Anti-slip valve clip and valve clip system

Abstract

The present invention provides a valve clamp and a valve clamp system that prevents slipping. The valve clamp system includes a pushing device and a valve clamp. The valve clamp includes a base and at least two clamp arms that open and close relative to the base, the clamp arms include a connecting end and a free end, the connecting ends of at least two clamp arms are rotatably connected to the base through the same rotating shaft, and the connecting ends of at least two clamp arms are partially staggered. The valve clamp provided by the present invention is rotatably connected to the base by the connecting ends of at least two clamp arms through the same rotating shaft, and the connecting ends of at least two clamp arms are partially staggered, so that the overall size of the valve clamp is small and the weight is light, so that it is easy to transport and has strong anti-slip performance.

Description

Technical Field

[0001] The present invention relates to the field of medical devices, and in particular to an anti-slip valve clamp and a valve clamp system. Background Art

[0002] See also Figure 1 The mitral valve 1 is a one-way valve located between the left atrium 2 and the left ventricle 3 of the heart. A normal and healthy mitral valve 1 can control the blood flow from the left atrium 2 to the left ventricle 3, while preventing the blood from the left ventricle 3 to the left atrium 2. The mitral valve 1 includes a pair of leaflets, called the anterior leaflet 1a and the posterior leaflet 1b. The anterior leaflet 1a and the posterior leaflet 1b are fixed to the papillary muscle of the left ventricle 3 by chordae tendineae 4. Under normal circumstances, when the left ventricle 3 of the heart contracts, the edges of the anterior leaflet 1a and the posterior leaflet 1b are completely aligned to prevent blood from flowing from the left ventricle 3 to the left atrium 2. Please refer to Figure 2 When organic or functional changes occur in the leaflets of the mitral valve 1 or its related structures, such as partial rupture of the chordae tendineae 4, the anterior leaflet 1a and the posterior leaflet 1b of the mitral valve 1 are not properly aligned. As a result, when the left ventricle 3 of the heart contracts, the mitral valve 1 cannot be completely closed, causing blood to flow back from the left ventricle 3 to the left atrium 2, thereby causing a series of pathophysiological changes, known as "mitral regurgitation".

[0003] There is a minimally invasive treatment surgery, which is based on the edge-to-edge surgical principle of the valve, and the valve clamp is delivered to the mitral valve through an interventional catheter, and then the anterior leaflet and the posterior leaflet of the mitral valve are clamped at the same time by the relative opening of the clamp, so that the anterior leaflet and the posterior leaflet of the mitral valve are fixed, thereby achieving the purpose of reducing the leaflet gap and reducing mitral regurgitation. In order to ensure the clamping effect, a wider clamp arm is required. However, in the prior art, the two clamp arms of the valve clamp are fixed on the base in a matching manner and a connecting rod is used to drive the clamp arms to open and close, resulting in a larger base size of the clamp, and multiple connecting rod parts also result in a longer axial size of the clamp, and a larger diameter delivery sheath is required, which increases the difficulty of delivery; furthermore, the connecting rod assembly and the larger base will cause the overall weight of the clamp to be heavier. After being implanted in the patient's body, the clamp falls under the mitral valve for a long time, which is not only easy to slip off, but also may strain the valve leaflet or even cause heart dysfunction. Summary of the invention

[0004] In view of this, the present invention provides a valve clamp and a valve clamp system. The valve clamp has a small overall size, a light weight, is easy to transport and has a strong anti-slip performance.

[0005] The present invention provides an anti-slip valve clamp, comprising a base and at least two clamp arms that open and close relative to the base, the clamp arms comprising a connecting end and a free end, at least two connecting ends of the clamp arms being rotatably connected to the base via the same rotating shaft, and at least two connecting ends of the clamp arms being partially staggered.

[0006] The present invention also provides a valve clamping system, including a pushing device and the above-mentioned valve clamper, wherein the pushing device includes an operating handle and a pushing assembly, the proximal end of the pushing assembly is connected to the operating handle, and the distal end of the pushing assembly is detachably connected to the valve clamper.

[0007] The valve clamp and valve clamp system provided by the present invention are characterized by rotating the connecting ends of at least two clamp arms to a base via the same rotating shaft, and the connecting ends of at least two clamp arms are partially staggered, so that the overall size of the valve clamp is small and the weight is light, thereby facilitating transportation and having strong anti-slip performance. BRIEF DESCRIPTION OF THE DRAWINGS

[0008] In order to more clearly illustrate the technical solution of the embodiment of the present invention, the drawings required for use in the implementation mode will be briefly introduced below. Obviously, the drawings described below are some implementation modes of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0009] Figure 1 This is a schematic diagram of the mitral valve in its normal state.

[0010] Figure 2 This is a schematic diagram of a mitral valve disease.

[0011] Figure 3 It is a schematic diagram of the three-dimensional structure of the valve clip provided by the first embodiment of the present invention in an open state.

[0012] Figure 4 yes Figure 3 Schematic diagram of the three-dimensional structure of the valve clip in the folded state.

[0013] Figure 5 yes Figure 3 Schematic diagram of the structure of the valve clip from another perspective.

[0014] Figure 6 yes Figure 3 Schematic diagram of the three-dimensional structure of the base of the valve clip.

[0015] Figure 7 yes Figure 6 Schematic cross-section of the base.

[0016] Figure 8 yes Figure 3 Schematic diagram of the three-dimensional structure of the driving rod of the valve clamp.

[0017] Fig. 9 yes Figure 4 A cross-sectional schematic diagram of the drive rod and the base when the valve clip is in a folded state.

[0018] Fig.10 yes Figure 3 Schematic diagram of the three-dimensional structure of the clamp arm of the valve clip.

[0019] Fig.11 yes Figure 3 Schematic diagram of the three-dimensional structure of the clamping arm of the valve clamp.

[0020] Fig.12 yes Figure 3 Schematic diagram of the valve clip in use.

[0021] Fig.13 yes Fig.12 Schematic diagram of the mitral valve during heart contraction after the valve leaflets are clamped by the valve clip in the figure.

[0022] Fig.14 yes Fig.12 Schematic diagram of the mitral valve during diastole after the valve leaflets are clamped by the valve clip in the figure.

[0023] Fig.15 It is a three-dimensional structural schematic diagram of a partial structure of a valve clamping system provided by one embodiment of the present invention.

[0024] Fig.16 yes Fig.15 Schematic cross-section of .

[0025] Fig.17 It is a schematic diagram of the use of a liner and an expansion tube.

[0026] Figures 18 to 21 This is a schematic diagram of the use process of the valve clip.

[0027] Fig. 22 It is a schematic diagram of the three-dimensional structure of the valve clip provided by the second embodiment of the present invention in the open state.

[0028] Fig.23 yes Fig. 22 Schematic diagram of the three-dimensional structure of the clamp arm of the valve clip.

[0029] Fig.24 It is a schematic diagram of the three-dimensional structure of the valve clip provided by the third embodiment of the present invention in the open state.

[0030] Fig.25 yes Fig.24 Schematic diagram of the three-dimensional structure of the clamp arm of the valve clip.

[0031] Fig.26 It is a cross-sectional schematic diagram of a part of the structure of the valve clipper provided by the fourth embodiment of the present invention when it is in a folded state.

[0032] Fig. 27 yes Fig.26 Schematic diagram of the three-dimensional structure of the driving rod.

[0033] Fig.28 is with Fig. 27 Schematic diagram of the three-dimensional structure of the core shaft used in conjunction with the driving rod.

[0034] Fig.29 yes Fig.26 Schematic diagram of the three-dimensional structure of the locking block.

[0035] Fig.30 is with Fig.29 Schematic diagram of the three-dimensional structure of the liner used in conjunction with the locking block. DETAILED DESCRIPTION

[0036] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0037] In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", etc. indicate positions or positional relationships based on the positions or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific position, be constructed and operated in a specific position, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", "third", etc. are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0038] In the description of the present invention, it should be noted that in the field of interventional medical devices, the proximal end refers to the end closer to the operator, while the distal end refers to the end farther from the operator; the axial direction refers to the direction parallel to the line connecting the distal center and the proximal center of the medical device. The above definitions are only for the convenience of expression and cannot be understood as limitations of the present invention.

[0039] See also Figures 3 to 5 The present invention provides a valve clipper 100, comprising a base 10 and at least two clamp arms 21 opened relative to the base 10. The clamp arms 21 include a connecting end 211 and a free end 212, and the connecting ends 211 of at least two clamp arms 21 are rotatably connected to the base 10 through the same rotating shaft 40, and the connecting ends 211 of at least two clamp arms 21 are partially staggered, so that the overall size of the valve clipper 100 is small and the weight is light, so that it is easy to transport and has strong anti-slip performance.

[0040] Among them, in order to ensure safety after implantation, the base 10, the clamp arm 21 and the rotating shaft 40 are all made of biocompatible metal materials, and the metal materials are selected from commonly used implantation metal materials such as stainless steel, cobalt alloy, cobalt-chromium alloy, titanium alloy or nickel-titanium alloy, preferably stainless steel or cobalt-chromium alloy with higher hardness.

[0041] The valve clipper 100 further includes a driving assembly 30 for driving the clamp arms 21 to open and close relative to the base 10. The driving assembly 30 includes a driving rod 31 slidably disposed in the base 10 along the axial direction, the driving rod 31 being movably connected to the connecting ends 211 of at least two clamp arms 21, and the driving rod 31 slides along the axial direction to drive at least two clamp arms 21 to rotate simultaneously and open and close relative to the base 10.

[0042] For details, please refer to Figures 6 to 9 The base 10 includes a first base body 11 and a second base body 12 connected to the distal end of the first base body 11. The base 10 is provided with a sliding channel 13 that penetrates the first base body 11 and the second base body 12 along the axial direction, and the driving rod 31 is slidably disposed in the sliding channel 13. The first base body 11 and the second base body 12 can be an integral structure or a non-integrated structure. In this embodiment, the first base body 11 and the second base body 12 are a non-integrated structure.

[0043] In this embodiment, the first seat body 11 is a circular tube body with a first channel 131, and the second seat body 12 is a square column body with a second channel 132. The first channel 131 and the second channel 132 are coaxially connected to form a sliding channel 13. The diameters of the first channel 131 and the second channel 132 are both larger than the diameter of the driving rod 31, and the diameter of the first channel 131 is larger than the diameter of the second channel 132. An inner step 14 is formed at the connection between the first seat body 11 and the second seat body 12.

[0044] like Figure 6 and Figure 7 As shown, the proximal end of the first seat body 11 is provided with a first engaging portion 111, and the first engaging portion 111 is used to connect with the outer tube of the pushing device. In this embodiment, the first engaging portion 111 is a pair of inverted T-shaped grooves opened on the proximal outer wall of the first seat body 11. Specifically, each inverted T-shaped groove includes a first groove section 1112 and a second groove section 1114 perpendicularly intersecting the first groove section 1112, the second groove section 1114 is located at the distal end of the first groove section 1112, the extension direction of the first groove section 1112 is the same as the axial direction of the first seat body 11, and the proximal end of the first groove section 1112 passes through the proximal end face of the first seat body 11. Preferably, the pair of inverted T-shaped grooves are symmetrically arranged about the axis of the first seat body 11.

[0045] In other embodiments, the pair of inverted T-shaped grooves may be arranged asymmetrically.

[0046] In other embodiments, the number of the inverted T-shaped slots may be 1, 3, or other reasonable numbers.

[0047] In other embodiments, the first engaging portion 111 may be a connection structure in other forms other than an inverted T-shaped groove, including but not limited to an L-shaped groove, a cross groove, and the like.

[0048] Furthermore, a second engaging portion 112 is provided in the middle of the first seat body 11, and the second engaging portion 112 is used to lock the position of the driving rod 31 in the sliding channel 13. In this embodiment, the second engaging portion 112 is a pair of spring plates provided in the middle of the first seat body 11. Specifically, a pair of openings are provided on the outer wall in the middle of the first seat body 11, and an inwardly inclined spring plate is provided in each opening, and each spring plate includes a connecting end and a free end opposite to the connecting end, the connecting end is connected to the distal edge of the opening, and the free end extends into the first channel 131. In a natural state, the free end of the spring plate is inclined relative to the connecting end toward the first channel 131 of the first seat body 11. Preferably, the pair of spring plates are symmetrically arranged about the axis center line of the first seat body 11.

[0049] It should be noted that, in the present embodiment, the width of the spring sheet (i.e., the length in the direction perpendicular to the axial direction of the first seat body 11) is smaller than the width of the opening, and there is a gap between the spring sheet and the two opposite sides of the opening. The operator can use auxiliary tools such as hooks to reach into the first channel 131 from the gap, hook the free end of the spring sheet and pull it outward, so that the free end of the spring sheet is flush with the outer wall of the first seat body 11 or protrudes from the outer wall of the first seat body 11, so as to facilitate the insertion of the liner of the pushing device.

[0050] In other embodiments, a pair of spring sheets may be arranged asymmetrically.

[0051] In other embodiments, the number of the spring pieces may be 1, 3, or other reasonable numbers.

[0052] like Figure 6 and Figure 7 As shown, two first guide grooves 121 are provided on opposite sides of the second seat body 12, and the two first guide grooves 121 are symmetrically arranged about the axis of the sliding channel 13. Each first guide groove 121 extends along the axial direction of the second seat body 12, that is, each first guide groove 121 is a vertical groove provided in the second seat body 12. Each first guide groove 121 is connected to the second channel 132, that is, connected to the sliding channel 13.

[0053] Two first connecting holes 122 are formed at the far ends of the first guide groove 121 on opposite sides of the second seat body 12. The first connecting holes 122 extend in a direction perpendicular to the axial direction of the second seat body 12. Similarly, each first connecting hole 122 is connected to the second channel 132, that is, connected to the sliding channel 13.

[0054] Preferably, in this embodiment, the center of the first connecting hole 122 is located on the center line of the first guide groove 121 in the length direction.

[0055] It is understandable that only one embodiment of the base 10 is provided here. In fact, the base 10 may also be other structures, which will not be described in detail here.

[0056] See also Figure 8 and Fig. 9 The drive assembly 30 includes a drive rod 31 axially slidably disposed in the base 10. The drive rod 31 is movably connected to the connecting ends 211 of at least two clamp arms 21. The drive rod 31 slides axially to drive at least two clamp arms 21 to rotate simultaneously and open and close relative to the base 10. In this embodiment, the drive rod 31 is a round rod body. An internal threaded hole 311 is axially provided on the proximal end face of the drive rod 31. The internal threaded hole 311 is used to connect with the core shaft of the pushing device. The outer peripheral surface of the proximal end of the drive rod 31 is circumferentially provided with a circle of card slots 312. The card slots 312 are used to cooperate with the second clamping portion 112 (i.e., the spring sheet) of the first seat body 11 to lock the position of the drive rod 31 in the sliding channel 13. Specifically, as Fig. 9 As shown, the driving rod 31 is disposed in the sliding channel 13 of the base 10. When the free end of the spring sheet on the first base 11 is not inserted into the slot 312 of the driving rod 31, the driving rod 31 can slide along the axial direction of the base 10. When the driving rod 31 slides axially toward the proximal direction until the valve clamp 100 is in the retracted state, the free end of the spring sheet is inserted into the slot 312 to prevent the driving rod 31 from continuing to slide axially, thereby ensuring that the valve clamp 100 remains in the retracted state. Further, as Figure 8 As shown, a pin hole 313 is radially provided at the distal end of the outer circumference of the driving rod 31 , and the pin hole 313 is used to set a driving pin or a driving bolt (not shown in the figure).

[0057] See also Figure 3 and Fig.10 The clamp arm 21 includes a connecting end 211 at the distal end and a free end 212 at the proximal end. The connecting end 211 includes at least one connecting piece, and the free end 212 includes a clamping piece. The proximal end of each connecting piece is connected to the distal end of the clamping piece, and the distal end of each connecting piece is rotatably connected to the base 10 through the rotating shaft 40. Specifically, in this embodiment, the connecting end 211 of the clamp arm 21 includes two connecting pieces spaced opposite to each other, and the two connecting pieces are respectively located on opposite sides of the clamping piece, and the area between the two connecting pieces is hollowed out to reduce the overall weight of the valve clip 100.

[0058] A second guide slot 2111 is provided at the proximal end of each connecting piece, and the extension direction of the second guide slot 2111 forms a certain angle with the direction from the proximal end to the distal end of the connecting piece, that is, the second guide slot 2111 is an oblique slot provided at the proximal end of the connecting piece. A second connecting hole 2112 is provided at the distal end of each connecting piece, and the rotating shaft 40 passes through the second connecting hole 2112 to rotatably connect the distal end of the connecting piece to the second seat body 12 of the base 10.

[0059] In this embodiment, two connecting pieces spaced opposite to each other at the connecting end 211 of each clamp arm 21 are respectively located on opposite sides of the second base body 12. The connecting pieces of the connecting ends 211 of the two clamp arms 21 located on the same side of the second base body 12 are at least partially staggered and stacked on each other, the second connecting holes 2112 of the two connecting pieces located on the same side of the second base body 12 are correspondingly connected to the first connecting holes 122 of the second base body 12, and the second guide grooves 2111 of the two connecting pieces located on the same side of the second base body 12 are correspondingly connected to the first guide grooves 121 of the second base body 12.

[0060] The rotating shaft 40 is disposed in the first connecting hole 122 of the correspondingly connected second seat body 12 and the second connecting holes 2112 of the two connecting pieces. Specifically, one end of the rotating shaft 40 sequentially passes through the second connecting holes 2112 of the two connecting pieces of the two clamp arms 21 located on the same side of the second seat body 12, then passes through the first connecting hole 122 of the second seat body 12, and finally is inserted into the second connecting holes 2112 of the two connecting pieces of the two clamp arms 21 located on the other side of the second seat body 12. A first stopper is welded at the end of the rotating shaft 40 to prevent the rotating shaft 40 from slipping off, so that the distal ends of the connecting ends 211 of the two clamp arms 21 are rotatably connected to the second seat body 12 of the base 10 through the same rotating shaft 40, and the clamp arms 21 can rotate around the rotating shaft 40.

[0061] The rotating shaft 40 may be a rotating pin or a rotating bolt. In this embodiment, the rotating shaft 40 is a rotating pin.

[0062] In the present invention, the connecting pieces of the connecting ends 211 of the two clamp arms 21 are at least partially staggered and overlapped with each other, and are rotatably connected to the base 10 through the same rotating shaft 40. The outer diameter of the base 10 is smaller than the outer diameter of the base used in the prior art, so that the outer diameter of the valve clip 100 in the folded state is smaller, which is convenient for transportation. Moreover, the smaller base 10 can also reduce the weight of the valve clip 100. Furthermore, after being implanted in the patient's body, the valve clip 100 falling below the mitral valve has a strong anti-slip performance due to its light weight and is not easy to tear the valve leaflet.

[0063] Further, such as Figure 3As shown, in this embodiment, the driving assembly 30 also includes a driving pin 32, which is inserted into the pin hole 313 of the driving rod 31 and the first guide groove 121 of the corresponding second seat body 12 and the second guide groove 2111 of the connecting plate. Specifically, one end of the driving pin 32 passes through the second guide grooves 2111 of the two connecting plates of the two clamp arms 21 on the same side of the second seat body 12, then passes through the first guide groove 121 of the second seat body 12, and finally is inserted into the second guide grooves 2111 of the two connecting plates of the two clamp arms 21 on the other side of the second seat body 12. A second baffle is welded at the end of the driving pin 32 to prevent the driving pin 32 from slipping off, so that the proximal ends of the connecting ends 211 of the two clamp arms 21 are movably connected to the driving rod 31 in the base 10 through the same driving pin 32. Therefore, when the driving rod 31 slides axially in the sliding channel 13 of the base 10, the driving rod 31 can drive the driving pin 32 to slide in the first guide groove 121 and the second guide groove 2111, thereby driving the clamp arm 21 to rotate around the rotating shaft 40, and the free end 212 of the clamp arm 21 opens and closes relative to the base 10. That is to say, the driving rod 31 drives the driving pin 32 to slide in the first guide groove 121 and the second guide groove 2111 , so that the axial linear motion of the driving rod 31 can be converted into the rotation of the clamp arm 21 around the rotating shaft 40 .

[0064] The driving pin 32 may be replaced by a driving bolt.

[0065] Among them, when the driving rod 31 slides axially and drives the driving pin 32 to slide to different positions of the first guide groove 121 and the second guide groove 2111, the degree of opening and closing of the free end 212 of the clamp arm 21 relative to the base 10 is different, and the angle between the two clamp arms 21 is also different.

[0066] For details, please refer to Figure 3 and Figure 4 Preferably, in this embodiment, the length of the first guide groove 121 is equal to that of the second guide groove 2111 (i.e., the length of the guide groove along its center line direction). Figure 3 As shown, when the driving rod 31 slides axially toward the distal end and drives the driving pin 32 to slide to the farthest end of the first guide slot 121, the driving pin 32 simultaneously slides to the farthest end of the second guide slot 2111. At this time, the distal ends of the connecting ends 211 of the two clamp arms 21 are staggered and stacked, and the free ends 212 of the two clamp arms 21 are fully opened relative to the base 10, and the angle between the two clamp arms 21 is the largest. Figure 4As shown, when the driving rod 31 slides axially toward the proximal direction and drives the driving pin 32 to slide to the nearest end of the first guide groove 121, the driving pin 32 synchronously slides to the nearest end of the second guide groove 2111. At this time, most of the connecting ends 211 of the two clamp arms 21 are staggered and stacked, and the free ends 212 of the two clamp arms 21 are completely retracted relative to the base 10, and the angle between the two clamp arms 21 is minimized.

[0067] In other embodiments, the length of the second guide groove 2111 can be smaller than the length of the first guide groove 121. When the driving pin 32 slides to the nearest end of the first guide groove 121, the free ends 212 of the two clamp arms 21 are completely retracted relative to the base 10, and the angle between the two clamp arms 21 is minimized. At this time, the driving pin 32 is located between the distal center and the proximal center of the first guide groove 121 and at a position close to the proximal center; the length of the second guide groove 2111 can also be greater than the length of the first guide groove 121. When the driving pin 32 slides to the nearest end of the first guide groove 121, the free ends 212 of the two clamp arms 21 are completely retracted relative to the base 10, and the angle between the two clamp arms 21 is minimized. At this time, the driving pin 32 is located between the distal center and the proximal center of the second guide groove 2111 and at a position close to the proximal center.

[0068] It can be understood that after the clamp arms 21 rotate around the rotation axis 40 and are fully opened or fully closed relative to the base 10, the angle between the two clamp arms 21 is related to the rotation center of the clamp arms 21 (i.e., the center of the second connecting hole 2112) and the two extreme positions of the driving pin 32 in the second guide slot 2111 of the clamp arms 21. In this embodiment, the two extreme positions of the driving pin 32 in the second guide slot 2111 of the clamp arms 21 are the closest end and the farthest end of the second guide slot 2111.

[0069] For details, please refer to Figure 5 The angle between the line L connecting the distal center of the second guide groove 2111 and the center of the second connecting hole 2112 (not shown) and the length direction of the clamp arm 21 is the first angle α, and the angle between the line M connecting the proximal center and the distal center of the second guide groove 2111 and the length direction of the clamp arm 21 is the second angle β.

[0070] The first angle α and the second angle β may be equal or unequal. In this embodiment, the first angle α and the second angle β are equal.

[0071] In this embodiment, when the driving pin 32 slides to the farthest end of the second guide slot 2111, the clamp arm 21 is fully opened relative to the base 10. At this time, the line L between the distal center of the second guide slot 2111 and the center of the second connecting hole 2112 is the same as the axial direction of the base 10. Therefore, the first angle α is the angle between the length direction of the clamp arm 21 and the axial direction of the base 10. That is to say, in this embodiment, the maximum angle that each clamp arm 21 can open relative to the base 10 is α, and the maximum angle between the two clamp arms 21 is 2α. Among them, the angle range of the first angle α is 30 to 80 degrees, that is, the maximum angle that each clamp arm 21 can open relative to the base 10 is 80 degrees, and the maximum angle between the two clamp arms 21 is 160 degrees, which is conducive to clamping the valve leaflet. Preferably, the first angle α is preferably 45 to 60 degrees, and more preferably 60 degrees.

[0072] like Figure 5 As shown, the line N between the proximal center of the second guide slot 2111 and the center of the second connecting hole 2112 (not shown) may be parallel to or not parallel to the length direction of the clamp arm 21. Specifically, in this embodiment, the line N between the proximal center of the second guide slot 2111 and the center of the second connecting hole 2112 (not shown) is parallel to the length direction of the clamp arm 21. Further, in this embodiment, when the driving pin 32 slides to the nearest end of the second guide slot 2111, the clamp arm 21 is completely retracted relative to the base 10. At this time, the line N between the proximal center of the second guide slot 2111 and the center of the second connecting hole 2112 is the same as the axial direction of the base 10. Therefore, when the clamp arm 21 is completely retracted relative to the base 10, the axial direction of the clamp arm 21 is the same as the axial direction of the base 10, and the angle between the two is 0 degrees, and the angle between the two clamp arms 21 is also 0 degrees. That is to say, in this embodiment, when the forceps arm 21 is fully retracted relative to the base 10, the free end 212 of the forceps arm 21 is parallel to the base 10, so that the outer diameter of the valve clip 100 in the retracted state remains consistent from the proximal end to the distal end, which is conducive to delivery in the patient's body.

[0073] In other embodiments, the line N connecting the proximal center of the second guide groove 2111 and the center of the second connecting hole 2112 (not shown) may not be parallel to the length direction of the clamp arm 21. Specifically, when the clamp arm 21 is fully retracted relative to the base 10, the free end 212 of the clamp arm 21 is close to the first seat body 11 and forms a certain angle with the axial direction of the base 10. At this time, the outer diameter of the valve clamp 100 in the retracted state gradually increases from the proximal end to the distal end. The maximum outer diameter of the valve clamp 100, that is, the distal outer diameter of the valve clamp 100, is also conducive to transportation.

[0074] As described above, in the present invention, the driving rod 31 slides along the axial direction and drives the driving pin 32 to slide in the connected first guide slot 121 and the second guide slot 2111, so that the clamp arm 21 can be opened and closed relative to the base 10. Compared with the prior art, no connecting rod assembly is required, so that the axial dimension of the valve clip 100 is small, which is convenient for transportation and can reduce the overall weight of the valve clip 100. Furthermore, the driving rod 31 drives the driving pin 32 to slide to different positions in the oblique slot (i.e., the second guide slot 2111) of the clamp arm 21, so that the clamp arm 21 can be opened and closed relative to the base 10. This structure enables the driving rod 31 to move a small stroke to achieve a large angle of the clamp arm 21 relative to the base 10, which means that the lengths of the first guide slot 121 and the second guide slot 2111 do not need to be too long, so that the axial dimension of the second seat body 12 with the first guide slot 121 is small, thereby reducing the axial dimension of the valve clip 100. In addition, the size of the corresponding angle between the two clamp arms 21 can be known based on the feed stroke of the driving rod 31, which helps the operator to adjust the opening angle of the clamp arms 21 in real time according to the relative position between the clamp arms 21 and the leaflets during the process of clamping the leaflets.

[0075] like Fig.10 As shown, the clamp arm 21 also includes a first surface facing the base 10, that is, the clamping piece of the free end 212 faces the inner surface of the base 10. Preferably, in this embodiment, a clamping anti-skid structure 2113 is provided on the first surface, and the clamping anti-skid structure 2113 can be a protrusion, a groove provided on the first surface, or a gasket made of a biocompatible material with a high friction coefficient and attached to the first surface. By providing a protrusion, a groove or a gasket on the first surface, the friction force when the clamp arm 21 contacts the leaflet is enhanced, thereby providing a stable clamping force and preventing the clamp arm 21 from causing damage to the leaflet. Specifically, in this embodiment, the clamping anti-skid structure 2113 is a plurality of grooves arranged at intervals along the axial direction of the clamp arm 21.

[0076] It should be noted that in order to ensure a stable clamping force and correspond to the size of the leaflets, the clamp arm 21 has certain size regulations. Specifically, the length of the clamp arm 21 must be within a certain range. When the length of the clamp arm 21 is too long, the clamp arm 21 is easy to clamp too many anterior leaflets and posterior leaflets together. When the valve clamp 100 is closed, the two leaflets are forcibly pulled toward each other and fixed together. When the heart beats and the leaflets move, too many leaflets are restricted from moving, which not only easily leads to mitral valve dysfunction, but also may cause leaflet tearing and other serious consequences; when the clamp arm 21 is too short, the valve clamp 100 can only clamp a small part of the leaflets, making the leaflets easy to slip out, and the clamping and fixing effect is poor. In the embodiment of the present invention, the length of the clamp arm 21, that is, the distance from the connecting end 211 to the free end 212, should be greater than or equal to 4mm, preferably 6-10mm. In addition, the width of the forceps arm 21 is also limited to a certain extent, so as to avoid the forceps arm 21 being too narrow and causing damage to the valve leaflets, and also to avoid the valve clip 100 affecting the movement of the valve leaflets when the forceps arm 21 is too wide. The width of the forceps arm 21, i.e., the length in the direction perpendicular to the axial direction of the forceps arm 21, should be greater than or equal to 2 mm, preferably 4-6 mm.

[0077] Preferably, active drugs can be applied to the first surface of the clamp arm 21, or at least one opening can be opened to promote the crawling and growth of endothelial cells of the valve tissue on the inner surface of the clamp arm 21; furthermore, the opening can also reduce the overall weight of the valve clamp 100, thereby preventing the overweight valve clamp 100 from falling under the leaflet for a long time and causing slippage or damage to the leaflet.

[0078] For further information, see Figure 3 and Fig.11 In this embodiment, the valve clipper 100 further includes an elastic clamping arm 22, which is located between the base 10 and the clamp arm 21, and the clamping arm 22 corresponds to the clamp arm 21. The width of the clamp arm 21 (i.e., the length of the clamp arm 21 along a direction perpendicular to the axial direction) is greater than the width of the clamp arm 22 (i.e., the length of the clamp arm 22 along a direction perpendicular to the axial direction).

[0079] In this embodiment, when the clamp arm 21 is opened relative to the base 10 , the clamp arm 22 is released, and the clamp arm 22 cooperates with the clamp arm 21 to clamp the leaflet between the clamp arm 21 and the clamp arm 22 .

[0080] In other embodiments, the valve clip 100 may only include the forceps arm 21 , and the forceps arm 21 is opened and closed relative to the base 10 to clamp or loosen the valve leaflet between the forceps arm 21 and the base 10 .

[0081] The clamping arm 22 includes a connecting end 221 and a free end 222 that are arranged opposite to each other, and the connecting end 221 is fixed to the base 10. In this embodiment, the connecting ends 221 of the two clamping arms 22 are connected as a whole through a connecting frame 223, and the connecting frame 223 is fixedly connected to the distal end of the second base 12 to achieve relative fixation of the connecting ends 221 of the two clamping arms 22 and the base 10. Obviously, in other embodiments, the connecting end 221 of the clamping arm 22 can be directly fixed to the distal end of the second base 12 by welding or the like.

[0082] The clamping arm 22 is at least partially made of an elastic material with shape memory function and is heat-set. In the natural state, the clamping arm 22 extends outward and radially toward the proximal end relative to the base 10, so as to cooperate with the clamp arm 21 to clamp the leaflet. In this embodiment, the clamping arm 22 is cut from nickel-titanium alloy and placed in a shaping mold, and then the shaping mold is placed in an electrically heated circulating air box furnace, and a shaping heat treatment is performed at 300-650°C. It is taken out and quickly placed in purified water for cooling, and the shaping mold is removed to obtain a shaped clamping arm 22. Specifically, in this embodiment, the clamping arm 22 is made of superelastic nickel-titanium alloy as a whole, thereby providing elastic force for the clamping arm 22 to drive the clamping arm 22 to move closer to the clamp arm 21 to clamp the leaflet. In addition, in this embodiment, the connecting frame 223 can also be made of elastic nickel-titanium alloy and integrally formed with the clamping arm 22 to reduce the difficulty of the production process, simplify the process flow, and reduce production costs; in other embodiments, the connecting frame 223 can also be made of rigid stainless steel and then welded to the clamping arm 22 to increase the connection strength between the connecting frame 223 and the second seat body 12.

[0083] In other embodiments, the connection end 221 of the clamping arm 22 is made of elastic material, and the free end 222 of the clamping arm 22 can be made of non-elastic material such as aluminum alloy, and the clamping arm 22 is driven toward the clamp arm 21 by the elastic force of the connection end 221 .

[0084] It should be noted that the free end 222 of the clamp arm 22 is provided with an adjustment line hole 225 for connecting the adjustment line of the pushing device, and the free end 222 of the clamp arm 22 can be controlled by the adjustment line extending outside the patient's body. In the delivery state, the free end 222 of the clamp arm 22 is tightened by the adjustment line and fits against the surface of the base 10, and after the control of the adjustment line on the free end 222 is released, the clamp arm 22 rebounds due to its own elastic memory performance, and the clamp arm 22 returns to a natural state and presses the leaflet toward the clamp arm 21. Preferably, the angle between the two clamping arms 22 in the naturally expanded state should be slightly larger than the angle between the two clamp arms 21 to provide a more stable clamping force, that is, the angle between the clamp arm 22 and the base 10 is larger than or equal to the angle between the clamp arm 21 and the base 10 when the clamp arm 21 corresponding to the side is fully opened relative to the base 10, thereby ensuring that there is a certain clamping force between the clamp arm 21 and the clamp arm 22 to clamp the leaflet between the clamp arm 21 and the clamp arm 22. Specifically, the angle between the length direction of the free end 222 and the axial direction of the base 10 is a third angle (not shown in the figure), and the angle range of the third angle is 0 to 80 degrees. In this embodiment, the third angle is preferably 80 degrees.

[0085] Furthermore, the clamping arm 22 also includes a second surface facing the clamp arm 21, and a clamping reinforcement is provided on the second surface to increase the friction between the clamping arm 22 and the leaflet, thereby improving the clamping force of the valve clip 100 on the leaflet. Specifically, in this embodiment, the clamping reinforcement is two rows of barbs 224 arranged at intervals on opposite sides of the second surface. The barbs 224 can be formed on the clamping arm 22 in an integrated manner, or the barbs 224 can be formed of the same or different materials as the clamping arm 22 and then connected to the second surface of the clamping arm 22. For example, a nickel-titanium wire or a nickel-titanium rod can be fixed on the second surface through a sleeve. The root of the barb 224 is connected to the clamp arm 22, and the end of the barb 224 opposite to its root is a suspended end. In the naturally expanded state, the suspended end of the barb 224 faces the clamp arm 21. The angle between the extension direction of the barb 224 and the second surface is less than or equal to 90 degrees, so as to enhance the clamping force of the valve clip 100 on the valve leaflet. Furthermore, the suspended end of each barb 224 is a smooth arc surface, so as to avoid damaging the valve tissue.

[0086] In other embodiments, the number of barbs 224 may be 1, 2, or other reasonable number.

[0087] In other embodiments, the clamping reinforcement may be a ridge, a boss or other irregularly distributed protrusions protruding from the second surface, or may be a rough surface at least partially covering the second surface to increase the clamping force on the leaflet.

[0088] The clamping arm 22 may also be provided with at least one opening 226 to reduce the weight of the clamping arm 22 and facilitate the climbing and growth of endothelial cells.

[0089] The valve clip 100 provided in this embodiment can be used to alleviate or treat "mitral regurgitation". Figure 12 to Figure 14 The valve clipper 100 is placed at the position where the anterior leaflet 1a and the posterior leaflet 1b of the mitral valve cannot be normally aligned, so that a corresponding set of forceps arms 21 and clamping arms 22 clamp the edge of the anterior leaflet 1a of the mitral valve, and another set of corresponding forceps arms 21 and clamping arms 22 clamp the edge of the posterior leaflet 1b of the mitral valve, so as to clamp the position where the anterior leaflet 1a and the posterior leaflet 1b of the mitral valve cannot be normally aligned together. Fig.13 and Fig.14 The arrows in the figure indicate the direction of blood flow. Fig.13 As shown in the figure, when the heart contracts, the anterior leaflet 1a and the posterior leaflet 1b are closed, and the positions where the anterior leaflet 1a and the posterior leaflet 1b cannot be normally closed are partially or completely closed together, the area A of the mitral valve opening becomes smaller or the mitral valve can be completely closed, and only a small amount of blood flows back from the mitral valve opening into the left atrium, thereby alleviating or treating "mitral valve regurgitation". Fig.14 As shown, when the heart is in diastole, the anterior leaflet 1a and the posterior leaflet 1b are only clamped together at position B where the valve clamp 100 is clamped, and the other positions of the anterior leaflet 1a and the posterior leaflet 1b are still normally relaxed, so that blood can enter the left ventricle from the left atrium, thereby ensuring the normal circulation of blood.

[0090] See also Fig.15 and Fig.16 The present invention also provides a valve clamping system, which includes a pushing device and the aforementioned valve clamp 100. The valve clamp 100 can be delivered to the mitral valve by the pushing device, and the valve clamp 100 can be adjusted to a suitable position of the mitral valve. The pushing device includes an operating handle and a pushing assembly, the proximal end of the pushing assembly is connected to the operating handle, and the distal end of the pushing assembly is detachably connected to the valve clamp 100. Specifically, the pushing assembly includes a core shaft 210, a liner 220, and an outer tube 230 that are coaxially sleeved together, and the liner 220 is located between the core shaft 210 and the outer tube 230. The operating handle can drive the core shaft 210, the liner 220, and the outer tube 230 to move or rotate relative to each other.

[0091] The core shaft 210 is detachably connected to the driving rod 31, and is used to drive the driving rod 31 to slide along the axial direction of the base 10, so as to drive the clamp arm 21 to open and close relative to the base 10. Specifically, in this embodiment, the core shaft 210 is a round rod having a stud 211 at the distal end, and the external thread of the stud 211 corresponds to the internal thread hole 311 at the proximal end of the driving rod 31. When the push assembly is connected to the valve clipper 100, the distal end of the core shaft 210 is threadedly connected to the proximal end of the driving rod 31, and the core shaft 210 is driven to move by the operating handle, thereby realizing the axial movement of the driving rod 31 along the base 10.

[0092] The liner 220 is used to push the T-shaped spring piece of the outer tube 230 and the spring piece in the middle of the first seat body 11 (ie, the second engaging portion 112 ) to achieve the connection between the outer tube 230 and the first seat body 11 and the free sliding of the driving rod 31 along the axial direction. Specifically, as mentioned above, in this embodiment, the operator can first use auxiliary tools such as a hook to reach into the first channel 131 from the gap between the spring piece and the opening in the middle of the first seat body 11, and hook the free end of the spring piece and pull it outward, so that the free end of the spring piece is flush with the outer wall of the first seat body 11 or protrudes from the outer wall of the first seat body 11; then, drive the liner 220 sleeved in the outer tube 230 to move to the position in the first channel 131 and below the spring piece, and release the restraint of the hook on the spring piece. At this time, the inverted T-shaped spring piece of the outer tube 230 and the spring piece at the second engaging portion 112 are lifted up by the liner 220 in turn, so that the first seat body 11 and the outer tube 230 are in a connected state, and the drive rod 31 threadedly connected to the core shaft 210 can slide freely along the axial direction under the drive of the core shaft 210.

[0093] In other embodiments, the liner 220 can be used in conjunction with the expansion tube 240 to push the spring sheet in the middle of the first seat body 11. Fig.17 As shown, the expansion tube 240 is coaxially sleeved in the liner 220, the distal outer wall of the liner 220 has a chamfer, and the distal end of the expansion tube 240 has a cone tip, and the chamfer of the liner 220 and the cone tip of the expansion tube 240 together form a cone surface, and the liner 220 and the expansion tube 240 are synchronously moved into the first sliding channel 131 and under the spring piece at the second clamping portion 112 by operating the handle. Under the action of the cone surface, the spring piece at the second clamping portion 112 is gradually lifted up, and then the expansion tube 240 is withdrawn, and the core shaft 210 is coaxially sleeved in the liner 220 for connection with the drive rod 31.

[0094] The outer tube 230 is provided with a first connection portion 231 at the distal end thereof, and the outer tube 230 is detachably connected to the first engaging portion 111 of the base 10 through the first connection portion 231, so as to be used for pushing the valve clip 100. Specifically, in this embodiment, the first connection portion 231 is a pair of inverted T-shaped spring pieces 231 arranged axially symmetrically, and is used to cooperate with the first engaging portion 111 (i.e., inverted T-shaped groove) at the proximal end of the first seat body 11, so as to realize the connection between the outer tube 230 and the first seat body 11. Specifically, in the natural state, one end of each inverted T-shaped spring piece is connected to the distal end of the outer tube 230, and the other end is inclined toward the axis position of the outer tube 230. When the pushing assembly is connected to the valve clamp 100, the operating handle drives the liner 220 to move distally, so that the liner 220 pushes the T-shaped spring piece of the outer tube 230 and is inserted into the first seat body 11, and the inverted T-shaped spring piece is embedded in the inverted T-shaped groove of the first seat body 11. At this time, the first seat body 11 and the outer tube 230 are in a connected state; when the liner 220 is moved proximally and leaves the first seat body 11 by the operating handle, the inverted T-shaped spring piece of the outer tube 230 returns to its natural state, and the inverted T-shaped spring piece deforms inwardly and disengages from the inverted T-shaped groove at the proximal end of the first seat body 11. At this time, the first seat body 11 and the outer tube 230 are unlocked.

[0095] Furthermore, the pushing device further comprises a control member, which is the aforementioned adjustment wire, and is used to fix the free end 222 of the clamping arm 22 to the surface of the base 10. The adjustment wire can be made of metal or polymer materials such as PTFE.

[0096] The following takes the mitral valve repair process as an example to illustrate the operation method of the valve clipping system of the present invention, which mainly includes the following steps:

[0097] Step 1: Use the adjustment line to tie the free end 222 of the clamping arm 22 to the surface of the base 10, and then connect the push assembly to the valve clip 100. Specifically, as mentioned above, use the liner 220 to lift the inverted T-shaped spring sheet of the outer tube 230 and the spring sheet in the middle of the first seat body 11, so that the inverted T-shaped spring sheet is embedded in the inverted T-shaped groove of the first seat body 11, so that the first seat body 11 and the outer tube 230 are in a connected state; rotate the core shaft 210 of the push assembly so that the core shaft 210 is screwed and fixed with the driving rod 31. Then, the core shaft 210 is moved toward the proximal direction by the operating handle to drive the driving rod 31 to slide axially toward the proximal direction, so that the valve clip 100 is in a fully retracted state. At this time, the clamp arm 21 and the clamping arm 22 are close to the surface of the base 10, and the retracted state remains unchanged.

[0098] Step 2: Using the trans-atrial septal approach, the valve clipper 100 connected thereto is pushed from the left atrium through the mitral valve to the left ventricle via the pushing assembly.

[0099] Step 3: The relative position of the valve clip 100 and the mitral valve is adjusted through the outer tube 230 so that the valve clip 100 is close to the anterior leaflet 1a and the posterior leaflet 1b of the mitral valve. Fig.18 shown.

[0100] Step 4: Move the core shaft 210 in the distal direction by operating the handle, thereby driving the driving rod 31 to slide in the distal direction to drive the clamp arm 21 to open relative to the base 10, and adjust the direction of the valve clamp 100 so that the clamp arm 21 is perpendicular to the mitral valve coaptation line.

[0101] Step 5: withdraw the entire valve clip 100 toward the proximal end, so that the clamp arm 21 holds the valve leaflet on the left ventricle side. Fig.19 shown.

[0102] Step 6: Release the restraint of the adjusting wire on the clamping arm 22, and the clamping arm 22 rebounds and opens relative to the base 10, so that the valve leaflet is clamped between the clamp arm 21 and the clamp arm 22, that is, the anterior leaflet 1a and the posterior leaflet 1b of the mitral valve are clamped between the corresponding clamp arm 21 and the clamp arm 22, respectively. Fig. 20 shown.

[0103] Step 7: Move the mandrel 210 toward the proximal direction again, and the mandrel 210 drives the driving rod 31 to slide axially toward the proximal end, thereby driving the clamp arm 21 to close relative to the base 10 until it is completely retracted. Fig.21 shown.

[0104] Step 8: The outer tube 230 is fixed, and the liner 220 is retracted toward the proximal end for a certain distance until the free end of the spring piece in the middle of the first seat body 11 is inserted into the slot 312 of the drive rod 31 to lock the position of the drive rod 31 in the sliding channel 13 of the base 10, ensuring that the clamp arm 21 is always in a fully retracted state relative to the base 10.

[0105] Step 9: The core shaft 210 is rotated by operating the handle to unlock the threads between the core shaft 210 and the driving rod 31, and then the liner 220 and the core shaft 210 are withdrawn proximally until the inverted T-shaped spring piece of the outer tube 230 is unlocked and separated from the inverted T-shaped groove of the first seat body 11, and the valve clip 100 is completely separated from the push assembly. Finally, the push assembly is withdrawn from the patient's body, and the valve clip 100 is left in the patient's body to complete the edge-to-edge repair of the mitral valve leaflets.

[0106] It is understandable that the valve clipping system of the present invention may also deliver the valve clipper 100 to the mitral valve via a transapical route or the like.

[0107] The valve clamping system of the present invention can be operated in vitro to clamp the valve leaflets with the valve clamp 100, thereby reducing or avoiding the problem of "mitral regurgitation". In addition, the valve clamp 100 has a small overall size and light weight, is easy to transport, and has strong anti-slip performance.

[0108] Please also read Fig. 22 and Fig.23 The structure of the valve clamp 100b provided in the second embodiment of the present invention is similar to that of the valve clamp 100 in the first embodiment, except that: in the second embodiment, the connection end 211 of the clamp arm 21b only includes a connection piece, and the connection ends 211 of the two clamp arms 21b are respectively located on the opposite sides of the second seat body 12. In this embodiment, there is only one connection piece on each of the opposite sides of the second seat body 12, which can reduce the axial size of the valve clamp 100b along the rotating shaft 40, improve the passability of the valve clamp 100b, and facilitate transportation. Furthermore, the connection end 211 of the clamp arm 21b only includes a connection piece, which can also reduce the weight of the valve clamp 100b, and the valve clamp 100b after release has a smaller pulling effect on the valve leaflet, thereby avoiding or reducing damage to the valve leaflet and improving the anti-slip performance of the valve clamp 100b.

[0109] Please also read Fig.24 and Fig.25 The structure of the valve clipper 100c provided in the third embodiment of the present invention is similar to that of the valve clipper 100 in the first embodiment, except that: in the third embodiment, a receiving groove 2114 is provided in the region of the clamp arm 21c corresponding to the barb 224 of the clamp arm 22. When the clamp arm 21c is aligned with the clamp arm 22, the barb 224 of the clamp arm 22 can be received in the corresponding receiving groove 2114 to compress the leaflet between the clamp arm 21c and the clamp arm 22, so that the clamping effect between the clamp arm 21c, the leaflet and the clamp arm 22 is more stable, and the damage to the leaflet is reduced. Furthermore, in this embodiment, the barb 224 is received in the corresponding receiving groove 2114, which can minimize the volume of the valve clipper 100c when it is folded, which is convenient for transportation.

[0110] Please also read Figures 26 to 30 The structure of the valve clipper 100d provided in the fourth embodiment of the present invention is similar to that of the valve clipper 100 in the first embodiment, except that: in the fourth embodiment, the locking method of the driving rod 31d in the sliding channel 13 is different. Specifically, in this embodiment, the driving assembly 30 further includes a locking block 33, which is screwed to the driving rod 31d to lock the position of the driving rod 31d in the sliding channel 13.

[0111] The driving rod 31d includes a screw section at the proximal end and a cylindrical section at the distal end. The screw section is provided with an external thread 314 for threading with the core shaft 210d, and the cylindrical section is provided with a pin hole 313 for inserting a driving pin 32 (not shown) in the radial direction. The distal end of the core shaft 210d is provided with an internal thread hole corresponding to the external thread 314 of the driving rod 31d.

[0112] The locking block 33 is cylindrical, and its proximal end is provided with a third engaging portion 331 for detachably connecting with the liner 220d. In this embodiment, the third engaging portion 331 is a docking groove radially opened at the proximal end of the locking block 33 and penetrating the outer wall surface of the locking block 33. Further, the distal end of the locking block 33 is provided with an internal threaded hole 332 penetrating along the axial direction, and the internal thread of the internal threaded hole 332 corresponds to the external thread 314 of the driving rod 31d. The locking block 33 is screwed to the screw section of the driving rod 31d through the internal threaded hole 332.

[0113] At least one docking piece is disposed at the distal end of the liner 220d, and the docking piece can dock in the docking groove of the locking block 33, so that the threaded position of the locking block 33 on the driving rod 31d can be adjusted by rotating the liner 220d. In this embodiment, a group of docking pieces are disposed axially symmetrically at the distal end of the liner 220d.

[0114] In this embodiment, when the driving rod 31d is driven to slide in the axial direction by moving the core shaft 210d, the locking block 33 screwed on the driving rod 31d will slide synchronously with the driving rod 31d, and in order to prevent the spring sheet in the middle of the first seat body 11 from preventing the driving rod 31d from sliding freely in the axial direction, the docking piece of the liner 220d needs to dock in the docking groove of the locking block 33 and slide synchronously with the locking block 33, so as to lift the spring sheet in the middle of the first seat body 11 through the liner 220d, thereby ensuring that the driving rod 31d can slide freely in the axial direction under the drive of the core shaft 210d. That is to say, when the driving rod 31d is driven to slide in the axial direction by the core shaft 210d, the core shaft 210d, the liner 220d, the driving rod 31d and the locking block 33 will slide synchronously as a whole.

[0115] Further, such as Fig.26As shown in the figure, when the position of the driving rod 31d in the sliding channel 13 needs to be locked, the core shaft 210d is kept stationary, and only the liner 220d (not shown) is rotated to rotate the liner 220d and the locking block 33 together and move to the distal end until the locking block 33 is located below the spring plate in the middle of the first seat body 11, and the distal end surface of the locking block 33 abuts against the stopper (i.e., the aforementioned inner step 14) in the sliding channel 13, so that the driving rod 31d screwed to the locking block 33 will not be able to move to the distal end. The liner 220d slides in the proximal direction and then withdraws the liner 220d toward the proximal end so that the docking piece of the liner 220d disengages from the docking groove of the locking block 33 and withdraws from the first seat body 11. At this time, the free end of the spring piece in the middle of the first seat body 11 (that is, the end of the spring piece tilted toward the sliding channel 13) deforms and rebounds inward and abuts against the proximal surface of the locking block 33. Under the action of the spring piece, the drive rod 31d screwed to the locking block 33 will not be able to slide in the proximal direction, and the position of the drive rod 31d is locked.

[0116] The difference from the first embodiment is that the connecting end of the spring piece in the middle of the first seat body 11 is connected to the proximal end of the opening in the middle of the first seat body 11 , while the free end of the spring piece in the middle of the first seat body 11 is located at the distal end and inclined toward the sliding channel 13 .

[0117] It should be noted that the above contents are all described by taking the valve clipper used to alleviate or treat "mitral valve regurgitation" as an example. It is understandable that in other embodiments, the valve clipper can also be used to alleviate or treat "tricuspid valve regurgitation", and its principle and structure are roughly the same as the principle and structure of the valve clipper used to solve "mitral valve regurgitation" in the embodiment of the present invention, and it only needs to clamp a valve leaflet respectively through multiple sets of clamp arms and clamping arms, which will not be described in detail here.

[0118] Obviously, in other embodiments, the valve clip provided by the present invention can also be applied to other minimally invasive surgical operations that require clamping three or more sheet-like valve tissues together.

[0119] The above is an implementation of the embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the embodiment of the present invention. These improvements and modifications are also considered to be within the scope of protection of the present invention.

Claims

1. A valve clipping device that prevents slipping, characterized in that: include: Pedestal; At least two clamp arms that open and close relative to the base, the clamp arms comprising a connecting end and a free end, the connecting ends of at least two of the clamp arms being rotatably connected to the base via the same rotating shaft, the connecting ends of at least two of the clamp arms being partially staggered, and each connecting end of the clamp arms being provided with a first guide groove; A driving assembly, the driving assembly comprising a driving pin and a driving rod axially slidably arranged in the base, the driving pin being arranged at the distal end of the driving rod, and the driving pin being passed through a first guide groove at the connecting end of at least two of the pliers arms; when the driving rod slides axially in the base, the driving rod drives the driving pin to slide in the first guide groove to drive the pliers arms to open and close relative to the base.

2. The valve clip according to claim 1, characterized in that: The base includes a first base body and a second base body connected to the distal end of the first base body, and the connecting end is rotatably connected to the second base body.

3. The valve clip according to claim 2, characterized in that: The connecting end includes at least one connecting piece, the free end includes a clamping piece, the proximal end of at least one connecting piece is connected to the distal end of the clamping piece, and the distal end of at least one connecting piece is rotatably connected to the second seat body through the rotating shaft.

4. The valve clip according to claim 3, characterized in that: A first connecting hole is formed at the distal end of the second seat body, and a second connecting hole is formed at the distal end of the connecting sheet; the rotating shaft passes through the first connecting hole and the second connecting hole, and the clamp arm rotates around the rotating shaft.

5. The valve clip according to claim 4, characterized in that: The proximal end of the second seat body is provided with a second guide slot, the first guide slot is provided at the proximal end of the connecting piece, and the lengths of the second guide slot and the first guide slot are equal or unequal.

6. The valve clip according to claim 5, characterized in that: The angle between the line connecting the distal center of the first guide groove and the center of the second connecting hole and the length direction of the clamp arm is the first angle, and the angle between the line connecting the proximal center and the distal center of the first guide groove and the length direction of the clamp arm is the second angle; the first angle and the second angle are equal or unequal in size.

7. The valve clip according to claim 6, characterized in that: The first angle ranges from 30 to 80 degrees.

8. The valve clip according to claim 5, characterized in that: A line connecting the proximal center of the first guide groove and the center of the second connecting hole is parallel or non-parallel to the length direction of the clamp arm.

9. The valve clip according to any one of claims 2 to 8, characterized in that: The base is provided with a sliding channel which penetrates the base in the axial direction, and the driving rod is slidably arranged in the sliding channel.

10. The valve clip according to claim 9, characterized in that: The base is provided with a second engaging portion, and the second engaging portion is used for locking the position of the driving rod in the sliding channel.

11. The valve clip according to claim 10, characterized in that: The second engaging portion is a spring sheet with one end inclined toward the inside of the sliding channel.

12. The valve clip according to claim 11, characterized in that: The outer peripheral surface of the proximal end of the driving rod is provided with a slot along the circumferential direction. When the inclined end of the spring piece is inserted into the slot, the position of the driving rod in the sliding channel is locked.

13. The valve clip according to claim 11, characterized in that: The driving assembly also includes a locking block, which is threadedly connected to the driving rod, and a stop portion is arranged in the sliding channel; when the stop portion stops at the distal end surface of the locking block and the inclined end of the spring plate abuts against the proximal end surface of the locking block, the position of the driving rod in the sliding channel is locked.

14. The valve clip according to claim 9, characterized in that: A pin hole is radially opened at the distal end of the driving rod, a second guide slot is opened at the proximal end of the second seat body, the first guide slot is opened at the proximal end of the connecting plate, and the driving pin is inserted into the pin hole, the second guide slot and the first guide slot; when the driving rod slides axially in the sliding channel, the driving rod drives the driving pin to slide in the second guide slot and the first guide slot to drive the clamp arm to open and close relative to the base.

15. The valve clip according to claim 1, characterized in that: The valve clipper also includes a clamping arm located between the base and the clamp arm; the clamping arm cooperates with the clamp arm to clamp valve tissue.

16. The valve clip according to claim 15, characterized in that: The clamping arm extends radially outward relative to the base, and an angle between a length direction of the clamping arm and an axial direction of the base is a third angle, and an angle range of the third angle is 0 to 80 degrees.

17. The valve clip according to claim 15, characterized in that: A clamping reinforcement piece is arranged on the surface of the clamping arm facing the clamp arm, and the clamping reinforcement piece is at least one barb protruding from the surface.

18. The valve clip according to claim 17, characterized in that: The clamp arm is provided with a receiving groove in the area corresponding to the barb. When the clamp arm is matched with the clamp arm, at least one barb is received in the receiving groove.

19. The valve clip according to claim 15, characterized in that: The clamp arm and / or the clamping arm is provided with at least one opening.

20. A valve clamping system, characterized in that: It comprises a pushing device and the valve clamp according to any one of claims 1 to 14, wherein the pushing device comprises an operating handle and a pushing assembly, wherein the proximal end of the pushing assembly is connected to the operating handle, and the distal end of the pushing assembly is detachably connected to the valve clamp.

21. The valve clipping system according to claim 20, characterized in that: The pushing assembly comprises a core shaft, a liner and an outer tube which are coaxially sleeved together movably, and the liner is located between the core shaft and the outer tube.

22. The valve clipping system according to claim 21, characterized in that: A first connection portion is disposed at the distal end of the outer tube, and the outer tube is detachably connected to the base via the first connection portion.

23. The valve clipping system according to claim 21, characterized in that: The core shaft is detachably connected to the driving rod, and the core shaft is used to drive the driving rod to slide along the axial direction of the base to drive the clamp arm to open and close relative to the base.

24. The valve clamping system according to claim 20, characterized in that: The valve clamp also includes a clamping arm located between the base and the clamp arm, and the clamping arm cooperates with the clamp arm to clamp the valve tissue; the pushing device also includes a control member connected to the clamping arm, and the control member is used to fix the clamping arm to fit the base.

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