Preparation method of conductive drug-loaded composite fiber

A composite fiber and drug-loading technology, which is applied in the manufacture of conductive/antistatic filaments, fiber treatment, and pharmaceutical formulations. It can solve problems such as physical damage and damage to drug molecular activity, achieve good compatibility, and improve drug loading. volume effect

CN114525598AInactive Publication Date: 2022-05-24SUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2022-05-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of a conductive drug-loaded composite fiber, which comprises the following steps: S1, taking PVP (Polyvinyl Pyrrolidone) and SA (Styrene Acrylate), respectively adding water, stirring and heating to obtain a PVP solution and an SA solution; s2, mixing the PVP solution and the SA solution, and then adding APP to form a PVP / SA / AAP solution; s3, a PEDOT: PSS aqueous solution is added into the PVP / SA / AAP solution, and a PVP / SA / AAP / PEDOT: PSS mixed spinning solution is formed; s4, taking the mixed spinning solution as a core layer, taking a CaCl2 solution as a sheath flow laminar flow, and preparing the continuous conductive drug-loaded composite fiber in a coaxial microfluid spinning mode. The conductive drug-loaded fiber is prepared by using an ionic cross-linking curing method and a coaxial microfluid spinning technology, so that the prepared conductive drug-loaded fiber has the capability corresponding to an electric field, and AAP controllable release of the conductive drug-loaded fiber is realized under stimulation of voltage.
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Description

technical field

[0001] The invention relates to a conductive drug-loaded composite fiber, in particular to a preparation method of a conductive drug-loaded composite fiber. Background technique

[0002] Drug controlled release system refers to the use of some intelligent polymer materials as the carrier of drugs to form a drug loading system, which can achieve directional release and control the release rate of drugs, so that the efficacy of drugs can be fully exerted and the bioavailability of drugs can be further improved. , reduce the toxic and side effects of high-concentration drugs. The current research on intelligent drug controlled release systems that can respond to certain external stimuli include pH response, temperature response, electric field response, magnetic field response, etc. Among them, electro-responsive biomaterials are often characterized by rapid responses compared to other types of stimulus responsiveness. At the same time, the electric field resp...

Examples

preparation example Construction

[0043] like figure 1 As shown, a flow chart of the preparation of a microfluidic-based composite drug-loaded fiber provided by the present invention is shown. The preparation method of the microfluidic composite drug-loaded fiber comprises the following steps:

[0044]S1, get PVP and SA, stir and heat after adding water respectively, obtain PVP solution and SA solution;

[0045] S2. Mix the PVP solution and the SA solution, and then add APP to form a PVP / SA / AAP solution;

[0046] S3, adding PEDOT:PSS aqueous solution to the PVP / SA / AAP solution to form a PVP / SA / AAP / PEDOT:PSS mixed spinning solution;

[0047] S4. Preparation of continuous conductive drug-loaded composite fibers by microfluidic spinning, namely PSAP composite fibers

Embodiment 1

[0049] In this example, the PSA composite drug-loaded fiber is taken as an example to verify the influence of different spinning solution concentrations on the forming of PSA composite drug-loaded fiber, and then to verify the morphology characterization of PEDOT:PEDOT:PSS at different concentrations on the forming of PSAP composite fiber .

[0050] Among them, the difference between the preparation method of the PSA composite drug-loaded fiber and the above-mentioned PSAP composite fiber is whether PEDOT:PSS is added to the mixed spinning solution. First, through the verification of the solution concentration, ratio and microfluidic spinning process related parameters in the PSA composite drug-loaded fiber, the concentration of the PVP / SA / AAP mixed spinning solution that can continuously prepare the fiber is found. The PVP / SA / AAP / PEDOT:PSS mixed spinning solution with a mass fraction of 30wt%, 40wt% and 50wt% of the PVP / SA / AAP solution was used for morphology characterization...

Embodiment 2

[0064] In the above preparation method, the microfluidic spinning process parameters have a certain influence on the fiber forming. Therefore, this example aims to explore the influence of microfluidic spinning process parameters on fiber formation.

[0065] The microfluidic spinning machine is mainly composed of a microfluidic syringe pump and a fiber receiving platform. The first part of the microfluidic syringe pump is used to control the output speed and output of the spinning solution, mainly including: dual-channel syringe pump, syringe, Teflon tube and coaxial needle. The second part of the fiber receiving platform is used to receive fibers, and mainly includes a drum receiver, a rotating motor, a circular stepping translation platform, a heater and a control panel. The dual-channel syringe pump can independently control the two syringes and set different advancing speeds. The components of the microfluidic spinning device are connected by polytetrafluoroethylene tubes...