A freeze-dried reagent packaging component and packaging method

Abstract

The present application discloses a freeze-dried reagent subpackaging component and a subpackaging method, and relates to the technical field of biological reagent production. The freeze-dried reagent subpackaging component includes: a storage device, including a plurality of reagent container units, the reagent container unit having a storage cavity, and the storage cavity is used to store freeze-dried reagents; a fixed frame, used to fix the storage device; a slot plate, provided with a plurality of reagent slots, each reagent slot corresponding to each reagent container unit, and the size of the reagent slot matches the freeze-dried reagent. During subpackaging, the freeze-dried reagent is dropped into each reagent slot, and then the storage device is turned upside down on the slot plate, and each reagent container unit is aligned with each reagent slot in the slot plate, and then the slot plate is kept in contact with the storage device and the slot plate is flipped, and finally the slot plate is vibrated, so that the freeze-dried reagent in the reagent slot falls into the corresponding reagent container unit, so that the freeze-dried reagent is quickly subpacked into each reagent container unit, and the subpackaging efficiency of the freeze-dried reagent is improved.

Description

Technical Field

[0001] The present application relates to the technical field of biological reagent production, and in particular to a freeze-dried reagent packaging component and a packaging method. Background Art

[0002] Freeze drying technology has been widely used in the fields of medicine, biological products, food, blood products, and active substances. The structure of freeze-dried reagents is stable, the biological activity is basically unchanged, and the loss of volatile components and heat-volatile components in the drugs is very small. However, the current freeze-dried reagent packaging usually uses mechanical clamping or negative pressure adsorption of freeze-dried reagents, and then moves them into test tubes. This method is inefficient and inconvenient to operate, which is not conducive to efficient packaging of freeze-dried reagents. Summary of the invention

[0003] The present application aims to solve at least one of the technical problems existing in the prior art. To this end, the present application proposes a freeze-dried reagent packaging component, which can effectively improve the packaging efficiency of the freeze-dried reagent.

[0004] The present application also provides a method for packaging a freeze-dried reagent.

[0005] According to one aspect of an embodiment of the present application, a freeze-dried reagent packaging component includes: a storage device, including a plurality of reagent container units, each of which has a storage cavity for storing freeze-dried reagents; a fixed frame for fixing the storage device; a slot plate, provided with a plurality of reagent slots, each of which corresponds to each of the reagent container units, and the size of the reagent slot matches the freeze-dried reagent.

[0006] According to an embodiment of one aspect of the present application, the freeze-dried reagent is spherical, the diameter of the freeze-dried reagent is D, the maximum diameter of the inscribed circle of the cross-sectional profile of the reagent tank is d, wherein 2D>d>D, the depth of the reagent tank is H, satisfying: (n+1)*D>H≥n*D, wherein n>0, and n is an integer.

[0007] According to an embodiment of one aspect of the present application, a connecting portion is provided at the connection between the reagent tank and the end surface of the tank plate.

[0008] According to an embodiment of one aspect of the present application, the connecting portion is rounded or chamfered.

[0009] According to an embodiment of one aspect of the present application, the fixing frame includes a supporting portion, and the supporting portion is provided with a positioning hole matching the reagent container unit.

[0010] According to an embodiment of one aspect of the present application, the fixing frame further includes a positioning portion, one end of which is connected to the supporting portion, the other end of which extends in a direction away from the supporting portion, and the contour of the positioning portion matches the outer periphery of the reagent container unit.

[0011] According to an embodiment of one aspect of the present application, the fixing frame further includes a base, the base is arranged around the periphery of the supporting portion, and a protrusion is arranged on the periphery of the base.

[0012] According to an embodiment of one aspect of the present application, the positioning hole is a tapered hole.

[0013] According to an embodiment of one aspect of the present application, the storage device includes at least two reagent container groups, and each of the reagent container groups is provided with a plurality of the reagent container units.

[0014] According to an embodiment of one aspect of the present application, the slot plate is made of a transparent material.

[0015] According to an embodiment of one aspect of the present application, recesses are provided on both sides of the trough plate, and the recesses are sunken into the trough plate.

[0016] The freeze-dried reagent packaging method of another embodiment of the present application is applied to the freeze-dried reagent packaging component described above, and also includes the following steps: placing the slot plate horizontally, placing a certain amount of the freeze-dried reagent on the slot plate, and allowing the freeze-dried reagent to fall into the reagent slot; fixing the storage device with the fixing frame, so that the reagent container unit is aligned with the reagent slot; keeping the slot plate in contact with the storage device, flipping the slot plate and the storage device, and then vibrating the slot plate to allow the freeze-dried reagent in the reagent slot to fall into the corresponding reagent container unit.

[0017] The freeze-dried reagent packaging assembly of an embodiment of one aspect of the present application has at least the following beneficial effects: when packaging the freeze-dried reagent, a certain amount of the freeze-dried reagent is scattered on a horizontally placed slot plate, so that the freeze-dried reagent falls into each reagent slot, and then the storage device is turned upside down on the slot plate, and each reagent container unit is aligned with each reagent slot in the slot plate, and then the slot plate and the storage device are kept in contact with each other and the slot plate is flipped over, and finally the slot plate is vibrated to make the freeze-dried reagent in the reagent slot fall into the corresponding reagent container unit, so that the freeze-dried reagent can be quickly packaged into each reagent container unit, thereby improving the packaging efficiency of the freeze-dried reagent.

[0018] Additional aspects and advantages of the present application will be given in part in the description below, and in part will become apparent from the description below, or will be learned through the practice of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The present application is further described below with reference to the accompanying drawings and embodiments, wherein:

[0020] Figure 1 This is a schematic diagram of the overall structure of a freeze-dried reagent packaging assembly according to one embodiment of the present application;

[0021] Figure 2 This is an exploded schematic diagram of a freeze-dried reagent packaging assembly according to one embodiment of the present application;

[0022] Figure 3 A schematic top view of a freeze-dried reagent packaging assembly according to one embodiment of the present application;

[0023] Figure 4 for Figure 3 Schematic cross-sectional view of AA in the figure;

[0024] Figure 5 This is a schematic diagram of a tank plate and a lyophilized reagent in an embodiment of one aspect of the present application;

[0025] Figure 6 for Figure 5 Schematic cross-sectional view in the middle BB direction;

[0026] Figure 7 This is a schematic diagram of the structure of the slot plate in one embodiment of the present application;

[0027] Figure 8 This is a schematic diagram of the structure of a fixing frame in an embodiment of one aspect of the present application;

[0028] Fig. 9 Schematic diagram of the structure of a storage device in one embodiment of the present application.

[0029] Reference numerals:

[0030] 1. Freeze-dried reagent;

[0031] 110. Reagent container set; 111. Reagent container unit;

[0032] 200, fixing frame; 210, supporting portion; 211, positioning hole; 220, positioning portion; 230, base; 231, protrusion;

[0033] 300, slot plate; 310, reagent slot; 320, recess; 330, connecting portion. DETAILED DESCRIPTION

[0034] The embodiments of the present application are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present application, and cannot be understood as limiting the present application.

[0035] In the description of the present application, it should be understood that descriptions involving orientation, such as up, down, front, back, left, right, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0036] In the description of this application, "several" means more than one, "more" means more than two, "greater than", "less than", "exceed", etc. are understood to exclude the number itself, and "above", "below", "within", etc. are understood to include the number itself. If there is a description of "first" or "second", it is only used for the purpose of distinguishing technical features, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.

[0037] In the description of this application, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in this application based on the specific content of the technical solution.

[0038] In the description of the present application, the description with reference to the terms "one embodiment", "some embodiments", "illustrative embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials, or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0039] like Figure 1 As shown, one embodiment of the present application discloses a freeze-dried reagent packaging component, which includes a storage device, a fixing frame 200 and a slot plate 300.

[0040] For details, see Figure 1 and Figure 2 The storage device includes a plurality of reagent container units 111, each of which has a storage cavity for storing the freeze-dried reagent 1; the fixing frame 200 fixes the plurality of reagent container units 111 into an integral structure, thereby facilitating batch packaging of the freeze-dried reagent 1; the slot plate 300 is provided with a plurality of reagent slots 310, each of which corresponds to each of the reagent container units 111, and the size of the reagent slot 310 matches the freeze-dried reagent 1.

[0041] like Figure 1 and Figure 2As shown, a plurality of positioning holes 211 for positioning the reagent container unit 111 are provided on the fixing frame 200, and the setting positions of the positioning holes 211 correspond one-to-one to the positions of the reagent slots 310 in the slot plate 300, so as to facilitate the freeze-dried reagent 1 in each reagent slot 310 to slide into the corresponding reagent container unit 111, thereby completing the rapid packaging of the freeze-dried reagent 1.

[0042] Depend on Figure 2 It can also be known that in this embodiment, the slot plate 300 and the fixing frame 200 are of split design.

[0043] In some other embodiments, the fixing frame 200 and the slot plate 300 are connected by a rotating connection structure, so that the fixing frame 200 and the slot plate 300 can rotate around the rotation axis of the rotating connection structure, so that the reagent container unit 111 fixed to the fixing frame 200 can be quickly aligned with the reagent slot 310 in the slot plate 300, thereby improving the convenience of operation. Among them, the rotating connection structure can adopt a structure such as a hinge.

[0044] When packaging the freeze-dried reagent 1, a certain amount of the freeze-dried reagent 1 is sprinkled on the horizontally placed slot plate 300, so that the freeze-dried reagent 1 falls into each reagent slot 310, and then the storage device is turned upside down on the slot plate 300, and each reagent container unit 111 is aligned with each reagent slot 310 in the slot plate 300, and then the slot plate 300 and the storage device are kept in abutment state and the slot plate 300, the storage device and the fixing frame 200 are turned over as a whole, and finally the slot plate 300 is vibrated to make the freeze-dried reagent 1 in the reagent slot 310 fall into the corresponding reagent container unit 111.

[0045] In the present application examples, see Figure 3 and Figure 4 As shown, a plurality of reagent slots 310 are arranged on the slot plate 300 and a fixing frame 200 is used to enable a plurality of reagent container units 111 to be aligned with each reagent slot 310 in the slot plate 300. By flipping the slot plate 300, the storage device and the fixing frame 200, the freeze-dried reagent 1 spilled in the reagent slot 310 can slide into the reagent container unit 111 aligned with the reagent slot 310, thereby enabling the freeze-dried reagent 1 to be quickly dispensed into each reagent container unit 111, thereby improving the dispensing efficiency of the freeze-dried reagent 1.

[0046] After a certain amount of freeze-dried reagent 1 is sprinkled on the horizontally placed slot plate 300, the slot plate 300 can be shaken to make the freeze-dried reagent 1 fall into each reagent slot 310 as much as possible. Before the storage device is turned upside down on the slot plate 300, the freeze-dried reagent 1 located on the end surface of the slot plate 300 needs to be separated from the slot plate 300.

[0047] It should be understood that in order to avoid the occurrence of voids in the reagent slots 310 in the slot plate 300 (i.e., there is no freeze-dried reagent 1 in the reagent slots 310), the amount of freeze-dried reagent 1 spilled on the slot plate 300 should be greater than or equal to the total amount of freeze-dried reagent 1 that each reagent slot 310 can accommodate.

[0048] In this embodiment, after the trough plate 300 is evenly filled with the freeze-dried reagent 1, the trough plate 300, the fixing frame 200 and the reagent container unit 111 are turned over 180° as a whole, so that the opening of the reagent trough 310 of the trough plate 300 is facing downward. The opening of the reagent trough 310 is directly opposite to the nozzle end of the reagent container unit 111. Therefore, after turning over, the trough plate 300 can be knocked to accelerate the freeze-dried reagent 1 in the reagent trough 310 to slide into the reagent container unit 111, thereby completing the packaging of the freeze-dried reagent 1.

[0049] As an improvement of the above embodiment, the slot plate 300 is made of a transparent material, which can facilitate technicians to observe whether there is freeze-dried reagent 1 stuck in the reagent slot 310 when packaging the freeze-dried reagent 1, which is helpful to ensure that the freeze-dried reagent 1 in each reagent slot 310 fully falls into the corresponding reagent container unit 111.

[0050] As another improvement of the above embodiment, the reagent container unit 111 is made of a transparent material, so that it is convenient to confirm whether each reagent container unit 111 contains the freeze-dried reagent 1 .

[0051] In some embodiments of this application, see Figure 5 and Figure 6 As shown, Figure 5 is a schematic diagram of the freeze-dried reagent 1 being spilled into the reagent tank 310 of the tank plate 300, Figure 6 for Figure 5 Schematic cross-sectional view of BB. As can be seen from the figure, the freeze-dried reagent 1 is spherical. The diameter of the freeze-dried reagent 1 is D, the maximum diameter of the inscribed circle of the cross-sectional profile of the reagent tank 310 is d, wherein 2D>d>D, the depth of the reagent tank 310 is H, and satisfies: (n+1)*D>H≥n*D, wherein n>0, and n is an integer.

[0052] It should be understood that the depth H of the reagent tank 310 is greater than or equal to n*D, which means that the depth H of the reagent tank 310 is greater than or equal to n times the diameter D of the freeze-dried reagent ball; the reagent tank 310 is used to quantitatively package the freeze-dried reagent 1 into different reagent container units 111, therefore, the minimum size of the reagent tank 310 needs to be able to accommodate the freeze-dried reagent 1.

[0053] The value of n can be selected as 1, 2, 3, etc. according to the packaging capacity of each reagent container unit 111. For example, when n is 2, the depth of the reagent tank 310 is 3D>H≥2D, and a single reagent tank 310 can just accommodate 2 freeze-dried reagent balls. In other words, when the tank plate 300 is used for packaging, the number of freeze-dried reagents 1 placed in the storage cavity of each reagent container unit 111 is 2.

[0054] The appearance of a single freeze-dried reagent 1 is basically the same. Therefore, by limiting the size of the reagent tank 310 , the dosage of the freeze-dried reagent 1 spilled into the reagent tank 310 can be controlled, thereby achieving quantitative and rapid packaging of the freeze-dried reagent 1 .

[0055] It should be noted that when it is necessary to realize the subpackaging of freeze-dried reagents 1 of different doses, it can be realized by replacing the slot plate 300. The depths of the reagent slots 310 in different slot plates 300 are different.

[0056] As one embodiment, the lyophilized reagents 1 after screening are all spherical reagents with similar diameters, and the cross-sectional profile of the reagent tank 310 is circular, and the diameter of the profile is larger than the diameter of the spherical lyophilized reagent 1 and smaller than twice the diameter of the spherical lyophilized reagent 1. When the number of lyophilized reagents 1 loaded into the reagent volume unit 111 is 3, the depth of the reagent tank 310 in the tank plate 300 is H, and 4D>h≥3D.

[0057] In some embodiments of this application, see Figure 6 and Figure 7 As shown, a connecting portion 330 is provided at the connection between the reagent tank 310 and the end surface of the tank plate 300. As can be seen from the figure, along the direction close to the center of the reagent tank 310, the profile of the cross section of the connecting portion 330 gradually decreases. In other words, the connecting portion 330 is trumpet-shaped from bottom to top. The setting of the connecting portion 330 can cause the freeze-dried reagent 1 scattered near the reagent tank 310 to slide into the reagent tank 310, thereby improving the efficiency of the freeze-dried reagent 1 entering the reagent tank 310. Among them, the connecting portion 330 is rounded or chamfered.

[0058] In some embodiments of this application, see Figure 7 As shown, recesses 320 are provided on both sides of the slot plate 300, and the recesses 320 are sunken into the slot plate 300. After the slot plate 300 is turned over, the recesses 320 can serve as a fulcrum for taking the slot plate 300, effectively preventing the slot plate 300 from slipping or being taken unsteadily.

[0059] In some embodiments of this application, see Figure 4 and Figure 8As shown, the fixing frame 200 includes a support portion 210, and the support portion 210 is provided with a positioning hole 211 matching the reagent container unit 111. Among them, the shape and size of the support portion 210 match the slot plate 300, and the positioning hole 211 in the support portion 210 corresponds one-to-one with the reagent slot 310 on the slot plate 300, so that the open end of the reagent container unit 111 installed on the support portion 210 can also be aligned with the reagent slot 310, which facilitates the freeze-dried reagent 1 in the reagent slot 310 to enter the reagent container unit 111. The reagent container unit 111 can be specifically selected as a common test tube. Further, the positioning hole 211 is a tapered hole, which can play a guiding and fixing role for the reagent container unit 111.

[0060] As one embodiment, the positioning hole 211 and the reagent container unit 111 are in transitional fit, so that the reagent container unit 111 can be fixed on the support portion 210 .

[0061] In some embodiments of this application, please continue to refer to Figure 4 As shown, the fixing frame 200 further includes a positioning portion 220, one end of which is connected to the supporting portion 210, and the other end of the positioning portion 220 extends in a direction away from the supporting portion 210, and the contour of the positioning portion 220 matches the outer periphery of the reagent container unit 111. As can be seen from the figure, the positioning portion 220 extends downward for a certain distance, and the inner wall of the positioning portion 220 abuts against the outer wall of the reagent container unit 111, which can effectively prevent the reagent container unit 111 from shaking significantly when it is turned over.

[0062] In some embodiments of this application, see Figure 8 As shown, the fixing frame 200 further includes a base 230, which is arranged around the outer periphery of the supporting portion 210, and a protrusion 231 is arranged on the outer periphery of the base 230. As can be seen from the figure, the protrusion 231 is L-shaped as a whole, which can be used as a fulcrum for flipping the storage unit and the fixing frame 200.

[0063] In some embodiments of this application, see Fig. 9 As shown, the storage device includes at least two reagent container groups 110, and each reagent container group 110 is provided with a plurality of reagent container units 111. Connecting a plurality of reagent container units 111 into one reagent container group 110 can achieve the effect of convenient operation and fixation.

[0064] On the other hand, an embodiment of the present application discloses a freeze-dried reagent packaging method, which is applied to the freeze-dried reagent packaging assembly described above, and also includes the following steps: placing the slot plate 300 horizontally, placing a certain amount of freeze-dried reagent 1 on the slot plate 300, and allowing the freeze-dried reagent 1 to fall into the reagent slot 310; fixing the storage device with a fixing frame 200, so that the reagent container unit 111 is aligned with the reagent slot 310; flipping the slot plate 300 and the storage device, and vibrating the slot plate 300, so that the freeze-dried reagent 1 in the reagent slot 310 falls into the corresponding reagent container unit 111.

[0065] In the process of flipping the slot plate 300 and the storage device, the reagent container unit 111 of the storage device needs to be kept in contact at all times to prevent the freeze-dried reagent 1 from detaching from the reagent slot 310 or the reagent container unit 111; when flipping the slot plate 300, the freeze-dried reagent 1 on the end face of the slot plate 300 needs to be detached from the slot plate 300 in advance to ensure that the reagent container unit 111 can be in contact with the slot plate 300.

[0066] The embodiments of the present application are described in detail above in conjunction with the accompanying drawings, but the present application is not limited to the above embodiments. Various changes can be made within the knowledge of ordinary technicians in the relevant technical field without departing from the purpose of the present application. In addition, the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.

Claims

1. A freeze-dried reagent packaging method using a freeze-dried reagent packaging assembly, characterized in that: The lyophilized reagent packaging kit includes: A storage device, comprising a plurality of reagent container units, wherein the reagent container units have a storage cavity, wherein the storage cavity is used to store a freeze-dried reagent, wherein the freeze-dried reagent is in a spherical shape, and the diameter of the freeze-dried reagent is D; A fixing frame, used to fix the storage device, the fixing frame comprising a supporting portion, the supporting portion being provided with a positioning hole matching the reagent container unit; A slot plate is provided with a plurality of reagent slots, each of which corresponds to each of the reagent container units, the size of the reagent slot matches the freeze-dried reagent, the maximum diameter of the inscribed circle of the cross-sectional profile of the reagent slot is d, wherein 2D>d>D, the depth of the reagent slot is H, and satisfies: (n+1)*D>H≥n*D, wherein n>0, and n is an integer; The freeze-dried reagent packaging method using the freeze-dried reagent packaging assembly comprises the following steps: Placing the slot plate horizontally, placing a certain amount of the freeze-dried reagent on the slot plate, and allowing the freeze-dried reagent to fall into the reagent slot; The reagent container unit is fixed on the supporting part, and the storage device is fixed by the fixing frame so that the reagent container unit is aligned with the reagent tank; The slot plate is kept in contact with the storage device, the slot plate and the storage device are turned over, and the slot plate is vibrated to make the freeze-dried reagent in the reagent tank fall into the corresponding reagent container unit.

2. The freeze-dried reagent packaging method using the freeze-dried reagent packaging assembly according to claim 1, characterized in that: A connecting portion is provided at the connection between the reagent tank and the end surface of the tank plate.

3. The freeze-dried reagent packaging method using the freeze-dried reagent packaging assembly according to claim 2, characterized in that: The connecting portion is rounded or chamfered.

4. The freeze-dried reagent packaging method using the freeze-dried reagent packaging assembly according to claim 1, characterized in that: The fixing frame further includes a positioning portion, one end of which is connected to the supporting portion, and the other end of which extends in a direction away from the supporting portion, and a contour of the positioning portion matches an outer circumference of the reagent container unit.

5. The freeze-dried reagent packaging method using the freeze-dried reagent packaging assembly according to claim 4, characterized in that: The positioning hole is a tapered hole.

6. The freeze-dried reagent packaging method using the freeze-dried reagent packaging assembly according to claim 1, characterized in that: The storage device comprises at least two reagent container groups, and each of the reagent container groups is provided with a plurality of the reagent container units.

7. The freeze-dried reagent packaging method using the freeze-dried reagent packaging assembly according to claim 1 or 6, characterized in that: The slot plate is made of transparent material.

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