed into tablets.

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating pelvic floor achalasia type constipation and a preparation method thereof. Background technique

[0002] Constipation is one of the most common gastrointestinal symptoms clinically. It often manifests as strained defecation, decreased frequency of defecation, induration or dry ball of defecation, feeling of incomplete defecation, anorectal blockage, and even assisted defecation with manipulation. Chronic constipation has been underestimated by people for quite a long time in the past. In recent years, the prevalence of constipation has gradually increased, and studies have shown that it is closely related to acute cardiovascular and cerebrovascular diseases, dementia, and colorectal cancer. More and more attention.

[0003] The Rome II standard was introduced in 2000, and the international concept of constipation uses the Ro...

Examples

Embodiment 1

[0037] The preparation of embodiment 1 compound tablet

[0038]

[0039] Preparation process: mix buspirone, polyethylene glycol 4000 and microcrystalline cellulose, add 6% PVP ethanol solution to the mixture, and pass through a 20-mesh sieve to granulate. The wet granules are dried at 50°C. After drying, the granules are passed through a 20-mesh sieve for granulation, and the fine powder in the dry granules is sifted out, mixed with magnesium stearate, and then mixed with the dry granules, and pressed into tablets to obtain the product.

Embodiment 2

[0040] The preparation of embodiment 2 compound suppositories

[0041]

[0042]

[0043] Preparation process: Take Tween and mix it with glycerin in a vessel, stir evenly, add the prescribed amount of paroxetine and lactulose, continue to stir evenly, pour into the plug mold coated with lubricant until it slightly overflows the mold mouth, cool, and solidify Finally, the overflow part is cut off, demoulding, quality inspection, and packaging.

Embodiment 3

[0044] The preparation of embodiment 3 dispersible tablets

[0045]

[0046] Preparation process: Weigh and mix citalopram and polyethylene glycol 5000 according to the prescription quantity, use microcrystalline cellulose as filler, polyvinylpyrrolidone as disintegrant, 60% ethanol solution as binder, and micronized silica gel as flow aid , using a fluidized bed to granulate in one step, and then compressed into tablets.

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