Cold compress preparation method, cold compress and use method thereof

Abstract

The invention relates to a method for preparing a cold compress, a cold compress and a method for using the same. The method comprises the following steps: preparing a carbomer solution; wherein, in terms of mass percentage, the carbomer solution comprises the following components: 0.03-0.1% carbomer gel matrix, 0.03-0.1% pH adjuster, 0.01-0.2% preservative, 10-30% moisturizer, 0.05-2% active ingredient, 0.02-1% penetration enhancer, 0.03-1% antibacterial agent, 0.01-0.1% osmotic pressure regulator, 0.02-0.5% dispersant, 0.2-1% antioxidant, and 70-85% purified water; placing a bamboo fiber diaphragm in an aluminum-plastic bag, and taking the carbomer solution and putting it in the aluminum-plastic bag, so that the carbomer solution adheres to the bamboo fiber diaphragm to form a cold compress. The present invention can solve the problem that the oral health food products for relieving visual fatigue in the related art are slow to take effect and cannot effectively and quickly relieve consumers' visual fatigue, dry eyes, sore eyes, eye pain and other problems.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a method for preparing a cold compress, a cold compress and a method of using the same. Background Art

[0002] Eyes are one of the important organs of the human body. Visual fatigue, dry eyes, astringent eyes, eye pain, etc. are currently common occupational eye diseases. With the development of society, electronic products have become popular. Most work is done online, relying on computers and mobile phones. However, long-term use of electronic products will lead to a series of eye discomfort problems such as visual fatigue, dry eyes, astringent eyes, eye pain, poor eye skin, etc., and will also cause fatigue of the brain and body and mind, which will directly affect work efficiency. At present, consumers mainly take health foods, eye drops or apply some single-function patches for a long time to relieve visual fatigue, dry eyes, astringent eyes, eye pain, etc. caused by electronic office. These products are slow to take effect, have a long use time, and have a short effect duration. They cannot effectively and quickly relieve consumers' eye discomfort during electronic office.

[0003] For example, Chinese patent CN201811003047.8 discloses a medical ophthalmic cold compress and a preparation method thereof. The product prepared by the method mainly has moisturizing and disinfecting effects, and its function is relatively simple. In addition, when preparing the carbomer gel matrix, the carbomer used in the method is left to swell overnight for a time of ≥15h. After the swelling is completed, other excipients are added, and finally triethylamine is added to adjust the pH value. The efficiency of this preparation method is relatively low, and the carbomer is not completely swollen. During the final addition of triethylamine, the local solubility of the solution is too large, resulting in uneven products. In addition, Chinese patent CN201811618042.6 discloses a cold compress eye patch for improving dry eyes, astringent eyes, and eye fatigue. Some traditional Chinese medicines are used to extract active substances and hydrogels to prepare cold compress patches to improve dry eyes, astringent eyes, and eye fatigue. The organic solvents dichloromethane and ethanol are used to extract the active substances, which are relatively irritating and not suitable for all consumers. And traditional Chinese medicine has an unpleasant smell, which is easy to cause consumers to be disgusted.

[0004] Therefore, in response to the above problems, it is necessary to develop external cold compress products that can quickly relieve visual fatigue, dry eyes, eye astringency, eye pain, etc., so as to provide more choices for people with eye discomfort. Summary of the invention

[0005] The present invention provides a method for preparing a cold compress patch, a cold compress patch and a method of using the cold compress patch, so as to solve the problem that products for relieving visual fatigue, dry eyes, eye astringency, eye pain, etc. in the related art are slow to take effect, have a long use time, have a short duration of effect, and cannot effectively and quickly relieve consumers' eye discomfort.

[0006] In a first aspect, the present invention provides a method for preparing a cold compress patch, comprising the following steps:

[0007] Prepare a carbomer solution; wherein, according to mass percentage, the carbomer solution includes the following components: 0.03-0.1% carbomer gel base, 0.03-0.1% pH adjuster, 0.01-0.2% preservative, 10-30% moisturizer, 0.05-2% active ingredient, 0.02-1% penetration enhancer, 0.03-1% antibacterial agent, 0.01-0.1% osmotic pressure regulator, 0.02-0.5% dispersant, 0.2-1% antioxidant, and 70-85% purified water;

[0008] Put the bamboo fiber diaphragm into an aluminum-plastic bag, and put the carbomer solution into the aluminum-plastic bag, so that the carbomer solution adheres to the bamboo fiber diaphragm to form a cold compress.

[0009] In some embodiments, during the step of "preparing a carbomer solution", the carbomer solution further comprises 0.02-1% of a deodorant in terms of mass percentage.

[0010] In some embodiments, the step of "preparing a carbomer solution" comprises the following steps:

[0011] Measure the formulated amount of purified water, weigh the formulated amount of carbomer, and add a certain multiple of the formulated amount of carbomer purified water into a container, then slowly add the weighed carbomer into the container, and then place the container in a homogenizer for homogenization and swelling treatment to form a carbomer swelling solution.

[0012] In some embodiments, after the step of "forming a carbomer swelling solution", the following steps are included:

[0013] Weigh the formulated amount of active ingredients and place them in a container, then add a certain multiple of the formulated amount of active ingredients into purified water and add it to the container, stirring to fully dissolve the active ingredients to form an active solution;

[0014] Weigh the formulated amount of preservative and moisturizer into a container, and stir to dissolve to form a preservative solution;

[0015] Weigh the formulated amount of dispersant, deodorant and antibacterial agent and place them in a container, and stir and emulsify them evenly to form an emulsion.

[0016] In some embodiments, after the step of "forming a carbomer swelling solution", the following steps are included:

[0017] Taking out the carbomer swelling solution from the homogenizer, adding the formulated amount of pH adjuster to the carbomer swelling solution, and stirring to form a transparent gel;

[0018] Take the remaining amount of purified water and add it to the transparent gel, stir and mix evenly with the transparent gel to form a gel solution.

[0019] In some embodiments, after the step of "forming a gel solution", the following steps are included:

[0020] Add a formulated amount of moisturizer, a formulated amount of osmotic pressure regulator and a formulated amount of antioxidant to the gel solution and stir evenly;

[0021] Add the formulated amount of penetration enhancer, prepared active solution, prepared preservative solution and prepared emulsified solution into the gel solution, and stir evenly to form a finished product solution.

[0022] In some embodiments, the penetration enhancer is water-soluble mint;

[0023] The osmotic pressure regulator is sodium chloride.

[0024] In some embodiments, the active ingredient is one or more of sodium hyaluronate, lutein, and fish oil;

[0025] The pH regulator is one or more of triethanolamine, sodium hydroxide and sodium bicarbonate.

[0026] In some embodiments, the preservative is one or more of ethylparaben, benzoic acid, and sodium benzoate;

[0027] The moisturizing agent is one or more of propylene glycol, butylene glycol and glycerin.

[0028] In some embodiments, the antioxidant is one or more of cysteine, L-cysteine, L-cysteine ​​hydrochloride, acetyl L-cysteine, and acetyl L-cysteine ​​hydrochloride;

[0029] The dispersant is one or more of polysorbate 20 and polysorbate 80;

[0030] The deodorant is one or more of blueberry anthocyanin, water lotus essence, and blue ocean fantasy essence;

[0031] The antibacterial agent is tea tree essential oil.

[0032] In some embodiments, in the step of "putting the bamboo fiber membrane into an aluminum-plastic bag, and taking the carbomer solution into the aluminum-plastic bag", the bamboo fiber membrane has a length of 90 to 110 mm and a width of 50 to 70 mm;

[0033] The weight of the carbomer solution loaded into the aluminum-plastic bag is 6.0 to 8.0 g.

[0034] In a second aspect, the present invention provides a cold compress patch, which is made using the cold compress patch preparation method described above.

[0035] In a third aspect, the present invention provides a method for using a cold compress patch, wherein the cold compress patch as described above is applied to the eyes for 10 to 20 minutes to relieve eye fatigue.

[0036] The beneficial effects brought by the technical solution provided by the present invention include: in the process of making the cold compress patch, a certain amount of active ingredients, osmotic pressure regulators and antioxidants are added. Among them, the active ingredients can act on the eyes, nourish and lubricate the eyes, provide nutrition for the eyes, and relieve eye fatigue; and the osmotic pressure regulator not only has the function of regulating the osmotic pressure of the solution, but also can regulate the viscosity of the solution, so that the active ingredients in the solution are more easily absorbed by the eyes, and the effect is better; and the antioxidant has a relatively good antioxidant effect, and also has a whitening effect, and can also coordinate with the active ingredients. Compared with traditional products for relieving visual fatigue, the cold compress patch prepared by the preparation method proposed by the present invention can be directly applied to the eyes to act on the eyes, is easy to use, has a relatively faster effect, has low risk, and lasts for a long time, and can effectively and quickly relieve consumers' visual fatigue, dry eyes, astringent eyes, eye pain and other problems during electronic office. And the production cycle is short, the production process is simple, and the use cost of consumers can be effectively reduced. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0038] Figure 1 The present invention is a flowchart of a method for preparing a cold compress patch according to an embodiment of the present invention. DETAILED DESCRIPTION

[0039] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0040] At present, consumers mainly take health food, drop eye drops or apply some single-function patches for a long time to relieve visual fatigue, which is slow to take effect, short-term effect, long use time, short duration, etc., and cannot effectively and quickly relieve the eye discomfort of consumers in electronic office. Therefore, it is necessary to develop external cold compress products that can quickly relieve visual fatigue, dry eyes, astringent eyes, eye pain, etc., so as to give more choices to the majority of people with visual fatigue. Therefore, the present invention proposes a preparation method of a cold compress patch, a cold compress patch and a method of using the same.

[0041] like Figure 1 As shown, the preparation method of the cold compress patch proposed by the present invention comprises the following steps:

[0042] S100, preparing a carbomer solution; wherein, the carbomer solution comprises the following components in percentage by mass: 0.03-0.1% carbomer gel base, 0.03-0.1% pH adjuster, 0.01-0.2% preservative, 10-30% moisturizer, 0.05-2% active ingredient, 0.02-1% penetration enhancer, 0.03-1% antibacterial agent, 0.01-0.1% osmotic pressure regulator, 0.02-0.5% dispersant, 0.2-1% antioxidant, and 70-85% purified water;

[0043] That is, in the finally prepared carbomer solution, the mass of the carbomer gel matrix accounts for 0.03-0.1% of the total mass of the carbomer solution, the mass of the pH regulator accounts for 0.03-0.1% of the total mass of the carbomer solution, the mass of the preservative accounts for 0.01-0.2% of the total mass of the carbomer solution, the mass of the moisturizer accounts for 10-30% of the total mass of the carbomer solution, the mass of the active ingredient accounts for 0.05-2% of the total mass of the carbomer solution, the mass of the penetration enhancer accounts for 0.02-1% of the total mass of the carbomer solution, the mass of the antibacterial agent accounts for 0.03-1% of the total mass of the carbomer solution, the mass of the osmotic pressure regulator accounts for 0.01-0.1% of the total mass of the carbomer solution, the mass of the dispersant accounts for 0.02-0.5% of the total mass of the carbomer solution, the mass of the antioxidant accounts for 0.2-1% of the total mass of the carbomer solution, and the mass of purified water accounts for 70-85% of the total mass of the carbomer solution.

[0044] S200, placing the bamboo fiber diaphragm into an aluminum-plastic bag, and placing the carbomer solution into the aluminum-plastic bag, so that the carbomer solution adheres to the bamboo fiber diaphragm to form a cold compress.

[0045] The prepared carbomer solution and bamboo fiber membrane are put into an aluminum-plastic bag, so that the carbomer solution adheres to the bamboo fiber membrane in the form of gel to form a cold compress, which can be conveniently applied around the user's eyes to relieve visual fatigue.

[0046] Moreover, in the above step S100, i.e., the step of "preparing carbomer solution", the carbomer solution further includes 0.02-1% of a deodorant in terms of mass percentage, i.e., the mass of the deodorant accounts for 0.02-1% of the total mass of the carbomer solution, and the deodorant is used to deodorize and enhance the aroma of the carbomer solution.

[0047] In addition, in the above step S100, the step of "preparing a carbomer solution" includes the following steps:

[0048] S110, measuring the formulated amount of purified water, weighing the formulated amount of carbomer, and adding a certain multiple of the formulated amount of carbomer purified water into a container, then slowly adding the weighed carbomer into the container, and then placing the container in a homogenizer for homogenization and swelling treatment to form a carbomer swelling solution.

[0049] In conventional methods, the gel matrix is ​​swollen by standing still, and the swelling time is greater than or equal to 15 hours, the swelling effect is poor, and there are lumps, resulting in poor product quality. However, in the swelling process of the gel matrix, the present invention adopts a high-speed homogenization method to make the gel matrix fully contact with purified water, greatly reducing the swelling time, and reducing the swelling time from more than 15 hours to less than 4 hours.

[0050] In addition, after the above step S110, i.e. the step of "forming a carbomer swelling solution", the following steps are included:

[0051] S120, weighing a formulated amount of active ingredient and placing it in a container, then taking a certain multiple of the formulated amount of the active ingredient and adding purified water into the container, stirring to fully dissolve the active ingredient to form an active liquid;

[0052] S130, weighing a formula amount of a preservative and a moisturizer, placing them in a container, stirring and dissolving them to form a preservative solution;

[0053] S140, weigh out the dispersant, deodorant, and antibacterial agent in the formula, put them in a container, and stir and emulsify them evenly to form an emulsion.

[0054] That is, after the carbomer swelling solution is formed by using purified water and carbomer, it is also necessary to prepare an active solution formed by an activating component, a preservative solution formed by a preservative and a moisturizer, and an emulsion formed by a dispersant, a deodorant, and an antibacterial agent. In addition, it should be pointed out that the above three steps S120, S130, and S140 can be performed in no particular order and can be performed simultaneously, or any step can be performed first.

[0055] In addition, after the above step S110, i.e. the step of "forming a carbomer swelling solution", the following steps are included:

[0056] S150, taking out the carbomer swelling solution from the homogenizer, adding a formulated amount of pH regulator to the carbomer swelling solution, and stirring to form a transparent gel;

[0057] S160, taking the remaining amount of purified water and adding it to the transparent gel, stirring and mixing with the transparent gel to form a gel solution.

[0058] In conventional processes, various ingredients are added first, and then the pH regulator is added to form a gel, which easily makes the components of the product uneven. However, in the present invention, the pH regulator is added to form a gel after the carbomer matrix is ​​completely swollen, and then water is added to dilute it, and then the components are added, so that the quality of the entire gel system is more uniform. That is, the present invention uses a pH regulator to form a gel first, and then dilutes it with water, so that the final gel system is more uniform, and the pH value of the solution can be conveniently controlled at 5.5 to 7.5, which will not cause the decomposition of active ingredients sensitive to acid and alkali.

[0059] Moreover, after the above step S160, i.e. the step of "forming a gel solution", the following steps are included:

[0060] S170, adding a formulated amount of moisturizer, a formulated amount of osmotic pressure regulator, and a formulated amount of antioxidant to the gel solution, and stirring evenly; adding the osmotic pressure regulator to ensure that the osmotic pressure of the cold compress is close to that of the eye, promotes the absorption of nutrients, and improves the effect of the cold compress;

[0061] S180, adding the formulated amount of penetration enhancer, the prepared active solution, the prepared preservative solution, and the prepared emulsified solution into the gel solution, and stirring evenly to form a finished product solution.

[0062] In addition, it should be noted that the prepared active liquid and the prepared preservative liquid can also be added to the gel solution in step S170 for stirring and mixing. Moreover, there is no order of precedence between step S170 and step S180.

[0063] In addition, in some embodiments, the above-mentioned penetration promoter uses water-soluble mint. Water-soluble mint can have refreshing, cooling, antipruritic and skin-tightening effects on the skin, mucous membrane, sense of smell, taste, etc., giving people a cold and cool comfortable feeling; and water-soluble mint has a good penetration-promoting effect, which is conducive to the absorption of cold compresses by the eyes. In addition, the above-mentioned osmotic pressure regulator uses sodium chloride, which itself has the function of regulating the osmotic pressure of the solution, has a good osmotic pressure regulating effect, and can also regulate the viscosity of the solution, so that the active ingredients in the solution are more easily absorbed by the eyes, and the effect is better. At the same time, it is ensured that the solution is completely adsorbed on the bamboo fiber eye mask, and there will be no phenomenon of solution dripping when using it, which is more convenient for consumers to use.

[0064] In addition, in some embodiments, the above-mentioned active ingredients are one or more of sodium hyaluronate, lutein, and fish oil. Sodium hyaluronate is an inherent component in the human body. It is a glucuronic acid with no species specificity. It is widely present in tissues such as the placenta, amniotic fluid, lens, articular cartilage, and skin dermis. In organs, it is distributed in the cytoplasm and intercellular matrix, and plays a lubricating and nourishing role on the cells and cell organs contained therein. Lutein is a kind of fat-soluble vitamin, and its absorption spectrum contains near-blue-violet light, which can help the retina of the eye resist ultraviolet rays. For the eyes, lutein is an important antioxidant. Supplementing a large amount of lutein to the human body helps to maintain the durability of vision, improve visual reaction time, and reduce visual damage. For myopic people, supplementing lutein can delay the increase of their myopia, and regular use of lutein can effectively prevent computer radiation from damaging the human body. Fish oil is a kind of oil extracted from fatty fish, rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA, commonly known as brain gold) and various n-3 polyunsaturated fatty acids (n-3PUFA). These active ingredients can provide nutrition for the eyes and relieve eye fatigue.

[0065] In addition, the pH regulator is one or more of triethanolamine, sodium hydroxide, and sodium bicarbonate. Triethanolamine is a high-quality additive that can achieve thickening and moisturizing effects, optimize the product experience, and reduce skin irritation. Moreover, triethanolamine, sodium hydroxide, and sodium bicarbonate are all alkaline substances with good pH regulating effects, which are conducive to the formation of gel in the carbomer swelling solution.

[0066] In addition, the preservative is one or more of ethylparaben, benzoic acid, and sodium benzoate. Ethylparaben, benzoic acid, and sodium benzoate all have good antibacterial effects and good preservative effects. The antibacterial agent is tea tree essential oil. Tea tree essential oil has the effects of sterilization and anti-inflammatory, astringent pores, clear mind, rejuvenation, and anti-depression. In addition, the moisturizer is one or more of propylene glycol, butylene glycol, and glycerol. Propylene glycol, butylene glycol, and glycerol all have good moisturizing effects.

[0067] In addition, the above antioxidants are selected from one or more of cysteine, L-cysteine, L-cysteine ​​hydrochloride, acetyl L-cysteine, and acetyl L-cysteine ​​hydrochloride. Cysteine, L-cysteine, L-cysteine ​​hydrochloride, acetyl L-cysteine, and acetyl L-cysteine ​​hydrochloride all have the functions of removing free radicals in the body, antioxidants, and copper integrators, and are good antioxidants. L-cysteine ​​series antioxidants are relatively good antioxidants, all have whitening effects, and can also coordinate with active ingredients to promote the absorption of active ingredients.

[0068] In addition, the above-mentioned dispersant adopts one or more of polysorbate 20 and polysorbate 80. Polysorbate 20 and polysorbate 80 can be used as solubilizers or emulsifiers, which are conducive to the dissolution and emulsification of other viscous substances (such as tea tree essential oil). In addition, the above-mentioned deodorant adopts one or more of blueberry anthocyanidin, water lotus essence, and blue sea fantasy essence. Blueberry anthocyanidin has the effect of enhancing vision and eliminating eye fatigue. Moreover, blueberry anthocyanidin, water lotus essence, and blue sea fantasy essence all have very fragrant smells, which can cover the smells of other substances and make people feel happy when they smell them.

[0069] In addition, in the step of "putting the bamboo fiber diaphragm into the aluminum-plastic bag, and taking the carbomer solution into the aluminum-plastic bag" in the above step S200, the length of the above bamboo fiber diaphragm can be 90-110 mm and the width can be 50-70 mm. Moreover, the bamboo fiber diaphragm can be set to a special shape to fit the shape of the eye and act better on the eye. In addition, the weight of the carbomer solution loaded into the aluminum-plastic bag can be 6.0-8.0 g, and the number of bamboo fiber diaphragms can be 2 pieces, so that the bamboo fiber diaphragm can fully absorb the carbomer solution. In addition, as needed, the weight of the carbomer solution loaded into the aluminum-plastic bag can be changed (such as greater than 8.0 g), and the number of bamboo fiber diaphragms put into the aluminum-plastic bag can also be changed (such as set to 3 pieces, 4 pieces or more pieces) to achieve a good adsorption effect.

[0070] In addition, the present invention provides a cold compress patch, which is made by the cold compress patch preparation method described above. The cold compress patch comprises the bamboo fiber membrane sheet described above, and a carbomer solution attached to the bamboo fiber membrane sheet.

[0071] In addition, the present invention provides a method for using a cold compress patch, wherein the cold compress patch is applied to the eyes for 10 to 20 minutes to relieve eye fatigue.

[0072] The beneficial effects brought by the technical solution provided by the present invention include: in the process of making the cold compress, a certain amount of active ingredients, osmotic pressure regulators and antioxidants are added. Among them, the active ingredients can act on the eyes, nourish and lubricate the eyes, provide nutrition for the eyes, and relieve eye fatigue; and the osmotic pressure regulator not only has the effect of regulating the osmotic pressure of the solution, but also can regulate the viscosity of the solution, so that the active ingredients in the solution are more easily absorbed by the eyes, and the effect is better; and the antioxidant has a relatively good antioxidant effect, and also has a whitening effect, and can also coordinate with the active ingredients; and by adding a corrective, the smell of the product can be improved, which makes people feel pleasant and will not cause consumers to be disgusted. Compared with traditional oral health foods, eye drops or long-term application of some single-function patches to relieve visual fatigue, the effect is relatively slow, the effect time is short, and the use time is long. Problems such as time cannot effectively and quickly relieve consumers' visual fatigue during electronic office. The cold compress patch made by the preparation method proposed in the present invention can be directly applied to the eyes to act on the eyes, is easy to use, has a relatively quick effect, has low risk, and can effectively and quickly alleviate the problem of visual fatigue of consumers in electronic office work. In addition, the production cycle is short and the production process is simple, which can effectively reduce the use cost of consumers.

[0073] Example 1

[0074] In this embodiment, a carbomer solution with a total mass of 1000 g is prepared according to the formula amount shown in Table 1 below:

[0075] Table 1

[0076] Serial number name Mass / g 1 Carbomer (gel base) 0.6 2 Triethanolamine (pH adjuster) 0.6 3 Ethylparaben (preservative) 1.5 4 Propylene glycol (humectant) 50 5 Butylene glycol (humectant) 100 6 Glycerin (humectant) 130 7 Sodium Hyaluronate (active ingredient) 0.5 8 Water-soluble mint (penetration enhancer) 0.2 9 Lotus essence (deodorant) 0.2 10 Tea tree essential oil (antibacterial agent) 0.3 11 Sodium chloride (osmotic pressure regulator) 0.1 12 Polysorbate 20 (dispersant) 0.2 13 L-Cysteine ​​(antioxidant) 2 14 Purified water 713.8 15 total 1000

[0077] In this embodiment, the preparation method of the cold compress patch is as follows:

[0078] First, prepare the carbomer solution according to the formula in Table 1. The process steps are as follows:

[0079] 1. Measure the formula amount (713.8 g) of purified water, weigh the formula amount (0.6 g) of carbomer (i.e., gel matrix), take 200 times the weight of carbomer (i.e., 120 g) of purified water in a container, slowly add the formulated amount of carbomer, place in a homogenizer, and homogenize at high speed for 30 min at a speed of 2000 rpm. After the homogenization is completed, let it stand for swelling for 3 h to form a carbomer swelling solution;

[0080] 2. Weigh the formulated amount (0.5 g) of sodium hyaluronate (active ingredient), add 100 times (i.e. 50 g) of purified water to the formulated amount of sodium hyaluronate (active ingredient), and stir to fully dissolve the sodium hyaluronate (active ingredient) to form an active solution;

[0081] 3. Weigh the formula amount (1.5 g) of ethylparaben (preservative) and the formula amount (50 g) of propylene glycol (humectant), add them into a container and stir for 15 minutes to completely dissolve the ethylparaben to form an ethylparaben preservative solution;

[0082] 4. Weigh the formula amount (0.2 g) of polysorbate 20 (dispersant), the formula amount (0.2 g) of lotus essence (deodorant), and the formula amount (0.3 g) of tea tree essential oil (antibacterial agent), add them into the container and stir for 15 minutes to form an emulsion;

[0083] 5. Weigh the formulated amount (0.6 g) of triethanolamine (pH regulator), take out the swollen carbomer swelling solution, add the formulated amount of triethanolamine to the carbomer swelling solution, and stir for 15 minutes to form a transparent gel;

[0084] 6. Add the remaining amount (543.8 g) of purified water to the transparent gel and stir for 15 minutes to mix well to form a gel solution;

[0085] 7. Weigh the formula amount (100 g) of 1,3-butanediol (humectant), the formula amount (130 g) of glycerol (humectant), the formula amount (0.1 g) of sodium chloride (osmotic pressure regulator) and the formula amount (2 g) of L-cysteine ​​(antioxidant), add them to the gel solution in sequence, and stir for 15 minutes;

[0086] 8. Weigh the formula amount (0.2 g) of water-soluble mint (penetration enhancer), add the water-soluble mint, the prepared active solution, the prepared preservative solution and the prepared emulsified solution to the gel solution in turn, and stir evenly; stir for 15 minutes, and let it stand for more than 30 minutes after stirring to form a carbomer finished solution.

[0087] Then, the carbomer solution is filled, and the process steps are as follows:

[0088] Put two pieces of special-shaped bamboo fiber membranes (90*50mm) into an aluminum-plastic bag; take a certain amount (such as 6.5g) of prepared carbomer solution into the aluminum-plastic bag, and seal the aluminum-plastic bag; make the carbomer solution adhere to the bamboo fiber membrane to form a cold compress.

[0089] Moreover, when filling the carbomer solution, the pH value, osmotic pressure and microorganisms of the solution can also be tested to check whether the product is qualified.

[0090] Example 2

[0091] In this embodiment, a carbomer solution with a total mass of 1000 g is prepared according to the formula amount shown in Table 2 below:

[0092] Table 2 Serial number name Mass / g 1 Carbomer (gel base) 0.8 2 Sodium bicarbonate (pH adjuster) 0.6 3 Benzoic acid (preservative) 1 4 Propylene glycol (humectant) 100 5 Butylene glycol (humectant) 80 6 Glycerin (humectant) 90 7 Sodium Hyaluronate (active ingredient) 0.5 8 Water-soluble mint (penetration enhancer) 0.4 9 Blueberry Anthocyanin (Deodorant) 0.4 10 Tea tree essential oil (antibacterial agent) 0.5 11 Sodium chloride (osmotic pressure regulator) 0.1 12 Polysorbate 80 (dispersant) 0.4 13 Cysteine ​​(antioxidant) 4 14 Purified water 721.3 15 total 1000

[0093] In this embodiment, the preparation method of the cold compress patch is as follows:

[0094] First, the carbomer solution was prepared according to the formula in Table 2. The process steps are as follows:

[0095] 1. Measure the formula amount (721.3 g) of purified water, weigh the formula amount (0.8 g) of carbomer (i.e., gel matrix), take 200 times the weight of carbomer (i.e., 160 g) of purified water in a container, slowly add the formulated amount of carbomer into the container, place in a homogenizer, and homogenize at high speed for 30 min at a speed of 2500 rpm. After the homogenization is completed, let it stand for 2.5 h to swell and form a carbomer swelling solution;

[0096] 2. Weigh the formulated amount (0.5 g) of sodium hyaluronate (active ingredient), add 100 times (i.e. 50 g) of purified water to the formulated amount of sodium hyaluronate (active ingredient), and stir to fully dissolve the sodium hyaluronate (active ingredient) to form an active solution;

[0097] 3. Weigh the formula amount (1 g) of benzoic acid (preservative) and the formula amount (100 g) of propylene glycol (humectant), add them into a container and stir for 15 minutes to completely dissolve the benzoic acid to form a benzoic acid preservative solution;

[0098] 4. Weigh the formula amount (0.4 g) of polysorbate 80 (dispersant), the formula amount (0.4 g) of blueberry anthocyanin (deodorant), and the formula amount (0.5 g) of tea tree essential oil (antibacterial agent), add them into the container and stir for 15 minutes to form an emulsion;

[0099] 5. Weigh the formulated amount (0.6 g) of sodium bicarbonate (pH regulator), take out the swollen carbomer solution, add the formulated amount of sodium bicarbonate to the carbomer solution, and stir for 15 minutes to form a transparent gel;

[0100] 6. Add the remaining amount (511.3 g) of purified water to the transparent gel and stir for 15 minutes to mix well to form a gel solution;

[0101] 7. Weigh the formulated amount (80 g) of 1,3-butanediol (humectant), the formulated amount (90 g) of glycerol, the formulated amount (0.1 g) of sodium chloride (osmotic pressure regulator) and the formulated amount (4 g) of cysteine ​​(antioxidant), add them to the gel solution in sequence, and stir for 15 minutes;

[0102] 8. Weigh the formulated amount (0.4 g) of water-soluble mint (penetration enhancer), add the water-soluble mint, the prepared active solution, the prepared preservative solution and the prepared emulsified solution to the gel solution in sequence, and stir evenly; stir for 15 minutes, and leave it for more than 30 minutes after stirring to form a finished carbomer solution.

[0103] Then, the carbomer solution is filled, and the process steps are as follows:

[0104] Put two pieces of special-shaped bamboo fiber membranes (100*60mm) into an aluminum-plastic bag; take a certain amount (such as 7.0g) of prepared carbomer solution into the aluminum-plastic bag, and seal the aluminum-plastic bag; make the carbomer solution adhere to the bamboo fiber membrane to form a cold compress.

[0105] Moreover, when filling the carbomer solution, the pH value, osmotic pressure and microorganisms of the solution can also be tested to check whether the product is qualified.

[0106] Example 3

[0107] In this embodiment, a carbomer solution with a total mass of 1000 g is prepared according to the formula amount shown in Table 3 below:

[0108]

[0109]

[0110] In this embodiment, the preparation method of the cold compress patch is as follows:

[0111] First, prepare the carbomer solution according to the formula in Table 3. The process steps are as follows:

[0112] 1. Measure the formula amount (716 g) of purified water, weigh the formula amount (1 g) of carbomer (i.e., gel matrix), take 200 times the weight of carbomer (i.e., 200 g) of purified water in a container, slowly add the formulated amount of carbomer into the container, place in a homogenizer, homogenize at high speed for 30 min at a speed of 3000 rpm, and after the homogenization is completed, let it stand for 2 h to swell to form a carbomer swelling solution;

[0113] 2. Weigh the formula amount (10 g) of sodium hyaluronate (active ingredient), add 20 times (i.e. 200 g) of purified water as the formula amount of sodium hyaluronate (active ingredient), and stir to fully dissolve the sodium hyaluronate (active ingredient) to form an active solution;

[0114] 3. Weigh the formula amount (1 g) of sodium benzoate (preservative) and the formula amount (70 g) of propylene glycol (humectant), add them into a container and stir for 15 minutes to completely dissolve the sodium benzoate to form a sodium benzoate preservative solution;

[0115] 4. Weigh the formula amount (5 g) of polysorbate 20 (dispersant), the formula amount (8 g) of fish oil (active ingredient), the formula amount (0.5 g) of Vernis essence (deodorant) and the formula amount (5 g) of tea tree essential oil (antibacterial agent), add them into a container and stir for 15 minutes to form an emulsion;

[0116] 5. Weigh the formulated amount (0.5 g) of sodium hydroxide (pH regulator), take out the swollen carbomer swelling solution, add the formulated amount of sodium hydroxide to the carbomer swelling solution, and stir for 15 minutes to form a transparent gel;

[0117] 6. Add the remaining amount (316 g) of purified water to the transparent gel and stir for 15 minutes to mix well to form a gel solution;

[0118] 7. Weigh the formula amount (70 g) of 1,3-butanediol (humectant), the formula amount (100 g) of glycerol (humectant), the formula amount (1 g) of sodium chloride (osmotic pressure regulator), and the formula amount (4 g) of L-cysteine, add them to the gel solution in sequence, and stir for 15 minutes;

[0119] 8. Weigh the formula amount (8 g) of water-soluble mint (penetration enhancer), add the water-soluble mint, the prepared active solution, the prepared preservative solution and the prepared emulsified solution to the gel solution in turn, and stir evenly; stir for 15 minutes, and let it stand for more than 30 minutes after stirring to form a carbomer finished solution.

[0120] Then, the carbomer solution is filled, and the process steps are as follows:

[0121] Put two pieces of special-shaped bamboo fiber membranes (110*70cm) into an aluminum-plastic bag; take a certain amount (such as 7.5g) of prepared carbomer solution into the aluminum-plastic bag, and seal the aluminum-plastic bag; make the carbomer solution adhere to the bamboo fiber membrane to form a cold compress.

[0122] Moreover, when filling the carbomer solution, the pH value, osmotic pressure and microorganisms of the solution can also be tested to check whether the product is qualified.

[0123] Example 4

[0124] In this embodiment, a carbomer solution with a total mass of 1000 g is prepared according to the formula amount shown in Table 4 below:

[0125] Table 4

[0126]

[0127]

[0128] In this embodiment, the preparation method of the cold compress patch is as follows:

[0129] First, the carbomer solution was prepared according to the formula in Table 4, and the process steps were as follows:

[0130] 1. Measure the formula amount (706.5 g) of purified water, weigh the formula amount (0.9 g) of carbomer (i.e., gel matrix), take 200 times the weight of carbomer (i.e., 180 g) of purified water in a container, slowly add the formulated amount of carbomer into the container, place in a homogenizer, homogenize at high speed for 30 min at a speed of 3500 rpm, and after the homogenization is completed, let it stand for 2 h to swell to form a carbomer swelling solution;

[0131] 2. Weigh the formula amount (8 g) of sodium hyaluronate, add 20 times (i.e. 160 g) of purified water as the formula amount of sodium hyaluronate (active ingredient), and stir to fully dissolve the sodium hyaluronate to form an active solution;

[0132] 3. Weigh the formula amount (0.8 g) of ethylparaben (preservative) and the formula amount (80 g) of propylene glycol (humectant), add them into a container and stir for 15 minutes to completely dissolve the ethylparaben to form an ethylparaben preservative solution;

[0133] 4. Weigh the formula amount (2.5 g) of polysorbate 20 (dispersant), the formula amount (2.5 g) of polysorbate 80 (dispersant) and the formula amount (8 g) of tea tree essential oil (antibacterial agent), add them into the container and stir for 15 minutes to form an emulsion;

[0134] 5. Weigh the formulated amount (0.9 g) of triethanolamine (pH regulator), take out the swollen carbomer swelling solution, add the formulated amount of triethanolamine to the carbomer swelling solution, and stir for 15 minutes to form a transparent gel;

[0135] 6. Add the remaining amount (366.5 g) of purified water to the transparent gel and stir for 15 minutes to mix well to form a gel solution;

[0136] 7. Weigh 80 g of 1,3-butanediol (humectant), 90 g of glycerol (humectant), 7 g of lutein (active ingredient), 0.9 g of sodium chloride (osmotic pressure regulator), and 6 g of acetyl L-cysteine ​​(antioxidant), add them to the gel solution in sequence, and stir for 15 minutes.

[0137] 8. Weigh the formula amount (6 g) of water-soluble mint (penetration enhancer), add the water-soluble mint, the prepared active solution, the prepared preservative solution and the prepared emulsified solution to the gel solution in turn, and stir evenly; stir for 15 minutes, and let it stand for more than 30 minutes after stirring to form a carbomer finished solution.

[0138] Then, the carbomer solution is filled, and the process steps are as follows:

[0139] Put two pieces of special-shaped bamboo fiber membranes (110*50mm) into an aluminum-plastic bag; take a certain amount (such as 8.0g) of prepared carbomer solution into the aluminum-plastic bag, and seal the aluminum-plastic bag; make the carbomer solution adhere to the bamboo fiber membrane to form a cold compress.

[0140] Moreover, when filling the carbomer solution, the pH value, osmotic pressure and microorganisms of the solution can also be tested to check whether the product is qualified.

[0141] Example 5

[0142] In this embodiment, a carbomer solution with a total mass of 1000 g is prepared according to the formula amount shown in Table 5 below:

[0143] Table 5

[0144]

[0145]

[0146] In this embodiment, the preparation method of the cold compress patch is as follows:

[0147] First, prepare the carbomer solution according to the formula in Table 5, and the process steps are as follows:

[0148] 1. Measure the formula amount (706.1 g) of purified water, weigh the formula amount (0.9 g) of carbomer (i.e., gel matrix), take 200 times the weight of carbomer (i.e., 180 g) of purified water in a container, slowly add the formulated amount of carbomer into the container, place in a homogenizer, and homogenize at high speed for 30 min at a speed of 3500 rpm. After the homogenization is completed, let it stand for 2 h to swell and form a carbomer swelling solution;

[0149] 2. Weigh the formula amount (8 g) of sodium hyaluronate (active ingredient), add 20 times (i.e. 160 g) of purified water as the formula amount of sodium hyaluronate (active ingredient), and stir to fully dissolve the sodium hyaluronate to form an active solution;

[0150] 3. Weigh the formula amount (0.8 g) of ethylparaben (preservative) and the formula amount (80 g) of propylene glycol (humectant), add them into a container and stir for 15 minutes to completely dissolve the ethylparaben to form an ethylparaben preservative solution;

[0151] 4. Weigh the formula amount (2.5 g) of polysorbate 20 (dispersant), the formula amount (2.5 g) of polysorbate 80 (dispersant), the formula amount (0.4 g) of Blue Ocean Fragrance (deodorant) and the formula amount (8 g) of tea tree essential oil (antibacterial agent), add them into the container and stir for 15 minutes to form an emulsion;

[0152] 5. Weigh the formulated amount (0.9 g) of triethanolamine (pH regulator), take out the swollen carbomer swelling solution, add the formulated amount of triethanolamine to the carbomer swelling solution, and stir for 15 minutes to form a transparent gel;

[0153] 6. Add the remaining amount (366.1 g) of purified water to the transparent gel and stir for 15 minutes to mix well to form a gel solution;

[0154] 7. Weigh 80 g of 1,3-butanediol (humectant), 90 g of glycerol (humectant), 7 g of lutein (active ingredient), 0.9 g of sodium chloride (osmotic pressure regulator), and 6 g of acetyl L-cysteine ​​(antioxidant), add them to the gel solution in sequence, and stir for 15 minutes.

[0155] 8. Weigh the formula amount (6 g) of water-soluble mint (penetration enhancer), add the water-soluble mint, the prepared active solution, the prepared preservative solution and the prepared emulsified solution to the gel solution in turn, and stir evenly; stir for 15 minutes, and let it stand for more than 30 minutes after stirring to form a carbomer finished solution.

[0156] Then, the carbomer solution is filled, and the process steps are as follows:

[0157] Put two pieces of special-shaped bamboo fiber membranes (100*70mm) into an aluminum-plastic bag; take a certain amount (such as 8.0g) of prepared carbomer solution into the aluminum-plastic bag, and seal the aluminum-plastic bag; make the carbomer solution adhere to the bamboo fiber membrane to form a cold compress.

[0158] Moreover, when filling the carbomer solution, the pH value, osmotic pressure, and microorganisms of the solution can also be tested to check whether the product is qualified.

[0159] The test data of the above embodiments 1-5 are analyzed, as shown in the following Table 6:

[0160] Table 6

[0161]

[0162]

[0163] In addition, Examples 1-5 were placed in a 40°C environment for accelerated aging for 30 days, and the pH value, osmotic pressure, and microorganisms of the solution were tested as shown in Table 7 below:

[0164] Table 7

[0165]

[0166] Test Example 1

[0167] 100 patients who use electronic office for a long time were asked to use the cold compresses of Examples 1-5 respectively, and apply them to the eyes for 15 minutes. The irritation and the effect of relieving visual fatigue were scored respectively. The scoring criteria are as follows:

[0168] Irritation:

[0169] 10 points: No stinging or discomfort around the eyes;

[0170] 9 points: There is slight stinging and discomfort in the skin around the eyes;

[0171] 8 points: There is some stinging and discomfort in the skin around the eyes;

[0172] 7 points: There is a strong stinging and discomfort in the skin around the eyes.

[0173] Relieve visual fatigue effect:

[0174] 10 points: Rapidly and effectively relieve visual fatigue, with obvious effect;

[0175] 9 points: Effectively relieves visual fatigue, but the effect is average;

[0176] 8 points: Can relieve visual fatigue, but the effect is poor;

[0177] 7 points: Cannot relieve visual fatigue, no effect

[0178] The average of the scores of 100 patients was taken and the results are shown in Table 8 below.

[0179] Table 8

[0180] Serial number Irritant Relieve visual fatigue Example 1 9.8 9.9 Example 2 9.7 9.7 Example 3 9.5 9.8 Example 4 9.8 9.3 Example 5 9.9 9.8

[0181] The results from Tables 6 to 8 show that:

[0182] The pH value, osmotic pressure, and microorganisms of the cold compress provided by each embodiment of the present invention under the test conditions all meet the requirements of the internal control standards of the enterprise. Moreover, the changes before and after acceleration are small, indicating that the quality of the cold compress prepared by the prescription is stable. The wet linting test meets the internal control standards. Compared with the analysis before accelerated aging, the increase in the number of particles is small and within the test error range, indicating that the prescription is very compatible with the bamboo fiber eye mask and will not cause the bamboo fiber eye mask to dissolve, indicating that the cold compress prepared by the prescription is safe to use.

[0183] Moreover, the cold compress provided by each embodiment of the present invention is basically non-irritating, will not cause stinging and discomfort to the skin around the eyes, and can effectively and quickly relieve visual fatigue when used. Moreover, in the process of preparing the carbomer swelling solution, the present invention adopts a high-speed homogenization method for swelling, and the carbomer can be fully in contact with water, and the swelling time is short, which can not only make the swelling time less than or equal to 5h, but also make the swelling solution swell more completely; moreover, in the process of forming the gel, the present invention first adds a pH adjuster to form a gel, dilutes it with water, and then adds each component, which can make the final gel system more uniform, and the pH value of the solution is 5.5 to 7.5, which will not cause decomposition of active ingredients that are sensitive to acid and alkali.

[0184] Moreover, the present invention adds an osmotic pressure regulator sodium chloride when making the cold compress, which itself has the function of regulating the osmotic pressure of the solution and can also regulate the viscosity of the solution, so that the active ingredients in the solution are more easily absorbed by the eyes and have a better effect; and, by adding L-cysteine ​​series antioxidants when making the cold compress, the product has relatively good antioxidant properties and a whitening effect, and can play a coordinated role with the active ingredients.

[0185] The above description is only a specific embodiment of the present invention, so that those skilled in the art can understand or implement the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but should conform to the widest scope consistent with the principles and novel features invented herein.

Claims

1. A method for preparing a cold compress patch for relieving eye fatigue, characterized in that: The steps include: Prepare a carbomer solution; wherein, according to mass percentage, the formula of the carbomer solution includes the following ingredients: 0.03-0.1% carbomer gel base, 0.03-0.1% pH adjuster, 0.01-0.2% preservative, 10-30% moisturizer, 0.05-2% active ingredient, 0.02-1% penetration enhancer, 0.03-1% antibacterial agent, 0.01-0.1% osmotic pressure regulator, 0.02-0.5% dispersant, 0.2-1% antioxidant, and 70-85% purified water; the active ingredient is lutein; the antioxidant is one or more of cysteine, L-cysteine, L-cysteine ​​hydrochloride, acetyl L-cysteine, and acetyl L-cysteine ​​hydrochloride; The preparation of the carbomer solution comprises the following steps: Measure the formulated amount of purified water, weigh the formulated amount of carbomer, add part of the purified water into a container, then slowly add the weighed carbomer into the container, and then place the container in a homogenizer for homogenization and swelling treatment to form a carbomer swelling solution; Preparation of active liquid, preservative liquid and emulsion: Weigh the active ingredient in the formula, add part of the purified water, stir and dissolve to form an active solution; Weigh the preservative in the formula, weigh part of the moisturizer, add them into the container and stir to completely dissolve the preservative to form a preservative solution; Weigh the formulated amount of dispersant and antibacterial agent, add them into a container and stir to form an emulsion; Taking out the carbomer swelling solution from the homogenizer, adding the formulated amount of pH adjuster to the carbomer swelling solution, and stirring to form a transparent gel; Add the remaining purified water to the transparent gel, stir and mix evenly with the transparent gel to form a gel solution; Add the remaining moisturizer, the formulated amount of osmotic pressure regulator and the formulated amount of antioxidant to the gel solution and stir evenly; add the formulated amount of penetration enhancer, the formulated active solution, the formulated preservative solution and the formulated emulsified solution to the gel solution in sequence, stir evenly and place for more than 30 minutes to form a finished carbomer solution; Put the bamboo fiber diaphragm into an aluminum-plastic bag, and put the carbomer solution into the aluminum-plastic bag, so that the carbomer solution adheres to the bamboo fiber diaphragm to form a cold compress.

2. The method for preparing the cold compress patch for relieving eye fatigue according to claim 1, characterized in that: According to the mass percentage, the formula of the carbomer solution also includes 0.02-1% of a deodorant.

3. The method for preparing the cold compress patch for relieving eye fatigue according to claim 1 or 2, characterized in that: The penetration enhancer is water-soluble mint; The osmotic pressure regulator is sodium chloride.

4. The method for preparing the cold compress patch for relieving eye fatigue according to claim 1 or 2, characterized in that: The active ingredients also include one or more of sodium hyaluronate and fish oil; The pH regulator is one or more of triethanolamine, sodium hydroxide and sodium bicarbonate.

5. The method for preparing the cold compress patch for relieving eye fatigue according to claim 1 or 2, characterized in that: The preservative is one or more of ethylparaben, benzoic acid, and sodium benzoate; The moisturizing agent is one or more of propylene glycol, butylene glycol and glycerin.

6. The method for preparing the cold compress patch for relieving eye fatigue according to claim 2, characterized in that: The dispersant is one or more of polysorbate 20 and polysorbate 80; The deodorant is one or more of blueberry anthocyanin, water lotus essence, and blue ocean fantasy essence; The antibacterial agent is tea tree essential oil.

7. The method for preparing the cold compress patch for relieving eye fatigue according to claim 1 or 2, characterized in that: In the step of "putting the bamboo fiber membrane into an aluminum-plastic bag, and taking the carbomer solution into the aluminum-plastic bag", the bamboo fiber membrane has a length of 90 to 110 mm and a width of 50 to 70 mm.

8. A cold compress for relieving eye fatigue, characterized in that: The cold compress patch for relieving eye fatigue is made by the preparation method of any one of claims 1 to 7.

Images