A mouse restraint device for a mouse skin radiation ulceration experiment

Abstract

The present invention belongs to the technical field of mouse experimental devices, and provides a mouse fixing device for mouse skin radiation ulcer experiment, including a base, a baffle, a side plate and a cover plate, and also includes: a water-soluble line; a winding component, which includes: a first rotating shaft, the bottom end of which is rotatably connected to the base and the top end freely extends upward; and a reel, which is sleeved on the first rotating shaft, when the reel rotates forward, the reel reels the water-soluble line, and when the reel rotates reversely, the reel releases the water-soluble line; a limiting component, which is used to limit the reverse rotation of the reel, and when the torque applied to the reel for prompting the reel to rotate reversely exceeds a preset value, the reel can rotate reversely, and when the torque disappears, the reel can return to its original position; and a clutch component, which is used to clutch the reel component and the limiting component. The mouse fixing device provided by the present invention has a simple structure, saves resources, is convenient for fixing mice, and has a high fixing efficiency.

Description

Technical Field

[0001] The invention relates to the technical field of mouse experimental devices, and in particular to a mouse fixing device used for a mouse skin radiation ulcer experiment. Background Art

[0002] When conducting a radiation ulcer experiment on the legs of mice, the mice were first fixed using a fixing device, and then the legs of the mice were vertically irradiated from top to bottom using a cobalt-60 gamma irradiator.

[0003] The mouse fixing device in the prior art includes a base, two side baffles arranged opposite to each other on the top of the base, a stopper plate provided with a plurality of through holes for the mouse's hind legs to pass through, a cover plate for preventing radiation from reaching the mouse's trunk, and a rubber band for fixing the mouse. When in use, one end of the rubber band is fixed to the mouse's hind legs, and the other end is fixed to the base after passing through the through hole of the baffle plate, the mouse's hind legs are pulled out of the through hole by the rubber band, and the cover plate is covered to prevent radiation from reaching the mouse's trunk.

[0004] The above-mentioned mouse fixing device has the following disadvantages: when releasing the fixation of a mouse, the rubber band usually needs to be cut, which is inconvenient to release the fixation, and because the length of the cut rubber band is insufficient, it usually cannot be used to fix the mouse again, thereby causing a waste of resources. In addition, when fixing another mouse, the two ends of the rubber band need to be re-fixed, and the fixing efficiency is low. Summary of the invention

[0005] In view of the defects in the prior art, the purpose of the present invention is to provide a mouse fixation device for use in mouse skin radiation ulcer experiments, so as to facilitate the release of the fixation of the mouse and save resources, while improving the fixation efficiency.

[0006] In order to achieve the above object, the present invention provides a mouse fixing device for mouse skin radiation ulcer experiment, comprising a base, a baffle, a side plate and a cover plate, and also comprising:

[0007] Water-soluble thread;

[0008] A winding assembly for winding and releasing the water-soluble thread, which is arranged on the base, comprises:

[0009] A first rotating shaft, the bottom end of which is rotatably connected to the base and the top end of which freely extends upward; and

[0010] a reel, which is coaxially sleeved on the first rotating shaft and detachably connected to the first rotating shaft, and when the reel rotates in the forward direction, the reel reels the water-soluble line, and when the reel rotates in the reverse direction, the reel releases the water-soluble line;

[0011] a limit assembly, which is arranged at the rotation center of the first rotating shaft, and is used to limit the reverse rotation of the reel, and when the torque applied to the reel for causing the reel to rotate in the reverse direction exceeds a preset value, the reel can rotate in the reverse direction, and when the torque disappears, the reel can return to its original position; and

[0012] A clutch assembly is arranged at the rotation center of the first rotating shaft, and is used to clutch the winding assembly and the limiting assembly.

[0013] Furthermore, the clutch assembly comprises:

[0014] A second rotating shaft, which is coaxially sleeved on the bottom end of the first rotating shaft and is rotatably connected to the first rotating shaft and the base;

[0015] a clutch disc, which is coaxially sleeved on the second rotating shaft and can rotate together with the second rotating shaft, and can reciprocate linearly between a first working position and a second working position along the axis direction of the second rotating shaft, and when the clutch disc is in the second working position, the clutch disc is engaged with the first rotating shaft or the reel; and

[0016] A driving mechanism is arranged on the base and is used to drive the clutch disc to perform reciprocating linear motion between the first working position and the second working position.

[0017] Furthermore, the driving mechanism comprises:

[0018] A slider, which is arranged in the base and has a slide groove thereon, and is slidably connected to the second rotating shaft through the slide groove, and can make reciprocating linear motion between a first working position and a second working position in the base in a lateral direction, and a receiving groove for receiving the clutch disc is arranged on the top of the slider, the receiving groove is trumpet-shaped and the top end is a larger end, and a second driving rod extending out of the base is also arranged on the top of the slider; and

[0019] A locking structure is provided on the base and / or the slider, and is used to keep the slider at the first working position and the second working position.

[0020] Furthermore, the locking structure comprises:

[0021] A spring, which is arranged at one end of the slider, and whose two ends are respectively in contact with the slider and the base;

[0022] A locking rod, a first end of which is hinged to the base and a second end of which has a sliding portion; and

[0023] The guide groove is arranged on the sliding block, which is used to guide the sliding of the sliding part. The guide groove is heart-shaped and includes a sliding-in and sliding-out guide part, a first guide part, a temporary part and a second guide part. The sliding part slides along the sliding-in and sliding-out guide part and the first guide part to the temporary part and can be temporarily positioned at the temporary part. After the sliding part leaves the temporary part, it slides along the second guide part and the sliding-in and sliding-out guide part.

[0024] Furthermore, the limiting component comprises:

[0025] A third rotating shaft, which is coaxially arranged with the first rotating shaft and rotatably connected with the first rotating shaft, and is connected to the clutch assembly via a ratchet structure; and

[0026] A torsion spring is arranged at the rotation center of the third rotating shaft, and in a natural state, the torsion spring has a tendency to make the third rotating shaft rotate in the opposite direction.

[0027] Beneficial effects of the present invention:

[0028] The mouse fixing device for mouse skin radiation ulcer experiment provided by the present invention achieves the purpose of facilitating unbinding by arranging water-soluble thread to bind the mouse and utilizing the water-soluble property of the water-soluble thread. Since only part of the water-soluble thread needs to be dissolved when unbinding, the purpose of saving resources is also achieved. By arranging a winding component, the water-soluble thread can be wound and released. When fixing the mouse, only the free end of the water-soluble thread needs to be tied to the leg of the mouse, thereby achieving the purpose of improving the fixing efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] In order to more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the following is a brief introduction to the drawings required for the specific embodiments or the description of the prior art. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, the elements or parts are not necessarily drawn according to the actual scale.

[0030] Figure 1 A stereoscopic view of a mouse fixing device for a mouse skin radiation ulcer experiment provided by an embodiment of the present invention;

[0031] Figure 2 for Figure 1 A front view of a mouse fixation device for use in a mouse skin radiation ulcer experiment is shown;

[0032] Figure 3 for Figure 2 A partial cross-sectional view in the AA direction shown;

[0033] Figure 4 for Figure 3A partial cross-sectional view in the BB direction shown;

[0034] Figure 5 for Figure 4 An enlarged view of point C is shown;

[0035] Figure 6 for Figure 4 An enlarged view of D is shown;

[0036] Figure 7 for Figure 4 An enlarged view of point E is shown;

[0037] Figure 8 for Figure 4 A partial cross-sectional view in the FF direction shown;

[0038] Fig. 9 for Figure 4 A partial cross-sectional view in the GG direction shown;

[0039] Fig.10 for Figure 8 An enlarged view at H is shown;

[0040] Fig.11 for Fig. 9 An enlarged view of point I is shown.

[0041] Reference numerals:

[0042] Base 1, mounting cavity 11, baffle 2, through hole 21, side plate 3, cover plate 4, water-soluble line 5, winding assembly 6, first rotating shaft 61, reel 62, first driving rod 621, toothed disc 601, limiting assembly 7, third rotating shaft 71, torsion spring 72, clutch assembly 8, second rotating shaft 81, clutch disc 82, driving mechanism 83, slider 831, slide groove 8311, accommodating groove 8312, second driving rod 8313, locking structure 832, spring 8321, locking rod 8322, guide groove 8323, sliding part 8301, sliding in and out guide part 8302, first guide part 8303, temporary part 8304, second guide part 8305, ratchet structure 9. DETAILED DESCRIPTION

[0043] The following embodiments of the technical solution of the present invention are described in detail in conjunction with the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solution of the present invention, and are therefore only used as examples, and cannot be used to limit the protection scope of the present invention.

[0044] It should be noted that, unless otherwise specified, the technical terms or scientific terms used in this application should have the common meanings understood by those skilled in the art to which the present invention belongs.

[0045] In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0046] In addition, the terms "first", "second", etc. are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. In the description of the present invention, the meaning of "plurality" is more than two, unless otherwise clearly and specifically defined.

[0047] In this application, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0048] In the present application, unless otherwise clearly specified and limited, a first feature being “above” or “below” a second feature may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, a first feature being “above”, “above”, and “above” a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being “below”, “below”, and “below” a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0049] like Figure 1-11 As shown, the present invention provides a mouse fixing device for mouse skin radiation ulcer experiment, comprising a base 1, a baffle 2, a side plate 3 and a cover plate 4. Specifically, the baffle 2 and a plurality of side plates 3 are arranged on the top of the base 1 to form a placement cavity. The baffle 2 is arranged in the middle of the base 1, and a through hole 21 for the mouse's legs to pass through is provided on the baffle 2. The cover plate 4 is a lead plate, which is arranged on the top of the placement cavity, and one end of the cover plate 4 is hinged to the placement cavity. Preferably, a plurality of partitions are arranged in the placement cavity. These are all prior arts and will not be elaborated here.

[0050] The mouse fixing device further comprises a water-soluble line 5 , a winding component 6 , a limiting component 7 and a clutch component 8 .

[0051] The free end of the water-soluble line 5 is used to tie up the legs of the mouse, and the other end is wrapped around the winding component 6 and fixedly connected to the winding component 6.

[0052] The winding assembly 6 is used for winding and releasing the water-soluble line 5, which is installed on the base 1 and includes a first rotating shaft 61 and a reel 62. Specifically, one end of the water-soluble line 5 is wound around the reel 62 and fixedly connected to the reel 62, and the other end is freely extended to tie up the legs of the mouse. When in use, the free end of the water-soluble line 5 is used to tie up the legs of the mouse, and then the water-soluble line 5 is wound by the reel 62, so that the legs of the mouse can be pulled out from the through hole 21 of the baffle 2, thereby achieving the purpose of fixing the mouse. When it is necessary to release the mice, a certain amount of water is dripped on the water-soluble thread 5 near the legs of the mice. Due to the water solubility of the water-soluble thread 5, the part of the water-soluble thread 5 that is stained with water will be disconnected, thereby releasing the fixation of the mice. Since only the small section of the water-soluble thread 5 that is used to tie the legs of the mice is consumed, it will not affect the continued use of other water-soluble threads 5 to fix the mice, thereby achieving the purpose of saving resources. At the same time, when fixing the next batch of mice, it is only necessary to rotate the reel 62 to release the water-soluble thread 5 to continue fixing the mice, and the fixation efficiency is relatively high.

[0053] The bottom end of the first rotating shaft 61 is rotatably connected to the base 1, and the top end freely extends upward. The reel 62 is coaxially sleeved on the first rotating shaft 61 and is detachably connected to the first rotating shaft 61. The reel 62 is detachably connected to the rotating shaft, and when the water-soluble line 5 is used up, it is convenient to replace a new reel 62 wound with the water-soluble line 5. Specifically, when the reel 62 rotates forward, the reel 62 reels the water-soluble line 5; when the reel 62 rotates reversely, the reel 62 releases the water-soluble line 5. Preferably, the top end of the reel 62 has a first driving rod 621 for driving the reel 62 to rotate so as to rotate the reel 62 to reel and release the water-soluble line 5.

[0054] The limit assembly 7 is installed at the rotation center of the first rotating shaft 61, and is used to limit the reverse rotation of the reel 62. When the torque applied to the reel 62 for causing the reel 62 to rotate in the reverse direction exceeds a preset value, the reel 62 can rotate in the reverse direction, and when the torque is cancelled, the reel 62 can return to its original position. Specifically, when in use, the water-soluble line 5 is rolled up by rotating the reel 62 to pull the mouse's legs out of the through hole 21 on the baffle 2. After that, since the limit assembly 7 limits the reverse rotation of the reel 62, the mouse's legs can be kept outside the through hole 21 to facilitate the cobalt 60 gamma irradiator to irradiate it. When the torque that causes the reel 62 to rotate in the opposite direction exceeds a preset value, the reel 62 can still rotate in the opposite direction, and when the torque disappears, the reel 62 can return to its original position. This allows the force applied by the mouse to the water-soluble line 5 to exceed a certain value, that is, when the torque applied by the water-soluble line 5 to the reel 62 exceeds a preset value, the reel 62 can rotate in the opposite direction, and after the force disappears, it can return to its original position, thereby giving the mouse a certain range of movement, rather than firmly pulling the mouse, thereby avoiding damage to the mouse caused by excessive pulling force of the water-soluble line 5.

[0055] The clutch assembly 8 is installed at the rotation center of the first rotating shaft 61, and is used to clutch the winding assembly 6 and the limiting assembly 7. Specifically, when the water-soluble line 5 is used to tie up the legs of the mouse, the clutch assembly 8 separates the rotation relationship between the winding assembly 6 and the limiting assembly 7, so that the winding assembly 6 can freely release and wind up the water-soluble line 5, so as to tie and fix the legs of the mouse. After the legs of the mouse are fixed, the clutch assembly 8 keeps the winding assembly 6 and the limiting assembly 7 in a transmission connection relationship, so as to achieve the purpose of limiting the reverse rotation of the winding assembly 6.

[0056] In one embodiment, the clutch assembly 8 includes a second rotating shaft 81 , a clutch disc 82 and a driving mechanism 83 .

[0057] The second rotating shaft 81 is coaxially sleeved at the bottom end of the first rotating shaft 61 and is rotatably connected to the first rotating shaft 61 and the base 1. The clutch disc 82 is coaxially sleeved on the second rotating shaft 81 and can rotate with the second rotating shaft 81. It can reciprocate linearly along the axis of the second rotating shaft 81 between the first working position and the second working position, and when the clutch disc 82 is in the second working position, the clutch disc 82 is engaged with the first rotating shaft 61 or the reel 62.

[0058] Specifically, a first tooth structure is provided on the end surface of the top end of the clutch disc 82, and a toothed disc 601 matching the first tooth structure is provided on the first rotating shaft 61 or the end of the reel 62 facing the clutch disc. When the clutch disc 82 is in the second working position, the clutch disc 82 is engaged with the toothed disc 601, and when the clutch disc 82 is in the first working position, the clutch disc 82 is separated from the toothed disc 601. The driving mechanism 83 is installed on the base 1, and is used to drive the clutch disc 82 to perform reciprocating linear motion between the first working position and the second working position.

[0059] When in use, when the driving mechanism 83 drives the clutch disk 82 to the second working position, the clutch disk 82 engages with the toothed disk 601, thereby maintaining a transmission connection relationship between the winding assembly 6 and the limiting assembly 7; and when the driving mechanism 83 drives the clutch disk 82 to the first working position, the clutch disk 82 separates from the toothed disk 601, thereby disconnecting the transmission relationship between the winding assembly 6 and the limiting assembly 7.

[0060] The clutch assembly 8 of this structure is simple in structure.

[0061] In one embodiment, the driving mechanism 83 includes a slider 831 and a locking structure 832 .

[0062] The slider 831 is slidably installed in the base 1. Specifically, the base 1 is provided with an installation cavity 11, and the slider 831 is slidably installed in the installation cavity 11. The slider 831 is provided with a slide groove 8311, and the slider 831 is slidably connected with the second rotating shaft 81 through the slide groove 8311, that is, the second rotating shaft 81 is inserted in the slide groove 8311. The slider 831 can make reciprocating linear motion between the first working position and the second working position in the base 1 in the horizontal direction. The top of the slider 831 is provided with a receiving groove 8312 for receiving the clutch disc 82. Specifically, when the clutch disc 82 corresponds to the receiving groove 8312, under the action of gravity, the bottom end of the clutch disc 82 is inserted into the receiving groove 8312, so that the clutch disc 82 is separated from the gear disc 601. The receiving groove 8312 is trumpet-shaped and the top end is the larger end, that is, the side wall of the receiving groove 8312 is an inclined surface. When the clutch disk 82 needs to move upward to the second working position, the slider 831 is moved, and the clutch disk 82 moves upward under the action of the side wall of the receiving groove 8312, so that the clutch disk 82 moves to the second working position. Preferably, the top of the slider 831 also has a second driving rod 8313 extending from the base 1 so that the slider 831 can be driven to move by the second driving rod 8313. Specifically, when the slider 831 is in the first working position, the receiving groove 8312 corresponds to the clutch disk 82.

[0063] The locking structure 832 is installed on the base 1 and / or the slider 831, and is used to keep the slider 831 in the first working position and the second working position. Specifically, when the slider 831 is in the first working position, the locking structure 832 keeps it in the first working position, and when the slider 831 is in the second working position, the locking structure 832 keeps it in the second working position.

[0064] The driving structure of this structure is simple.

[0065] In one embodiment, the locking structure 832 includes a spring 8321 , a locking rod 8322 , and a guide groove 8323 .

[0066] The spring 8321 is installed at one end of the slider 831. Specifically, the spring 8321 is installed in the installation cavity 11 and is located at one end of the slider 831. The two ends of the spring 8321 are respectively abutted against the slider 831 and the base 1. In the natural state, the spring 8321 has a tendency to move the slider 831 from the second working position to the first working position.

[0067] The first end of the locking rod 8322 is hinged to the base 1 , and the second end has a sliding portion 8301 .

[0068] The guide groove 8323 is provided on the slider 831, and is used to guide the sliding of the sliding portion 8301. Specifically, the guide groove 8323 includes a slide-in and slide-out guide portion 8302, a first guide portion 8303, a temporary portion 8304, and a second guide portion 8305, wherein the slide-in and slide-out guide portion 8302, the first guide portion 8303, the temporary portion 8304, and the second guide portion 8305 are sequentially connected end to end to form a heart-shaped groove.

[0069] The sliding portion 8301 slides along the sliding in and out guide portion 8302 and the first guide portion 8303 to the temporary portion 8304 and can be temporarily positioned at the temporary portion 8304. This process is the process of the slider 831 moving from the first working position to the second working position, and when the sliding portion 8301 is temporarily positioned at the temporary portion 8304, the slider 831 stays at the second working position.

[0070] After the sliding portion 8301 leaves the temporary portion 8304, it slides along the second guide portion 8305 and the sliding-in and sliding-out guide portion 8302. This process is the process of the slider 831 moving from the second working position to the first working position, and when the sliding portion 8301 returns to the initial position (that is, at the end of the sliding-in and sliding-out guide portion 8302 away from the temporary portion 8304), the slider 831 stays in the first working position.

[0071] The locking structure 832 of this structure is simple in structure, and the second driving rod 8313 pushes the slider 831 once to move the slider 831 from the first working position to the second working position. The second driving rod 8313 pushes the slider 831 again to move the slider 831 from the second working position to the first working position, and the operation is convenient.

[0072] In one embodiment, the limiting assembly 7 includes a third rotating shaft 71 and a torsion spring 72 .

[0073] Among them, the third rotating shaft 71 is coaxially arranged with the first rotating shaft 61 and is rotatably connected to the first rotating shaft 61. Specifically, the third rotating shaft 71 is coaxially sleeved outside the second rotating shaft 81 and is rotatably connected to the second rotating shaft 81. And the third rotating shaft 71 is connected to the clutch assembly 8 through the ratchet structure 9. Specifically, when the reel 62 rotates forward to reel the water-soluble line 5, even if the clutch disc 82 is engaged with the toothed disc 601, under the action of the ratchet structure 9, the second rotating shaft 81 will not drive the third rotating shaft 71 to rotate, so that the reel 62 can be freely driven to rotate forward to reel the water-soluble line 5 through the first driving rod 621; the clutch disc 82 is engaged with the toothed disc 601, when the reel 62 rotates in the reverse direction, the first rotating shaft 61 drives the second rotating shaft 81 to rotate in the reverse direction, and under the action of the ratchet structure 9, the second rotating shaft 81 drives the third rotating shaft 71 to rotate in the reverse direction. The torsion spring 72 is installed at the rotation center of the third rotating shaft 71. Specifically, the torsion spring 72 is sleeved on the third rotating shaft 71, and its two ends are respectively connected to the third rotating shaft 71 and the base 1. In the natural state, the torsion spring 72 has a tendency to make the third rotating shaft 71 rotate in the opposite direction.

[0074] During use, when the clutch disk 82 is engaged with the toothed disk 601, under the action of the ratchet structure 9, the reel 62 rotates forward and will not drive the third rotating shaft 71 to rotate. When the reel 62 rotates reversely, the reel 62 drives the third rotating shaft 71 to rotate, thereby achieving the purpose of limiting the reverse rotation of the winding assembly 6 under the action of the torsion spring 72. At the same time, since the torsion spring 72 can be deformed, the elastic force of the torsion spring 72 can be used to keep the mouse's legs outside the through hole 21, thereby avoiding damage to the mouse due to excessive pulling force.

[0075] In the specification of the present invention, a large number of specific details are described. However, it is understood that embodiments of the present invention can be practiced without these specific details. In some instances, well-known methods, structures and techniques are not shown in detail so as not to obscure the understanding of this specification.

[0076] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein by equivalents. These modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present invention, and they should all be included in the scope of the claims and specification of the present invention.

Claims

1. A mouse fixing device for mouse skin radiation ulcer experiment, comprising a base, a baffle, a side plate and a cover plate, characterized in that: Also includes: Water-soluble thread; A winding assembly for winding and releasing the water-soluble thread, which is arranged on the base, comprises: A first rotating shaft, the bottom end of which is rotatably connected to the base and the top end of which freely extends upward; and a reel, which is coaxially sleeved on the first rotating shaft and detachably connected to the first rotating shaft, and when the reel rotates in the forward direction, the reel reels the water-soluble line, and when the reel rotates in the reverse direction, the reel releases the water-soluble line; a limit assembly, which is arranged at the rotation center of the first rotating shaft, and is used to limit the reverse rotation of the reel, and when the torque applied to the reel for causing the reel to rotate in the reverse direction exceeds a preset value, the reel can rotate in the reverse direction, and when the torque disappears, the reel can return to its original position; and A clutch assembly, which is arranged at the rotation center of the first rotating shaft and is used to clutch the winding assembly and the limiting assembly; The clutch assembly comprises: A second rotating shaft, which is coaxially sleeved on the bottom end of the first rotating shaft and is rotatably connected to the first rotating shaft and the base; a clutch disc, which is coaxially sleeved on the second rotating shaft and can rotate together with the second rotating shaft, and can reciprocate linearly between a first working position and a second working position along the axis direction of the second rotating shaft, and when the clutch disc is in the second working position, the clutch disc is engaged with the first rotating shaft or the reel; and A driving mechanism, which is disposed on the base and is used to drive the clutch disc to perform reciprocating linear motion between the first working position and the second working position; The driving mechanism comprises: A slider, which is arranged in the base and has a slide groove thereon, and is slidably connected to the second rotating shaft through the slide groove, and can make reciprocating linear motion between a first working position and a second working position in the base in a lateral direction, and a receiving groove for receiving the clutch disc is arranged on the top of the slider, the receiving groove is trumpet-shaped and the top end is a larger end, and a second driving rod extending out of the base is also arranged on the top of the slider; and A locking structure is provided on the base and / or the slider, and is used to keep the slider at the first working position and the second working position.

2. The mouse fixing device for mouse skin radiation ulcer experiment according to claim 1, characterized in that: The locking structure comprises: A spring, which is arranged at one end of the slider, and whose two ends are respectively in contact with the slider and the base; A locking rod, a first end of which is hinged to the base and a second end of which has a sliding portion; and The guide groove is arranged on the sliding block, which is used to guide the sliding of the sliding part. The guide groove is heart-shaped and includes a sliding-in and sliding-out guide part, a first guide part, a temporary part and a second guide part. The sliding part slides along the sliding-in and sliding-out guide part and the first guide part to the temporary part and can be temporarily positioned at the temporary part. After the sliding part leaves the temporary part, it slides along the second guide part and the sliding-in and sliding-out guide part.

3. The mouse fixing device for mouse skin radiation ulcer experiment according to any one of claims 1-2, characterized in that: The limiting component comprises: A third rotating shaft, which is coaxially arranged with the first rotating shaft and rotatably connected with the first rotating shaft, and is connected to the clutch assembly via a ratchet structure; and A torsion spring is arranged at the rotation center of the third rotating shaft, and in a natural state, the torsion spring has a tendency to make the third rotating shaft rotate in the opposite direction.

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